Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPPL3P1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:71225703-71227465  UCSC
Coordinates (T2T) chr18:71447283-71449046  UCSC
Coordinates (hg19) chr18:68892939-68894701  UCSC
Strand +
Parental Sequence NM_139015.5
Parental seq. overlap 1271 bp
Parental seq. overlap (%) 30.6%
Genomic Region Intergenic
Retrocopy Summary SPPL3P1, located on chr18:71225703-71227465, is a retrocopy of the parental gene SPPL3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPPL3
Full Name signal peptide peptidase like 3
Also known as IMP2|MDHV1887|PRO4332|PSH1|PSL4
Coordinate chr12:120762510-120904358
Strand -
Gene summary Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SPPL3P1
Bonobo Pan paniscus SPPL3P1
Gorilla Gorilla gorilla SPPL3P1
Orangutan Pongo abelii SPPL3P1
Gibbon Nomascus leucogenys SPPL3P1
Green monkey Chlorocebus sabaeus SPPL3P1
Crab-eating macaque Macaca fascicularis SPPL3P1
Rhesus Macaca mulatta SPPL3P1
Baboon Papio anubis SPPL3P1
Golden snub-nosed monkey Rhinopithecus roxellana SPPL3P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPPL3P1
CAGAAAGACAATAATAGTTCTTCTGGGTCTTTCAATGGCAACAGCACCAATAATAGCATCAAATAATTGAATCTACCCAGGCTCTGTTCCTTCCGATTGGAGCATCTGTCTCTCTTTTATTGTTGTTTTGCTTCTTTGACTGAGCTCAAGTAGTTTTCACAATATGTACAGCAGTTCTTACAATGATAACTTTTGCTTTTCTTCTTCTCCTGATGTGCGAGTATTTAACTAGACTCTATTCACCTCAGAACAAGATTTCCCTGGGTTCCCCTGGATGTTTCACTGCTGCTGAGTTGTTGTTATTATCTCTGTCTGTCGTGCTCATACTCACCTGGGTTCTCACTGGCCATTGACTTCTCATGGATGCAATGGCTGTGGGTCTCCGTCTCACTGTAATTTTCTTTGTCTGCCTGTTGGGCTTCAAAGTCCCCTGCCTGCTTCTCTCAGGGCTTTTAATCTATGATGTCTTTTAGGTAGTTTTCTCAGCCTACATCTTTAATAGCAGTGTCATGGTGAATGTGGCCATGGCAGCTGGCCGAAAATCCCCTTTACGTTCTATCTCAGAAGCTCAGCCTGGGGCCTGGTGTTGGGCGTGATGTTCCTCGCCTGTCTCTGCCTGGAAAACTGGTCTTCCCACGTTCTACTGGGAGCCACTTCCTCATGTTGGGCATTGGAGACATTGTTATGCCTGGTCATCTGCTATGCTTTGACCTTCACTATGACAATTACAAAATCAAGCCCGTGGGGACTCCTGTGGTGGCCCTGGACCTGCCAACATCTCTGGGCGCATGCAGAAGGTCTTCTACTTTCACTGCACGCTCATGGGATACTTTGTAGATCTGCTCACGGCTACTGTGGCCTCTCACATTCACCAGGCCGCCCAGCCTGCCCTTCTCTGTTTGGTGCCATTTACCTTATTGCCACTCCTCATGATGGCCTATTTAAAGGGTGACCTCCGGTGGATGTGGTCTAAGCTATTCCACTCCAAGACCAGTAGCTCCCAATTCCTGGAAGTATGATGGATCACGTAGAAAGTGACCAGATGCCCATGATAGTCCTTTTCTCTCAACTTGTGGTTTTGTTTCCTCTCAGAACTGGCCTGGTATTCAGAGATGTACCTATGTAAGGAACTGCTGGGTGACTGGGTTTCACATTTAAAAGGAGCTTGTTTGCAGGAGAGAAGTGCTGGAGCCCTGTTTGGTTCCTTCTCTCcGGTTCCTTCTCTTTCTGCAGATGTAGAGGTGGAGCCCCTTCCAGAGGGACAGGCCTCTCCCTGGTGCGCCTTCCTCCCTGTTTTTTATGGATCTGCACTACGTGGTTACTTTGTGGGTAGAGAGAGATGTGACTGTTTCAAAACTGAAAACAAGGAGTTGTTCAGATCTTTTGACCACTAAAAGGATAAAAAAAAAATTAGTAAACTAAAATTTCTTCAATGAGCCCTCGAAAACTTTGGGAC
