Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SLC25A6P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:21742513-21742957  UCSC
Coordinates (T2T) chr20:21799522-21799966  UCSC
Coordinates (hg19) chr20:21723151-21723595  UCSC
Strand -
Parental Sequence NM_001636.4_2
Parental seq. overlap 367 bp
Parental seq. overlap (%) 25.2%
Genomic Region Intergenic
Retrocopy Summary SLC25A6P1, located on chr20:21742513-21742957, is a retrocopy of the parental gene SLC25A6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SLC25A6
Full Name solute carrier family 25 member 6
Also known as AAC3|ANT|ANT 2|ANT 3|ANT3|ANT3Y
Coordinate chrX:1386152-1392113
Strand -
Gene summary This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LOC107972834P3
Orangutan Pongo abelii SLC25A6P3
Green monkey Chlorocebus sabaeus SLC25A6P1
Baboon Papio anubis SLC25A6P2
Golden snub-nosed monkey Rhinopithecus roxellana SLC25A6P2
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SLC25A6P1
GCATCTCCAAGGAGCATGGGGCTGTCTTCCTGGAAGGGCAACCTTGCCAGTGCCATCCATTACTTCCCATGCAAGCCCTTAACTTTGCCTTCAAGGATAAGTACAAGCAGTTCTTCCTGGGGGTGCAGACAAGCGCATGCAGTTCTGGAGGTGCTTCGCTGGCCACCCGGCCTTGGGTGGCCTGGCTGGCACCACCTCACTCTGCTTCATGTACCCCCTGGATTTCCCAGAACCTCCTGGCAGCAGACATTGGGAAATTGGGCACAGTGCATGAGTTCAAAGACCTGGGAGCCTGGCCGGTGAGGATCACCAAATCCAATGGACCCAGGGCCTGTACCAGGGCTTCAGCATCTCATGCAAGACATCATCATCTACCCAGCAGCCTCCTTCTGCTAGTAGGATACAGCTGAGGGCATGCTCCCCAGCCCCAAGAACATGCACATCC
>NM_001636.4_2
CCTTTCGGTCCAGGCGGCGGCAGGGCTGAGCCAGCGACGCCCTCCATTCACTCTCCGCGCCCGTTCTCCGGCTGTCCTCCCGTTCCGCTGCCCGCCCTGCCACCATGACGGAACAGGCCATCTCCTTCGCCAAAGACTTCTTGGCCGGAGGCATCGCCGCCGCCATCTCCAAGACGGCCGTGGCTCCGATCGAGCGGGTCAAGCTGCTGCTGCAGGTCCAGCACGCCAGCAAGCAGATCGCCGCCGACAAGCAGTACAAGGGCATCGTGGACTGCATTGTCCGCATCCCCAAGGAGCAGGGCGTGCTGTCCTTCTGGAGGGGCAACCTTGCCAACGTCATTCGCTACTTCCCCACTCAAGCCCTCAACTTCGCCTTCAAGGATAAGTACAAGCAGATCTTCCTGGGGGGCGTGGACAAGCACACGCAGTTCTGGAGGTACTTTGCGGGCAACCTGGCCTCCGGCGGTGCGGCCGGCGCGACCTCCCTCTGCTTCGTGTACCCGCTGGATTTCGCCAGAACCCGCCTGGCAGCGGACGTGGGAAAGTCAGGCACAGAGCGCGAGTTCCGAGGCCTGGGAGACTGCCTGGTGAAGATCACCAAGTCCGACGGCATCCGGGGCCTGTACCAGGGCTTCAGTGTCTCCGTGCAGGGCATCATCATCTACCGGGCGGCCTACTTCGGCGTGTACGATACGGCCAAGGGCATGCTCCCCGACCCCAAGAACACGCACATCGTGGTGAGCTGGATGATCGCGCAGACCGTGACGGCCGTGGCCGGCGTGGTGTCCTACCCCTTCGACACGGTGCGGCGGCGCATGATGATGCAGTCCGGGCGCAAAGGAGCTGACATCATGTACACGGGCACCGTCGACTGTTGGAGGAAGATCTTCAGAGATGAGGGGGGCAAGGCCTTCTTCAAGGGTGCGTGGTCCAACGTCCTGCGGGGCATGGGGGGCGCCTTCGTGCTGGTCCTGTACGACGAGCTCAAGAAGGTGATCTAAGGGCCGCGGCCTCCTCcacacacacacacacacCAGGGGAACCAAGAGAACCACGTAGAATCCTCAACCGTGCGGACCATCAACCTTCGAGAAATTCCAGTTGTCTTTTTCCCAGCCGCATCCTGCCTGTAGATGGCCGGGGAAGGCTCTAGAAAAGGGGCGCATTGCGATCCAACCATCGGCAGCCGATTCCGTGTCTTGATCACGGGGTGGGAGGGAACCGTGGCGTCCCTGCGTGGGGCCCATGGGTGAGACACTCCAGTACTGAGACCTAGAGTCCAGATGCTTGTAGGAGCCAAGTCGTGTTCTAAGTATTTATTTAAAACAAAAGAATCACGTTTTCCCATTTGTACTTCAGCGCTAGCCCCTGTTTTGCACAGCCGAGTACTGGCGAGTATGTTCTATGTTGGGCCTCCTGCTGCAAAACAATAAACAGAGGACGCAGAGGTC

Publications

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