Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MSX2P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:58157026-58159104  UCSC
Coordinates (T2T) chr17:59024923-59027000  UCSC
Coordinates (hg19) chr17:56234387-56236465  UCSC
Strand +
Parental Sequence NM_002449.5
Parental seq. overlap 1869 bp
Parental seq. overlap (%) 84.3%
Genomic Region Intergenic
Retrocopy Summary MSX2P1, located on chr17:58157026-58159104, is a retrocopy of the parental gene MSX2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MSX2
Full Name msh homeobox 2
Also known as CRS2|FPP|HOX8|MSH|PFM|PFM1
Coordinate chr5:174724582-174730896
Strand +
Gene summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Orangutan Pongo abelii MSX2P1
Gibbon Nomascus leucogenys MSX2P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MSX2P1
CTGTTTTCGTCCAATGAGAAGGGGCCAGCGGTGGCGGTCGGGCCAGGTCCGGGGCCTGGGGACGCCGAGGCGGCCGCGGAGGAGCGCCGCGTCAAGGTCTCCAGCCTGCCCTACAGTGTGGATGCGCTCGTGTCGGACAAGAAGCCGCCCAAGGAGGCATCCCCAGTGCCGGCCAAAAGCGCCTCTTCCGGGGCCACCCTGCGGCTACTGCTGCTGCCGGGGCACGGCGCTCGGGAAGCGCACAGCCCCGGGCCGCTGATCAAGCCCTTCGAGACCGCCTCGGTCAAGTGGGAAAACTCCCTAAGACGGAGCGGCGTGGATGCAGGAACCCTGCTGATAATTCGCCGCCGCCAAGACACGTGAGCCCTACCACCTGCACCCTGAGAAAACACAAGACCAATCCGAAGCCGCGCACAGCCTTTACCACGTCCCAGCTCCTCGCTCTGGAGGGCAAGTTGCTCCAGAAACAGTACCTCTCCATTGCAGAGGGTGCGGACTTCTCCAGCTCTCCGAACCTCACGGAGACTCAGGTCAAAATCTTGTTCCAGAACCGAAGGGCCAAGACGAAAAGACTGCAGGAGTCAGAACTGGAAAAGCTGAAAATGGCTGCAAAACCTATGCTACCCTCCAGCTTCAGTCTCCCTTTCCCCATCAGCTCGCCCCTGCAGGCAGCGTCCATATACGCAGCATCCTACCCGTTCCATAGACCTGTGCTTCCCATCCCGCCCGTGGGACTCTATGCCACGCCAGTGGGATATGGCATGTACCACCTGTCCTAAGGAAGACCAGATCAATAGACTCCATGATGGATGTTTGTTTCAAAGGGTTTCCTCTCCCTCTCCAAGAAGGCAGGACCAGCCAATACTCCTGTTCTGCAAACCCTGAGTGCACCACCCTAAGCGGCTAGGCCGGCAGGGCCACACGACACAGCTGAAGTTTGTTCTTTAGGCGGAGGCACCAAGCCTTGTTTTCTTGGTGTAATCTTCCAGGTGCCCCCTTCTCCTTTCACAAAGATTGGCTCTGATGGTTTTaCAGTAGATGTAAAAATTCAAATTATTTTAAAAGGCAAAATTTATATACATATGTGCTTTTTTCCTATATGTCACCTTCTTAAAGAGACTGTGTAAGTCCATTTGTTGTGTTTTCTTAAAGAGGGAGACAAATTATTTGCAAAACTTGCTAAAGTCAATGATTTTGATGGGATGATTGACTTCTGCTTATGGAAAACAAATATTAGAATTGGACATAATGCACATAGAAAGTATTAGATATGGAGAGGTTTTTCAAAGTGAAGGGGACACATCACATTTCTGCATTTTACTTGCATTAAAAGAAACCTTTTTATATACTACCATATTTGTTCCTATCTCTCCCCACGCCCACCCCCCCCCCACACACACATTTTTACAGTTTTACCTTTTTGAAGAATTTTTTTTTTGTAAGACCAATAACCGGGATGAGAAGAATCCTGAGAATGCCTGGAGGTGAGGTAGAAAATTAGAAATACTTCCTAATTCTTCTCAAGGCTGTTGCTTTACTTCATTTCAGATAATTGGAGAGTAAAAAGTTAAAGCCTGTTGGGAGGAGTTGATGGTTTCTGAGAAATACTAGGTACTTTCATCCTCACAGATTGCAAAGATTATTTGGGTGGGGGGGTACAGTAATTTTCTGCTTAAAAAATGAGTACCTTGTAACCATTACCTGTATGCTAAATATTCTTGAACAATTGGTAGATCCAGAAAGAAAAAAAATTATGCTTTCTCTGTGTGTGTACCTGCTGTATATGCTAAACTTATTAGAAAATTTTATATACTTTTTAACATGTCCAGGGCAGAAGATAAAGCCATGTTTTGACTTGGTGAAAATGGAGTTGCCAAACAGCCCATTAAGCTCCCTGGTATTTCACCTTCCTCTCCATCTCTCCCATCCCTCCAGTATGCCTTTACCCCTTTGAAAGGGTGCCTTGTACAATTGTATATATTTTATTGAAGAGTTATTATATCTTATTCTGAATTAAATTAAACATGTTTTATTGCA
