Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MND1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:92931577-92932158  UCSC
Coordinates (T2T) chr1:92776779-92777360  UCSC
Coordinates (hg19) chr1:93397134-93397715  UCSC
Strand +
Parental Sequence NM_001253861.1
Parental seq. overlap 429 bp
Parental seq. overlap (%) 46.1%
Genomic Region Intragenic (DIPK1A)
Retrocopy Summary MND1P1, located on chr1:92931577-92932158, is a retrocopy of the parental gene MND1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MND1
Full Name meiotic nuclear divisions 1
Also known as GAJ
Coordinate chr4:153344649-153415118
Strand +
Gene summary The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MND1P1
Bonobo Pan paniscus MND1P1
Gorilla Gorilla gorilla MND1P1
Orangutan Pongo abelii MND1P1
Gibbon Nomascus leucogenys MND1P1
Green monkey Chlorocebus sabaeus MND1P2
Crab-eating macaque Macaca fascicularis MND1P1
Rhesus Macaca mulatta MND1P1
Baboon Papio anubis MND1P1
Golden snub-nosed monkey Rhinopithecus roxellana MND1P1
Marmoset Callithrix jacchus MND1P4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MND1P1
aAGACATGGAGAGGACTGCTCCCAAAGAGAAAGGCATTACTGCTGTGTTAGTAAAAGAAAAAAGTCCTTCAAAGTTTAGTTGATAATGATATGGTTGACTGTGAGAGAACTGGAACTTCTAATTATTATCAGTCTTTTCCAAGTAAAATTCTTCATGCAAGAACGTATAAATTGGAGGTTCTGAAATCTCAGTTGTTTCAGGGAAGCCAAAAGCATGCAAACTTACAGAAAAGCATCAGAAAAACTAAAATTGGCCAACATGAGATGAAGGAGTGAACCGTGTTAGCCAAAGAGCATTCTTCACTCTTGGATCAAAGGCAGAAGTTGAAAAATGCAAATAATGTGACCCGCAAGTTGTTGAAGAAATACATCAGGCAAATAAAGTACTTGCTAACAGATAGACTGATAACATATTTGCAATAAAATCTTGGGCCAAAAGAAAATTTGGGTTTGAAGAAAATAAAATTGATAAAACTTTCGGAATTCCAGAAGACTCTGACTACATAGATTAAAATATACCAGGGTGGTAAAGAATCTACGAGCTCGCAAATATGTAAATTTTTAAATATTATCCAACTA
>NM_001253861.1
AGTCGGCGCCAAAATCAAACGCGTCCTGGCCTGTcccgcccctctccccaagcgcgggcccggccagcggaagcccctgcgcccgcgccATGTCAAAGAAAAAAGGACTGAGTGCAGAAGAAAAGAGAACTCGCATGATGGAAATATTTTCTGAAACAAAAGATGTATTTCAATTAAAAGACTTGGAGAAGATTGCTCCCAAAGAGAAAGGCATTACTGCTATGTCAGTAAAAGAAGTCCTTCAAAGCTTAGTTGATGATGGTATGGTTGACTGTGAGAGGATCGGAACTTCTAATTATTATTGGGCTTTTCCAAGTAAAGCTCTTCATGCAAGGAAACATAAGTTGGAGGTTCTGGAATCTCAGTTGTCTGAGGGAAGTCAAAAGCATGCAAGCCTACAGAAAAGCATTGAGAAAGCTAAAATTGGCCGATGTGAAACGGCCAAGCAAATAAAGTAGCCAAAGAAGCTGCTAACAGATGGACTGATAACATATTCGCAATAAAATCTTGGGCCAAAAGAAAATTTGGGTTTGAAGAAAATAAAATTGATAGAACTTTTGGAATTCCAGAAGACTTTGACTACATAGACTAAAATATTCCATGGTGGTGAAGGATGTACAAGCTTGTGAATATGTAAATTTTAAACTATTATCTAACTAAGTGTACTGAATTGTCGTTTGCCTGTAACTGTGTTTATCATTTTATTAATGTTAAATAAAGTGTAAAATGCAGATGTTCTTCACCCCTTTTGGTAGAACAAAAGCAGGATGATAACCATATCCCCCCAGTGCTCATCAAAGTAGGACAATAAAAATCCATCCATCTCAGTC

Publications

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