Retrocopy Name | PIGPP4 |
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Species | Homo sapiens | |
Coordinates (hg38) | chr18:9880577-9880869 UCSC | |
Coordinates (T2T) | chr18:10044045-10044337 UCSC | |
Coordinates (hg19) | chr18:9880574-9880866 UCSC | |
Strand | - | |
Parental Sequence | NM_001320480.2 | |
Parental seq. overlap | 235 bp | |
Parental seq. overlap (%) | 27.2% | |
Genomic Region |
Intergenic |
|
Retrocopy Summary | PIGPP4, located on chr18:9880577-9880869, is a retrocopy of the parental gene PIGP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
Gene Name | PIGP |
Full Name | phosphatidylinositol glycan anchor biosynthesis class P |
Also known as | DCRC|DCRC-S|DEE55|DSCR5|DSRC|EIEE55|PIG-P |
Coordinate | chr21:37065364-37073071 |
Strand | - |
Gene summary | This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016] |
Species | Scientific Name | Retrocopy | |
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Chimpanzee | Pan troglodytes | PIGPP3 |
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Bonobo | Pan paniscus | PIGPP2 |
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Gorilla | Gorilla gorilla | PIGPP4 |
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Orangutan | Pongo abelii | PIGPP3 |
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Gibbon | Nomascus leucogenys | PIGPP2 |
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Crab-eating macaque | Macaca fascicularis | PIGPP5 |
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Rhesus | Macaca mulatta | PIGPP5 |
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Baboon | Papio anubis | PIGPP5 |
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Golden snub-nosed monkey | Rhinopithecus roxellana | PIGPP5 |
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Marmoset | Callithrix jacchus | PIGPP3 |
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Green monkey | Chlorocebus sabaeus | Without Homology |
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Mouse lemur | Microcebus murinus | Without Homology |
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Mouse | Mus musculus | Without Homology |
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Rat | Rattus norvegicus | Without Homology |
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Chinese hamster | Cricetulus griseus | Without Homology |
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Rabbit | Oryctolagus cuniculus | Without Homology |
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Pig | Sus scrofa | Without Homology |
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Cow | Bos taurus | Without Homology |
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Sheep | Ovis aries | Without Homology |
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Dolphin | Tursiops truncatus | Without Homology |
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Horse | Equus caballus | Without Homology |
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Dog | Canis familiaris | Without Homology |
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Panda | Ailuropoda melanoleuca | Without Homology |
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Cat | Felis catus | Without Homology |
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Pale spear-nosed bat | Phyllostomus discolor | Without Homology |
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Velvety free-tailed bat | Molossus molossus | Without Homology |
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Greater mouse-eared bat | Myotis myotis | Without Homology |
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Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
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Greater horseshoe bat | Rhinolophus ferrumequinum | Without Homology |
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Egyptian rousette | Rousettus aegyptiacus | Without Homology |
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Sloth | Choloepus didactylus | Without Homology |
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Tasmanian Devil | Sarcophilus harrisii | Without Homology |
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Opossum | Monodelphis domestica | Without Homology |
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Platypus | Ornithorhynchus anatinus | Without Homology |
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Chicken | Gallus gallus | Without Homology |
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Turkey | Meleagris gallopavo | Without Homology |
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Zebra Finch | Taeniopygia guttata | Without Homology |
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Budgerigar | Melopsittacus undulatus | Without Homology |
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Painted Turtle | Chrysemys picta | Without Homology |
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Lizard | Anolis Carolinensis | Without Homology |
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Frog | Xenopus tropicalis | Without Homology |
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Zebrafish | Danio rerio | Without Homology |
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Drosophila | Drosophila melanogaster | Without Homology |
>PIGPP4 |
TTATTTCTGAATTTTGGTGAAAATCCTTAGGCTTAACCTATTGGCATCAAAAACACTGGGCAGTTGTGTTATGTGTCTCCCTCCTTATTACTTATTTTAGTCATTGGCCAGGAACTCGTGTTTGGAATTAACATGATGAATCCCTCTCCACTCAACTCCATTCAGGCAATCACAGACTACTAAACTAAAAATCAACAATGGAAGAAATGCCAGGAAGAGGCCATCCCAGCATTAAGAGATACTCTTATCATCAAAGTAAACCAAATGTTCTTTCTTGCAGCCAAATAACt |
>NM_001320480.2 |
CTTTCCCTCAGGTTTTCCTCTTCCCCACTGCGGCTCCCCAGTCGGCGCTTGCGCGGAGAACTCAGCGCTGAGGTGGCCGAGGTGTCGGGAGGGGCCTGGGTGGGCGTATGAAGGACCCGAGGTCGAGGGCCCCCCCATACCCCGCCTCGAATGAGAAATAGAAGTCTCCACGAATGGGCAGGGCCCGGGGCCTGGGCGCCGCGACCTAGTAGGCCCGCATGCTGATTGTCTAAAGCCCCAGGAAAAATGGTGGAAAATTCACCGTCGCCATTGCCAGAAAGAGCGATTTATGGCTTTGTTCTTTTCTTAAGCTCCCAATTTGGCTTCATACTTTACCTCGTGTGGGCCTTTATTCCTGAATCTTGGCTAAACTCTTTAGGTTTAACCTATTGGCCTCAAAAATATTGGGCAGTTGCATTACCTGTCTACCTCCTTATTGCTATAGTAATTGGCTACGTGCTCTTGTTTGGGATTAACATGATGAGTACCTCTCCACTCGACTCCATCCATACAATCACAGATAACTATGCAAAAAATCAACAGCAGAAGAAATACCAAGAGGAGGCCATTCCAGCCTTAAGAGATATTTCTATTAGTGAAGTAAACCAAATGTTCTTTCTTGCAGCCAAAGAACTTTACACCAAAAACTGAACTGTGTGTAACCATAGTAACACCAAGCACGTATTTATTTATAAGTTTTTGCCATTATAATTTTGACCATAAATTAATTTGACCATCTCTCTTATTAATAGAGAAGTAAAAAATGTAAGTTGACCTTCTCTTAGATTATGTTCAATGAATATTGTAAATGTTCAAGTATTGTTAATGAATAGAATAAATACAATATTGCATTCCCATA |
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