Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TDGF1P7
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:39534458-39536333  UCSC
Coordinates (T2T) chr19:42338716-42340591  UCSC
Coordinates (hg19) chr19:40025098-40026973  UCSC
Strand +
Parental Sequence NM_003212.4
Parental seq. overlap 1363 bp
Parental seq. overlap (%) 69.1%
Genomic Region Intergenic
Retrocopy Summary TDGF1P7, located on chr19:39534458-39536333, is a retrocopy of the parental gene TDGF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TDGF1
Full Name teratocarcinoma-derived growth factor 1
Also known as CR|CR-1|CRGF|CRIPTO
Coordinate chr3:46574535-46582457
Strand +
Gene summary This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TDGF1P5
Bonobo Pan paniscus TDGF1P5
Gorilla Gorilla gorilla TDGF1P5
Golden snub-nosed monkey Rhinopithecus roxellana TDGF1P4
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TDGF1P7
GAGCTATGGACTGCAGGAAGATGGCCTGCTTCTCTTCCAGTGTGATTTGGATCATGGCCATTTTGAAGCCTTTGAACTGGGATTAGTTGCTGGGCTGGGTCATCAGGAACTTGCGTGTCCATCTCAGGGAGACCTGGCCTTCAGAAATGACAGCATTCGGCCCCAGGAGGAGCCTGCAATTCGGCCTCAGTCTTCCCAGCGTGTGCTGCCCATGGGGATACAGGACAGTAAGGAGCTAAGCAGAACCTGCTGCCTGAATGGGGGAACCTGCATTGGGGTCCTTTTGTGCCTGCCCCCCGTCCTTCTATGGATGGAACTGTGAGCACGATGTGTGCAAAGAGAACTGTGGGTCTGTGCTCCATGACACCTGGCTGCCCAAGAAGTGTTCCCTGTGTAAATGCTGGCACGGCCAGCTCTGCTGCTTTCCTCAGGCATTTTACTGGCTGTGATGGCCTTGTGATGGATGAGCATCTCATGGCTTCCAGGACTCCAGAACTACCACCGTCTGCATGTACCACTTTTATGCTAGCTGGCATCTGCCTTTCTATACAAAGTTACTATTAATTGACACTGACCTATTTCCAGAAATACCATTTTAGATATCATGCAAATTTCATGACCAGTAAAAGCTGCTGCTACAATGAAAGATGATCATTTGTTAGTTTACTTAAAATAATGAGTATATTTCCAAAATGGTCTCTAACATTTCCTTACAGTATCAACAACTTCTTACTTCTTTGCCCTGCCCTCTCCCAAAAAACGACTTCTTTTTTCAAAAGAAAGTCAGCCATATCTCCACTGCACCCAAGTCCAGTGTCAAGGCCTCGTGTTTATTGATACATGTAATTCTACCAAGGTCTTCTTAATATGTTCTTTTAAACGACTGAATTATATCTTCAGATTATTAAAGACTAATCTTAATGTGGACCTTAGGATACAGTTTTGAGTAGAGTTGATCAAAATCAATTAACATTGTCTCTTTAAAAGGAAAGACAGCCTCTTTAAGGCGAGGAACCAGAGTGATGAAGGAATGGAAGTCTGTCTGCATGTGTGCAGGGAGACTGGGTAAGAAAGAGGAAGCAAATGGGAGAGAGAGGTTGGAAAACATAAAATAGGTTATTTAACTGGTGATTAGGTGGGTGTAGAGAAGCAAGTTAAAAGGCTAAATGGAAGGGCAAGTTTCCATCATCTAATGAAAGATATATAAGACAAGGACTCCCCTTTTTTTCCTAAAGGCATTGTAAAAAGAATTGAtTTGTAAAAAGTCTTTTTAGAAAAAATATTATACCTCAATGTCCCCAACAAAATTGCTTAATAAATTATGCTTCCTCCAAGCTATGCAATTCTTTTAACTGTTGTAGAAGAGAAAATGTTCAGTGTATTTAGTTGTAAACCAAGTGATAAAACCACATATTGTAAAGCTCATTTAAAAAATACATTGTATATATGTGTATGCACAGTAAAAATGGAAAATATATTGA
