Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PTGES3P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:89103519-89104951  UCSC
Coordinates (T2T) chr1:88946872-88948304  UCSC
Coordinates (hg19) chr1:89569202-89570634  UCSC
Strand -
Parental Sequence NM_006601.7
Parental seq. overlap 1378 bp
Parental seq. overlap (%) 72.5%
Genomic Region Intergenic
Retrocopy Summary PTGES3P1, located on chr1:89103519-89104951, is a retrocopy of the parental gene PTGES3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PTGES3
Full Name prostaglandin E synthase 3
Also known as P23|TEBP|cPGES
Coordinate chr12:56663349-56689575
Strand -
Gene summary This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PTGES3P1
Bonobo Pan paniscus PTGES3P1
Gorilla Gorilla gorilla PTGES3P1
Orangutan Pongo abelii PTGES3P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PTGES3P1
GCGCAGTGCATTCTGGGGACCGAGGTCGAGCCAGCCACTGCTGCCGTCGCCTGAGGGAAGCGAGAAGAGGCCGCGACCGGGAAGAAAACGCTGAGTCGCCACTGGAGAGAAGTGGACTCCATAGCAGCAGACCCCGCCAGAGAGGCCCGCCCACCCGTTCGCCCCTCCCCCTGCCCCGTTCACAATGCAGCCTGCTTCTGCAAAGTGGTACGATCAAAGGCACTATGTCTTCATTGAATTTTGTGTTGAAGACAGTAAGGATGTTAATGTAAATTTTGAAAAATCCAAACTTACATTCAGTTGTCTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGATACAAACGATTCCAAGCATAAAAGAACGGACAGATCAATTTTATGTTGTTTACGAAAAGGAGAATCTGGACAGTCATGGCCAAGGTTAACAAAAGAAAGGGCAAAGCTTAATTGGCTTAGTGTTGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAATAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGCAGTAAGGAATATTGTCATCACCTGGGTTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATGATTGAGAGAATTCCTGAGTTGATCTAAAAGCAGATGCTGTAGCTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAGGGCTTCACTAAGGGTTGATATGTACCATTGTAGGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCGGCAGTTGTGATAAATAAAAACATCTCACCTAAGTCTCCTTTTCTTCATAATATAGATACTGACATGATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAGCTAAATTTTAGATTATAGAACATGGATTCAAAAGTGGCTGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCCTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATCACTTGTCAGTGTTCCAGGTGTATATTAGCTAAAATTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTGTACATTTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAAGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCATTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGTAt
>NM_006601.7
CTCACCACCCCTCGTTTGCACGCACGCACGTTCATTCTCCGTCCTCGCGCCCCTTTTCCTACACTTTCCTCTTCTCCCCGACCGGAGGAGCCGCTCTTTCCGCGCGGTGCATTCTGGGGCCCGAGGTCGAGCCCGCCGCTGCCGCCGTCGCCTGAGGGAAGCGAGAAGAGGCCGCGACCGGAGAGAAAAAGCGGAGTCGCCACCGGAGAGAAGTCGACTCCCTAGCAGCAGCCGCCGCCAGAGAGGCCCGCCCACCAGTTCGCCCGTCCCCCTGCCCCGTTCACAATGCAGCCTGCTTCTGCAAAGTGGTACGATCGAAGGGACTATGTCTTCATTGAATTTTGTGTTGAAGACAGTAAGGATGTTAATGTAAATTTTGAAAAATCCAAACTTACATTCAGTTGTCTCGGAGGAAGTGATAATTTTAAGCATTTAAATGAAATTGATCTTTTTCACTGTATTGATCCAAATGATTCCAAGCATAAAAGAACGGACAGATCAATTTTATGTTGTTTACGAAAAGGAGAATCTGGCCAGTCATGGCCAAGGTTAACAAAAGAAAGGGCAAAGCTTAATTGGCTTAGTGTCGACTTCAATAATTGGAAAGACTGGGAAGATGATTCAGATGAAGACATGTCTAATTTTGATCGTTTCTCTGAGATGATGAACAACATGGGTGGTGATGAGGATGTAGATTTACCAGAAGTAGATGGAGCAGATGATGATTCACAAGACAGTGATGATGAAAAAATGCCAGATCTGGAGTAAGGAATATTGTCATCACCTGGATTTTGAGAAAGAAAAATAACTTCTCTGCAAGATTTCATAATTGAGAGAATTCCTGAGTTGATAGCTCTAAAGGCAGATATGCTGTATTTGCCTACTTTAACCCATTTTTCAACCTGTTTGTTTTTTAAAAGGCTTCACTAAGGGTTGATATGTACCATTGTATGGGGCAATTTTAAGTCAGCTAAGGCAATAACCTTATGCATGAACATTTCCCAGACTTTCATGAAGCTGTTGAGGTCCTAGGCAATTAATGCAGCAGTTGCGATAAATAAAAACATCTCACCTAAGTCTCCTTTTCTTCATAACATAGATACTGACATGATAGGAAGCTCTCAGCTTAGGGAAAGAGAATAAATTTTAGATTATAGAACATGGATTCAAAAGTGACTGGAACAAATTGGCTGACACCTTACTGGTAACCTGCTATTCTTCTGGTGTTATCCTTCAGGATTGTTCCACTAAAATTTATTTTTCAAAAAATTTACTTCACATTATTCTATGTAAGTGATGACTTGTCAGTGTTCCAGGTGTATCTTAGCTAAAACTAGAGAATGCCCTAACTTAGATGGTTTTTGAAGCCTATACAATTGGTATTGTTTGACCCTTAAGCTTTTACATCTCTTAGCATGGAGGACGAAGAAAGCTGTACATTGTTGCTTGAGAGTCTGTACATTTAGTCCAGATTTGTATTTGCACTGTCAGTATGGCAAATGAGTGAAAAATGTTTAATACACTATTGGATTTTTTATTTCCTTTTTTTGATTCAGCTTATACCCGGGCTGAAAACCTCAATTTATGTTCATGACAGTGGGGATTTTTTTAAATGTCTACATTCTTTCTAATAAACTGTTGGAAGACTTCTTGGCTGTCCTTTTAAGTGTCTGGCTTACTGTAATTTTTATGTATTTACCATTTACTGGAATGGAGTTTATTTGAGGAAGAATTTGGGATTATTCCTCTGTTTGAAAAAAGAGGCTTGCTGTAATGTCACAGGAAACCTTTTAAAAGTGGATCTGTAATAGCATATTGTAGATGCACTTTGCAGCAGTTGGAAAAGAAAGTGTTGTGTGATTTGATTGAAATAAAACTAAATGTGTTGTCCTCCTAAA

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