Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPICP6
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:6927464-6928085  UCSC
Coordinates (T2T) chr17:6828165-6828786  UCSC
Coordinates (hg19) chr17:6830783-6831404  UCSC
Strand -
Parental Sequence NM_152323.3
Parental seq. overlap 518 bp
Parental seq. overlap (%) 42.4%
Genomic Region Intergenic
Retrocopy Summary SPICP6, located on chr17:6927464-6928085, is a retrocopy of the parental gene SPIC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPIC
Full Name Spi-C transcription factor
Also known as SPI-C
Coordinate chr12:101475276-101486997
Strand +
Gene summary The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SPICP5
Bonobo Pan paniscus SPICP5
Gorilla Gorilla gorilla SPICP4
Orangutan Pongo abelii SPICP4
Gibbon Nomascus leucogenys SPICP2
Green monkey Chlorocebus sabaeus SPICP1
Crab-eating macaque Macaca fascicularis SPICP1
Rhesus Macaca mulatta SPICP2
Baboon Papio anubis SPICP2
Golden snub-nosed monkey Rhinopithecus roxellana SPICP4
Marmoset Callithrix jacchus SPICP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPICP6
CATGTCAGAGGAGATTCCAACTGCTATGGAATGTTGCTTACAGAGGAATCTATTTATAATTGGAGAACTTTAATAAATAATGCTGCAGACTTCTATTTTGAAGGAACCATTCATTGATCTTTGTGGAACATAACTGAAAGCCAGCTGGTGCAGTCTGCTGTTTTCCAGCAACAGGGAGGACAAGGCGGGAAGCTTCTCTGACTGTTTGAATAACTTCACAAATCTCAGTATAATCCCAAGATGGCATCTGCATTCAGTAAGTAGATAAAACCAAAGGCAGTTTCCAGTTTGTATCAAAAAATGAAGAAAAATTTGCCAAACTTTGAGGAATAAGAAAGGGCAATAGGAAGACCATGGTCTATCAGAAAATGGCCAGGGAACTGAGGAATTATGGAAAAACTCAGGAAATCAACAAAATCTGGAGAAAGCTCATTTACCAATGAGCTTCAGTGGGGCCATTCTCTGAAGATCTCTCCATCTTGTTTCTCTGAGAAAGAGATCGTCTACTCACAGTATGTTCAACTGATCAAGAACATCTCAGTTTAAGTAATTGGAATGCAAACTAAAATTTTACATATGCCAGTTACCATGAGCTTAGTCACCATGATTGCTAAATATACTC
>NM_152323.3
GATGGTTATGTCTTAACAATTCTAATTTTTAAAAAAAATATTACTATTTTTTTTCATCAGAGCCATTGCACTGGAAAATAATTTTTTATTTTCATGATAGCCTACCGTTGAATTTACCGTTCTGATATTAATGAAACATCTCTATAAAGGGTTGAAGTGTCTTCCCGGATTGTCAACTTATTTTATTTTATTTTCTTCAAGCAACAATTGCTAAGGAACAGAATTGTCAATTTATTAATGAAATATGACGTGTGTTGAACAAGACAAGCTGGGTCAAGCATTTGAAGATGCTTTTGAGGTTCTGAGGCAACATTCAACTGGAGATCTTCAGTACTCGCCAGATTACAGAAATTACCTGGCTTTAATCAACCATCGTCCTCATGTCAAAGGAAATTCCAGCTGCTATGGAGTGTTGCCTACAGAGGAGCCTGTCTATAATTGGAGAACGGTAATTAACAGTGCTGCGGACTTCTATTTTGAAGGAAATATTCATCAATCTCTGCAGAACATAACTGAAAACCAGCTGGTACAACCCACTCTTCTCCAGCAAAAGGGGGGAAAAGGCAGGAAGAAGCTCCGACTGTTTGAATACCTTCACGAATCCCTGTATAATCCGGAGATGGCATCTTGTATTCAGTGGGTAGATAAAACCAAAGGCATCTTTCAGTTTGTATCAAAAAACAAAGAAAAACTTGCCGAGCTTTGGGGGAAAAGAAAAGGCAACAGGAAGACCATGACTTACCAGAAAATGGCCAGGGCACTCAGAAATTACGGAAGAAGTGGGGAAATTACCAAAATCCGGAGGAAGCTGACTTACCAGTTCAGTGAGGCCATTCTCCAAAGACTCTCTCCATCCTATTTCCTGGGGAAAGAGATCTTCTATTCACAGTGTGTTCAACCTGATCAAGAATATCTCAGTTTAAATAACTGGAATGCAAATTATAATTATACATATGCCAATTACCATGAGCTAAATCACCATGATTGCTAAATATACTTTCATATTTCATGGTTTACTGGCATCGGAAATCTCTACAAGTTTTAATGATTTCTCCCTCCCTCTCTTTTTTTCCTCCTCTGAAGAAATTTAGGATTTTTCTCTTAAAGCAAATACTAAAGAGGAAAAAAAATTAACTTTATTGTTGCTTTTATCAAAGAGTATGTAATCTATACTAACTTGTTGGGAAATTCTGCCAATGAACAACTTTTTTATAATA

Publications

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