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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AKR1B1P6
Plot displaying the genomic locations of a retrocopy (in chr18) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr18:8546446-8547189  UCSC
Coordinates (T2T) chr18:8709602-8710345  UCSC
Coordinates (hg19) chr18:8546444-8547187  UCSC
Strand +
Parental Sequence NM_001628.4
Parental seq. overlap 642 bp
Parental seq. overlap (%) 47.1%
Genomic Region Intergenic
Retrocopy Summary AKR1B1P6, located on chr18:8546446-8547189, is a retrocopy of the parental gene AKR1B1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKR1B1
Full Name aldo-keto reductase family 1 member B
Also known as ADR|ALDR1|ALR2|AR
Coordinate chr7:134442350-134459239
Strand -
Gene summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKR1B1P6
Bonobo Pan paniscus AKR1B1P6
Gorilla Gorilla gorilla AKR1B1P7
Orangutan Pongo abelii AKR1B1P5
Gibbon Nomascus leucogenys AKR1B1P2
Green monkey Chlorocebus sabaeus AKR1B1P5
Crab-eating macaque Macaca fascicularis AKR1B1P7
Rhesus Macaca mulatta AKR1B1P7
Baboon Papio anubis AKR1B1P8
Golden snub-nosed monkey Rhinopithecus roxellana AKR1B1P11
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKR1B1P6
AACTCAAGAGAACTTAATCCAGTACTACCAGTCCAAGGCAGCATAGTGACCGCCTACAGCCCCCTTGGCTCTCCCGACAGGCCCAGGGCCAAGCCTGAGGACCCTTCCCTCCTGGAAGACCCCAGGATCAAAGTGATTGCAGCCAAGCACAATGAAACTGTAGCCAGGTTCTGATGTGGCTCCTCACACAGAGGAACTTGGTGGTGACCCCCACATCTGTGACACTGGATCGCATTGCTGAGAACTTCAAGGTCTTTGACTTTGAACTGAGCAGCCAGGATATGACCTCCTTACTCAGCTGCAACAGGAACTGAAGGGTCTGTGCCTTGGTAAGCTGAACCGCCCCCAAGGATCACCCATTCCATGAAGAGTTTCGAAGCTGTGGATGTCTGCTCTTCCGCAAGTAACCTACACCTGGTTTTCCCGCCTCATTGTTTTCTTGCAAATGTAGTATGGCCTGTATCCCTTGGCAGTGGGGCAGCAATCTGCAGACTGACCAGCAAGGGTCTGTCAAGCTTGACGTCAGGTCTGAAGAGCAGCATCAGTAGAGTGGAATTCTTTTCCCACTTTCTTTGCCATTTTTGTTCAGCTGAAGGAAGTGCAACCTGAATACCCTTTTCTGACCAAAGAGAAGCAAAATCTACAGAGTCAAAATAGTGCCTCTAACAGTTGAGTTTCGGCTGATGGAACTGTAATCCTTACGGCAAGACTTCTCTTTGCCTCAAATAATAAGTGCTTTTGTGA
>NM_001628.4
GCACCGTACTGGGCGGGGGTCTGGGGAGCGCAGCAGCCATGGCAAGCCGTCTCCTGCTCAACAACGGCGCCAAGATGCCCATCCTGGGGTTGGGTACCTGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCATTGACGTCGGGTACCGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGTGGCCATTCAGGAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAGCTGTGGTGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCCTGCCAGAAGACACTCAGCGACCTGAAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCGACTGGCTTTAAGCCTGGGAAGGAATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGACACGTGGGCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCCAACTTCAACCATCTCCAGGTGGAGATGATCTTAAACAAACCTGGCTTGAAGTATAAGCCTGCAGTTAACCAGATTGAGTGCCACCCATATCTCACTCAGGAGAAGTTAATCCAGTACTGCCAGTCCAAAGGCATCGTGGTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGGGCCAAGCCCGAGGACCCTTCTCTCCTGGAGGATCCCAGGATCAAGGCGATCGCAGCCAAGCACAATAAAACTACAGCCCAGGTCCTGATCCGGTTCCCCATGCAGAGGAACTTGGTGGTGATCCCCAAGTCTGTGACACCAGAACGCATTGCTGAGAACTTTAAGGTCTTTGACTTTGAACTGAGCAGCCAGGATATGACCACCTTACTCAGCTACAACAGGAACTGGAGGGTCTGTGCCTTGTTGAGCTGTACCTCCCACAAGGATTACCCCTTCCATGAAGAGTTTTGAAGCTGTGGTTGCCTGCTCGTCCCCAAGTGACCTATACCTGTGTTTCTTGCCTCATTTTTTTCCTTGCAAATGTAGTATGGCCTGTGTCACTCAGCAGTGGGACAGCAACCTGTAGAGTGGCCAGCGAGGGCGTGTCTAGCTTGATGTTGGATCTCAAGAGCCCTGTCAGTAGAGTAGAAGTCTCTTCCAGTTTGCTTTGCCCTTCTTTCTACCCTGCTGGGGAAAGTACAACCTGAATACCCTTTTCTGACCAAAGAGAAGCAAAATCTACCAGGTCAAAATAGTGCCACTAACGGTTGAGTTTTGACTGCTTGGAACTGGAATCCTTTCAGCAAGACTTCTCTTTGCCTCAAATAAAAAGTGCTTTTGTGA

Publications

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