>NM_002449.5
GCAGCAAAAAAGTTTGAGTCGCCGCTGCCGGGTTGCCAGCGGAGTCGCGCGTCGGGAGCTACGTAGGGCAGAGAAGTCATGGCTTCTCCGTCCAAAGGCAATGACTTGTTTTCGCCCGACGAGGAGGGCCCAGCAGTGGTGGCCGGACCAGGCCCGGGGCCTGGGGGCGCCGAGGGGGCCGCGGAGGAGCGCCGCGTCAAGGTCTCCAGCCTGCCCTTCAGCGTGGAGGCGCTCATGTCCGACAAGAAGCCGCCCAAGGAGGCGTCCCCGCTGCCGGCCGAAAGCGCCTCGGCCGGGGCCACCCTGCGGCCACTGCTGCTGTCGGGGCACGGCGCTCGGGAAGCGCACAGCCCCGGGCCGCTGGTGAAGCCCTTCGAGACCGCCTCGGTCAAGTCGGAAAATTCAGAAGATGGAGCGGCGTGGATGCAGGAACCCGGCCGATATTCGCCGCCGCCAAGACATATGAGCCCTACCACCTGCACCCTGAGGAAACACAAGACCAATCGGAAGCCGCGCACGCCCTTTACCACATCCCAGCTCCTCGCCCTGGAGCGCAAGTTCCGTCAGAAACAGTACCTCTCCATTGCAGAGCGTGCAGAGTTCTCCAGCTCTCTGAACCTCACAGAGACCCAGGTCAAAATCTGGTTCCAGAACCGAAGGGCCAAGGCGAAAAGACTGCAGGAGGCAGAACTGGAAAAGCTGAAAATGGCTGCAAAACCTATGCTGCCCTCCAGCTTCAGTCTCCCTTTCCCCATCAGCTCGCCCCTGCAGGCAGCGTCCATATATGGAGCATCCTACCCGTTCCATAGACCTGTGCTTCCCATCCCGCCTGTGGGACTCTATGCCACGCCAGTGGGATATGGCATGTACCACCTGTCCTAAGGAAGACCAGATCAATAGACTCCATGATGGATGCTTGTTTCAAAGGGTTTCCTCTCCCTCTCCACGAAGGCAGTACCAGCCAGTACTCCTGCTCTGCTAACCCTGCGTGCACCACCCTAAGCGGCTAGGCTGACAGGGCCACACGACATAGCTGAAATTTGTTCTGTAGGCGGAGGCACCAAGCCCTGTTTTCTTGGTGTAATCTTCCAGATGCCCCCTTTTCCTTTCACAAAGATTGGCTCTGATGGTTTTtatgtataaatatatatatataataaaatataatacatttttataCAGCAGACGTAAAAATTCAAATTATTTTAAAAGGCAAAATTTATATACATATGTGCTTTTTTTCTATATCTCACCTTCCCAAAAGACACTGTGTAAGTCCATTTGTTGTATTTTCTTAAAGAGGGAGACAAATTATTTGCAAAATGTGCTAAAGTCAATGATTTTTACGGGATTATTGACTTCTGCTTATGGAAAACAAAGAAACAGACACAATGCACACAGAAAATATTAGATATGGAGAGATTATTCAAAGTGAAGGGGACACATCATATTTCTGCATTTTACTTGCATTAAAAGAAACCTCTTTATATACTACAGTTGTTCCTATCTCTCCCCCGCCCCCCACCGCCCCACCACACACATATTTTTAAAGTTTTTCCTTTTTTAAGAATATTTTTGTAAGACCAATACCTGGGATGAGAAGAATCCTGAGACTGCCTGGAGGTGAGGTAGAAAATTAGAAATACTTCCTAATTCTTCTCAAGGCTGTTGGTAACTTTATTTCAGATAATTGGAGAGTAAAATGTTAAAACCTGTTGAGAGGAATTGATGGTTTCTGAGAAATACTAGGTACATTCATCCTCACAGATTGCAAAGGTGATTTGGGTGGGGGTTTAGTAATTTTCTGCTTAAAAAATGAGTATCTTGTAACCATTACCTATATGCTAAATATTCTTGAACAATTAGTAGATCCAGAAAGAAAAAAAAATATGCTTTCTCTGTGTGTGTACCTGTTGTATGTCCTAAACTTATTAGAAAATTTTATATACTTTTTTACATGTTGGGGGGCAGAAGGTAAAGCCATGTTTTGACTTGGTGAAAATGGGATTGTCAAACAGCCCATTAAGTTCCCTGGTATTTCACCTTCCTGTCCATCTGTCCCCTCCCTCCGGTATACCTTTATCCCTTTGAAAGGGTGCTTGTACAATTTGATATATTTTATTGAAGAGTTATCTCTTATTCTGAATTAAATTAAGCATTTGTTTTATTGCAGTAAAGTTTGTCCAAACTCACAA

Publications

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