Retrocopy Name | ACY1P1 |
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Species | Homo sapiens | |
Coordinates (hg38) | chr18:68992628-68993213 UCSC | |
Coordinates (T2T) | chr18:69209293-69209878 UCSC | |
Coordinates (hg19) | chr18:66659865-66660450 UCSC | |
Strand | - | |
Parental Sequence | NM_000666.3 | |
Parental seq. overlap | 492 bp | |
Parental seq. overlap (%) | 34.5% | |
Genomic Region |
Intragenic (CCDC102B) |
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Retrocopy Summary | ACY1P1, located on chr18:68992628-68993213, is a retrocopy of the parental gene ACY1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
Gene Name | ACY1 |
Full Name | aminoacylase 1 |
Also known as | ACY-1|ACY1D|HEL-S-5 |
Coordinate | chr3:51983535-51989197 |
Strand | + |
Gene summary | This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010] |
Species | Scientific Name | Retrocopy | |
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Chimpanzee | Pan troglodytes | ACY1P1 |
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Bonobo | Pan paniscus | ACY1P1 |
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Orangutan | Pongo abelii | ACY1P1 |
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Gibbon | Nomascus leucogenys | LOC100603023P1 |
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Green monkey | Chlorocebus sabaeus | ACY1P1 |
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Crab-eating macaque | Macaca fascicularis | LOC101867505P1 |
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Rhesus | Macaca mulatta | LOC698851P1 |
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Baboon | Papio anubis | LOC101019806P1 |
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Golden snub-nosed monkey | Rhinopithecus roxellana | LOC115898588P1 |
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Marmoset | Callithrix jacchus | ACY1P1 |
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Gorilla | Gorilla gorilla | Without Homology |
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Mouse lemur | Microcebus murinus | Without Homology |
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Mouse | Mus musculus | Without Homology |
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Rat | Rattus norvegicus | Without Homology |
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Chinese hamster | Cricetulus griseus | Without Homology |
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Rabbit | Oryctolagus cuniculus | Without Homology |
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Pig | Sus scrofa | Without Homology |
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Cow | Bos taurus | Without Homology |
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Sheep | Ovis aries | Without Homology |
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Dolphin | Tursiops truncatus | Without Homology |
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Horse | Equus caballus | Without Homology |
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Dog | Canis familiaris | Without Homology |
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Panda | Ailuropoda melanoleuca | Without Homology |
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Cat | Felis catus | Without Homology |
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Pale spear-nosed bat | Phyllostomus discolor | Without Homology |
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Velvety free-tailed bat | Molossus molossus | Without Homology |
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Greater mouse-eared bat | Myotis myotis | Without Homology |
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Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
