Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSP90B3P
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:91642525-91644338  UCSC
Coordinates (T2T) chr1:91487112-91488925  UCSC
Coordinates (hg19) chr1:92108082-92109895  UCSC
Strand +
Parental Sequence NM_003299.3
Parental seq. overlap 1623 bp
Parental seq. overlap (%) 57.9%
Genomic Region Intergenic
Retrocopy Summary HSP90B3P, located on chr1:91642525-91644338, is a retrocopy of the parental gene HSP90B1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSP90B1
Full Name heat shock protein 90 beta family member 1
Also known as ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1
Coordinate chr12:103930410-103947926
Strand +
Gene summary This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSP90B1P1
Bonobo Pan paniscus HSP90B1P1
Gorilla Gorilla gorilla HSP90B1P1
Orangutan Pongo abelii HSP90B1P1
Gibbon Nomascus leucogenys HSP90B1P2
Green monkey Chlorocebus sabaeus HSP90B1P1
Crab-eating macaque Macaca fascicularis HSP90B1P1
Rhesus Macaca mulatta HSP90B1P1
Baboon Papio anubis HSP90B1P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSP90B3P
TTGAAACTGTTGAGGAGCCCATGGAGGTaATCAAAGACTAAAAAAGTTGAAAACACTGTCTGAGACTGGGAACTTATGAATGATATCAAACCAGTATGGCAGAGACCATCAAAAGAAGTAAAAAAAAAAAAAGGTAGAAGATGAATACAAAGCTTTTTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTATATTCACTTTACCACTGAAGGGGAAGTTACCTTCAAATCAATTTTATTTGTACCCACATCTGATCCACGTGGTCTATTTGATGAATATGGATCTAAAAAGAGTGATTACATTAAGCTGTATGTGCTCTGTGTATTCATCACAGATGAATTCCATGATATGATGCCTAAGTACCTTAATTTTGTCAAGGGTGTGGTGGACTCAGATGATCTCCCCTTGAATGTTTCCCTTGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAAGAAGCTTGTTTGTAAAACTCTGGACAAGATCAAGAAGATTGCTGGTGAGAAATACAATGATAATTTTTGGAAAGAATTTGGTACCAACATCAAGCTTGGTGTGATTGAAGACCACTCCAATCAAACATGTCTTGCTAAACTTCTTATGTTCCAGTCTTCTCATCATCCAACTGACATTACTACACTAGACCAGTATGTGGAAAGAATGAAGGGAAAACAAGACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTCCTCCATCTGTTGAACGACTTCTGAAAAAGGGCTGTGAAGTTATTTACCTCACAGAACCTGTGGATGAACACTGCATTCAGGCCTTTCCCAAATTTGATGGGAAGAGGTTCCAGAATGTTGTCAAGGAAGGAATGAAGTTTGATAAAAGTGAGAAAACTAAGGAGAGTCATGAAGCAGTTGAGAAAGAATTTGAGCCTCTGCTCAATTGGATGAAAGATAAAGCCCTTAAGGACAAAATTGAGAAGGCTGTGGTGTCTCAGCACCTGACAGAATCTCTGTGTGCTTTGGTGGCCAGCCAGTACGGACGGTCTGGCAACACGGAGAGAATCATGAAAGCACAAGCATACCAAACGAGCAAGGACAGCTCTGCAAATTACTATGCAAGTCAGAAGAAAACATTTGAAATTAATCCCAGACACCCACTGATCAGAGACATGCTTTGATGAATTAAGGAAGGTGAAGATGATAAAATAGTTTTGGTTCTTGCTGTAGTTTTGTGTGAAACAGCAACGCTTCGGTCAGGATATCTTTTACCAGACACTAAAGCATATGGAGATAGAATAGAAAGAATCCTTCGCTCAGTTTGAACATTGACCCTGATGCAAAGGTGGAAGAAGAACCCAAAGAAGAACTTGAAGACACAACAGAAGACACAGAGCAAGATGAAGACAAAGAAACGGATGTAGGAACAGATGAAGAAGAACAAGAAACAGCAAAGGAATCTACAGCTGAAAACGATAAATTGTAAATTATACTCTCACTGTTTGGATCCTGTGTGGAGAGCGAATGTGGAATTTAAGTCATTTCTTTTGGGAGAGACTTGTTTTGGATGCTCCCCACAGTCCCCTTCTCCCCTGCACTGTAAAATTTGGGATTATGGGTCACAGGAAGAAGTGGGTTTTTTAGTTGAATTTCTTTAACACTCCTCATGTATGTTAAATTTGTACTATTAAACTGACCATTCTTGATGTAAAACCTTGTCATGTGTATAAAAAAAAAAGAT
