Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NFKB2P1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:12091517-12093086  UCSC
Coordinates (T2T) chr18:12254278-12255847  UCSC
Coordinates (hg19) chr18:12091516-12093085  UCSC
Strand -
Parental Sequence NM_001322934.2
Parental seq. overlap 1406 bp
Parental seq. overlap (%) 46.3%
Genomic Region Intergenic
Retrocopy Summary NFKB2P1, located on chr18:12091517-12093086, is a retrocopy of the parental gene NFKB2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NFKB2
Full Name nuclear factor kappa B subunit 2
Also known as CVID10|H2TF1|LYT-10|LYT10|NF-kB2|p100|p49/p100|p52
Coordinate chr10:102394110-102402529
Strand +
Gene summary This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NFKB2P1
Bonobo Pan paniscus NFKB2P1
Gorilla Gorilla gorilla NFKB2P1
Orangutan Pongo abelii NFKB2P1
Gibbon Nomascus leucogenys NFKB2P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NFKB2P1
CCTCCAGGACCCCTCCCCAGTGCCAGCTGCAGGCCCTGGAGATGCTGCAGTGAGCCCGAGAGTACAACGCTCTTCAGCCTGGTGTGGCACGGCACAGCGCAGCGCCCAGGCCCTACTCAACTATGGTGTCACCACGGACGCCAGCACACTGCTGGCGGGACAATGCCACCTGCTGGAGCAGGACGAGAACAGAGACACGCCACTATACCTGTCCATCATCCATGGGCCGACCAGGGTCATCAAGCACATAGCCCATGTCATCTACCACACCCAGCACCTTGGCATCGTCAACCTCACCAACCACCTGCACCAGACACCCCTGCACCTGGCAGTGATCACCAGGCAGATGAGGGTGGTGAGCTTTCTGCTTCAGGTGGATGCAGACCCAGCACTGCTGATTGGCATGGAGACTCAGCCATGCACCTGGCACTGCAGGCAGGCCCTGGTGCCTCTGAGCTGCTGCATGCACTGCTTTGGAGTGGAGCTCCCGCTGTGCCTCGGCTGTTGCACATGCCTGACTTTGCAGTACACCTGGCGGCCCAAGCCCAAAGCCCCAAGTGCCTGGATCTGCTGGTGGACAGTGGGGCTGAAGTGGAGGCCACAGAGTAGCAGGGGGCCAAACAGCCTTGCATCTAGCCACAGAGATGGAGGAGCTGGGGTTGGTCACCCATCTGGTCACCAAGCTTCGGGCCAATGGGAATGCTCACACCTTTGTGGGAAACACACCCCTGCACCTGGCAGCTGGACTGGAGTCCCCAACCCTCACCCTCCTTCTGAAGGCTAGTGCTGACATCTATGCTGAGAATGAGGAGCCCCTGTGCCCACTGCCCTCACCCCCTACCTCTGATAACGACTGGGACTCAGAGGGGCCTGAGAAGGACACCCAAAGCAGCTTCCAGGGCCACACGCCTCGACCTTATCCACAGCACCAAGGTGAAGACCTTGCTGCTAAATGCCACTCTGAACACCATGGAGCTAGCTGCCCCTGACCCCACCCAGCCCTGCAGGGCCAGGGCTGTCACTTGGTGACACAGCCCTGCAGAACCTGGAGCAGCTGCTAGATGGGCCAGAAGCCCAGGGCAGCTGGGCAGAGCTGGCAGAGCGGCTGGGGCTGCGCAGCCTGGTGGACATGTACCAACAGACGGCCTCGCCCAGTGACAGCCTCCTGCACAGCTATGAGCTGGCTGGCGAGGACTTGGCAGGTCTGCTGGAGGCGCTGTCTGGCATTGGCCTAGAGGAGGGAGTGAGGCTGCTGAGGGGTCCAGAGACCTGAGACAAGCTGCCCAGCACAGCAGAGATGAAGGAAGACGGGGGTACGGGAGCCAATCAGTGGAGCAGGAGGCAGAGAAGCTGGCCCACCCCCTGAGCCACCAGGAGGCCTCTGCCATGGGCACCCCCAGCTTCAGGTGCACTGACCTGCTGCCTGGCCCCAGCCCCCTTCCCGGACCCCCCTGTACAGCATCCCCACCTATTTCAAATCTTAAATTTAACACCCCACACCCACCCCTCAGTTGGGACAAATAAAGGTTTCTAATGGGAAGGGAAGGACCCCTCCTTCCCAACTTT
>NM_001322934.2
