Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPIAP1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:61957241-61958016  UCSC
Coordinates (T2T) chr18:62160989-62161764  UCSC
Coordinates (hg19) chr18:59624474-59625249  UCSC
Strand -
Parental Sequence NM_144563.3
Parental seq. overlap 671 bp
Parental seq. overlap (%) 37%
Genomic Region Intergenic
Retrocopy Summary RPIAP1, located on chr18:61957241-61958016, is a retrocopy of the parental gene RPIA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPIA
Full Name ribose 5-phosphate isomerase A
Also known as RPI|RPIAD
Coordinate chr2:88691673-88750929
Strand +
Gene summary The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPIAP1
Bonobo Pan paniscus RPIAP1
Gorilla Gorilla gorilla RPIAP1
Orangutan Pongo abelii RPIAP1
Gibbon Nomascus leucogenys RPIAP1
Green monkey Chlorocebus sabaeus RPIAP1
Crab-eating macaque Macaca fascicularis RPIAP1
Rhesus Macaca mulatta RPIAP1
Baboon Papio anubis RPIAP1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104669317P1
Marmoset Callithrix jacchus RPIAP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPIAP1
GCAGTGCCCTGGGCCCTTCAGCAACCTCTACAGGCGGCTGCTGGTGCTGCTCTGGGGTGGGCTGGGGGTGCATCCTCCAGCGGAGGTGGGAACAGCTGGAACCTCCAGGGCTCCCACGTGCAGCTCTCAGGGCATACACAGTCCAGGACCTGCTGCAATGCTGGCAGCACAAGCACCAGCTATGGGAACTCCAACAGCGTCTGCCTGGCCCCCTCCATGATGTCCAAGGCCAAGGAGGCTAAGAACTGGCGGGACACGGGGTGGTGGAGAACCACATGAGGAATAACCAAGTGCTGGGAACTGGAAGTGATTCTACAAGTGTCCATGCTGTGCAGCGAGTAGCTGAAAGGTGAAGCAGGAGATTCTGACCTGGTCTGCGTTCCCACTTCCCTCCAGGCCTGTCAGCTTCTTTCCCGTCATCAGGAAAGATTCAAAGAACCCTGGGGATCAGTGGCACAAGGGAATCCCAGTGGCCTTCGTCCCAGTGAGCTGAGCTATGAGCCAGAAGTTTACAGGTGTGGTTGAATTCCAAATGGCTGTCAACAAGGCAGGTCCAGTGGTGACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCAGGTACATAAATGGGGTGAAGTGAACAGAGCTGCCAGAATGGTCCCACGTGTGGTGGACACAGGCCTGTTCATCCACATGGCTGAGAGAGCCTACTTCAGGATGCAGGATGGCTCAGTGAACAGGAGGGAACAGCCTTTCTGTTGACCTTGCAAGCAGCAGAGTGTCTTCACCC
>NM_144563.3
AGCGGAGGCCGGAGCGAGGCGTCGGGATGCAGCGCCCCGGGCCCTTCAGCACCCTCTACGGGCGGGTCTTGGCCCCGCTGCCCGGGAGGGCCGGGGGCGCGGCCTCCGGCGGAGGAGGGAACAGCTGGGACCTCCCGGGTTCCCACGTGCGGCTGCCGGGGCGTGCACAGTCTGGGACCCGTGGCGGTGCTGGCAACACAAGCACCAGCTGCGGGGACTCCAACAGCATCTGCCCGGCCCCCTCCACGATGTCCAAGGCCGAGGAGGCCAAGAAGCTGGCGGGCCGCGCGGCTGTGGAGAACCACGTGAGGAATAACCAAGTGCTGGGAATTGGAAGTGGTTCTACAATTGTCCATGCTGTGCAGCGAATAGCTGAAAGGGTGAAGCAAGAGAATCTGAACCTCGTCTGTATTCCCACTTCCTTCCAGGCCCGCCAGCTCATCCTGCAGTATGGCTTGACCCTCAGTGATCTGGATCGACACCCAGAGATCGACCTTGCCATCGATGGTGCTGATGAAGTAGATGCTGATCTCAATCTCATCAAGGGTGGCGGAGGCTGCCTGACCCAGGAGAAGATTGTGGCTGGCTATGCTAGTCGCTTCATCGTGATCGCTGATTTCAGGAAAGATTCGAAGAATCTCGGGGATCAGTGGCACAAGGGAATCCCCATCGAGGTCATCCCAATGGCCTATGTCCCAGTGAGCCGAGCTGTGAGCCAGAAGTTTGGGGGCGTGGTTGAACTTCGAATGGCTGTCAACAAGGCTGGTCCTGTGGTGACAGATAATGGGAATTTTATCTTGGACTGGAAGTTTGACCGGGTACACAAATGGAGTGAAGTGAATACAGCTATCAAAATGATCCCAGGTGTGGTGGACACAGGCCTATTCATCAACATGGCTGAGAGAGTCTACTTTGGGATGCAGGATGGCTCAGTGAACATGAGGGAGAAGCCTTTCTGTTGACCCTGCAAGGAGCAGAGTGTGTTCACCTTGAGTCTCCAGCCCACAGCCAAGGTGGACGTACCTCTCCAGGAGCCTTTGCCTTAATGTATCTCTGCCTGGACAACTTGTGGTGGGGGGTGGGGGGAAGAGTGGGAGGGGGAGTTAAATCCAGTCTTATGAAGTATTGTTATTAAATGTCTTTTTAAAAAGAGAAATATAAACATATATTTTTACTATTAAAATATTCAGTTTTTTAAATGAAGTAGAACTTGAGTTCATGTTTTATATGAAATATTTACCAAAAAAAAAAAATGAGGTAAACTGTATTTAAAACCTTTGACTTGAGTCTGCTGGTAAAGCTTCTGAATATTGAGTTTGCTGAGAAATAAAAATCAAAACTTCTTTAAGCTGGTAAAGTGAGGGGCCCACCAGCAGTGATCTCCTGATGCCTTACTGGAAACTTTGTTTACTTGTCTGCTACCCTCTGATTTGTTTTTAGTTAGTTTTTATTGTGAGCACACATAGTACCTAGTTACATCTTAAGATCAGGTTTATAAAACTGTGGAGTGGAGCGGTATGGTATGGAATGACTTGGAATGTAAGCTGTCAGGGAGAAAATGTTGTTACACTTTTGCTAAGATCTGGGGGTTTCTTCATATTCCTGCTGTTGGAAGCAGTTGACCAGAAATGCTTGCCAGTACTGCCAAAGCACTGCTGTGAAATGTGAAGTACTTTGTTTTTTTATTTTTAATGATTTTCTTTTTGTTATTAATATTTTTCTCTGTTCCTTTGTTATTACTTGCATGGTTTGGCGTCAGAAGTCCTTACCTCTTTATATTGTTTGCAGGTTTAAATAAAACAGTGTGGTGCCA

Publications

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