>NM_139015.5
CTCCCCTCGGCGGGTGTGATCGAGTGGCCTCGCCTCATCGCCTAGCGCCCCCCTCAGTCGCCGCCGCCTCCGCCCGCCGGCCATGTCCCCCGGCCGCCGCCGCCGCCGCCCGAGCGCGGCGCTCCCGCGGCCCCGCGCGCAGTGAGCGCGGGCCCGTCTTGCCGTTCGCCCGCCCCAGGGCCCCCTTGTTCTCCGCGCCGCCGCCGCCGCCATGTTGGGTTTGGAGCTGCAGCGGAgccgccgccgccgccgcGGGTGAGGGAGGCCGAGAGCGGAGCCCGCCCCGCCCCGGGGCCCAGGGAGCGGGGCCGCTTCGGAGCCCGGCCTCTCcccgccagccgccttcccggcccgccgtgcagccagcgagccagcgagcgagcaagcaagcaagcACCGGACCCCGGCCGCGCCTTCAGCTACGGCCCGAGCGAGCCCGCCGCCGCCGGGCCCGGCCACAGCCTGCAGCGGAGCCCACGAGAGGCAGCGCCATGGCGGAGCAGACCTACTCGTGGGCCTATTCCCTGGTGGATTCCAGTCAAGTGTCTACATTTCTGATTTCCATTCTTCTTATAGTCTATGGTAGTTTCAGGTCCCTTAATATGGACTTTGAAAATCAAGATAAGGAGAAAGACAGTAATAGTTCTTCTGGGTCTTTCAATGGCAACAGCACCAATAATAGCATCCAAACAATTGACTCTACCCAGGCTCTGTTCCTTCCAATTGGAGCATCTGTCTCTCTTTTAGTAATGTTCTTCTTCTTTGACTCAGTTCAAGTAGTTTTTACAATATGTACAGCAGTTCTTGCAACGATAGCTTTTGCTTTTCTTCTCCTCCCGATGTGCCAGTATTTAACAAGACCCTGCTCACCTCAGAACAAGATTTCCTTTGGTTGCTGTGGACGTTTCACTGCTGCTGAGTTGCTGTCATTCTCTCTGTCTGTCATGCTCGTCCTCATCTGGGTTCTCACTGGCCATTGGCTTCTCATGGATGCACTGGCCATGGGCCTCTGTGTCGCCATGATCGCCTTTGTCCGCCTGCCGAGCCTCAAGGTCTCCTGCCTGCTTCTCTCAGGGCTTCTCATCTATGATGTCTTTTGGGTATTTTTCTCAGCCTACATCTTCAATAGCAACGTCATGGTGAAGGTGGCCACTCAGCCGGCTGACAATCCCCTTGACGTTCTATCCCGGAAGCTCCACCTGGGGCCCAATGTTGGGCGTGATGTTCCTCGCCTGTCTCTGCCTGGAAAACTGGTCTTCCCAAGCTCCACTGGCAGCCACTTCTCCATGTTGGGCATCGGAGACATCGTTATGCCTGGTCTCCTACTATGCTTTGTCCTTCGCTATGACAACTACAAAAAGCAAGCCAGTGGGGACTCCTGTGGGGCCCCTGGACCTGCCAACATCTCCGGGCGCATGCAGAAGGTCTCCTACTTTCACTGCACCCTCATCGGATACTTTGTAGGCCTGCTCACTGCTACTGTGGCGTCTCGCATTCACCGGGCCGCCCAGCCCGCCCTTCTCTATTTGGTGCCATTTACTTTATTGCCACTCCTCACGATGGCCTATTTAAAGGGCGACCTCCGGCGGATGTGGTCTGAGCCTTTCCACTCCAAGTCCAGCAGCTCCCGATTCCTGGAAGTATGATGGATCACGTGGAAAGTGACCAGATGGCCGTCATAGTCCTTTTCTCTCAACTCATGGTTTGTTTCCTCTTAGAGCTGGCCTGGTACTCAGAAATGTACCTGTGTTTAAGGAACTGCCGTGTGACTGGATTTGGCATTTAAAGGGAGCTCGTTTGCAGGAGAGAGGTGCTGGAGCCCTGTTTGGTTCCTTCTCTTCCTGCGGATGTAGAGGTGGGGCCCCTTCCAAGAGGGACAGGCCTCTCCCCAGCGCGCCTTCCTCCCACGTTTTTATGGATCTGCACCAGACTGTTACCTTCTGGGGGAGATGGAGATTTGACTGTTTAAAAACTGAAAACAGCGAGGAGTCTTTCTAGAACTTTTGAACACTAAAAGGATGAAAAAAATTAGCAAACCGAAGTTTCTTCAATGACCCCTCGAGAACTTTGGGACCAGTTTCCTATAGGGGACTCAGTTTCAGAGAACTGAGACAGAAGCTCTTCTGTCGTTATATTCTTCTTTCCTTTTTTTGGATTTATTAAATATTTTCTGTGGTGTGAAGTGACTTATTAAATCCACAGACATTGAGTGACTTCTTACAACATCCACATAAGAATTTGTTGTAATGAGTTCATGTCCACCCAGATGTTGTGTTGGCAGTGAACAAGGGCACGGTTTTtatacatacgtacatatatatatataaacacacacatagatatatatGAATAAACAAAAATGAAATCCTGCTAAGATCACGCTGTGTAGCTGACAGGGGCTTGCTGTCGTTTTGAGCATGTCGAGCAGTTTACTGTGGCTTCCTTGTATATGGATAAGCTGCTGTCCTTCCCCTTCACAACTGACCCCGCAGTTACAAACTAGTATAGCATTTGTGCTGATTGATGATAGACTCATGGACTTCAGGAGCCCTTACTTGGTTTTGATCAGTGTAGCAAATTAGGGATGAAGAGTTCAAACCTTTTGGCCCTTTCTTTCTTTTCTAGGCTTCTCCCTCGCAGGGTGTTCCGTAGTTTCTTCTCGAGCCAATGCATGTATTATAGCAGCAGGTGTCTTTGTGCTTTCTCATCATAGTAACGTACTACTTGTAAATACAtttttctattttctatttttttgtatttttttttttGACATTTTGTTTCATTGGTGTGCTGTATATTTTCCATGCCCTCACTCCTTTAAGAAAAAAAAAAAGGAAAAAAGCAACACAATCCTGTCCTTGCTGTTGTGATTATAGTCTTGGTTTACCTGTGGTGACAACCGGGTGTTGGGGACACATGTCAAATGCCCCTCTGAGATGGGCCCTAAATTCCAGTAACTGGGGAAAGAACCAGCTGCTGTGTCCTGAGAGCCTGGCCCTGTGCTGTGGTCTCTGCTGCAAGCCCAGATTTCTGGGAGTAACTAGTGTTAGGTCTGCTGACCTTTACCTAAGCAGCCCCTGCCTGGTAAGAAGGTGCCCATTGTTCAGAGGCAAAGAGAAGCCTGCGGTTGGCATGAGGATGCCTGACAACAAAGGCTGGAGAAGGGCCCTGAGTTCCAGCCTCTCCCCAAGGGTCCCCGCCCCAGTGGCTGCCTCTGTCTTGACCTGTGTAATGAATTAGTGTGCTGTGTCACTGTGGCTTGAAGTCACTGTGGATCGAGCTCACAGGGGGCACCCATCCTGTTGTCAACAGAGTCTGAAGCAGTCAGGGTGTTGGATTCCTCTGTTGTTGTCATCAATTCCTGCTGAGGGGTTTCTGGGGTTTTGTTTTTAATAAATGACTCCTTTGTAGCCTTTGTCACATAATCTTCACTTTGGTTGTTGGTACCAAACAGAGCTCCCAGCCATCTCCTCCCTGTTCTGGAAGACTGATGGGAAGACTCTGTCTGTCCCCAGACCTGGTCATCTGCAGCTCTGGCCCAGTCATAGATACATCAAAGAACTGAAGCTTCTGCTGTCCACAGAACTCAAAACTGCCTCTGCATTGGGTGAAGACTAAAAATCCACTTGCGGACTCTCCCTTCCTTCCTTCTCAGCCCTCGAGGATGCATATAGCTAATTAAGCAGGCCCAGAGACAGAGAGGGGGGCTCCAAAATGACTCGGATTAAGGGCAAGTGCCAGTGATGGGTAGAAATAACGTTATCCTtcatgcctgtaatcccagcactttgggaggccgaggcaggtggatcacaaggttgggagctcgagaccagcctggccaacatggtgaaaccccgtctctactaaaaacacaaaaattagctgggcatggtggcaggcgcctgtaatcccagctatttgggaggctgaggcagaagaatcgcttgaacctggaaggcggaggttgcagtgagcagagattgcgccactgcactcaagtctgggcgacagggtgagactccatctcaaaaaaaaaaaaaaaaaggaaaTGTTATCCTGGCAGTGGGTCATTTTAATTTTTCTGTCTTTGTTTTCATAAGAAAATTAAATTCCAGACAGAAGGAACGTC

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