>NM_003212.4
AGTTTCCCCTGGACGCCTTGCTCCTGCTTCTGCTACGACCTTCTGGGGAAAACGAATTTCTCATTTTCTTCTTAAATTGCCATTTTCGCTTTAGGAGATGAATGTTTTCCTTTGGCTGTTTTGGCAATGACTCTGAATTAAAGCGATGCTAACGCCTCTTTTCCCCCTAATTGTTAAAAGCTATGGACTGCAGGAAGATGGCCCGCTTCTCTTACAGTGTGATTTGGATCATGGCCATTTCTAAAGTCTTTGAACTGGGATTAGTTGCCGGGCTGGGCCATCAGGAATTTGCTCGTCCATCTCGGGGATACCTGGCCTTCAGAGATGACAGCATTTGGCCCCAGGAGGAGCCTGCAATTCGGCCTCGGTCTTCCCAGCGTGTGCCGCCCATGGGGATACAGCACAGTAAGGAGCTAAACAGAACCTGCTGCCTGAATGGGGGAACCTGCATGCTGGGGTCCTTTTGTGCCTGCCCTCCCTCCTTCTACGGACGGAACTGTGAGCACGATGTGCGCAAAGAGAACTGTGGGTCTGTGCCCCATGACACCTGGCTGCCCAAGAAGTGTTCCCTGTGTAAATGCTGGCACGGTCAGCTCCGCTGCTTTCCTCAGGCATTTCTACCCGGCTGTGATGGCCTTGTGATGGATGAGCACCTCGTGGCTTCCAGGACTCCAGAACTACCACCGTCTGCACGTACTACCACTTTTATGCTAGTTGGCATCTGCCTTTCTATACAAAGCTACTATTAATCGACATTGACCTATTTCCAGAAATACAATTTTAGATATCATGCAAATTTCATGACCAGTAAAGGCTGCTGCTACAATGTCCTAACTGAAAGATGATCATTTGTAGTTGCCTTAAAATAATGAATACATTTCCAAAATGGTCTCTAACATTTCCTTACAGAACTACTTCTTACTTCTTTGCCCTGCCCTCTCCCAAAAAACTACTTCTTTTTTCAAAAGAAAGTCAGCCATATCTCCATTGTGCCTAAGTCCAGTGtttctttttttttttttttttgagacggagtctcactctgtcacccaggctggactgcaatgacgcgatcttggttcactgcaacctccgcatccggggttcaagccattctcctgcctcagcctcccaagtaactgggattacaggcatgtgtcaccatgcccagctaatttttttgtatttttagtagagatgggggtttcaccatattggccagtctggtctcgaactcctgaccttgtgatccactcgcctcagcctctcgaagtgctgagattacacacgtgagcaactgtgcaaggccTGGTGTTTCTTGATACATGTAATTCTACCAAGGTCTTCTTAATATGTTCTTTTAAATGATTGAATTATATGTTCAGATTATTGGAGACTAATTCTAATGTGGACCTTAGAATACAGTTTTGAGTAGAGTTGATCAAAATCAATTAAAATAGTCTCTTTAAAAGGAAAGAAAACATCTTTAAGGGGAGGAACCAGAGTGCTGAAGGAATGGAAGTCCATCTGCGTGTGTGCAGGGAGACTGGGTAGGAAAGAGGAAGCAAATAGAAGAGAGAGGTTGAAAAACAAAATGGGTTACTTGATTGGTGATTAGGTGGTGGTAGAGAAGCAAGTAAAAAGGCTAAATGGAAGGGCAAGTTTCCATCATCTATAGAAAGCTATATAAGACAAGAACTCCCCTTTTTTTCCCAAAGGCATTATAAAAAGAATGAAGCCTCCTTAGAAAAAAAATTATACCTCAATGTCCCCAACAAGATTGCTTAATAAATTGTGTTTCCTCCAAGCTATTCAATTCTTTTAACTGTTGTAGAAGACaaaatgttcacaatatatttagttgtaaaccaagtgatcaaactacatattgtaaagcccatttttaaaatacattgtatatatgtgtatgcacagtaaaaatggaaactatattga

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