AACTTTCCTGCCCCTTCCCCGGCCAAGCCCAACTCCGGATCTCGCTCTCCACCGGATCTCACCCGCCACACCCGGACAGGCGGCTGGAGGAGGCGGGCGTCTAAAATTCTGGGAAGCAGAACCTGGCCGGAGCCACTAGACAGAGCCGGGCCTAGCCCAGAGACATGGAGAGTTGCTACAACCCAGGTCTGGATGGTATTATTGAATATGATGATTTCAAATTGAACTCCTCCATTGTGGAACCCAAGGAGCCAGCCCCAGAAACAGCTGATGGCCCCTACCTGGTGATCGTGGAACAGCCTAAGCAGAGAGGCTTCCGATTTCGATATGGCTGTGAAGGCCCCTCCCATGGAGGACTGCCCGGTGCCTCCAGTGAGAAGGGCCGAAAGACCTATCCCACTGTCAAGATCTGTAACTACGAGGGACCAGCCAAGATCGAGGTGGACCTGGTAACACACAGTGACCCACCTCGTGCTCATGCCCACAGTCTGGTGGGCAAGCAATGCTCGGAGCTGGGGATCTGCGCCGTTTCTGTGGGGCCCAAGGACATGACTGCCCAATTTAACAACCTGGGTGTCCTGCATGTGACTAAGAAGAACATGATGGGGACTATGATACAAAAACTTCAGAGGCAGCGGCTCCGCTCTAGGCCCCAGGGCCTTACGGAGGCCGAGCAGCGGGAGCTGGAGCAAGAGGCCAAAGAACTGAAGAAGGTGATGGATCTGAGTATAGTGCGGCTGCGCTTCTCTGCCTTCCTTAGAGCCAGTGATGGCTCCTTCTCCCTGCCCCTGAAGCCAGTCATCTCCCAGCCCATCCATGACAGCAAATCTCCGGGGGCATCAAACCTGAAGATTTCTCGAATGGACAAGACAGCAGGCTCTGTGCGGGGTGGAGATGAAGTTTATCTGCTTTGTGACAAGGTGCAGAAAGATGACATTGAGGTTCGGTTCTATGAGGATGATGAGAATGGATGGCAGGCCTTTGGGGACTTCTCTCCCACAGATGTGCATAAACAGTATGCCATTGTGTTCCGGACACCCCCCTATCACAAGATGAAGATTGAGCGGCCTGTAACAGTGTTTCTGCAACTGAAACGCAAGCGAGGAGGGGACGTGTCTGATTCCAAACAGTTCACCTATTACCCTCTGGTGGAAGACAAGGAAGAGGTGCAGCGGAAGCGGAGGAAGGCCTTGCCCACCTTCTCCCAGCCCTTCGGGGGTGGCTCCCACATGGGTGGAGGCTCTGGGGGTGCAGCCGGGGGCTACGGAGGAGCTGGAGGAGGTGGCAGCCTCGGTTTCTTCCCCTCCTCCCTGGCCTACAGCCCCTACCAGTCCGGCGCGGGCCCCATGGGCTGCTACCCGGGAGGCGGGGGCGGGGCGCAGATGGCCGCCACGGTGCCCAGCAGGGACTCCGGGGAGGAAGCCGCGGAGCCAAGCGCCCCCTCCAGGACCCCCCAGTGCGAGCCGCAGGCCCCGGAGATGCTGCAGCGAGCTCGAGAGTACAACGCGCGCCTGTTCGGCCTGGCGCAGCGCAGCGCCCGAGCCCTACTCGACTACGGCGTCACCGCGGACGCGCGCGCGCTGCTGGCGGGACAGCGCCACCTGCTGACGGCGCAGGACGAGAACGGAGACACACCACTGCACCTAGCCATCATCCACGGGCAGACCAGTGTCATTGAGCAGATAGTCTATGTCATCCACCACGCCCAGGACCTCGGCGTTGTCAACCTCACCAACCACCTGCACCAGACGCCCCTGCACCTGGCGGTGATCACGGGGCAGACGAGTGTGGTGAGCTTTCTGCTGCGGGTAGGTGCAGACCCAGCTCTGCTGGATCGGCATGGAGACTCAGCCATGCATCTGGCGCTGCGGGCAGGCGCTGGTGCTCCTGAGCTGCTGCGTGCACTGCTTCAGAGTGGAGCTCCTGCTGTGCCCCAGCTGTTGCATATGCCTGACTTTGAGGGACTGTATCCAGTACACCTGGCAGTCCGAGCCCGAAGCCCTGAGTGCCTGGATCTGCTGGTGGACAGTGGGGCTGAAGTGGAGGCCACAGAGCGGCAGGGGGGACGAACAGCCTTGCATCTAGCCACAGAGATGGAGGAGCTGGGGTTGGTCACCCATCTGGTCACCAAGCTCCGGGCCAACGTGAACGCTCGCACCTTTGCGGGAAACACACCCCTGCACCTGGCAGCTGGACTGGGGTACCCGACCCTCACCCGCCTCCTTCTGAAGGCTGGTGCTGACATCCATGCTGAAAACGAGGAGCCCCTGTGCCCACTGCCTTCACCCCCTACCTCTGATAGCGACTCGGACTCTGAAGGGCCTGAGAAGGACACCCGAAGCAGCTTCCGGGGCCACACGCCTCTTGACCTCACTTGCAGCACCAAGGTGAAGACCTTGCTGCTAAATGCTGCTCAGAACACCATGGAGCCACCCCTGACCCCGCCCAGCCCAGCAGGGCCGGGACTGTCACTTGGTGATACAGCTCTGCAGAACCTGGAGCAGCTGCTAGACGGGCCAGAAGCCCAGGGCAGCTGGGCAGAGCTGGCAGAGCGTCTGGGGCTGCGCAGCCTGGTAGACACGTACCGACAGACAACCTCACCCAGTGGCAGCCTCCTGCGCAGCTACGAGCTGGCTGGCGGGGACCTGGCAGGTCTACTGGAGGCCCTGTCTGACATGGGCCTAGAGGAGGGAGTGAGGCTGCTGAGGGGTCCAGAAACCCGAGACAAGCTGCCCAGCACAGCAGAGGTGAAGGAAGACAGTGCGTACGGGAGCCAGTCAGTGGAGCAGGAGGCAGAGAAGCTGGGCCCACCCCCTGAGCCACCAGGAGGGCTCTGCCACGGGCACCCCCAGCCTCAGGTGCACTGACCTGCTGCCTGCCCCCAGCCCCCTTCCCGGACCCCCTGTACAGCGTCCCCACCTATTTCAAATCTTATTTAACACCCCACACCCACCCCTCAGTTGGGACAAATAAAGGATTCTCATGGGAAGGGGAGGACCCCTCCTTCCCAACTTA

Publications

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