Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SH3GL1P3
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:68133598-68135638  UCSC
Coordinates (T2T) chr17:69010390-69012430  UCSC
Coordinates (hg19) chr17:66129739-66131779  UCSC
Strand -
Parental Sequence NM_003025.4
Parental seq. overlap 1797 bp
Parental seq. overlap (%) 70.1%
Genomic Region Intergenic
Retrocopy Summary SH3GL1P3, located on chr17:68133598-68135638, is a retrocopy of the parental gene SH3GL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SH3GL1
Full Name SH3 domain containing GRB2 like 1, endophilin A2
Also known as CNSA1|EEN|SH3D2B|SH3P8
Coordinate chr19:4360369-4400547
Strand -
Gene summary This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Homology

Species Scientific Name Retrocopy
Baboon Papio anubis SH3GL1P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SH3GL1P3
GGTCTGGGCGGAAGGTTCCGCGGCAGGAGGCAGCATGTCGGTTGCCGGGCTGAAGAAGCAGTTCTACAAGGCGAGCCAACTGGTCAGTGAGAAGGTCGGAGGGGCTGAGGGGACCAAGCTGGATGATGACTTCGAAGAGATGGAGAAGGTGGATGTCATCAGCAAGGCGGTGACGTAAGTACTGTCCAGGACCATCGAGTACCCGCAGCCCAACCCAGCCTCGCAGGCTAAACTGACCATGCTCAACACCGCGTGCAAGATCCGGGGCCAGGTGAAGAACCCCGGCTACCTGCAGTCAGGGGGGCTCCTGGGCGAGTGCCTGATCCGCCATGGGAAGGAGCTGCGCGACGAGTCCAACTTCAGCGATGCACTGCTGGATGCCGGCGAGCCCATGAAGCACCTGGCAGAGGTGAAGGACTCCCTGGACATAGAGGTCAAGCATAACTTCATTGACCCCCTCCAGAACCTATGTGAGAAAGACCTGAAGGAGATCCAGCACCACCTGCAGAAGCTGGAGGGCCGCCGCCTGGACTTTGACTAAAAGAAGCGGCAGGGCAAGATCCCCGAAGAGGAGCTGCACCAGGCGCTGGAGAAGTTTGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACCGACATCCAGTAGGTGAGTCAACTCCCGGCCTTGGCAGAGGCGCAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACCAGCTGGCCCAGAAGTTCAAGTGCAGGATCCGGGAAGCTTCCTCACGACCCAGGCGGGAGTATAAGCCCAAGCCCCGGGAGTGCTTTGACCTCGGAAAGCCTGAGCAGTCCAACCGGGGCTTCCCCTGCACCACAGTCCCCAAGATCGCAGCTTCGTCCTCTTTCCGATCTTACGACAAGTCCATCTGGACTCCTAGCAGGAGCATGCCGCCCCTAGACCAGCCGAGCTGCAAGGGCTGTATGACTTGGAGCCGGAGAAAGATAGGGAGCTGGGCTTCCATGAGGGCGATGTCTTCATGCTGATCAACCAGATGAACGAGAACTGATACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCTGCTCAGCTATGTGGACGTGCTCGTGCCTCTGCCCAGTGACTCAGGGGCGCCCCCGCCCTGCCCCTCCATCCACACTGGGTGGCACCCCCTGCTGGGTATCCTGCCTTCCACGGGGCCCCTGCTGCCAGGGCAGTGTCCAAGCCTGCTGGCGCCACCCAGGCCGGGGCCCTTGAGGTACTCCCTGAGCAGGGCTCCACACTTGGGTGGGGGGCTTATCTGGGTGGGTGGAGATGCTCGTTTACACTAGCGGCTGATCCCCAACAGTGACGGCTCCCTTCCCCACTCCATGGCGCCGGCCTCCTCCCCGCTCCCCAACTCCTTGCCCAGCTGGCTGAGGCAGAGCAACACTAAGGTGCTCTCAGAAACACTAACGTTCCTCCAGGGCAGCCCCCACACCTCCATCCTGAACCCACGGTGGCCCAGCCCACTGCCTACCCTCGAGTTCCACGGCCTTAACAGGCTTGGATCAAGCGTCCCTGTGGGGTGGCTCAGAGACAGGACTCTGGTTTTAAATCCTCCCCGCGCCTGGTGCTGGCGATGAGCCCTAGCCCCACTCCAGGGCCACTGTATCCCAGCCTCACACATGCACTCCTTCTCCCCAAGGCCAGGGCAGAAGGCCTCACTGCTTCCCTGGCCTGCTGTCAGCTTGCAGCCCAGGGACAGGGGCCAGTTGGGATCTGCCCCACCTTCCCCCCCCCAACACCTCCCCCCTCCTAACCAGGACAGAGAACATGACGTCCTGCAGGGCCCCGCCTCCCAAGCCTTGCCCTCACAAAGCCAAGTACCTTTTCGGCTTTTTAACTGCCCCCAGCCAGGCCCACAGAAGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCTACACAACCCTCAGCACACCTTGCACGGGACCACAGCCCCAGCTGTGCTGCTGAGGGCCAAGCACAAAGGCTCCAGTGAGCA
>NM_003025.4
AATATCCTGGCCGCGCGGGCGCGCGAGCggctgaggcggcgccggggcgggcgcggagctggcaagcgggtggcggaggcggcgccgacggggactgctgaggcgCGCAGAGGGTCGGCGGCGCCCGGGAGCCTGTCGCTGGCGCGGTCCGGGCGGGAGGCTCGGCGGCGGGCGGCAGCATGTCGGTGGCGGGGCTGAAGAAGCAGTTCTACAAGGCGAGCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGAGGGGACCAAGCTGGATGATGACTTCAAAGAGATGGAGAAGAAGGTGGATGTCACCAGCAAGGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCGGGCTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGGTGAAGAACCCCGGCTACCCGCAGTCGGAGGGGCTTCTGGGCGAGTGCATGATCCGCCACGGGAAGGAGCTGGGCGGCGAGTCCAACTTTGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGCAGAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCCAGAACCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCGCCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCAGGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCTGGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTACCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCGGGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCCAAGCCCCGGGAGCCCTTTGACCTTGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGCTTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCcgccCCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCTGGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGAGGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCCCCTGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACCCCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGGCGGTGTCTGAGCCTGCCGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTGGGGGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTGACGGCTCCCTTCCCCACTCCATGGCGCCAGCCTCCTCCCCCGCTCCCCAACTTCTCGCCCAGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGCAGCCCCCACCTCCGTCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCGCAGCCTTAACAGGATGGGATCGAGGGTCCCCATGGGGTGGCTCAGAGATAGGACCCTGGTTTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGCACCCCCGCCTCACACACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCTCCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGACAGAGGCCAGCTGGGATCTGCCTGAGGACAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGTACCTTTTCAGCTTTTTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCACAAGCTGCCACCACCAGCCACCCACACCCACCCCAGCACACCTCACACGGGACCACAGCCGCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCCAGGCTCCCCTTGCTGAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCCTCTAGACCAAGGCAGGCAGCCCCGACATCTGCTTCCTCTATCGCCCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTGAAGCCTCCGGACCCCAGgctctgctctgccctgccctgcacccccctCGTCAGAAGTACATGAGGGGCGCAGAGATGAGCACACAGCTTTGGGCACGGTCCAGGGCAAACTGAAATGTACGCCTGAATTTTGTAAACAGAAGTATTAAATGTCTCTTTCTACA

Publications

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