Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name COP1P1
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:8412030-8414615  UCSC
Coordinates (T2T) chr18:8575180-8577765  UCSC
Coordinates (hg19) chr18:8412028-8414613  UCSC
Strand +
Parental Sequence NM_022457.7
Parental seq. overlap 2315 bp
Parental seq. overlap (%) 81.5%
Genomic Region Intergenic
Retrocopy Summary COP1P1, located on chr18:8412030-8414615, is a retrocopy of the parental gene COP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COP1
Full Name COP1 E3 ubiquitin ligase
Also known as CFAP78|FAP78|RFWD2|RNF200
Coordinate chr1:175944831-176209087
Strand -
Gene summary Enables ubiquitin protein ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COP1P2
Bonobo Pan paniscus COP1P2
Gorilla Gorilla gorilla COP1P2
Orangutan Pongo abelii COP1P2
Gibbon Nomascus leucogenys COP1P2
Green monkey Chlorocebus sabaeus RFWD2P2
Crab-eating macaque Macaca fascicularis RFWD2P2
Rhesus Macaca mulatta COP1P2
Baboon Papio anubis COP1P2
Golden snub-nosed monkey Rhinopithecus roxellana COP1P2
Marmoset Callithrix jacchus COP1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COP1P1
TCTCAGGATACACTAAGGCTGAGGAAAAGGGAGGTGGCAAAGGGTCAAGGTCATGGTCCCTCTCATCCAAGTGCCCGGCCAGATGGGAGGGAGTCGTAATGTCTGGTAGCCACCATGCCGGGTCAGACTCCACTGGGATGAGCCCCTGCTCCTCAGCCTCTTTGGTGACTTTAGCCTCCTTGTCCTTATCGTCTTCCCCATTGCCGCCGCTGTGGCAGCTTCGGCAGTAGTGCTGCTGTCCAGTGGGGCGGCCCAGGCCACCAGCTTGGATAGCCTTGGGGCCCAGTGTGGCCTGTGTTGGTGGTGCCCACTGTGTCAGGCAGTGGCAGGGTGCTGTCCATAGTCCTGTCCCGGCTCAGCTGCATGCCCAGGCCCCAGTGCTGGTATAGGAGGCAGCAGCTGTAGCCTAGGCAGCAGCAGGAAGCAACCTCTGCTTGCCCCTCCCCTCTCCAACAGGCTCATCAACTCATATAAGGACAACAGCAATGATTTCATATGCCCCATCTGCTTTGATATGATTGAAGAGGCATACACGACAAAATAAGGCCACAGCTTTTGCTATAAGTAGATTCACTAGAGTTCGGAGGACAATAATATATGTACCAAGTATAACTATGTTGTGGACAATACTAACCATCTGTTTCCTAATTTGTTGGTGAATGAGCTCATTCTCAAACAGAAGCAAAGATTTGAGGAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCAATGGCCACAGGTGGTGAATATTTCAAGATTTGTTGGGAACTGACCAAGATAACCTTGATTTGGCCAATATCAACCTCATGTTGGAGTTACTAGTTCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGAATCTTATACAATTCCTCAAGGTTGCAAGAAGAAATAGGAGAGAGCAACTGGGACACTTCCAGAAGGAGCTAAGTGTTTTGGAAGAGGATATTAAAAGAGTGGAAGAAATGAGTGGCTTACACTCTCCTGTCAGTGAGGATAGCACAGTGCCTCAACTTGAAGCTCCTCCTGCATCACACAGTAGTATTATGGATTCCACAGAATATAGCCAATATCCAGGTTTCAGTGGCAGTTCTTAGACAAAGAAACAGCCTTGATATAACAGCACATTAACATCAAAATTAAAATGGCCCACTGCTCATTTTGAAGACCTGGAGCACTGTTACTTTTCTACAAGGTTGTCTCGTATCTCAGATGACAGTTGAACTGCAAGCCAATTGGATGAACTTCAGAAATGCTTGTCCAAGGTTACTCAATATAAATCAATATGAACTTTAGCCACATTATCATGCCCTAGTGATCTCTATAATGATTCCAGGATAGTCTCTGGTATTGAATTTGACCAGGATTGTGACTATTTTGCAATTGCTGAGGTTACAATGAAGATTAAAGTCTATGAATATGGCACAGTCATCCAGGATGCAGTGGATATTCATTACCGTGTGAATGAAATGACCTCAATTCCAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAAGAACCTGTTAGCTAGCAGTGATTATGAAGGCATTGTTATCCTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTAACAGGAGCGTGAGAAGAGGTGTTGAAGTGTTTCATTTGATGGATCCTAAACTCCTGGCTTTGGGTTCTGATGATGTAAAAGTGAAGCTGTGATCTACCGGTCTAGACAACTCAGTGGCAAGCATTGAGGCAAAGGCTGATGTGTGCTGTGTTAAATTCAGCCGCTCTTCCAGATGCCATTTGGCTTTTGGCTGTGCGGATCATTGTGTCCATTACTATGATCTTCGTAGCACTAAACAGCCAATCATGGTATTCAAAGGACGCCAAAAAGCAGTCTCTTATGCAAAGTTTGCGAGTGGTGAGGAAATTGTCTTTGCCTCAACAGACAGCCAGCTAACACTGTGGAATGTAGGGAAACTGTACTGCCTACATTCCTTCAAGGGTCATATCAATGAAAAGAACTTTGTAGGCCTTGCTTCCCGTGGAGAGTATATAGCTTGTGGAAGTGAGAACAACTCTCTCAACCTGTGCTATAAAGCACTTTCTAAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTGGACAAAGAAGGAAAAGAAGATGATACAAATGAATTTGTTGGTGCTGCGTGCTGGAGGGCACAACCAGATGGAGAGTTCAACATGCTGATTGCTGCTAACAGTGAGGGTACAATTAAGGTGCTAGAATTGGTACGAAGGGTTTACTCAACCCTAAATGTACTTGATCCTGCTGATATACCTCTGCAGCTGACAATGATAGAAGAAACAGAAAATGTCATGTGATGTCTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTTGAGTATTTTTCTTTTTCTCTTTTTCCTCCTTTGTGACCTTTGGGACATTGGGAATACCCAGTGAACTCTCCACCATCGGTGCGACTCCATGGACATTGCTACTGTTGGTGGTGTGGTTGTGGTTATCTAATTTTTGTGATAGGGAAACACATTCTTTGAAATAAAAATAAATAACAAAA
>NM_022457.7
gctcgcgcgcgcgcgcacggccggccacggcgcgccggggttggctgctacagggaccgcggtggcggcggcggcctcgacagcggTAGTGCCTTCTACTCCGCTTTTTTAGTTTCCTCCGCCCCCTCCCGTGGGACGCTGTTGTGTGGCTGCCTTAAAAAAAAACGCAACTTTATTGTTCCTCAGCCCCACCTCCGGCTCGGCGGGCGTCCTCAGGATGCACTGAGGCTGAGGGGAGGGGAGGCGGCGGAGGGTCGAGGTCGCGGTCCCTCTCCTCCGAGCGCCCGGCTGGAGGGGAGGGAGTCACGATGTCTGGTAGCCGCCAGGCCGGGTCGGGCTCCGCTGGGACAAGCCCCGGGTCCTCGGCGGCCTCCTCGGTGACTTCCGCCTCCTCGTCTTTATCCTCTTCCCCGTCGCCGCCTTCCGTGGCGGTTTCGGCGGCAGCGCTGGTGTCCGGCGGGGTGGCCCAGGCCGCCGGCTCGGGCGGCCTCGGGGGCCCGGTGCGGCCTGTGTTGGTGGCGCCCGCCGTATCGGGTAGCGGCGGCGGGGCGGTGTCCACGGGCCTGTCCCGGCACAGCTGCGCGGCCAGGCCCAGCGCCGGCGTAGGAGGCAGCAGCTCCAGCCTAGGCAGCGGCAGCAGGAAGCGACCTCTCCTCGCCCCCCTCTGCAACGGGCTCATCAACTCCTACGAGGACAAAAGCAACGACTTCGTATGCCCCATCTGCTTTGATATGATTGAAGAAGCATACATGACAAAATGTGGCCACAGCTTTTGCTACAAGTGTATTCATCAGAGTTTGGAGGACAATAATAGATGTCCCAAGTGTAACTATGTTGTGGACAATATTGACCATCTGTATCCTAATTTCTTGGTGAATGAACTCATTCTTAAACAGAAGCAAAGATTTGAGGAAAAGAGGTTCAAATTGGACCACTCAGTGAGTAGCACCaatggccacaggtggcagatatttcaagattggttgggaactgaccaagataaccttgatttggccaatgtcaatcttatgttggagttactagtgCAGAAGAAGAAACAACTGGAAGCAGAATCACATGCAGCCCAACTACAGATTCTTATGGAATTCCTCAAGGTTGCAAGAAGAAATAAGAGAGAGCAACTGGAACAGATCCAGAAGGAGCTAAGTGTTTTGGAAGAGGATATTAAGAGAGTGGAAGAAATGAGTGGCTTATACTCTCCTGTCAGTGAGGATAGCACAGTGCCTCAATTTGAAGCTCCTTCTCCATCACACAGTAGTATTATTGATTCCACAGAATACAGCCAACCTCCAGGTTTCAGTGGCAGTTCTCAGACAAAGAAACAGCCTTGGTATAATAGCACGTTAGCATCAAGACGAAAACGACTTACTGCTCATTTTGAAGACTTGGAGCAGTGTTACTTTTCTACAAGGATGTCTCGTATCTCAGATGACAGTCGAACTGCAAGCCAGTTGGATGAATTTCAGGAATGCTTGTCCAAGTTTACTCGATATAATTCAGTACGACCTTTAGCCACATTGTCATATGCTAGTGATCTCTATAATGGTTCCAGTATAGTCTCTAGTATTGAATTTGACCGGGATTGTGACTATTTTGCGATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATGACACTGTCATCCAGGATGCAGTGGATATTCATTACCCTGAGAATGAAATGACCTGCAATTCGAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAAGAACCTGTTAGCTAGCAGTGATTATGAAGGCACTGTTATTTTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGAGAAGAGGTGTTGGAGTGTTGACTTTAATTTGATGGATCCTAAACTCTTGGCTTCAGGTTCTGATGATGCAAAAGTGAAGCTGTGGTCTACCAATCTAGACAACTCAGTGGCAAGCATTGAGGCAAAGGCTAATGTGTGCTGTGTTAAATTCAGCCCCTCTTCCAGATACCATTTGGCTTTCGGCTGTGCAGATCACTGTGTCCACTACTATGATCTTCGTAACACTAAACAGCCAATCATGGTATTCAAAGGACACCGTAAAGCAGTCTCTTATGCAAAGTTTGTGAGTGGTGAGGAAATTGTCTCTGCCTCAACAGACAGTCAGCTAAAACTGTGGAATGTAGGGAAACCATACTGCCTACGTTCCTTCAAGGGTCATATCAATGAAAAAAACTTTGTAGGCCTGGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAAAATAACTCTCTCTACCTGTACTATAAAGGACTTTCTAAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTCGACAAAGACCGAAAAGAAGATGATACAAATGAATTTGTTAGTGCTGTGTGCTGGAGGGCACTACCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTAGAATTGGTATGAAGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAAATACATCTGCAGCTGACAATGAGAGAAGAAACAGAAAATGTCATGTGATGTCTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTTCCCTCCTTTATGACCTTTGGGACATTGGGAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTGTTATCTAATTTTTGTGATAGGGAAACAAATTCTTTTGAATAAAAATAAATAACAAAACAATAAAAGTTTATTGAGCCACA

Publications

PMID - Link Title