Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PLEKHB2P1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:59929215-59931293  UCSC
Coordinates (T2T) chr18:60131888-60133966  UCSC
Coordinates (hg19) chr18:57596447-57598525  UCSC
Strand +
Parental Sequence NM_017958.3
Parental seq. overlap 1146 bp
Parental seq. overlap (%) 29.8%
Genomic Region Intergenic
Retrocopy Summary PLEKHB2P1, located on chr18:59929215-59931293, is a retrocopy of the parental gene PLEKHB2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLEKHB2
Full Name pleckstrin homology domain containing B2
Also known as EVT2
Coordinate chr2:131104847-131149847
Strand +
Gene summary Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PLEKHB2P1
Bonobo Pan paniscus PLEKHB2P1
Orangutan Pongo abelii PLEKHB2P1
Gibbon Nomascus leucogenys PLEKHB2P1
Crab-eating macaque Macaca fascicularis PLEKHB2P1
Rhesus Macaca mulatta LOC720588P1
Baboon Papio anubis LOC101025304P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104678109P1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLEKHB2P1
GGGTGAAGAGATGGCCTGAAGAGTGGCTGGTTGCTGCAACAGAGTGCTATATTGAAGTTCTGGAATAAGAATTGGTTTGACCTGTGGTCAGATGGTACCTGACCTATTATGATGACCAGACTTGGCAGAGTGTTGAGGATAAGGTCCGCATGCAAGTGGAATGCCTCAATATCCCTGCCAGGCAGGAATGTCGGGATAGTCAGCCTCTGCATGGAAAGTCAAAAGACTGCAAACTGGAAAAAGACTGCATGCTGCAGATTGTTTGCTCAGATGGGAAAACAATTAGTCTTTGTGCAGAAAACACAGTGATTGCTTGGCTTGGAAATTTACACTCCAAGATTCCAGGACAAACACAGCCTATGTGGGCTCCACAGTCATGACTGATGAGACACCCGTGGTTTCCTCCCCTCCACCACACACGGCCTATGCTGCACCAGCCACTGAGGAATAGGGCTATGAGCCATACAGTGGTGTGTGCCTGCCAGGAACTCAAATTGTCTATGCTGCTAATGGACAGGCGTATGCTGTGCCCTACCAGTACTCGTATGCAGGACTTTATGGACAGCAGCCTGCTAACCAAGTCATCATTCAAGAGTGATATCGAGACAATGACAGTGACCTGGCAGTGGGCATGTTGGCAGGAGTGGCCATAGTCATGCCCTTAGGGTCTCTATTCTTGGTCTTCTAGAGGCCGTAAGGTCTTGATGTGCCTAGCTCCTGATAACCCTGTGTGCAGTAATATGATTTACAGGGCATTTCTGTTTGTGACAAATGTTTTTAATAATAATTTTAATCGTTCCTTTGAAAGTAGTGACATCATAATTGTAACTAATCCACATAAGTACCACAGAGAAAGGTTTGAACTGTGCTAcAGAACTGTGCTATTTTGTTCAAACACGGGCTCTCCAGGGGCACTGGCTCATTCTAGGACTGTCCTTACGGAAGTCTCGGAATACTTTATTTGAGCCTAGCTGTTTTGAAAGGCATTTTCTTTTTAGAGTTAGGTGTAGTGCTTAAGGGATAATTTATTTTCATGTTATGCCAGTAATATAGCGTTGTATGCATCATGAGTGATTGTGGCAAGAAAATCTACAGCTCCTTTCTGTTTAACTTTTTCAAGCCACAGACCAGAACTGGTTGCATGTTACCTTAGGAGTTGTGGATTGGTAAGCTTCTGGTTACTTCTCCGAGGCTGTGGTGTGAGAGCCCCCTGACCCGCCTTCTGGGGCTCCACAGGCCCCCAGCAAGGGTGACTCCTCAGGATGAGAGGGCACAGCCAGCCTTTGAAAAAACGATGCTTCAGAAATCTGCGTAACCCTA
