Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name VDAC2P8
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:64112815-64113408  UCSC
Coordinates (T2T) chr17:64983543-64984136  UCSC
Coordinates (hg19) chr17:62190175-62190768  UCSC
Strand +
Parental Sequence NM_001324087.2
Parental seq. overlap 505 bp
Parental seq. overlap (%) 26.2%
Genomic Region Intragenic (ERN1)
Retrocopy Summary VDAC2P8, located on chr17:64112815-64113408, is a retrocopy of the parental gene VDAC2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name VDAC2
Full Name voltage dependent anion channel 2
Also known as POR
Coordinate chr10:75210170-75231448
Strand +
Gene summary This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes VDAC2P5
Bonobo Pan paniscus VDAC2P4
Gorilla Gorilla gorilla VDAC2P3
Orangutan Pongo abelii VDAC2P4
Gibbon Nomascus leucogenys VDAC2P4
Green monkey Chlorocebus sabaeus VDAC2P4
Crab-eating macaque Macaca fascicularis VDAC2P5
Rhesus Macaca mulatta VDAC2P5
Baboon Papio anubis VDAC2P4
Golden snub-nosed monkey Rhinopithecus roxellana VDAC2P5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>VDAC2P8
aAAGTCACCAACTCTAGTCTAATTGGAGTGGGCTACACACAGACTCTGAGGCCTGGTGTGAGGCTCACACTGTCTGCTCTGGTAGACAAGAGATCATCAATGCTGGAGATCACAAACTTGGGTGTGCTCTGGAGGTGGAGGCTTAATCTAGCTGAAAGAAACCTCTGGGAATGGATATCAGAAGATCGGGCCTTAATATATTTCCACTGTGACTAGCAGGCTTTTTTCCCAAGAAGGTGATCCAAAGGATGATCTAAACAAAAGCTGTATTTTAAATATTTTAACAGTTACTGGTTAGTTGGTTCCCTGGCTATCTAGTTACCAGTGCGGCATCATGCAGTGACCTATATGTTTAAGCTGTTAAATGTGCTACCCCCACCAATAATGAGATAGACTTTCATGAGAACTGTGCAGCTGTGTGGATGTTTGTTTTTATGTTCCCTTAACCACTGCATATTGCCATTGAATGAGATGGATCAGTGGATATTTTAGGATGAGGTTAAAAACATTTTATTAAATTCAACCATGATTCACATTACTTTTGCTATCCTAGACCATTACAAATTATGAATAAAACAAGTATACATAA
>NM_001324087.2
CTCTCAGGCACACAACCCAGCACAGCAAGGCAGTCACACCAAGGCGGTCCCCAGCGCGCTGCCTCCGCCGTTCCCCGCCCCCTCGCCTCTGAGGCTGCCCGGATAGCTGCCTGATCCAAGGCCCAGCAGCTTCTGCCTTCCGGATCCCCACCGACGGACGGAGGCAGCCCACCTGCAGGACCGGGGCGCTGTCGGTCCACGTGGCCGCTCTGGAGCAGGTTGGAGTTGGCAGCGGGCTGCGCTGCAGGGACAGGCGCGGCGGACAGCCCCGGGGGCAGCGGCGGGGTCCTGTCTGGGAGAGGACAGGGTTGCGGCGGGCGGAACGGTGTCTCCTTCACTTCGCCCTCCAGCTGCTGGAGCTGCAGCCCGACCGCGAGCGTGCCAAGCGGCTTCAGCAGCTAGCGGAGCGGTGGCGGCGGCCCCCCTCAGGACACCACCAGATTCCCCTCTTCCCGCGGCCTCGCCATGGCGACCCACGGACAGACTTGCGCGCGTCCAATGTGTATTCCTCCATCATATGCTGACCTTGGCAAAGCTGCCAGAGATATTTTCAACAAAGGATTTGGTTTTGGGTTGGTGAAACTGGATGTGAAAACAAAGTCTTGCAGTGGCGTGATATCACAATTTCTGGCTGTAGTCTCTTTATTATTTTCACATCAGCTGTCTTCCTTAGGCTTggcgtggtgatgcttgtgatcccagctactcaggaggctgagGAATTTTCAACGTCCGGTTCATCTAATACAGACACTGGTAAAGTTACTGGGACCTTGGAGACCAAATACAAGTGGTGTGAGTATGGTCTGACTTTCACAGAAAAGTGGAACACTGATAACACTCTGGGAACAGAAATCGCAATTGAAGACCAGATTTGTCAAGGTTTGAAACTGACATTTGATACTACCTTCTCACCAAACACAGGAAAGAAAAGTGGTAAAATCAAGTCTTCTTACAAGAGGGAGTGTATAAACCTTGGTTGTGATGTTGACTTTGATTTTGCTGGACCTGCAATCCATGGTTCAGCTGTCTTTGGTTATGAGGGCTGGCTTGCTGGCTACCAGATGACCTTTGACAGTGCCAAATCAAAGCTGACAAGGAATAACTTTGCAGTGGGCTACAGGACTGGGGACTTCCAGCTACACACTAATGTCAATGATGGGACAGAATTTGGAGGATCAATTTATCAGAAAGTTTGTGAAGATCTTGACACTTCAGTAAACCTTGCTTGGACATCAGGTACCAACTGCACTCGTTTTGGCATTGCAGCTAAATATCAGTTGGATCCCACTGCTTCCATTTCTGCAAAAGTCAACAACTCTAGCTTAATTGGAGTAGGCTATACTCAGACTCTGAGGCCTGGTGTGAAGCTTACACTCTCTGCTCTGGTAGATGGGAAGAGCATTAATGCTGGAGGCCACAAGGTTGGGCTCGCCCTGGAGTTGGAGGCTTAATCCAGCTGAAAGAAACCTTTGGGAATGGATATCAGAAGATTTGGCCTTAATATATTTCCATTGTGACCAGCAGCAGGCTTTTTTCCCCCAAGAAGATGATCAAAACAAAGGATGATCTCAACAAGAGCTGTATTTTAAGTATTTAGACAGTTCTTTGTTAGCTGGTTTCTAGTTGGTTATCTAGTTACCAATGCTGCAGTCCTGCAGTCACCTATACATTATTTAAATGTATTTAACTGTTAAATGCGCTACCCACCAATAATGAAATAGACCTTTATGAAAACTGTGCAATTGTGTGCATGTTTGTTTTTATGTTCCTTTAGAAAACATTGACTGTTACCATTGAATGAGATGGATCAGTGGATATTAAGATGAGGTTACAAATTTTGTTAAGTTCAGCCATTATTACTTTTGGTATCCCAGAACATGACAAATTATGAATAAAACAAGTATACATAA

Publications

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