Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COX20P3
Plot displaying the genomic locations of a retrocopy (in chr17) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr17:76595566-76595775  UCSC
Coordinates (T2T) chr17:77492271-77492480  UCSC
Coordinates (hg19) chr17:74591648-74591857  UCSC
Strand -
Parental Sequence NM_001312873.1
Parental seq. overlap 184 bp
Parental seq. overlap (%) 7.8%
Genomic Region Intergenic
Retrocopy Summary COX20P3, located on chr17:76595566-76595775, is a retrocopy of the parental gene COX20. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COX20
Full Name cytochrome c oxidase assembly factor COX20
Also known as FAM36A|MC4DN11
Coordinate chr1:244835306-244845063
Strand +
Gene summary This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COX20P2
Bonobo Pan paniscus LOC100992118P2
Gorilla Gorilla gorilla LOC101143171P2
Orangutan Pongo abelii LOC100442587P2
Gibbon Nomascus leucogenys LOC100606669P1
Crab-eating macaque Macaca fascicularis LOC102125892P2
Rhesus Macaca mulatta COX20P2
Baboon Papio anubis LOC101019361P2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104654195P3
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COX20P3
GGTAGAATTAGAAGATCATGTGACGTTGGAGTAGGGGGATTTATCTTGGTGACTTTGGGATGCTGGTTTCACTGGAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATTGCCAGAGAAGGAATGAAAACTAAGATCTATGAAAGTACTCACCTTGAGCCTGAAAGAAAAGAAACCAACAGCAACAGCGGCAATCGAACAAt
>NM_001312873.1
GCTGTGTGCCGAGCTTGGAAGAAAGTGTGACCCGTTCGACGGAACAAAGGACATGACAGCCCGGCCCCGTGCGGCCACTGCGGAGCGTTAGGAACATTCCCTAAAATGGCGGCCGGCGCGTCGGAACAGGGCGGGAGGCGGCGGCGCGTGGGGGCGGGACGGGGAGGGGCGCGGCCAGCCGGGCTTCTGCTTCCGCGACCCCGGCGGTGCAGGGCGGGTGGAGTCGCGGAGTAGTCCTCATGGCCGCCCCGCCGGAGCCCGGTAGAATTAGAAGATCATGTGATGTTGGAGTAGGAGGGTTTATCTTGGTGACTTTGGGATGCTGGTTTCATTGTAGGTATAATTATGCAAAGCAAAGAATCCAGGAAAGAATTGCCAGAGAAGAAATTAAAAAGAAGATATTATATGAAGGTACCCACCTCGATCCTGAAAGAAAACACAACGGCAGCAGCAGCAATTGAACAATCTTGAGCATAGAAGTCAATGTAAACGAAGTTAAGATCAACCACATAAAACATTTCATGTGCAATAAGCTCTCAATCAAGTAAATAAAGTTTAAGTTGTAGTCATTTTTTTCCCACACTTGTGTGGAATGAAAACTTGCCAGTTTATTCTGGCCCTGTGTCTACTGCCAGGATAGCATTCTTACGTGTTACATATAGTGGACTTGTCATCCTTAAAATGTGAACAGAATTTATTGGCAGTGTGGCAAAGAATTATAAAACATAGTGTTTAATGTACTTGGAGTTTCCTTGTAGTAGTAAGTATAGAGTTTGATGATAAGTAAACGTCCCTTAACAAAAACCTCAACCTTATTACTATCCCATTAAAAAACAGCAAATACTTACTGAGTTCTTGTAAGAGCTAATGTCATTGTAAGATTTAAAACTAAGGGCTTTTATCACTTTGCAAATTATTTTTTAAATGCATTCATCATTTGACAGTGTTCTCTCATTTCTTAAAATGCGAGTCATCTTCCAAAAGAGTTGTTTTTAACTGCCCTAAACATTTTTGGGGAAGTATGCAGGGTTTAAATTTTTAAGTATAATTAGTTCTGAATTAAAATATGCACATGGAACTTGTCTGGCAGACTGATGCAATAGTAAAACAACTGCAGAATTACTATTAATGTAAACAATCCATTTGAAAGTCAATCAGCTGCTCCCATTAAAATATTATTTAAAATACAATACCCACAGCATCTAACTAAATCCTCAGGATTTATTCTCCGGGAGAAATTATCCCTTTCTAGGAAAATGAAGTTATTTCTGGTTTTAATTCATACAATACTTTAAGAAAATCTGTTAAATATAACAAAACACAAGCTAGATGCTTAAGAAATGCTTAAAGAAATATTGGGGCGAAGGTAACAGCAGTCAACAGGATTGTGGCCATTACTGGTCCTATTATTTTGATGTACCATGGAAGGCACAGAAATCGAGCAAGGAAGAAAATATTAGTTATTTTGATCTACATCTTTTTCTAAAGAAAAGTGGAGCTTGCCTCCAGTTCAATTCACAAGAGCATTTTCCCTCCCATGCCCACCTTTTCTTGTGGCTGTCGCTAGGAAGGATGCAGAGGCTGTGTGGTTTACCAAATGCCTTAACTTAGCAGTGAATGACAACTGTCAAACACATGTTGAGGGAAAATTTTTACTGATTCACAAAAAGGAAGACAGTTTGCCCACTCTTAGTGGCACAAATCAAAGCTGCATGCACTACATTATCCAAATTAGTCGTAACCAAATAGTTAAAAAATTCTgctgggcacggtggctcatacctgtaatcccagcactttgggaggccgaggcagttggatcacctgaggttaggagtttgagaccagcctggccaacagggtgaaaccctgtctcgtctaaaaatacaaaaattagccgggcgtggtggtgcatgcctgtagtcccaggtactcaggaggctgaggcaggagaatcacttgaacccgaggtggggcaggcggaggttgcagtaagccaagatcgcgccattgcactctagcctaggtgacagagtgagactccatctcaaaaaaaaaaaaaaaTTCCATAGGATGTTCAACCATGTTTTCAGAGGCCGCACTGCATGAATGCGGGAAAATGTTGATGATCACTAATCAATAATCTGATATTTAACAAAATATGGACAGGCCACTTATGCTCAGTTTTACCTTAGTTATTCCTTGGTatccacaggcccaagtccctttaaataaaataccctcatatttccatataatctacatacattctcccatatactttaaatcatctctagattacttataatgtctaatacaaaataaatgctatgtaaatgtaattatta

Publications

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