Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IGLJCOR18
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:3394890-3395457  UCSC
Coordinates (T2T) chr18:3554264-3554831  UCSC
Coordinates (hg19) chr18:3394888-3395455  UCSC
Strand +
Parental Sequence NM_020070.4
Parental seq. overlap 466 bp
Parental seq. overlap (%) 52.7%
Genomic Region Intergenic
Retrocopy Summary IGLJCOR18, located on chr18:3394890-3395457, is a retrocopy of the parental gene IGLL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IGLL1
Full Name immunoglobulin lambda like polypeptide 1
Also known as 14.1|AGM2|CD179b|IGL1|IGL5|IGLJ14.1|IGLL|IGO|IGVPB|VPREB2
Coordinate chr22:23573125-23580290
Strand -
Gene summary The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IGLL1P1
Bonobo Pan paniscus IGLL1P1
Gorilla Gorilla gorilla IGLL1P1
Orangutan Pongo abelii IGLL1P1
Gibbon Nomascus leucogenys LOC115830352P1
Green monkey Chlorocebus sabaeus LOC103247548P2
Crab-eating macaque Macaca fascicularis IGLL1P2
Rhesus Macaca mulatta LOC698694P2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104680370P1
Marmoset Callithrix jacchus LOC100395096P1
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IGLJCOR18
TCTGCTGCAGCCCAGCTCCTGGACTGGCCCCAGGTTCTGGCCCTAAGGGTTTCGATCCAAGCATCATTCACTGTCGCACATGTTTGGCAGCAAGACCCAGCCCACTGTCTTAGGTAAGCCCAAGGCTCCCCGTTTGGTCACTCTGTTCCCGCCCTCCTCTGAGGAGTTCCAAGCTAACAAGGCCACCCTAGTGTGTCTCATGAATGACTTCTACCTGGGCACCGTGACAGTGGCCTGGAAGGCAGACGGCATCATCATCACCCAGGACGTGGAGACCACTAAGCCTCCCAAACAGAGCAAGAAACAGGCCAGCAGCTACCTGAGCCTGATGCCTGAACAGTGGAGATCCCGCAGCAGCTACAACTGCTGGGCCATGCATAAAAGGAGCACCCTGGAGAAGACAATGGCCCATACAGAATGTTCTTAGGTCCCTGGCCCTCACCCCACCCATGGAGGCCTGGAGCTGGAGGATCCCAGGGGAGGTGTCTCTCCTCCCATCCCAAGTCATCCAGCCCTTCTCCCTGTACCCAATAAACCCTCAATAAGTATCCTCATTGT
>NM_020070.4
GCAATGGGACAGCTGCTGCCAGCGAGAGGGACCAGGGCACCACTCTCTAGGGAGCCCACACTGCAAGTCAGGCCACAAGGACCTCTGACCCTGAGGGCCGATGAGGCCAGGGACAGGCCAGGGGGGCCTTGAGGCCCCTGGTGAGCCAGGCCCCAACCTCAGGCAGCGCTGGCCCCTGCTGCTGCTGGGTCTGGCCGTGGTAACCCATGGCCTGCTGCGCCCAACAGCTGCATCGCAGAGCAGGGCCCTGGGCCCTGGAGCCCCTGGAGGAAGCAGCCGGTCCAGCCTGAGGAGCCGGTGGGGCAGGTTCCTGCTCCAGCGCGGCTCCTGGACTGGCCCCAGGTGCTGGCCCCGGGGGTTTCAATCCAAGCATAACTCAGTGACGCATGTGTTTGGCAGCGGGACCCAGCTCACCGTTTTAAGTCAGCCCAAGGCCACCCCCTCGGTCACTCTGTTCCCGCCGTCCTCTGAGGAGCTCCAAGCCAACAAGGCTACACTGGTGTGTCTCATGAATGACTTTTATCCGGGAATCTTGACGGTGACCTGGAAGGCAGATGGTACCCCCATCACCCAGGGCGTGGAGATGACCACGCCCTCCAAACAGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGCCTGACGCCCGAGCAGTGGAGGTCCCGCAGAAGCTACAGCTGCCAGGTCATGCACGAAGGGAGCACCGTGGAGAAGACGGTGGCCCCTGCAGAATGTTCATAGGTTCCCAGCCCCGACCCCACCCAAAGGGGCCTGGAGCTGCAGGATCCCAGGGGAAGGGTCTCTCTCTGCATCCCAAGCCATCCAGCCCTTCTCCCTGTACCCAGTAAACCCTAAATAAATACCCTCTTTGTCAACCAGAAA

Publications

PMID - Link Title