Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPP6R3P1
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Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:88497683-88498658  UCSC
Coordinates (T2T) chr1:88341184-88342159  UCSC
Coordinates (hg19) chr1:88963366-88964341  UCSC
Strand -
Parental Sequence NM_001164164.2
Parental seq. overlap 806 bp
Parental seq. overlap (%) 23.7%
Genomic Region Intergenic
Retrocopy Summary PPP6R3P1, located on chr1:88497683-88498658, is a retrocopy of the parental gene PPP6R3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPP6R3
Full Name protein phosphatase 6 regulatory subunit 3
Also known as C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3
Coordinate chr11:68460724-68615334
Strand +
Gene summary Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPP6R3P1
Bonobo Pan paniscus PPP6R3P1
Gorilla Gorilla gorilla PPP6R3P1
Orangutan Pongo abelii PPP6R3P1
Gibbon Nomascus leucogenys PPP6R3P1
Green monkey Chlorocebus sabaeus PPP6R3P1
Crab-eating macaque Macaca fascicularis PPP6R3P1
Rhesus Macaca mulatta PPP6R3P1
Baboon Papio anubis PPP6R3P1
Golden snub-nosed monkey Rhinopithecus roxellana PPP6R3P1
Marmoset Callithrix jacchus PPP6R3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>PPP6R3P1
GTAGCAGGGAAAGGGTATGATGACCGGGAGGACAGTTCTTTTAAGGGTTGGAGGGTGCCAACCAGAGGATAGGGGTGAGTGTGCCCTCATTTTGTTTCTACTTTAATTTCTGTGTATCTGCCATATTGAACTGCGAGACTAAGAGCTGTCTGCAATACAATACCTGTATTAAAAATAACAAAAATAAGGCCCGATTCTGTTTCTAGAAAACCCATTGCAGCTGCCCTGGCAGCTCAGCCAGAAGCACCAGGCAATGTGGCCATGGAAGCCAGCTCGGATGGAGAGGAGGATGCAGAAATTACAGACGAGGTAACTGAGACAGTGATGAATGGAGGCATGAAGGAAACGCTCAGCCTTACTGTAGATGCCAAGACAGAGACTGCGGTCTTTAAAAGTGAAGAAGGGAAACTGTCTACCTCTCAAGACGCTGCTTGTAAAGACTTGGAAGAGGGCCCCAAGACCGCAGAGGCGAAGTGTGCTGGGCCCGGCCCTCAAGCAGTAGTCCCGAGCAGAGTGGTGTAGAGACTCCAGCACTCCAAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGCTCCCTTGACCTTTGCACGCCTCCTCAGGAACCGCCTTTCCCTGGTGAGCTCCTCTCTGAAGAGACTGTCCTCGGGCCTTCTCCTCTGGAACCAGCATCCCCAGAGGACAGGGCTCCTGCTGTCTCAGGGCTGCCTGACTTGTGTGGCGTTGGACCTCGGGGATTGCTGGTGGATAACACACTGTGGTCTTGCCTGGTGGCGAGTTTTGACGGCCATGGACAGGGTTTGGCTCCAGTGGTGGTGCACGTGGCCTCCGTGGTATGGACCTAGTGGCTTCTCCATCCCACCCAAGGTAACAGTGTCTCACTTCGTCCCACTAACTGCTAGGGAGAGAGCATCTGAGATTTTTCTTTGGGGTGGCa
>NM_001164164.2
GGGCGCTTCGCTGATGGTGTCGGTGAGCGCGTTTCCCGCCTGAGCGCAACTAGCGGCGGGTCGTGGGCACCTCCAGataagaaaacaagctcagagagatgtggtgacttgctcaaatagtgacagaactTCCTCGGCCATATGGAGGGGTCATATAATACCCTTGTGTCTTCAGTTTGAGGAGAGCTTGTTTCATATCCATATCCCACTGTATTCCTGCTAATCTGCTAATGCAGTAAATTGGAGGAAAACTGTTACCAGGATAACCTGTAATGGGCAAGGAGCCACAAAGAAGAAAACATTTCTTTTAATTTTTAAACTTGGTTTGAAAGACCAGCATGTTTTGGAAATTTGATCTTCACTCATCATCCCACATAGACACACTTCTAGAAAGAGAAGATGTAACACTGAAGGAGTTAATGGATGAGGAAGATGTTTTACAGGAATGTAAAGCTCAGAACCGCAAACTTATAGAGTTTCTGTTAAAAGCAGAATGTCTCGAAGATTTAGTCTCATTCATTATAGAAGAACCACCTCAAGACATGGATGAAAAGATCAGATACAAGTATCCAAATATATCTTGTGAGTTGCTCACTTCTGATGTCTCCCAGATGAATGATAGACTGGGAGAAGATGAATCCTTGCTAATGAAATTATATAGCTTCCTCCTAAACGATTCCCCTTTGAATCCACTACTTGCCAGTTTCTTCAGCAAGGTGCTAAGTATTCTTATCAGCAGAAAACCAGAACAGATTGTGGATTTCTTAAAGAAGAAGCATGATTTTGTAGACCTTATTATAAAGCACATAGGAACTTCTGCTATCATGGATTTGTTGCTCAGGCTCCTGACGTGTATCGAACCTCCACAGCCCAGGCAAGATGTGCTGAATTGGTTAAATGAGGAGAAAATTATCCAGAGGCTTGTGGAAATAGTTCATCCATCGCAAGAAGAAGATCGACATTCAAATGCATCACAATCACTTTGTGAAATTGTTCGCCTGAGCAGAGACCAGATGTTACAAATTCAGAACAGTACAGAGCCCGACCCCCTGCTTGCCACTCTAGAAAAGCAAGAAATTATAGAGCAGCTTCTATCAAATATTTTCCACAAGGAGAAAAATGAGTCAGCCATAGTCAGTGCAATCCAGATATTGCTGACTTTACTTGAGACACGACGACCAACATTTGAAGGCCATATAGAGATCTGCCCACCAGGCATGAGCCATTCAGCTTGTTCAGTAAACAAGAGTGTTCTAGAAGCCATCAGAGGAAGACTTGGATCTTTTCATGAACTCCTGCTGGAGCCACCCAAGAACATGTTCTTCAAGTATACATGGAATAACTTTTTGCATACACAAGTGGAAATTTGTATTGCACTGATTCTTGCAAGTCCTTTTGAAAACACAGAAAATGCCACAATTACCGATCAAGACTCCACTGGTGATAATTTGTTATTAAAACATCTTTTCCAAAAATGTCAATTAATAGAACGAATACTTGAAGCCTGGGAAATGAATGAGAAGAAACAGGCTGAGGGAGGAAGACGGCATGGTTACATGGGACACCTAACGAGGATAGCTAACTGTATCGTGCACAGCACTGACAAGGGCCCCAACAGTGCATTAGTGCAGCAGCTTATCAAAGATCTTCCCGACGAAGTCAGGGAACGATGGGAGACGTTCTGCACAAGCTCCTTAGGAGAAACTAACAAGAGGAACACGGTAGATCTAGCCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTTTGTTTCTAGAAA

Publications

PMID - Link Title
No publications available for this retrocopy