Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AKR1B10P2
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:68455908-68456344  UCSC
Coordinates (T2T) chr18:68675007-68675443  UCSC
Coordinates (hg19) chr18:66123145-66123581  UCSC
Strand +
Parental Sequence XM_011516417.2
Parental seq. overlap 362 bp
Parental seq. overlap (%) 20.5%
Genomic Region Intergenic
Retrocopy Summary AKR1B10P2, located on chr18:68455908-68456344, is a retrocopy of the parental gene AKR1B10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKR1B10
Full Name aldo-keto reductase family 1 member B10
Also known as AKR1B11|AKR1B12|ALDRLn|ARL-1|ARL1|HIS|HSI
Coordinate chr7:134527567-134541412
Strand +
Gene summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKR1B10P1
Bonobo Pan paniscus AKR1B10P2
Gorilla Gorilla gorilla AKR1B10P2
Orangutan Pongo abelii AKR1B10P2
Gibbon Nomascus leucogenys AKR1B10P1
Crab-eating macaque Macaca fascicularis LOC101865018P1
Rhesus Macaca mulatta LOC713150P2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104657859P1
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKR1B10P2
aGACTTCTATCTGCTCACTAAGAACCATTTTTGCACTAACCATGGCCACCTTTGTAGAGCTCAGTACCAAAGACAAGATGGCCATCATAGGCCTGGAGACCTGGAAGTCTCCTCCAGGCAAAGTTGAAGAAACTATGAAGGTGGCCCTTGATGTGAGATATTGCCACATTGACTGTGCCTGTCTATGTGAGAATGAAGATGAGGTGGGGAAGCCATCCAGGAGAAGATCCAAGAGAAGACTGTCAAACAGGAGTACCGCTTTATCATTAGCAAGTTGAGGCTCACCTTCTTTGAGAGACCCCTTGTTAAGGAGGCCTGTCAGAAGATCCACAGGTACCTGAAACTGAACTACCTGGACATCTGTTTTATTCGCTGGACACAGGGATTCCAGCCTGGGCAGTAGTTTCTCCCCAAAGATGATAAAGGTAATGTCATC
>XM_011516417.2
agctcacacctgtaatcccagcactttggaaggccgaggtgggcggatcacctgagctcaggagtttgagaccagcctgtctctactaacaatataaaaattagctgggagtcacggtgggcgcctgtaatcccagctactcgggaggctgaggcaggagaattgcttgaacccaggagacagaggttgtagtgagctgagatcgcaccactgcactctagccttggcaacagtgcaagactgtctcaaaaaCAGCAACAGAGAGCAGGACGTGAGACTTCTACCTGCTCACTCAGAATCATTTCTGCACCAACCATGGCCACGTTTGTGGAGCTCAGTACCAAAGCCAAGATGCCCATTGTGGGCCTGGGCACTTGGAAGTCTCCTCTTGGCAAAGTGAAAGAAGCAGTGAAGGTGGCCATTGATGCAGGATATCGGCACATTGACTGTGCCTATGTCTATCAGAATGAACATGAAGTGGGGGAAGCCATCCAAGAGAAGATCCAAGAGAAGGCTGTGAAGCGGGAGGACCTGTTCATCGTCAGCAAGTTGTGGCCCACTTTCTTTGAGAGACCCCTTGTGAGGAAAGCCTTTGAGAAGACCCTCAAGGACCTGAAGCTGAGCTATCTGGACGTCTATCTTATTCACTGGCCACAGGGATTCAAGTCTGGGGATGACCTTTTCCCCAAAGATGATAAAGGTAATGCCATCGGTGGAAAAGCAACGTTCTTGGATGCCTGGGAGGCCCAGCTTATACTCTACCTGAAGGACTCCCCTGACAACTGCGGGCTGTATGTATCTCTTCTTTCTCTGCCCTTTCTGACTCTGTCTATGCCGCTGTGATGTTATCTGAGGCAGCCTCAGTGTCATGATTGATGGCTCCATAGAAGGGAACTCTAGCACTTTAATTGGACTATAAGAATCCCAGAAAAAGGGAGCACATTGTATACATTTACATCCTGACAACTTCTGGGCAGGATCTGGAACATGTAATAGATGGCTACTAAATACATATTGCACTGGAGGCTGCTGCTAACATGTATGGTATCTTTGGGCAAGTTTGGAAAATGCCCAATATAGGCTAAAaattatacaaagattcccttccttgcgtgtccatgcagtttctgtaccaggaagcatggctggatatgcaaacagtgggtcaggcttcagtcccacacaactccatggccgggtgcccctatcagggtgtaatctgAATGCATGACCTTCCTGCAAACCAAAGCATGCTTAGTGTGGGAGAGAGGGACTCAGGACCCACAAGTGAGGCTTCTCCGTATGCTGCAGCCTCTTCCTGACTAACACAGCTTGCCCAGGTTTGGGTGTGCAATGCACACACACAACAGCAGCTCCCTGCTATCATTTGGATTCATTAAAAATTAAATCATCTCATAAGCTTACAAATGTTGATTTTTATTTACTTTTTATTTTTTTGCATTACAAAACTTTCATATTTCCCCTGTGTACAGGAAGTTTAATTTTTTATGTGTTTCTTCACGTGTAAGGTGAGAGTGGCAAGAACATAAAATCTTTACCTGTTACTCCTAGTTTTTCTTGCGCTGGGGAGGGGCAGTAGGGCTGGAACCAGTCACTGATGGGCACCCAGGCCCTGGACTAAAATTTCCTGTGAATGCTTCGGCTAACCCTGTTACGGTGGATCCTTTAGCAATTTCTGCCCCAGGGAGGACTAAGGCAAGCCAGGGTCCCTGTAGTCCCTCTAGAGCTGCCCATAAGGTATTCCT

Publications

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