>NM_003299.3
AGTGGGCGGACCGCGCGGCTGGAGGTGTGAGGATCCGAACCCAGGGGTGGGGGGTGGAGGCGGCTCCTGCGATCGAAGGGGACTTGAGACTCACCGGCCGCACGCCATGAGGGCCCTGTGGGTGCTGGGCCTCTGCTGCGTCCTGCTGACCTTCGGGTCGGTCAGAGCTGACGATGAAGTTGATGTGGATGGTACAGTAGAAGAGGATCTGGGTAAAAGTAGAGAAGGATCAAGGACGGATGATGAAGTAGTACAGAGAGAGGAAGAAGCTATTCAGTTGGATGGATTAAATGCATCACAAATAAGAGAACTTAGAGAGAAGTCGGAAAAGTTTGCCTTCCAAGCCGAAGTTAACAGAATGATGAAACTTATCATCAATTCATTGTATAAAAATAAAGAGATTTTCCTGAGAGAACTGATTTCAAATGCTTCTGATGCTTTAGATAAGATAAGGCTAATATCACTGACTGATGAAAATGCTCTTTCTGGAAATGAGGAACTAACAGTCAAAATTAAGTGTGATAAGGAGAAGAACCTGCTGCATGTCACAGACACCGGTGTAGGAATGACCAGAGAAGAGTTGGTTAAAAACCTTGGTACCATAGCCAAATCTGGGACAAGCGAGTTTTTAAACAAAATGACTGAAGCACAGGAAGATGGCCAGTCAACTTCTGAATTGATTGGCCAGTTTGGTGTCGGTTTCTATTCCGCCTTCCTTGTAGCAGATAAGGTTATTGTCACTTCAAAACACAACAACGATACCCAGCACATCTGGGAGTCTGACTCCAATGAATTTTCTGTAATTGCTGACCCAAGAGGAAACACTCTAGGACGGGGAACGACAATTACCCTTGTCTTAAAAGAAGAAGCATCTGATTACCTTGAATTGGATACAATTAAAAATCTCGTCAAAAAATATTCACAGTTCATAAACTTTCCTATTTATGTATGGAGCAGCAAGACTGAAACTGTTGAGGAGCCCATGgaggaagaagaagcagccaaagaagagaaagaagaatctgatgatgaagctgcagtagaggaagaagaagaagaaaagaaACCAAAGACTAAAAAAGTTGAAAAAACTGTCTGGGACTGGGAACTTATGAATGATATCAAACCAATATGGCAGAGACCATCAAAAGAAGTAGAAGAAGATGAATACAAAGCTTTCTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTATATTCACTTTACTGCTGAAGGGGAAGTTACCTTCAAATCAATTTTATTTGTACCCACATCTGCTCCACGTGGTCTGTTTGACGAATATGGATCTAAAAAGAGCGATTACATTAAGCTCTATGTGCGCCGTGTATTCATCACAGACGACTTCCATGATATGATGCCTAAATACCTCAATTTTGTCAAGGGTGTGGTGGACTCAGATGATCTCCCCTTGAATGTTTCCCGCGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAAGAAGCTTGTTCGTAAAACGCTGGACATGATCAAGAAGATTGCTGATGATAAATACAATGATACTTTTTGGAAAGAATTTGGTACCAACATCAAGCTTGGTGTGATTGAAGACCACTCGAATCGAACACGTCTTGCTAAACTTCTTAGGTTCCAGTCTTCTCATCATCCAACTGACATTACTAGCCTAGACCAGTATGTGGAAAGAATGAAGGAAAAACAAGACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTTCTCCATTTGTTGAGCGACTTCTGAAAAAGGGCTATGAAGTTATTTACCTCACAGAACCTGTGGATGAATACTGTATTCAGGCCCTTCCCGAATTTGATGGGAAGAGGTTCCAGAATGTTGCCAAGGAAGGAGTGAAGTTCGATGAAAGTGAGAAAACTAAGGAGAGTCGTGAAGCAGTTGAGAAAGAATTTGAGCCTCTGCTGAATTGGATGAAAGATAAAGCCCTTAAGGACAAGATTGAAAAGGCTGTGGTGTCTCAGCGCCTGACAGAATCTCCGTGTGCTTTGGTGGCCAGCCAGTACGGATGGTCTGGCAACATGGAGAGAATCATGAAAGCACAAGCGTACCAAACGGGCAAGGACATCTCTACAAATTACTATGCGAGTCAGAAGAAAACATTTGAAATTAATCCCAGACACCCGCTGATCAGAGACATGCTTCGACGAATTAAGGAAGATGAAGATGATAAAACAGTTTTGGATCTTGCTGTGGTTTTGTTTGAAACAGCAACGCTTCGGTCAGGGTATCTTTTACCAGACACTAAAGCATATGGAGATAGAATAGAAAGAATGCTTCGCCTCAGTTTGAACATTGACCCTGATGCAAAGGTGgaagaagagcccgaagaagaacctgaagagacagcagaagacacaacagaagacacagagcaagacgaagatgaagaaatggatgtgggaacagatgaagaagaagaaACAGCAAAGGAATCTACAGCTGAAAAAGATGAATTGTAAATTATACTCTCACCATTTGGATCCTGTGTGGAGAGGGAATGTGAAATTTACATCATTTCTTTTTGGGAGAGACTTGTTTTGGATGCCCCCTAATCCCCTTCTCCCCTGCACTGTAAAATGTGGGATTATGGGTCACAGGAAAAAGTGGGTTTTTTAGTTGAATTTTTTTTAACATTCCTCATGAATGTAAATTTGTACTATTTAACTGACTATTCTTGATGTAAAATCTTGTCATGTGTATAAAAATAAAAAAGATCCCAAATA

Publications

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