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Summary

Retrocopy Name NAXEP2
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Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:18040563-18041144  UCSC
Coordinates (T2T) chr19:18174643-18175224  UCSC
Coordinates (hg19) chr19:18151373-18151954  UCSC
Strand +
Parental Sequence NM_144772.3
Parental seq. overlap 474 bp
Parental seq. overlap (%) 42.4%
Genomic Region Intergenic
Retrocopy Summary NAXEP2, located on chr19:18040563-18041144, is a retrocopy of the parental gene NAXE. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NAXE
Full Name NAD(P)HX epimerase
Also known as AIBP|APOA1BP|PEBEL|YJEFN1
Coordinate chr1:156591776-156599818
Strand +
Gene summary The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NAXEP2
Bonobo Pan paniscus NAXEP2
Gorilla Gorilla gorilla NAXEP1
Orangutan Pongo abelii NAXEP2
Gibbon Nomascus leucogenys NAXEP1
Green monkey Chlorocebus sabaeus APOA1BPP1
Crab-eating macaque Macaca fascicularis APOA1BPP2
Rhesus Macaca mulatta NAXEP2
Baboon Papio anubis NAXEP2
Golden snub-nosed monkey Rhinopithecus roxellana NAXEP3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.20.4
log10(TPM+1)

Related Sequence

>NAXEP2
ATGGCCCAGGGAATAATGGAGAAGGTAGCCTGCTCTGTGCTTGACACCTCAAACATTTTGGTCACCAGCCAATCATCTTTGACCCCAAAAGACCCAACAAGCCACTCTACACTATGCTTGGTGACCCACTGTCAGGAAAGGGGCATTCTTTTGCTTGGTGAAGTGCCCCCAGAGCCCACGCTGATCAATGAGCTGTATGGGCTGGGGGTGGATGCCATCTTTGGCTTCAGCTTCAAGGGCAATGTTTGAAAGCCATTCTGTAACATTCTGAGTGTCCTGAATAGACTCACTGTGCCACTGCCAATGCTGACATTCCCTTGGGATGGGACATGGAGAAGGAAAACTCCGGAGGGATCCAGCCAGACCTGCTTCTCCCCCTGATAGCACCCAAAAAGTCTGAAACCTAGTTTACAGATTGCTACCACTACTTGAGGGGTTGTTGACTACCACCTGCTTGGGAAAAGAAGTACCAGCTAAAACCTGCCATTGTACCCTAACCCTGAGTATGTCTCATCATCTGCAGTGAAGGAAGGTGGATGGACATTCTTCCCAATAAAGACTTAGTGCCTCTGTCTCCCAGAA
>NM_144772.3
gggccgggggcgcgcgctctgcgagctggatgtccaggctgcgggcgctgctgggcctcgggctgctggttgcgggctcgcgcgtgccgcggATCAAAAGCCAGACCATCGCCTGTCGCTCGGGACCCACCTGGTGGGGACCGCAGCGGCTGAACTCGGGTGGCCGCTGGGACTCAGAGGTCATGGCGAGCACGGTGGTGAAGTACCTGAGCCAGGAGGAGGCCCAGGCCGTGGACCAGGAGCTATTTAACGAATACCAGTTCAGCGTGGACCAACTTATGGAACTGGCCGGGCTGAGCTGTGCTACAGCCATCGCCAAGGCATATCCCCCCACGTCCATGTCCAGGAGCCCCCCTACTGTCCTGGTCATCTGTGGCCCGGGGAATAATGGAGGAGATGGTCTGGTCTGTGCTCGACACCTCAAACTCTTTGGCTACGAGCCAACCATCTATTACCCCAAAAGGCCTAACAAGCCCCTCTTCACTGCATTGGTGACCCAGTGTCAGAAAATGGACATCCCTTTCCTTGGGGAAATGCCCGCAGAGCCCATGACGATTGATGAACTGTATGAGCTGGTGGTGGATGCCATCTTTGGCTTCAGCTTCAAGGGCGATGTTCGGGAACCGTTCCACAGCATCCTGAGTGTCCTGAAGGGACTCACTGTGCCCATTGCCAGCATCGACATTCCCTCAGGATGGGACGTGGAGAAGGGAAATGCTGGAGGGATCCAGCCAGACTTGCTCATATCCCTCACAGCCCCCAAAAAATCTGCAACCCAGTTTACCGGTCGCTACCATTACCTGGGGGGTCGTTTTGTGCCACCTGCTCTGGAGAAGAAGTACCAGCTGAACCTGCCACCCTACCCTGACACCGAGTGTGTCTATCGTCTGCAGTGAGGGAAGGTGGGTGGGTATTCTTCCCAATAAAGACTTAGAGCCCCTCTCTTCCAGAACTGTGGATTCCTGGGAGCTCCTCTGGCAATAAAAGTCAGTGAATGGTGGAAGTCAGAGACCAACCCTGGGGATTGGGTGCCATCTCTCTAGGGGTAACACAAAGGGCAAGAGGTTGCTATGGTATTTGGAAACAATGAAAATGGACTGTTAGATGCCAA

Publications

PMID - Link Title
No publications available for this retrocopy