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Summary

Retrocopy Name BOLA2P1
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Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:832142-832514  UCSC
Coordinates (T2T) chr18:986459-986831  UCSC
Coordinates (hg19) chr18:832143-832515  UCSC
Strand +
Parental Sequence NM_001031827.2
Parental seq. overlap 342 bp
Parental seq. overlap (%) 33.6%
Genomic Region Intergenic
Retrocopy Summary BOLA2P1, located on chr18:832142-832514, is a retrocopy of the parental gene BOLA2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BOLA2
Full Name bolA family member 2
Also known as BOLA2A|BOLA2B|My016
Coordinate chr16:29453588-29454964
Strand -
Gene summary This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BOLA2BP3
Bonobo Pan paniscus BOLA2BP3
Gorilla Gorilla gorilla BOLA2BP3
Orangutan Pongo abelii BOLA2BP3
Gibbon Nomascus leucogenys BOLA2BP2
Green monkey Chlorocebus sabaeus BOLA2BP3
Rhesus Macaca mulatta BOLA2BP3
Baboon Papio anubis BOLA2BP3
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>BOLA2P1
GGGAAGTGGCTCCTGTAAGGGCGCAAAGCAGCGTGGCAGGGGTCCGAGCTGGGGTTCTGTCCCCGCTGGGCTGCCGCCCCAGCTGGACTACCGCCAGGGAACTCAGCGCCAATTACCTCCAGGAGAAGCTGCAGCGGGACCTGGAGGCGGAGCATGTGGAGGTGGAGGACACGACCTTCAACCTGTAGCTTCCGAGTCCTGGTGGTGTCAGCTGCTGCTTCAGAGACACCAGCTGGTGAATGCGTGCCTAGCAGAAGAGCTCCCACACATCCATGCCTTTGAACAGAAAACCCTGACCCCAGAGCAGTGGGCCCGTGAGCAGCAGAAATGAGGGACTGGAAGCTGCACAGCCATTAAATTATAAATCTGGACC
>NM_001031827.2
CTTCCTCCCGGCACAGAAGGCCTCCCCCTCTCACCAGGGCCCTCGCCCGCTGGTCCGCCAGGCCCCGCCTTTTTTGCGGCCCCCATTGTGCTGCTGGACCCGACGAGCAGTGTTGACAGTGAACCCCACGTAGACGCGGCCCCGGTACCGGGGGTTCAGGCAGTAGAGCAGGTAGACGCCGAAAAAGCGCCCTGGCCTCGCCGCGACCCCCGCGGGACCCATCGGGCCTTGGGGTTCGGGAACCACAGCAGGGGGTTGATTGCCGTGACCTAGGGTCCAGGGGAGGGCTGGATCGCTAGGGCTGCAGGGTGCTTGCTTCGGAACAAGCTCTCGGGGACTATCCGGAGGCAGCCTGCAGGAAGCCGTAGCGCCGGTACGTGCCCCTCTCCTGTCTGGAGGCGGGTGTAGAAGTCCGACCGCGGAAGCCAGACTGCTGTCCAGTCGGCGAGCGCGTACCATTCAGCATCGGCTCCGCCCGAGTCCCACCTTCCTCAGGCTCTGATTGGCTGACACATGGCAAGCGCGAAAAGCCTGGACCGCTGGAAAGCCCGGCTGCTTGAGGGCGGAAGTACTGCGTTGACGTACGCCTTAGTAAGGGCGGAAGTGAGTTTTCCAGCGGAAGTGGCTCCTGTAAGGCAGCAAGGTAGCGTGGCCGGCGCCCGAGCTGGGGTTGTGTCCCTGCTGGGCTGCCGTTCCAGCTGGACTGCCGCCATGGAACTCAGCGCCGAATACCTCCGCGAGAAGCTGCAGCGGGACCTGGAGGCGGAGCATGTGGAGGTGGAGGACACGACCCTCAACCGTTGCTCCTGTAGCTTCCGAGTCCTGGTGGTGTCGGCCAAGTTCGAGGGGAAACCGCTGCTTCAGAGACACAGGCTGGTGAACGCGTGCCTAGCAGAAGAGCTCCCGCACATCCATGCCTTTGAACAGAAAACCCTGACCCCAGACCAGTGGGCACGTGAGCGACAGAAATGAGGGACTGGGATCTGCACAGCCATTAAATTATAAATCTGGACCAGC

Publications

PMID - Link Title
No publications available for this retrocopy