Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DCTN6P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:65654917-65655763  UCSC
Coordinates (T2T) chr17:66525537-66526383  UCSC
Coordinates (hg19) chr17:63651035-63651881  UCSC
Strand +
Parental Sequence NM_006571.4
Parental seq. overlap 787 bp
Parental seq. overlap (%) 74.6%
Genomic Region Intragenic (CEP112)
Retrocopy Summary DCTN6P1, located on chr17:65654917-65655763, is a retrocopy of the parental gene DCTN6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DCTN6
Full Name dynactin subunit 6
Also known as WS-3|WS3|p27
Coordinate chr8:30156369-30183639
Strand +
Gene summary The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DCTN6P1
Bonobo Pan paniscus DCTN6P1
Gorilla Gorilla gorilla DCTN6P1
Orangutan Pongo abelii DCTN6P1
Gibbon Nomascus leucogenys DCTN6P2
Green monkey Chlorocebus sabaeus DCTN6P1
Crab-eating macaque Macaca fascicularis DCTN6P1
Rhesus Macaca mulatta DCTN6P1
Baboon Papio anubis DCTN6P1
Golden snub-nosed monkey Rhinopithecus roxellana DCTN6P1
Marmoset Callithrix jacchus DCTN6P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DCTN6P1
ACTCGGACAGCGATCCATCCTAAAGCACAAATTATTGCGGAAGCCGGGCCAATAGTGATTGGCAAAGGGAACCTGATAGAAGAACAGGCCCTTATCATAAATGCTTCCTCGGATAGTATCACTCTTGACACTGGAGATCCAGAACCAAAACCTATGATCATTGGCACCAATAATGTGTTTAAAGTTGGCGTCATTCCCAAGCCATGGAGATGGGAGATAATAATGTCATTGAATTAAAAGTGTATGTAGGCAGAAATCTAATATTGACAAGTGGCTGTCTCACTGGCGCTTGTTGCAACCTAAACACTTTTGAAGTCATCCCGGAGAATACGGTGATCTATGGTGCAGACTGCCTTTGTTGGGTGCAGGCTGAGCGACCGCAGCCTCAGACACTACAGCTGGATTTCTCGATGAAAATCTTGCCAAATTACCACCACCTAAAGAAGACTACGAAAGGAAGCTCAACTCCAGTAAAGAACTAAGAACAGTACATGACATGAAGATAACATTTTGTCTTTGACTGCTGTCTTTTGAATGGGCCACAGTGTTTATGTACTCTTAGCAGCTCACAGAATAATACATGTTGACTTTATTTTGTAAAATTGGGTTGAGAGGAAAGTAATGGATTTTCATTGTAACTGTCCTTTATAATTCATGTAAAATGTATTATTTTCCTTTATCCTTGCTTCTTTTCTGATAATTTACAGATTTAGCTTTTCTTTTGTTATATAAACTGCTAGCCACAAATTTTAGTTATGTAAAAGACTACCCATTACAAGAAAGGACATATTGTTATGTATTTATATTCTGGCATAAGCTAAACTGAATAAAAATACTGGTAACAGGA
>NM_006571.4
AATTGGGGCCGTACCATGGCGGAGAAGACTCAAAAGAGTGTGAAGATTGCTCCTGGAGCAGTTGTATGTGTAGAAAGTGAAATCAGAGGAGATGTAACTATCGGACCTCGGACAGTGATCCACCCTAAAGCAAGAATTATTGCGGAAGCCGGGCCAATAGTGATTGGCGAAGGGAACCTAATAGAAGAACAGGCCCTTATCATAAATGCTTACCCAGATAATATCACTCCTGACACTGAAGATCCAGAACCAAAACCTATGATCATTGGCACCAATAATGTGTTTGAAGTTGGCTGTTATTCCCAAGCCATGAAGATGGGAGATAATAATGTCATTGAATCAAAAGCATATGTAGGCAGAAATGTAATATTGACAAGTGGCTGCATCATTGGGGCTTGTTGCAACCTAAATACATTTGAAGTCATCCCTGAGAATACGGTGATCTATGGTGCAGACTGCCTTCGTCGGGTGCAGACTGAGCGACCGCAGCCCCAGACACTACAGCTGGATTTCTTGATGAAAATCTTGCCAAATTACCACCACCTAAAGAAGACTATGAAAGGAAGCTCAACTCCAGTAAAGAACTAAGAACAGTGTATAACATGAAGATAACATTTTGTCTTTGACCACTGTCTTTTGAATGGGCCCACAGTGTTTATGTACTCTTAACAACTCACAGAATAATACATGTTCACTTTATTTTGTAAAATTGGGTTGAGAGGAAACTAATGGAGTTTCATTGTAACTGTCCTTTGTAATTTATATAAATGTATTATTTTCCTATATCCTTGGTTCTTTTCTGATAATTTACAGATTTAGCTTTTCTTTTGTTATATAAACTGCTAGCCACAAATTTTAGTTATGTAAAAGGCTACCCTTGACAAGAAAAGACATACTGTCATGTATTTATATTCTAGCATAGACTAAACTGAATAAAAATGCTGATAACAGGACCTTTAGTAAGCATACTTTAATCAGTTTTTCTCCTTGAATTAATCTTTTCTCTTAATTTTTATTATGTACTAGTTGTATTAAAGCTAATGTGTTTACTTTT

Publications

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