Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BIRC8
Plot displaying the genomic locations of a retrocopy (in chr19) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr19:53289544-53290893  UCSC
Coordinates (T2T) chr19:56369032-56370381  UCSC
Coordinates (hg19) chr19:53792797-53794146  UCSC
Strand -
Parental Sequence NM_001204401.2
Parental seq. overlap 1163 bp
Parental seq. overlap (%) 13.8%
Genomic Region Intergenic
Retrocopy Summary BIRC8, located on chr19:53289544-53290893, is a retrocopy of the parental gene XIAP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name XIAP
Full Name X-linked inhibitor of apoptosis
Also known as API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3
Coordinate chrX:123859708-123913972
Strand +
Gene summary This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes XIAPP4
Bonobo Pan paniscus XIAPP4
Gorilla Gorilla gorilla XIAPP3
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BIRC8
AATTGCAGGTTTATCCGCAGCTTTTATTTTGAAGACAGTGCCACGAAACCTGCAAATCCTGGTGTCCCAAATAGTCAATACCAAGTTGAAAACCATCTGGGAGAGGAAAAGCGTTGTGCTTTAGACAGGCCGTCTGAGACTCGTGCAGACCGGCTTTTGAGAGCTGGACAGGTGGTGGATAGATCAGACTCCATACACCCGAGGAGCCCCGCCATGCATAGTGAAGAAGCTAGATAACAGTCGTTTCACAACTGGCCAGCCTCTGCCCACTTGACCCCGAGAGAGCTGGCCAGTGCTGGGCTGTACTACACAGGCACTGATGACCAAGTGCAGTGCTTCTGTTGTGGCGGAAAACTGAAAAACTGGGAACCTGGTGATCGTGCCTGGTCAGAACACAGGAGACATTTTCCTAATTGCTTCTTTATTTTGGGCCACAACGTTAATATTCGAGGTGAATCTGATGTTGCGAGTTCTGATAGGAATTTCTCAAATTCAACAAGTTCTCCAAGGAATCCATCCATGACGGGTTATGAAGCCCGGCTCATTACTTTTGGGACATGGATGTACTCCGTTAACAAAGAGCAGCTTGCAAGAGCTGGATTTTATGCTATAGGTCAAGAGGATAAAGTACAGTGCTTTCACTGTGGAGGAGGGCTAGCCAACTGGAAGCCCAAGGAAGATCCTTGGGAACAGCATGCTAAATGGTATCCAGGTTGCAAATATCTGCTAGAAGAGAAGGGACATGAATATATAAACAACATTCATTTAACCCGTTCACTTGAGGGAGCTCTGGTACAAACTACCAAGAAAACACCATCACTAACTAAAAGAATCAGTGATACCATCTTCCCTAATCCTATGCTACAAGAAGCTATACGAATGGGATTTGATTTCAAGGACGTTAAGAAAATAATGGAGGAAAGAATTCAAACATCTGGGAGCAACTATAAAACGCTTGAGGTTCTTGTTGCAGATCTAGTGAGCGCTCAGAAAGACACTACAGAAAATGAATTGAATCAGACTTCATTGCAGAGAGAAATCAGCCCTGAAGAGCCGCTAAGGCGTCTGCAAGAGGAGAAGCTTTGTAAAATCTGCATGGACAGACATATCGCTGTTGTTTTTATTCCTTGTGGACATCTGGTCACTTGTAAACAATGTGCTGAAGCAGTTGACAGATGTCCCATGTGCAGCGCGGTTATTGATTTCAAGCAAAGAGTTTTTATGTCTTAATGTAACTCTACAGTGGGTGTGCTATGTTCTTATTACCCTGATTAAATGTGTGATGTGACTCAACTTTAAGTAGTCAGCACTGAATTCCATCAGCATTTGCTGCCAAGTAGAAAAAAAAAA
