Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACOT4P1
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:36421449-36422899  UCSC
Coordinates (T2T) chr19:39096383-39097833  UCSC
Coordinates (hg19) chr19:36912351-36913801  UCSC
Strand +
Parental Sequence NM_152331.4
Parental seq. overlap 1344 bp
Parental seq. overlap (%) 91.6%
Genomic Region Intergenic
Retrocopy Summary ACOT4P1, located on chr19:36421449-36422899, is a retrocopy of the parental gene ACOT4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACOT4
Full Name acyl-CoA thioesterase 4
Also known as PTE-Ib|PTE1B|PTE2B
Coordinate chr14:73591873-73595766
Strand +
Gene summary Enables acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Involved in carboxylic acid metabolic process; saturated monocarboxylic acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACOT4P1
Bonobo Pan paniscus ACOT4P1
Gorilla Gorilla gorilla ACOT4P1
Orangutan Pongo abelii ACOT4P1
Gibbon Nomascus leucogenys ACOT4P1
Green monkey Chlorocebus sabaeus ACOT4P1
Crab-eating macaque Macaca fascicularis ACOT4P1
Rhesus Macaca mulatta ACOT4P1
Baboon Papio anubis ACOT4P1
Golden snub-nosed monkey Rhinopithecus roxellana ACOT4P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACOT4P1
CGGACGCCCTCTGGACAATCGGCGCACTTGCCACGATCTTGGACGGGCCTCGGGCCTCGACCTTAAGATTCCCCGCTCCAGCTCCGAGATGTCAGCAACGCTGATCCTGGAGCCCGCGGGCCGCGGCTGCCGAGACAAGCCGGTGCGCATCACCATGCGCGGCCTGGCTTCGGAGCCGCTGGACACGCTGCGCGCGCGTCCCTGCGCGACGAGAAGGCTGGGCTCTTCCGCTACTGCGCCGACGCCCGCGGCGAGCTGGACCTGGAGCGCGCGCCCGTGCTGGGCGGCAGCTTTAGGGGGCTAGAGTCCATGGGGCTGCTCTGGGCCCTGGAATCCAAGAAACCTTTTTGGCGCTTTCTGAAGCGGGACGTACAGATTCCCTTTATCGTGGAGTTGGAGGTGCTGGACGGCCACGACCCCGAGCCTGGACGGCTGTTGTGACAGGCGCGGCACGAGCGCGACTTCCTCCCACAAGGGGTGCGGAGCGATTCGGTGCGCGCGGGCCGGGTGCGCGCCACGCTCTTCCTGCCGCCAGGACCTGGACCCTTCCTAGGGATCATTGGCATCTTTGGTAATGGAGGGAGCCTGTTGGAATATCGAGCCAGCCTCCTTGCTGGCCATGGCTTTGCCACGTTCGCTCTAGCTTGTTATAACTTTGAAGATCTCCCCAAGAACGTGGACAACATACCCCTGGAGTACTTCGAAGAAGCCCTATGCTACATGCTTCAACATCCCCAGGTAAAAGGCCCAGGCACTGGGCTTTGGGGCATTTCTCTAGGAGCTGATATTTGTCTCTCAATGGCCTCATTCTTGAAGAATGACTCAGACACAGTTTCCATCAATGGATCCGGGATCAGTGGGAACAGAGGCATAAACTGTAAGCAGAATAGCATTCCACCATTGGGCTATGACCTGAGGAGAATCAAGGTAGCTTTCTCAGGCCTCGTGGACGTCGTGGATATAAAGAATGATCTTGTAGGAGGGTATAAGAACCCCAGCATGATTTCAATGGAGAAGGCCCAGGGCCCCATCATTTTCATTGTTGGTCAGGATGACCATAACTGGAGGAGTGAGTTGTATGCCCAGTCTCTGAACGGTTACGGGCCCATGGAAAGGAAAAACCCCAGATCATCTGTTACCCTGGGACTGGGCTTTACACTGAGCCTCCTTACTTCCCCCTGTGCCCAGCTTCCCTTCACAAATTACTGAACAAACACGTGATATGGGTTGGGGAGCCAGGGCTCATTCTAAGGCCCAGGTAGATGCCTGGAAGCAAATTCTAGCCGCCTTCTGCAAACACCTGGGAGGTACCCAGAAAACAGCTTTCCCTAAATTGTAATGCGTTTGTCTGTTGTTGACATGAGAGAGTCAAGATCAGATTCTAGTGTTCAATAACCCTATGTGAATCAGCTGTCTCCTGGATAACATTAAAGCCATGTCTTTGTCATTAA
>NM_152331.4
GGACGCCGTCCGGACATTCGGCGCGCTTGCCACGATCTTGGACGGGTCTCGGGCCTCGACCTTTGAATTCCCCGCTCCGGCTCCAAGATGTCAGCAACGCTGATCCTGGAGCCCCCAGGCCGCTGCTGCTGGAACGAGCCGGTGCGCATTGCCGTGCGCGGCCTGGCCCCGGAGCAGCGGGTTACGCTGCGCGCGTCCCTGCGCGACGAGAAGGGCGCGCTCTTCCGGGCCCACGCGCGCTACTGCGCCGACGCCCGCGGCGAGCTGGACCTGGAGCGCGCACCCGCGCTGGGCGGCAGCTTCGCGGGACTCGAGCCCATGGGGCTGCTCTGGGCCCTGGAACCCGAGAAGCCTTTTTGGCGCTTCCTGAAGCGGGACGTACAGATTCCTTTTGTCGTGGAGTTGGAGGTGCTGGACGGCCACGACCCCGAGCCTGGACGGCTGCTGTGCCAGGCGCAGCACGAGCGCCACTTCCTCCCGCCAGGGGTGCGGCGCCAGTCGGTGCGAGCGGGCCGGGTGCGCGCCACGCTCTTCCTGCCGCCAGGACCTGGACCCTTCCCAGGGATCATTGACATCTTTGGTATTGGAGGGGGCCTCTTGGAATATCGAGCCAGCCTCCTTGCTGGCCATGGCTTTGCCACGTTGGCTCTAGCTTATTATAACTTTGAAGATCTCCCCAATAACATGGACAACATATCCCTGGAGTACTTCGAAGAAGCCGTATGCTACATGCTTCAACATCCCCAGGTAAAAGGCCCAGGCATTGGGCTTTTGGGCATTTCTCTAGGAGCTGATATTTGTCTCTCAATGGCCTCATTCTTGAAGAATGTCTCAGCCACAGTTTCCATCAATGGATCTGGGATCAGTGGGAACACAGCCATCAACTATAAGCACAGTAGCATTCCACCATTGGGCTATGACCTGAGGAGAATCAAGGTAGCTTTCTCAGGCCTCGTGGACATTGTGGATATAAGGAATGCTCTCGTAGGAGGGTACAAGAACCCCAGCATGATTCCAATAGAGAAGGCCCAGGGGCCCATCCTGCTCATTGTTGGTCAGGATGACCATAACTGGAGAAGTGAGTTGTATGCCCAAACAGTCTCTGAACGGTTACAGGCCCATGGAAAGGAAAAACCCCAGATCATCTGTTACCCTGGGACTGGGCATTACATCGAGCCTCCTTACTTCCCCCTGTGCCCAGCTTCCCTTCACAGATTACTGAACAAACATGTTATATGGGGTGGGGAGCCCAGGGCTCATTCTAAGGCCCAGGAAGATGCCTGGAAGCAAATTCTAGCCTTCTTCTGCAAACACCTGGGAGGTACCCAGAAAACAGCTGTCCCTAAATTGTAATGCATTTGTCTGTTGTTGACATGAGAGATTCAAGATCAGATTCTAGTGTTCAGTAACCCTATGTGAATCAGATGTCTCCTGGATAACATTAAAGCCATGTCTTTGTCATTAA

Publications

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