Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SNW1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:78749071-78750987  UCSC
Coordinates (T2T) chr1:78587912-78589828  UCSC
Coordinates (hg19) chr1:79214756-79216672  UCSC
Strand +
Parental Sequence NM_012245.3
Parental seq. overlap 1787 bp
Parental seq. overlap (%) 83.8%
Genomic Region Intergenic
Retrocopy Summary SNW1P1, located on chr1:78749071-78750987, is a retrocopy of the parental gene SNW1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SNW1
Full Name SNW domain containing 1
Also known as Bx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1
Coordinate chr14:77717599-77761156
Strand -
Gene summary This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SNW1P1
Bonobo Pan paniscus SNW1P1
Gorilla Gorilla gorilla SNW1P1
Orangutan Pongo abelii SNW1P1
Gibbon Nomascus leucogenys SNW1P1
Green monkey Chlorocebus sabaeus SNW1P1
Crab-eating macaque Macaca fascicularis SNW1P1
Rhesus Macaca mulatta SNW1P1
Baboon Papio anubis SNW1P1
Golden snub-nosed monkey Rhinopithecus roxellana SNW1P2
Marmoset Callithrix jacchus SNW1P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SNW1P1
CACCTGCACCTACTCAGTTATCTCAGGACCAGCTTGAGGCTGAAGAAAAGACAAGATCCCAGAGATCATGGCAGACTTCATTTGTCTCTTCCGGAAGAGAACCTTCCCGGTAAAGATACCGGAAAGGCTGGACGCTTCGGTTATTAGAGGATTTTGGAGATGGAGGTGCTTTTCCAGAAATCCATGTGGCTCAGTATCCACTGGATATGGGACGAAAGAAAAAAATATCTAGTGCGCTGGCCATTCAGGTGGATTCTGAAGGAAAAATCAAATATGATGGAATCACTCGACAAGGACAGTCAAAAGACAAGGTCATTTATAGCAAATACACTGTCCTGGTTCCAAAGGATGTTACGAATGCAAATGATCCAGACTTGCAAAGGCCCGATGAAGAAGCTATAAAAGAGATAACAGAAAAGACAAGAGTAGCCTTATAAAAAGCTGTACCACAGAAGGTCACCGCAGTCACGCCAGTTCAGGCAGCTGACAAACCGGCTCCTGCTCAGTATATCCGATACACACCATCTCAGCAAGGAGTGGCTTTCAACTCTGGAGTTAAACAGAGGGTTAGTCGGATGGTAGAAGTGCAGAAAGATCCAACGGAGCCTCCAAGGTTCAAGATTAATAAGAAAATTCCCCGGGGACCACCTTCTCCTCCTGTGCCTGTCATGCATTCTCCTAGCCGAAAGATGATTGTAAGGGAACAGCAAGAGTAAAAGTTTCCTCCTTTTATTTCTAACTGGAAAAATGCAAAGGGTTATACAATTCCATTAGACAAACGTCTGGCTGCCGAAGGAAGAGGACTACAGACAGTACACATAAAAGAAAATGTTGCCACATTGGTGATCCTCTACATTGCTGATCAGAAGGCTTGTGAAGCTGTGGAAATGCGTGCCCGAGTAGAGAGAAAAATGGCTCAGAAAGAAAAGGGAAAATATGAAGAGAAACTTAGAGAAATGGCACAGAAAGCCAGGGAGAGAAGAGCTGGGATCAAAACTCATGTGGAAAAAGAGGATAGGGAGGCACGTGAGAGGAATGAAATCCGGCATGACAGGCGAAAAGAGAGACAGCATGACCAGAATCTTTCCAGGGCAGCTCCTGATAAGAGGTCGAAACTGCAGAGAAATGAAAATGGGGATATCAGTGAAGTCATTGCTCTCTGTGTTCCTAATCCTTGAACTTCCAATGAAGGTCAGTACGACCAAAGGCTCGTCAACCAATCCAAGGGTATGGACAGTGGATTTGCAGGTGGAGAAGATGGAATTTATAATGTTTATGATCAAGCCTAGAGAGGTGGTAAAGATATGGCCCACAGTAGTTATAGGCCCAGTAAAAATCTGGACAAGGACATGTATAACGATGACCTAGAACCCAGAATAAAGACCAACAGATTTGTTCCCGACAAAGAGTTTTCTGGTTCAGGCTGTAAGCAGAGAGGCCGAGAAGGACCAGTTCAGTTTGAGGAAGATCCTTTTGGTTTGGACAAGTTTTTGGAAGAAGTGAAACAGCACGGTGGCTCTAAAAGACCCTCAGATAGCAGCCGCCCCATGGAATATGAGCATGAAGGCAAGAAGAGGAGGAAGGACTAGACACAATTTTCTTCCAAGTGAATTAATTATTATTATCTATAACCCTAATGATGCAAGTCATATGGGGGAACACTTTGTAAATGGTCAGGATAAAAACCAAATCTGGCTGCCAGATCCCAGCACTACTTTTTTACTGGAGAATGGAGGGGATAGAAAATTCTACTTTGAAGTATTTTTTTTAAAGAGTGGACTGTGTTTGTGCTTCTCCCACCTTTCAGCATTTATAGAACATGCTGTCCCACATGCAAAATCAAGACCACTTCCTTTTGTGTGACATTTATAGTTTGGGGTTAATATTTTGTGTGAGAACAGCTGCATATGAGTAAAG
>NM_012245.3
GTCGCTCGCGCTGGAAGAAGCGGAAGAAGATGGCGCTCACCAGCTTTTTACCTGCACCTACTCAGCTATCTCAGGACCAGCTTGAGGCTGAAGAAAAGGCAAGATCCCAGAGATCACGGCAGACCTCACTGGTCTCCTCCCGAAGAGAACCTCCCCCGTACGGATACCGGAAAGGCTGGATACCTCGGTTATTAGAGGATTTTGGAGATGGAGGTGCTTTTCCAGAGATCCATGTGGCCCAGTATCCACTGGATATGGGACGAAAGAAAAAAATGTCGAATGCGCTGGCCATTCAGGTGGATTCTGAAGGAAAAATTAAATATGATGCAATTGCTCGACAAGGACAGTCAAAAGACAAGGTCATTTATAGCAAATACACTGACCTGGTTCCAAAGGAGGTTATGAATGCAGATGATCCAGACCTGCAAAGGCCCGATGAAGAAGCTATTAAAGAGATAACAGAAAAGACAAGAGTAGCCTTAGAAAAATCTGTATCACAGAAGGTCGCCGCAGCCATGCCAGTTCGAGCAGCTGACAAATTGGCTCCTGCTCAGTATATCCGATACACACCATCTCAGCAAGGAGTGGCATTCAACTCTGGAGCTAAACAGAGGGTTATTCGGATGGTAGAAATGCAGAAAGATCCAATGGAGCCTCCAAGGTTCAaGATTAATAAGAAAATTCCCCGGGGACCACCTTCTCCTCCTGCGCCTGTCATGCATTCTCCTAGCCGAAAGATGACTGTAAAGGAACAACAAGAGTGGAAGATTCCTCCTTGTATTTCTAACTGGAAAAATGCAAAGGGTTATACAATTCCATTAGACAAACGTCTGGCTGCTGATGGAAGAGGACTACAGACAGTACACATAAATGAAAATTTCGCCAAATTGGCAGAAGCCCTCTACATTGCTGATCGGAAGGCTCGTGAAGCTGTGGAAATGCGTGCCCAAGTAGAGAGAAAAATGGCTCAGAAAGAAAAGGAAAAACATGAAGAGAAACTTAGAGAAATGGCCCAGAAAGCCAGGGAGAGAAGAGCTGGGATCAAAACTCATGTGGAAAAAGAGGATGGGGAGGCACGTGAGAGGGATGAAATCCGGCATGACAGGCGAAAAGAGAGACAGCATGACCGGAATCTTTCCAGGGCAGCTCCTGATAAGAGGTCGAAACTTCAGAGAAATGAAAATCGGGATATCAGTGAAGTTATTGCTCTCGGTGTTCCTAATCCTCGGACTTCCAATGAAGTTCAGTATGACCAAAGGCTCTTCAACCAATCCAAGGGTATGGACAGTGGATTTGCAGGTGGAGAAGATGAAATTTATAATGTTTATGATCAAGCCTGGAGAGGTGGTAAAGATATGGCCCAGAGTATTTATAGGCCCAGTAAAAATCTGGACAAGGACATGTATGGTGATGACCTAGAAGCCAGAATAAAGACCAACAGATTTGTTCCCGACAAGGAGTTTTCTGGTTCAGACCGTAGACAGAGAGGCCGAGAAGGACCAGTGCAGTTTGAGGAAGATCCTTTTGGTTTGGACAAGTTTTTGGAAGAAGCCAAACAGCATGGTGGCTCTAAAAGACCCTCAGATAGCAGCCGCCCCAAGGAACACGAGCATGAAGGCAAGAAGAGGAGGAAGGAATAGGCACAGGTCTCTCCAAAGTGAATGAACTCTTACCCATAACCCTAATGATGCAAGTCATATGGGGGAACACTTTGTAAATGGTCAGGATAAAAACCAAATCTGGGTGCCAGATCCCAGCACTACTTTTTATTACTGGAGAAATGGGGGGGATAGAAAATTCTACTTTGAATTATTTAGTTTTTTTTAAAGAGTGGGTTGTGTTTGTGCTTCTCCCACCTTTCAGCATTTATAGAACATGCTGCCCCACATACAAAGTCAAGACCACTTACTTTTATGTGACACTAGTAGTTTGGGGTTAATGTTTTGTGTAAGAACAGCTGCATATGAGTAAAGTTACCCCAACCACAGTGAGGAGGAAGATGTTCACATACTGGAACTGTCCTGCCAAATAAATTTTGCCCCTATTGTGCTCTGTTTTAATTTGGAGTGGGCAAAGTAACCTCTTGCTTGGTGCAACTATTTGTTTCAAATAAAAACATTTAGACAAAA

Publications

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