Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBXO36P1
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:68095067-68096490  UCSC
Coordinates (T2T) chr17:68971861-68973284  UCSC
Coordinates (hg19) chr17:66091208-66092631  UCSC
Strand +
Parental Sequence XM_005246317.2
Parental seq. overlap 1100 bp
Parental seq. overlap (%) 29%
Genomic Region Intergenic
Retrocopy Summary FBXO36P1, located on chr17:68095067-68096490, is a retrocopy of the parental gene FBXO36. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBXO36
Full Name F-box protein 36
Also known as Fbx36
Coordinate chr2:229922503-230013913
Strand +
Gene summary Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FBXO36P1
Bonobo Pan paniscus FBXO36P1
Gorilla Gorilla gorilla FBXO36P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FBXO36P1
AGAGGTAATCTTTGGATGGTGGAAGATCTCTCTAAGGAGTGAGTATTGATCAACAAAACCTGGAGAAGCAAAAGAAACCCACAAAGACTTCCTAGAGAATTTACATCTTCAAGGTCAAACTGCCTTAATATTTGGTGCAAGAATATTAGACTATGTTATCAATTTGTGCAAAGGTAAATTTGACTTCCTTGAACGGCTCTCAGACGATTTGCTCCTGAATATCATTTCTTATCTGGATCTTGAAGATATTGCTAGGCTTTGTCAAACATCACACAGATTTGCAAAGGAGGAAGTCAGGACACAGAGGGCCACAGCACAACAGGGCTGGCCAGGGCTGGTGGGCAAAAGTTAACAGAAGAATAGAATATCTTCTACATTCAAGACCAAGAAGTGCTCACACCTTGCAGGAATTGGAGAAGCTGTGCATGTCTGATAAACTGTGGGAACAGATAGTCCAGTCGATCTGCGACACCATCACTCCTGACGTGAGGTCCCTGGCGGAGGACACGGGCTGGAGACAGCTGTTCTTCACCAACAAGCTCCAGCTCCAGCGGCAGCTCCGCAAGAGGAAACAAAAATATGGAAGCTTGAGAGAAAAGCAACCTTAGGCACACATTTTCCTACCAGCAGGGAGCTGAGGCATGGCTGTGTTTCTCTTCGGTGTCCAAATCTCTTCCGTCTCCTTTTCTTAAGAACTAAGAGGTTTTGCTGGTGCATGGAGCCATTTGTAACTCATAGAGGATTTGCACACAAATGCAGCAGAATCTGGCTTCCCAGTGCCTTGCTAGAGTCACCATCATTCTGAGGTCAAATCATGGCCTGAGGACAAGGGCTGTAAGACAGGGAGCCCCATAGGCCATCATCGTCCTTATCCCACACTCATTAAAAAAGAGTGTTTTTAAATGATTGTTTTAATGTTTGTTTTAATTGTATATAAACAAACAATAAATGATTATTAGCAGGTTTTTATTAGACATCTATTTTATCTAGGCATTGGAAAGGGTAATGGGGCTTTTACTTTTTTTCCTGGCGTTGTGTCATCTGAGTCCAGCCATGAAGCTGGTGCCTGAGTGTCCCCACCAGGAACCGTGAAGGGCAGGTACCACAGGAGGCACAAGGGGTGAGTGCAGTTGCCTTCCCAACTTTGTTCTGCTAAGTCCATATTCAGGGCCCTGTCCTTGTGGGCCCAGGACGCCAGGCTCCATCCCCGCATGTGGACAGCTTCCGACCTGGCGCTGGGGCATGACTGGAGAAGTGCAGGAATACTGCTTGCGGACCTTGCTCAAAGTACAACTTCCCAGGACTACTTCACATTGT
>XM_005246317.2
ggttcccgggttcaagcgattctcctgcttcagcctcccaagtatctgggattacaggcatgagccaccgcgcccggcCCAACAGATACAACTTTCTACCTCGTAATAATGTTTCAAGGATTATATGAGGTAATCTTTAGATGGTGGAAGATCTCTCTAAGGAGTGAGTATCGATCAACAAAACCTGGAGAAGCAAAAGAAACCCATGAAGACTTCCTAGAGAATTCACATCTTCAAGGTCAAACTGCCTTAATATTTGGTGCAAGAATATTAGACTATGTCATCAATTTGTGCAAAGGTAAATTTGACTTCCTTGAACGGCTCTCAGACGATTTGCTCCTGACTATCATTTCTTATCTGGATCTTGAAGATATTGCCAGGCTTTGTCAAACATCACACAGATTTGCAAAGCTGTGCATGTCTGATAAACTGTGGGAACAGATAGTCCAGTCGACCTGCGACACCATCACTCCTGACGTGAGGGCCCTGGCGGAGGACACAGGCTGGAGACAGCTGTTCTTCACCAACAAGCTCCAGCTCCAGCGGCAGCTCCGCAAGAGGAAACAAAAATATGGAAACCTGAGAGAAAAGCAACCTTAGGCACACATTTTCCTACCAGCAGGGAGCTCAGGCATGGCTGTGTTTCTCTTCAGTGTCCAAATCTCTTCTGTCTCCTTTTCTTAAGAACTAAGAGGTTTTGTTGATGCGTGGAGCCATTTGAAACTCGTAGGGGATTTGCACACAAATGCAGCAGAGTCTGGCTCCCCAGTGCCTTGCTAGAGTCACCGTCATTCTGAGGTCAAATCATGGCCCGAGGACAAGGGCTGTAAGACAGGGAGCCCCATAGGCCATCATCATCCTTATCCCACACCCATTATAAAAGAGGTTTCTATTGTATATAAACAAACAATAAATGATTATTAGCAGGTTTTTATTAGACATCTATTTTATCTAGGCATTAGAAAGGGTAATGGGGCTTTTGAATTTTTTCCTGGCATTGTGTCGTCTGCGTCCAGCCATGAAGCTGGTGGCTGAGTGTCCCCACCAGGAACTGTGAAGGGCACGTACCACGGGAGGCACTCAGGGTGGGTGCAGCTGCCTTCCCAACTTTGTTCTGCTAAGTCCATATTCAGGGCCCTATCCTTGTGAGCCCAGGATGCCAGGGTCCATCCCCGCATGTAGACAGCTTCCGACCTGGTGCTGGAGCATGACTGGAGAAGTGCAGGCATCCTGCTTGCGGACCTTGCTCAAAGTACAACTTCCCAGGACTACTTCACATTGTTAAATAAACCTATAAACAtttcttttcttttctttttttttttttttttgtattttctttttagtagaggtggagtttcgccatgtaggccaggctggtcttgaactcctgacctcaagtgatctacctgctctggcttccaaagtgctgggattacaggcatgagccactatgtctggcTAAAACCTATAAACATTTCTTAGAGAAATGCTGTTCCCCAAAGGAATGTGAACAGCTACCACTTTTAACAAGGATATTTAAGAAAACAGACTATGAGTTAACTAAGTAAAAATGTAAATATGGTTTGCATGCTGTTAACATGGCAGAGGGGTAAAAAGAATACAGTCCTGGGGAGAAAGGTCACTTCACTGAGAAGGCTTACTTAAAAATGTTTTTCTCCCTGCACTTTCATGATTATTAAGTACCCCTAGAAAATGAACTCATAGCAGCAAATAATCTAATGACTCCTTTTAGGTTACAGAGCAAAGTAGCTTTCTACTTCCACATCACATTATAATATAGCCTTATAATTTCTTCTTTCCTGCAACCTTCACTTTCCTACCTAGGAAAACTCACCTCCGGTGCCAGAGAAACTTCCCAGGATGCACTAGGGCCCTGTGAACAATACAGAAGTTGTGGACTCTGGCTCTTTGTCCCACCTAAGTCCTTCCAGAAGGGCTCTACAGCATGGCTTAGTGACATTAAAAAAAAAAACTGAACCCATGTTAATATCAAACAAGATTTTAATCTTCATTCACACACCCTTAAAACCCAGTCACGGGGCTCCCCGGTGCCAGTTTGAGACCGTCAACCTAGCCCTCTCTGCTTCTCATTGCTGGAGGTACACACAGTCAAAAGTTTTCCGTGACTGTGAAATCCAGTGCAATCTGCTTCCCAGCAGATGAGGAGCCTGACGTGGTTATGTCTGGATTTAGTCCAAGAACAGAGCAAAGCTTTAATTGTCAAGAGACCCAGGCCTCATTCTCCACTTAGGAGAGTTTGCTAGGGCAGGTACAGGTAAAGGTAACCAGCAGGCAGCTGAGAGCAAGAAGGCACGTGCTCTGCAGAGCTCTAGCTGCCTTGGCTCTCCCTGAGCTCCCAGACTTCACTCATGGCCTAATTTTCAATGACAGAACGTAGGTTTTATCGTGAGGATGCAGACACAACCACAATTACGTATGTCAACATAACTTCATAAATATGTAACTGTAACTTATTGGTAACATCAGTGCAAGATGATTAAAGCTTCATGTGTAGTATTTTATCAACAAACAGATTCTGAAAGCTTATGGACATGCGCAATAGTTGATTCAGCTTCAATCAATAAGAACATAAATATGGCAATTTGAAAACACtatgtatatacctactcacatatatattatacttacgatatatacttatatgtagtatataataatattacatataaaaatgttataaaaataaatGCTAAAGTAAATAAAAAAAGAGCCATTAATATGTTAACTATTGTTAAATAATAGCTAAAATAATACAGATTATTAAATTATTTTAATACTTACTTGCCATAATAATCTGAGTGCCTTATTACTTGATTACAATTGTTTTTGCCAAAATAGGAACAATATCATCAAGTGAACATCCTGTGTCTCCCCAGCATCCTCAGTGGTTGAAACACTTTGTCCCTCCCTCCCCCATCTCATTTTCCATGTGAGGTTCCATGTGACGATCCCATAACATGGTAATAGGCAGCGATGGTCTTGACTTTCTGCTTCTATTAACAGCTTTCATTTCTATTTCTGCTTTCATGTGGATGGATAAATCTGCTTTATGTCTTAACATTTCAGAGTGAAATGCCACACAAtttttttttttttttttttttgaggcagagttttgctcttttcacccaggctggagtgcaatggtgcaatctcagttcatggaaccctccacctcctgggttcaagtgattctcctgcctcagtttcccgagtagctgggattataggagcctgccacaatgccctgctaatttttgtatttttagtaaaaacagggtttcaccatgttggccaggctggtctcgaactcttgacctcacgtgacctgcccgcctcagcctcccaaagtgctggaattacaggtgtgagccacgctgcccagccTTACAGCATTTTATAATCTTGTCCTTTTTCATCTTTTCAATCAACTGTGTTTCTACTCTGTTCTCATTTACCATTGTAATTATACAATACTGAAAATTTCCAATGGTTTATATATTTAGTGGTATAAGAACAATCTATTAACAATAGAAAATACATATTTTTAATTTATAACTAAATAATAAACATATTTTACTTAA

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