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Greater horseshoe bat | Rhinolophus ferrumequinum | Without Homology |
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Egyptian rousette | Rousettus aegyptiacus | Without Homology |
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Sloth | Choloepus didactylus | Without Homology |
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Tasmanian Devil | Sarcophilus harrisii | Without Homology |
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Opossum | Monodelphis domestica | Without Homology |
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Platypus | Ornithorhynchus anatinus | Without Homology |
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Chicken | Gallus gallus | Without Homology |
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Turkey | Meleagris gallopavo | Without Homology |
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Zebra Finch | Taeniopygia guttata | Without Homology |
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Budgerigar | Melopsittacus undulatus | Without Homology |
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Painted Turtle | Chrysemys picta | Without Homology |
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Lizard | Anolis Carolinensis | Without Homology |
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Frog | Xenopus tropicalis | Without Homology |
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Zebrafish | Danio rerio | Without Homology |
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Drosophila | Drosophila melanogaster | Without Homology |
>ACY1P1 |
GGCAGAGGCTGCAGTCAAACCCCTATCTAAAGGGTGGGGCTGTGACCTCCGTGAACCTGAGTAAGCTAGAGGGTGGCATGGCTTATAACATGGGCAACTGCCACTATAAGCGCCAGCTCAGACTTTGCTGTGGCACCAGATGTGGACCTGAAAGCTTTTGAGCAGCAGCTGCAGGGCTGGTGCCAGACAGCTGGAGACAGGGTCACATTTTCGAGTTTGCTCAGAAGCGGATGCAGCTCTGAGTGACACCTACTAATGACTCAGACCTCTGGTGGGCAGCTTTTAGCCAGGTCTGCAAGGGCATGAACCTCACACTCTGGCTGCCACTGACAGCTGTTTCTTCTGTGCCGTAGGGCTTCTCACCCATGAGCCACACACCTGTGCTGCTGCATGACCACGACGAGTGGCTACATGAGGCTGCGTTCCTCCTGGGTTGACACATATTCACACCTGCTGCCTGCCCTGGCCAGCATGCCCACACTGCCTGGCGAGAGCGGAGCCCCAGAACTCCCCAGCCTCTGCCCCTGGAGCTTCCATTCCAACTAGTGCCAAGGACCTCTTCTTCCCCCTTCCAAATAATAAAGTT |
>NM_000666.3 |
ACAGTCAGGGAAGGGCGCTGAGAGGCGAGCGTGAGCCCAGCGACAGGAGAGTGAGCTCACCACGCGCAGCGCCATGACCAGCAAGGGTCCCGAGGAGGAGCACCCATCGGTGACGCTCTTCCGCCAGTACCTGCGTATCCGCACTGTCCAGCCCAAGCCTGACTATGGAGCTGCTGTGGCTTTCTTTGAGGAGACAGCCCGCCAGCTGGGCCTGGGCTGTCAGAAAGTAGAGGTGGCACCTGGCTATGTGGTGACCGTGTTGACCTGGCCAGGCACCAACCCTACACTCTCCTCCATCTTGCTCAACTCCCACACGGATGTGGTGCCTGTCTTCAAGGAACATTGGAGTCACGACCCCTTTGAGGCCTTCAAGGATTCTGAGGGCTACATCTATGCCAGGGGTGCCCAGGACATGAAGTGCGTCAGCATCCAGTACCTGGAAGCTGTGAGGAGGCTGAAGGTGGAGGGCCACCGGTTCCCCAGAACCATCCACATGACCTTTGTGCCTGATGAGGAGGTTGGGGGTCACCAAGGCATGGAGCTGTTCGTGCAGCGGCCTGAGTTCCACGCCCTGAGGGCAGGCTTTGCCCTGGATGAGGGCATAGCCAATCCCACTGATGCCTTCACTGTCTTTTATAGTGAGCGGAGTCCCTGGTGGGTGCGGGTTACCAGCACTGGGAGGCCAGGCCATGCCTCACGCTTCATGGAGGACACAGCAGCAGAGAAGCTGCACAAGGTTGTAAACTCCATCCTGGCATTCCGGGAGAAGGAATGGCAGAGGCTGCAGTCAAACCCCCACCTGAAAGAGGGGTCCGTGACCTCCGTGAACCTGACTAAGCTAGAGGGTGGCGTGGCCTATAACGTGATACCTGCCACCATGAGCGCCAGCTTTGACTTCCGTGTGGCACCGGATGTGGACTTCAAGGCTTTTGAGGAGCAGCTGCAGAGCTGGTGCCAGGCAGCTGGCGAGGGGGTCACCCTAGAGTTTGCTCAGAAGTGGATGCACCCCCAAGTGACACCTACTGATGACTCAAACCCTTGGTGGGCAGCTTTTAGCCGGGTCTGCAAGGATATGAACCTCACTCTGGAGCCTGAGATCATGCCTGCTGCCACTGACAACCGCTATATCCGCGCGGTGGGGGTCCCAGCTCTAGGCTTCTCACCCATGAACCGCACACCTGTGCTGCTGCACGACCACGATGAACGGCTGCATGAGGCTGTGTTCCTCCGTGGGGTGGACATATATACACgcctgctgcctgcccttgccagtgtgcctgccctgccCAGTGACAGCTGAGCCCTGGAACTCCTAAACCTTTGCCCCTGGGGCTTCCATCCCAACCAGTGCCAAGGACCTCCTCTTCCCCCTTCCAAATAATAAAGTCTATGGACAGGGCTGTCTCTGAAGTACTAACACAA |
PMID - Link | Title |
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