>NM_017958.3
AGTTGCAGGCGAGCAGGCGAGGAATCGCCGTGGCGTCTTGGTGTTCTCCACGCTGGTTCGCAGGTGAAGAGATGGCGTTTGTGAAGAGTGGCTGGTTGCTGCGACAGAGTACTATTTTGAAGCGCTGGAAGAAGAACTGGTTTGATCTGTGGTCGGATGGTCACCTGATCTATTATGATGACCAGACTCGGCAGAATATCGAGGATAAGGTCCACATGCCAATGGACTGCATCAACATCCGCACGGGGCAGGAATGTCGGGATACTCAGCCCCCGGATGGAAAGTCAAAAGACTGCATGCTCCAGATTGTTTGTCGAGATGGGAAAACAATTAGTCTTTGTGCAGAAAGCACAGATGATTGCTTGGCCTGGAAATTTACACTCCAAGATTCTAGGACAAACACAGCGTATGTGGGCTCTGCAGTCATGACCGATGAGACATCCGTGGTTTCCTCACCTCCACCATACACGGCCTATGCTGCACCGGCCCCTGAGGCTTATGGCTATGGGCCATACGGTGGTGCGTACCCGCCAGGAACTCAAGTTGTCTACGCTGCGAATGGGCAGGCGTATGCCGTGCCCTACCAGTACCCATATGCAGGACTTTATGGACAGCAGCCTGCTAACCAAGTCATCATTCGAGAGCGCTATCGAGACAACGACAGCGACCTGGCACTGGGCATGCTGGCAGGAGCAGCCACGGGCATGGCCTTAGGGTCTCTATTTTGGGTCTTCTAGGGGCCTCAAGGTCTTGATGTGCATAGCTTCTGATAACCCTGTGTGCAATAATATGATTTGCAGGGCATTTCTGTTTGTGACAAAAGTTTTTAATAATAGTTTTAATCATTCCTTTGAAAGTAGTGATGTCATAATTGTACTAATCCACATAAGTACCACAGAGAAGGGTTTGAACTGTGCTATTTTGTTCAAATGTTGACTCTCCGGGGGCACTGGCTCATTCCAAGACTGTTCTTGTGCAACTCTCAGAATACCTTATTTGAGCATACCTGTTTTGAAAGGCATTTTCTTTTTAGAGTTAGGTGTAGTGCTTAAGGGTTAATTTATTTTCATGTTATGCCAGTAATATAGTGTTGTATGCCTATTGAGTGATTGTGGCAAGAAAAGCTACAGCTTCTTTGCGTTTAACTTTTTCAAACCACAGACCAGAACTGGTTGCATGTTACTTTAGGAGTTGTGGGTTGGTAAGCTCCCAGGTACTTCCCGAGGCTATGGTGTGAGAGCCCCCGTCCTGCCCTCTGGGGCTCCACAGGCCCCTGGCAAGGCCGATGGCTCAGGATGATGGGGCACAGCCCGCCTTTGAACAATCATGCTTCAGAAATCTGCCTGACCCTAGCTGCTGCTGCTGCTCACTTTATTCTTGTATGGCTTTGGTAGGCATACTTGGAGAACATATCCCACATTAGGAATTGATTTAAGCCTGAGAGTTTGAGGGCTTTAATCCTTTAAAACTTGGAGAAGCTggctgggcgcggtggctcacgcctgtaatcccagcactttgagagaccgaggcgggcggatcacgaggtcaggagatcgagaccatcctggctaacacggtgaaaccccatctctactaaaaatacaaaaaattagctgggcgtggtggcaggcgcctgtggtcccagctactcgggaggctgaggcaggagaatagtgtgaacccaggaggcggagcttgcagtgagccaagatagtgccactgcacttcagcctgggtgacagagtgagactctgtctcaaaaaaaaaaaaaaaaTCCTGGAGAAGCCAGAACAATATACAAACAAGTATGTGGAGGCAGATTTGCTTTATTCCAAGAGGCTGTTTGAGTGTGTGTCTGCCTAAGCCTCCTTATAGCCTATTTTTCTACTTGCTGAGAGAGTAATATTAAAGGAACAGTGAGGGAGTGGAAGGAGAGCCTTAGTTAGAGCGTTCCCATTTCTGGCCTTTGGGGGTTTGCACTGTGCGGGAGATGCTCTCTCATCACTCTGAAGGCCCATCCTGTGCAGAAGTGGGACTCTGTGGCTGTTCACTGAGCACCAGGGCAGACTGTAGCTGAGCAGACTTGGGTTATGGATGGGATATGGGGCCCAGGGACCCTCAGGACACAGGGACCGGCTCAAGGTACCACTCAGCCTGGCCAGGACCCCCAGCTTTGCTTTTGTTCTTGATCTCTTTGTGATAGAGAAGCTTAGAACATTGAATTTGGAACCCCAAAATGTGTGAGTCTTTGGAAAACCCATTCCAGCCTTTCTTCAAATGCTCTTATTTTCAGTATATGAAGTGTGTATTTGAAATATTCATATTTCTGTTATTTCTTGTTTTCAAGCTCTGAATTATTGCAGTTTTCTGTCCTGCATGCTTTCAACAGTGTGCTTTTACAGTGGCAGTTTAGCACAGCGAATGTCCCTGCCCCACACTCCATATGGTCCTGTTTTCCTGAAAATACACTCCAGGTAGCACAGACTTGTTATTTTGCCTGGCTGGTTACACACATGCTGTCTTGCTTTGCTGCTCAGCCACCTCCCTCTGAGGCCAACTTAGGCCAACCTACATAGGACTCCATCTTTAGCGAGACACCAGAGACACCTAGTGATGACCACGGGTCTGCTTTTCTCTCTGATCCTAGGGGACTTGTTGACATGGGAGTGTCTGTTTCCACATGGAAGGATGTCTGTTTATCTCTCATCTCTGAATAGATGTATGACAACTCTAGTGTCCATGGTTTAAAATGTTGCTTTGAGGATTTTCCATCCTGTATAAGAAGAATGGCTTTCTTCAGATTATAATCGTTATTAAAGCTGTATGTACACTTTACTTAAAAACTATTAACAGTTTTTCATGTTGCACTGGTGGTAATTTTGAACTTGGAATTACTGGGTGGGAATTCCAGGAACCACAGAGTATTGATTTTTGCTGCCAAAATGCTCTTGAAGCAGATGTCCCTGTGCTCCCCTGGCTGCTTCTGGCTGAAGGGGGGAGGTGTAGACTGAAGCTTGGGCACTCATGTGTGTCCCCTCCCCAGTCCCCATCCTAGTGGGGCCAGTCTCATTAGGCAGCCATAGATAAGCCTGGAACTTGGCTGTCATTAGTGACTTGATCCTGGTATGAAATGCATACTGGGTATAAGGTTGCTCAGGTATTTTATTTCCTTGGCCACAACTCCCATAGATGCCAATGTTTTGATAGCCTCAGTTTCTCAACGATGTCTTTTGTTTACAGTGCTACACTTAGTGTGAGTCAAGAAGTGCTTGAGTTACAAGAAACTTCTTATTCAGGTTTGAGTAAGCATTTTACTTCCATGTGTACTTTTAAATAATCCATACCTTGAAGAAGTTGGCCAATGATATTATATACATGCTGATCTGATTGTTCTTTTCATTCCTTGAGTCAACTTCAGGGTCTTGGATACTAAAGAGAAGGAGAACTGTGGTTAATGTTTTGGATCATCATTTGTGAACAAGGCCAGACTTTGCCCATTTTAGGCTATCCAGGACTTAAGGTAGCCATCTGGATCATAAGAAGGTCCTGCAGTTGAGACAAAATGACCCAAGTGTATTTTCCACAAGTTTTGATCCTGTGTAATATTTCTTTTTCCTTCCCTAGTGTATGTAGATACAAGGCATGGAATGCAGTTCCACTTTCTCCCCAGAGTTGATCTTTTTGTGATTGCTTTCCCGTCTCTAGTAGTATTCTGTTGTGTCTAGAGAACTGATTTTTTCCTACATACGCAAATTGTACATTTGTAAGTGAAAATGTCAATACATTAAAGCATTAACCTTAAAGCA

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