Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HIKESHIP2
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:10841839-10842269  UCSC
Coordinates (T2T) chr19:10968851-10969281  UCSC
Coordinates (hg19) chr19:10952515-10952945  UCSC
Strand +
Parental Sequence NM_001322404.2
Parental seq. overlap 413 bp
Parental seq. overlap (%) 39.4%
Genomic Region Intragenic (C19orf38)
Retrocopy Summary HIKESHIP2, located on chr19:10841839-10842269, is a retrocopy of the parental gene HIKESHI. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HIKESHI
Full Name heat shock protein nuclear import factor hikeshi
Also known as C11orf73|HLD13|HSPC138|HSPC179|L7RN6|OPI10
Coordinate chr11:86302229-86345943
Strand +
Gene summary This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HIKESHIP2
Bonobo Pan paniscus HIKESHIP2
Gibbon Nomascus leucogenys HIKESHIP2
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HIKESHIP2
GAACAATCCCATTTCCTGAGGGAATGGGAGGATCTGTCTACTTTTCTTATCCTGATTCAAATGGAATGCCAGTGTGGCAACTCCTAGGATTTGTCACGAATGGGAAGCCAAGTGCCATCTTCAAAATTTCAGGTCTTAAATCTGGAGAAGGAAGCCAACATCCTTTTGGAGCCATGAATATTGTCCGAACTCCATCTGTTGCTCAGATTGGAATTTCAGTGGAATTATTGGACAGTATGGCTCAGCAGACTCCCGTAGGTAATGCTGCTGTATCCTCAGTTGACTCATTCACTCAGGCCCAGATGACACCAAGCCCATCTGAAATGTTCATTCCGGCAAATGTGGTTCTGAAATGGTATGAAAACTTTCAGTGATGACTACCACAGAACCATCTCTTGGAAAACATAATTTGAATAAAATAC
>NM_001322404.2
GTTGCCTGAGCAGTGGGCTGCTTAGGAAGAGAAGGTCAGAGTTCGCGGGGGCAGAGGCATTCTTGCCGCTGGCCCAGTCACTATGTAGTGGAGGGGCAGACACCCTCCCGCAAATTCTGGAAGGTTCTTAGTCTCGACTAGGGCAGTAGCCCCAGGACTCCTAGTCGCCGGCTTCAGGTCACTGCCGGCTGAACGGAGCTGCCGTCGCCATGTTTGGCTGCTTGGTGGCGGGGAGGCTGGTGCAAACAGCTGCACAGCAAGTGGCAGAGGATAAATTTGTTTTTGACTTACCTGATTATGAAAGTATCAACCATGTTGTGGTTTTTATGCTGGGAACAATCCCATTTCCTGAGGGAATGGGAGGATCTGTCTACTTTTCTTATCCTGATTCAAATGGAATGCCAGTATGGCAACTCCTAGGATTTGTCACGAATGGGAAGCCAAGTGCCATCTTCAAAATTTCAGGTCTTAAATCTGGAGAAGGAAGCCAACATCCTTTTGGAGCCATGAATATTGTCCGAACTCCATCTGTTGCTCAGATTGGAATTTCAGTGGAATTATTAGACAGTATGGCTCAGCAGACTCCTGTAGGTAATGCTGCTGTATCCTCAGTTGACTCATTCACTCAGGCCCAGATGACACCAAGCCCATCTGAAATGTTCATTCCGGCAAATGTGGTTCTGAAATGGTATGAAAACTTTCAAAGACGACTAGCACAGAACCCTCTCTTTTGGAAAACATAATTTGAATAAAATAATTTTTAATGGATTCTGAAATTTGTCATGTTTTGAAGATAACTGACTCCATCTAAAAGTATGAGGTCAAAGGATCACGAAACCTAAGTTTAAAAACTGCTTAGAGACTGAAGCTTaattaaaaatctttattaaaaattaaaaacattgaaaaatgaaaaTATGTTCATCATTAAAGACTTTTTTCCCCTTAAGCTTAAAATACCATTCAAAGGCAAGACATTTTGTTTTGGCTATGATTCATTTTTTTTACTTAAAAATAAAACCTATACCAAACAGTAGTGTGCCAAGTA

Publications

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