>NM_001204401.2
CTTACTGCCCCCATCCGGTTCGGGGAGGTGGCGGGACCTTGGCGGCGCCCGGAGCCGGCGTGGCGCTCATCGAGGGACGCCCGGCCCAAGTGAAAAGGTGGACAAGTCCTATTTTCAAGAGAAGATGACTTTTAACAGTTTTGAAGGATCTAAAACTTGTGTACCTGCAGACATCAATAAGGAAGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACTTTTGCTAATTTTCCAAGTGGTAGTCCTGTTTCAGCATCAACACTGGCACGAGCAGGGTTTCTTTATACTGGTGAAGGAGATACCGTGCGGTGCTTTAGTTGTCATGCAGCTGTAGATAGATGGCAATATGGAGACTCAGCAGTTGGAAGACACAGGAAAGTATCCCCAAATTGCAGATTTATCAACGGCTTTTATCTTGAAAATAGTGCCACGCAGTCTACAAATTCTGGTATCCAGAATGGTCAGTACAAAGTTGAAAACTATCTGGGAAGCAGAGATCATTTTGCCTTAGACAGGCCATCTGAGACACATGCAGACTATCTTTTGAGAACTGGGCAGGTTGTAGATATATCAGACACCATATACCCGAGGAACCCTGCCATGTATAGTGAAGAAGCTAGATTAAAGTCCTTTCAGAACTGGCCAGACTATGCTCACCTAACCCCAAGAGAGTTAGCAAGTGCTGGACTCTACTACACAGGTATTGGTGACCAAGTGCAGTGCTTTTGTTGTGGTGGAAAACTGAAAAATTGGGAACCTTGTGATCGTGCCTGGTCAGAACACAGGCGACACTTTCCTAATTGCTTCTTTGTTTTGGGCCGGAATCTTAATATTCGAAGTGAATCTGATGCTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAATCTTCCAAGAAATCCATCCATGGCAGATTATGAAGCACGGATCTTTACTTTTGGGACATGGATATACTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGATTTTATGCTTTAGGTGAAGGTGATAAAGTAAAGTGCTTTCACTGTGGAGGAGGGCTAACTGATTGGAAGCCCAGTGAAGACCCTTGGGAACAACATGCTAAATGGTATCCAGGGTGCAAATATCTGTTAGAACAGAAGGGACAAGAATATATAAACAATATTCATTTAACTCATTCACTTGAGGAGTGTCTGGTAAGAACTACTGAGAAAACACCATCACTAACTAGAAGAATTGATGATACCATCTTCCAAAATCCTATGGTACAAGAAGCTATACGAATGGGGTTCAGTTTCAAGGACATTAAGAAAATAATGGAGGAAAAAATTCAGATATCTGGGAGCAACTATAAATCACTTGAGGTTCTGGTTGCAGATCTAGTGAATGCTCAGAAAGACAGTATGCAAGATGAGTCAAGTCAGACTTCATTACAGAAAGAGATTAGTACTGAAGAGCAGCTAAGGCGCCTGCAAGAGGAGAAGCTTTGCAAAATCTGTATGGATAGAAATATTGCTATCGTTTTTGTTCCTTGTGGACATCTAGTCACTTGTAAACAATGTGCTGAAGCAGTTGACAAGTGTCCCATGTGCTACACAGTCATTACTTTCAAGCAAAAAATTTTTATGTCTTAATCTAACTCTATAGTAGGCATGTTATGTTGTTCTTATTACCCTGATTGAATGTGTGATGTGAACTGACTTTAAGTAATCAGGATTGAATTCCATTAGCATTTGCTACCAAGTAGGAAAAAAAATGTACATGGCAGTGTTTTAGTTGGCAATATAATCTTTGAATTTCTTGATTTTTCAGGGTATTAGCTGTATTATCCATTTTTTTTACTGTTATTTAATTGAAACCATAGACTAAGAATAAGAAGCATCATACTATAACTGAACACAATGTGTATTCATAGTATACTGATTTAATTTCTAAGTGTAAGTGAATTAATCATCTGGATTTTTTATTCTTTTCAGATAGGCTTAACAAATGGAGCTTTCTGTATATAAATGTGGAGATTAGAGTTAATCTCCCCAATCACATAATTTGTTTTGTGTGAAAAAGGAATAAATTGTTCCATGCTGGTGGAAAGATAGAGATTGTTTTTAGAGGTTGGTTGTTGTGTTTTAGGATTCTGTCCATTTTCTTTTAAAGTTATAAACACGTACTTGTGCGAATTATTTTTTTAAAGTGATTTGCCATTTTTGAAAGCGTATTTAATGATAgaatactatcgagccaacatgtactgacatggaaagatgtcaaagatatgttaagtgtaaaatgcaagtggcaaaacactatgtatagtctgagccagatcaaagtatgtatgtttttaatatgcatagaacaaaagatttggaaagatatacaccaaactgttaaatgtggtttctcttcggggagggggggattgggggaggggccccagaggggttttataggggccttttcactttctacttttttcattttgttctgttcgaattttttataagtatgtattacttttgtaatcagaaTTTTTAGAAAGTATTTTGCTGATTTAAAGGCTTAGGCATGTTCAAACGCCTGCAAAACTACTTATCACTCAGCTTTAGTTTTTCTAATCCAAGAAGGCAGGGCAGTTAACCTTTTTGGTGCCAATGTGAAATGTAAATGATTTTATGTTTTTCCTGCTTTGTGGATGAAAAATATTTCTGAGTGGTAGTTTTTTGACAGGTAGACCATGTCTTATCTTGTTTCAAAATAAGTATTTCTGATTTTGTAAAATGAAATATAAAATATGTCTCAGATCTTCCAATTAATTAGTAAGGATTCATCCTTAATCCTTGCTAGTTTAAGCCTGCCTAAGTCACTTTACTAAAAGATCTTTGTTAACTCAGTATTTTAAACATCTGTCAGCTTATGTAGGTAAAAGTAGAAGCATGTTTGTACACTGCTTGTAGTTATAGTGACAGCTTTCCATGTTGAGATTCTCATATCATCTTGTATCTTAAAGTTTCATGTGAGTTTTTACCGTTAGGATGATTAAGATGTATATAGGACAAAATGTTAAGTCTTTCCTCTACCTACATTTGTTTTCTTGGCTAGTAATAGTAGTAGATACTTCTGAAATAAATGTTCTCTCAAGATCCTTAAAACCTCTTGGAAATTATAAAAATATTGGCAAGAAAAGAAGAATAGTTGTTTAAATATTTTTTAAAAAACACTTGAATAAGAATCAGTAGGGTATAAACTAGAAGTTTAAAAATGCTTCATAGAACGTCCAGGGTTTACATTACAAGATTCTCACAACAAACCTATTGTAGAGGTGAGTAAGGCATGTTACTACAGAGGAAAGTTTGAGAGTAAAACTGTAAAAAATTATATTTTTGTTGTACTTTCTAAGAGAAAGAGTATTGTTATGTTCTCCTAACTTCTGTTGATTACTACTTTAAGTGATATTCATTTAAAACATTGCAAAtttattttatttatttaattttctttttgagatggagtcttgcttgtcacccaggctggagtgcagtggagtgatctctgctcactgcaacctccgccttctgggttcaagcgattctcgtgcctcagcttcctgagtagctggaattacaggcaggtgccaccatgcccgactaatttttttttatttttagtagagacggggtttcaccatgttggccaggctggtatcaaactcctgacctcaagagatccactcgccttgccctcccaaagtgctgggattacaggcttgagccaccacgcccggcTAAAACATTGCAAATTTAAATGAGAGTTTTAAAAATTAAATAATGACTGCCCTGTTTCTGTTTTAGTATGTAAATCCTCAGTTCTTCACCTTTGCACTGTCTGCCACTTAGTTTGGTTATATAGTCATTAACTTGAATTTGGTCTGTATAGTCTAGACTTTAAATTTAAAGTTTTCTACAAGGGGAGAAAAGTGTTAAAATTTTTAAAATATGTTTTCCAGGACACTTCACTTCCAAGTCAGGTAGGTAGTTCAATCTAGTTGTTAGCCAAGGACTCAAGGACTGAATTGTTTTAACATAAGGCTTTTCCTGTTCTGGGAGCCGCACTTCATTAAAATTCTTCTAAAACTTGTATGTTTAGAGTTAAGCAAGACTTTTTTTCTTCCTCTCCATGAGTTGTGAAATTTAATGCACAACGCTGATGTGGCTAACAAGTTTATTTTAAGAATTGTTTAGAAATGCTGTTGCTTCAGGTTCTTAAAATCACTCAGCACTCCAACTTCTAATCAAATTTTTGGAGACTTAACAGCATTTGTCTGTGTTTGAACTATAAAAAGCACCGGATCTTTTCCATCTAATTCCGCAAAAATTGATCATTTGCAAAGTCAAAACTATAGCCATATCCAAATCTTTTCCCCCTCCCAAGAGTTCTCAGTGTCTACATGTAGACTATTCCTTTTCTGTATAAAGTTCACTCTAGGATTTCAAGTCACCACTTATTTTACATTTTAGTCATGCAAAGATTCAAGTAGTTTTGCAATAAGTACTTATCTTTATTTGTAATAATTTAGTCTGCTGATCAAAAGCATTGTCTTAATTTTTGAGAACTGGTTTTAGCATTTACAAACTAAATTCCAGTTAATTAATTAATAGCTTTATATTGCCTTTCCTGCTACATTTGGTTTTTTCCCCTGTCCCTTTGATTACGGGCTAAGGTAGGGTAGAGTGGGTGTAGTGAGTGTATATAATGTGATTTGGCCCTGTGtattatgatattttgttatttttgttgttatattattTACATTTCAGTAGTTGTTTTTTGTGTTTCCATTTTAGTGGATAAAATTTGTATTTTGAACTATGAATGGAGACTACCGCCCCAGCATTAGTTTCACATGATATACCCTTTAAACCCGAATCATTGTTTTATTTCCTGATTACACAGGTGTTGAATGGGGAAAGGGGCTAGTATATCAGTAGGATATACTATGGGATGTATATATATCATTGCTGTTAGAGAAATGAAATAAAATGGggctgggctcagtggctcacgcctgtaatcccagcactttgggaggctgaggcaggtggatcacgaggtcaggagatcgagaccatcctggctaacacggtgaaaccccgtctctactaaaaaacagaaaattagccgggcgtggtggcgggcgcctgtagtcccagctactcgggaggctgaggcaggagaatggtgtgaacccgggaggcagagcttgcagtgagccgagatctcgccactgcactccagcctgggcaacagagcaagactctgtctcaaaaaaaaaaaaaaaagaaataagaaaaTGGGAAGCAATATTTGACATAGTTCTTTTTAGTCAAATCTACTTGTTAAAAAAAGGGTAGcagtttattcatctgtgaaaggaaaataatacttatcttacaaggttgcaagagctcaaggagaccatgtatgtaaagttcctgctgtaaatatgaactcccatcctaatACCCTTTTACCTCTCTGTGGGTTTGTCTTGACCTGGAAATTTGGGCTAAAACTTAGAAAAAATTCTTACATGATAACTCAGTGATGCTTACTCATAGTTTTTGGTGTTTCTCatagataagatataaatcagctgggcgcggtggctcatgcctgtaatcccagcactttgggaggccgaggcgggcagatcacctgaggtcgggaggtcgagaccagcctgaccaacatggagaaaccccgtctctactaaaaatacaaaattagctgggcgtggtggctcatgcctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacccaggaggcggaggttgtggtgagcgaagatcgtgccattgcactccagcctgggcaacaagagcaaaactctgtctcaaaaaaaaaaaaagatataaatcacaataaataaataGGTCaatacaaatgttagccaggcgtggtggcacatgcccatagtcgcagctactctggaggcagaggcaggaggatcacttgagcccatgaatttgaggcagcagtgagctatgattgtgccactgtactccagtctgggtgacagagtgagaccccatctctaaataaaTAGGTCAAACCCTTAAAAATATTTAAATTCTTAAAAAATTGAAAAGATTATTCTTCTCAAATTTAGTTGAGCTTTCTAAGAGAAGCAATTGGCTTTTTCCCACTTCAATAATCATTTTCAGTTTGACTCATACAGTTAACACAATGTGAATTTCTTCCTCAGCataacagagttatagaatgacagggctggaagtgaccttagagagtatccagttctttcattttacaggtgaggcaactgagactcaaaggtgatgtaatttgtgcaaagattatagctaattagtagcagagccctgactgggacatagTTTGAAGGTGAAAAACTTCACCAAGCTACCTTTCTTGAAAGGTCCAAATGTTTATGTTTTCAACTACTCTTTCCACTGTACCATAACTTTCACTACATATTAAATGACACTTTATAACTAATATAATAGGACAATCATCAATGCATATATagccagcccttcatatctgtgggttttgcatccatggattcaaccaaggaggaattgaaaacactgagaaaaaaaaaAAAGACCACACaataaaaaaaaaaaatacaaaataatacaaagaaaaaGCCAAAATTGTCATACTGTTGTtaagcaacagtataacaactatttacatagcattAAGGTTGGTGCAAAAATGCAAAAAAAAAAAAAGCAATTATTTTTAAACCAACCTAAtatattgtattaggtattaaagtcatctggacatgaattaaagtatatgATGccagcctggacaaaaggcaaaaccctgtctctacaaaaaatacaaaaattagctgggcatggtggtgtgtgcctgtagtcctggctactccggagcctgaggtgggaggatcgcttgagtctgggaggcagaggctgcattgagctatgatcatggcactgcattccagcctgggtgacagtgcaagaccttgtctcagaataaataaaGTATGTGATGAAGATGTGCATACATTATATGCAAATACTGttttttttttttttaatttaaacagtctcactgtgttgcccaggatggagtgcaatggcacaatcttggctcatggcaaactctgcctcgcaagcagctgggactacaggcatgctccacggtgcccagttaattttttttgtattcttagtagagacagggtttcaccatgttggccaggctagtcttgaatttctgacctcaagtgattcatctcccaaagtgctgggattacaggcgtgagccaccacggccggctaatttttgtattttttagtagtgactggtttcgcggtgttgaccaggctggtctcgaactcctgatctcaggtgatctgcctgcctcggcctcacaaagtgctgggattacaggtgtgaaccactgctcccggccTTGTGTGattttatctaagggacttaagcgtcctcaggtcctagggggtcgtgaaaccaaaaccccagggatagcaagggacaattgTATCTTCAAAGTAGACAAATGGCgccgggcacggtggctcacgcctgtaatcccagcagtttccgaggctgaggcaggcggctcacctgaggtcaggagttggagaccagcctggccaacatgctgaaaccctgtctgtacaaaaatacaaaaatagctgggcatggtggcgcatgcctgtagtcccagctactagagcgactgaggcaggagaattgcttgaacctgggaggcggaggttgcagggagccaagatggcgccaccgcactccagcctaggtgatagagtgagactccctctcaaaaacaaaacaaaacaaaaaaaTTAGACAAATGCTACATTAATGTTTGGGTGGTCAGATTCTACTTTGAATCTGAAGTTTGCAGATATGCCTATAGATTTTTGGAGTTTACCACTTTCTTATTCTGTATCATTAATGTAATATTTTAAATTACTATATATGTTACCATTTTTCTGGATTTAGTAAGAAATTTGCAGTTTTGGTTTGATGTAACAAGGGTTTTAATGTAATTTATGTTAGATTTTGCATTTTTTTCATTACTGTTATATTTTAACCTGACTGACTGATCTAATTGTATTAGTATTGTGAATAATCATGTGAAATGTTTTGAGACAGAGTACTATATTTGTGAATATAATTTTATGGTTTTTTTCACTTAGAACCTTTCTGTGTGGAAAACTAAGAAAATTGCTTTCTGCTGTATAATCTGGCATTCATTGTAGATTAAAGCTTATTTTTCTGTGAATAAAACGTATTCAATAAAATACTATTCTTTAAAATTA

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