Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name HMGB2P1
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:1203126-1203736  UCSC
Coordinates (T2T) chr19:1171665-1172275  UCSC
Coordinates (hg19) chr19:1203125-1203735  UCSC
Strand +
Parental Sequence NM_002129.4
Parental seq. overlap 551 bp
Parental seq. overlap (%) 38.1%
Genomic Region Intergenic
Retrocopy Summary HMGB2P1, located on chr19:1203126-1203736, is a retrocopy of the parental gene HMGB2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HMGB2
Full Name high mobility group box 2
Also known as HMG2
Coordinate chr4:173331376-173334358
Strand -
Gene summary This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HMGB2P1
Orangutan Pongo abelii HMGB2P1
Gibbon Nomascus leucogenys HMGB2P1
Green monkey Chlorocebus sabaeus HMGB2P1
Crab-eating macaque Macaca fascicularis HMGB2P2
Rhesus Macaca mulatta HMGB2P2
Golden snub-nosed monkey Rhinopithecus roxellana LOC104667647P7
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HMGB2P1
GGAGGGAAGTGTCTCTGTTGGGTCCGGGTGCTCTGTGGGACTCTGAGGAAAAGCTCGCACCAGGTAGATGCTGTTCTGTCCCCATGGGTAAAGGACACCCCAACAAACCGAGGAGCAAAATGTCCTCGTATGCCCTCTTCGCGCAGACCTGCCAGGAAGAGCACAAGAAGAAACACCCGGACTCTTCTGTCAATTTCGTGGAATTCTCCAAGAAGTGTTTGGAGAGATGGAAGACCACGTCTGCAAAGGAGAAGTGAAGTTTGAAGAGAAGGCAAAAAGTGACAAAGCTCGCTGTGACAGGGAGATTAAAAATTACATTCCTCCGAAATGTAAGAAAGGGTAAGAAAGGAAAGAAAAAGGATCGCAATGCTCCTAGAAGGCCACCATCTGCCTTCTTCCTGTTTTGCTCTGAACATCGCCCAAAGATCAAAAGTGGACACCCAGGCCTATTTGTCGTGGAAACTGCAAAGAAACTGGGTGAAATGTGGTCTGGGCAGTCAGCCAAAGATAAACAACCATATGAGCAGAAAGCAGTTAAGCTACAGGAGAGATATGAAAAGGGTATTGCTGCATATCGTGCTAAGGGCAAAAGTGAAGCAGGAAAGAAGGGC
>NM_002129.4
AAACCAGTTCACGCCGGAGCCCCGTGAGGGAAGCGTCTCCGTTGGGTCCGGCCGCTCTGCGGGACTCTGAGGAAAAGCTCGCACCAGGTGGACGCGGATCTGTCAACATGGGTAAAGGAGACCCCAACAAGCCGCGGGGCAAAATGTCCTCGTACGCCTTCTTCGTGCAGACCTGCCGGGAAGAGCACAAGAAGAAACACCCGGACTCTTCCGTCAATTTCGCGGAATTCTCCAAGAAGTGTTCGGAGAGATGGAAGACCATGTCTGCAAAGGAGAAGTCGAAGTTTGAAGATATGGCAAAAAGTGACAAAGCTCGCTATGACAGGGAGATGAAAAATTACGTTCCTCCCAAAGGTGATAAGAAGGGGAAGAAAAAGGACCCCAATGCTCCTAAAAGGCCACCATCTGCCTTCTTCCTGTTTTGCTCTGAACATCGCCCAAAGATCAAAAGTGAACACCCTGGCCTATCCATTGGGGATACTGCAAAGAAATTGGGTGAAATGTGGTCTGAGCAGTCAGCCAAAGATAAACAACCATATGAACAGAAAGCAGCTAAGCTAAAGGAGAAATATGAAAAGGATATTGCTGCATATCGTGCCAAGGGCAAAAGTGAAGCAGGAAAGAAGGGCCCTGGCAGGCCAACAGGCTCAaagaagaagaacgaaccagaagatgaggaggaggaggaggaagaagaagatgaagatgaggaggaagaggatgaagatgaagaataaATGGCTATCCTTTAATGATGCGTGTGGAATGTGTGTGTGTGCTCAGGCAATTATTTTGCTAAGAATGTGAATTCAAGTGCAGCTCAATACTAGCTTCAGTATAAAAACTGTACAGATTTTTGTATAGCTGATAAGATTCTCTGTAGAGAAAATACTTTTAAAAAATGCAGGTTGTAGCTTTTTGATGGGCTACTCATACAGTTAGATTTTACAGCTTCTGATGTTGAATGTTCCTAAATATTTAATGGTTTTTTTAATTTCTTGTGTATGGTAGCACAGCAAACTTGTAGGAATTAGTATCAATAGTAAATTTTGGGTTTTTTAGGATGTTGCATTTCGTTTTTTTAAAAAAAATTTTGTAATAAAATTATGTATATTATTTCTATTGTCTTTGTCTTAATATGCTAAGTTAATTTTCACTTTAAAAAAGCCATTTGAAGACCAGAGCTATGTTGATTTTTTTCGGTATTTCTGCCTAGTAGTTCTTAGACACAGTTGACCTAGTAAAATGTTTGAGAATTAAAACCAAACATGCTCATATTTGCAAAATGTTCTTTAAAAGTTACATGTTGAACTCAGTGAACTTTATAAGAATTTATGCAGTTTTACAGAACGTTAAGTTTTGTACTTGACGTTTCTGTTTATTAGCTAAATTGTTCCTCAGGTGTGTGtatatatatatacatatatatatatatatatat

Publications

PMID - Link Title