Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CYB5AP4
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:22885489-22886038  UCSC
Coordinates (T2T) chr20:22944962-22945512  UCSC
Coordinates (hg19) chr20:22866127-22866676  UCSC
Strand -
Parental Sequence NM_148923.4
Parental seq. overlap 490 bp
Parental seq. overlap (%) 15.2%
Genomic Region Intergenic
Retrocopy Summary CYB5AP4, located on chr20:22885489-22886038, is a retrocopy of the parental gene CYB5A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CYB5A
Full Name cytochrome b5 type A
Also known as CYB5|MCB5|METAG
Coordinate chr18:74250846-74291980
Strand -
Gene summary The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CYB5AP3
Bonobo Pan paniscus LOC100968898P2
Gorilla Gorilla gorilla LOC101127736P2
Orangutan Pongo abelii LOC100456800P2
Gibbon Nomascus leucogenys LOC100582484P1
Green monkey Chlorocebus sabaeus LOC103244088P1
Crab-eating macaque Macaca fascicularis LOC102134776P3
Rhesus Macaca mulatta CYB5AP3
Baboon Papio anubis LOC101012602P3
Golden snub-nosed monkey Rhinopithecus roxellana LOC104656984P3
Marmoset Callithrix jacchus LOC100392617P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CYB5AP4
GAAGAAGTCTTAAAGGAAGAAGCTGGAGGTGACGCTACTGCAAACTTTGAGGATGTTGGGCACTCTACAGATGCTAGGGAATTGTCCAAAACATATATCATTGAGGAGTTCCATCCAGATGATAAACTTAAGTTAAGCAAGCTTTCAGAAACTTTTATCGCTACTGTTGTTTCTAGTTCCAGCTGGTGGACCAACTGGGTGATCCCTGCCATCTCAACAGTGGCCGTTGCCTTGATGTATTGCCTGTACATGGCAGAAGACTAAACAACTCCTCAGAAGCCAGTGCAGGAAAAGCCTGCTTTGGACACAGGAGAAAAGAAGCCAATGCTAACTACTTCAACAGACAGAAACCTTCACTTGAAAAAATAGTTTTCATGTCTCTTTCTCTTTCTTCAGGCATTAGAAACAAAACAAAAATAACTGTCCTTTCTGCTGTTGAATTTTTCAAGTATGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTACTATGTAATTTGCTTATTATAAGCATGATCTTTTAAAAATATATCTGACTTTTAGAGTAA
>NM_148923.4
GAATGTCCCGGGTGGAGCTGGCTGAGTCGCGCGCTCTGCTCCACCCGACGGGGCTGTGTGTGCTGGGCCTGGCTCGCGGCGAACCGAGATGGCAGAGCAGTCGGACGAGGCCGTGAAGTACTACACCCTAGAGGAGATTCAGAAGCACAACCACAGCAAGAGCACCTGGCTGATCCTGCACCACAAGGTGTACGATTTGACCAAATTTCTGGAAGAGCATCCTGGTGGGGAAGAAGTTTTAAGGGAACAAGCTGGAGGTGACGCTACTGAGAACTTTGAGGATGTCGGGCACTCTACAGATGCCAGGGAAATGTCCAAAACATTCATCATTGGGGAGCTCCATCCAGATGACAGACCAAAGTTAAACAAGCCTCCGGAAACTCTTATCACTACTATTGATTCTAGTTCCAGTTGGTGGACCAACTGGGTGATCCCTGCCATCTCTGCAGTGGCCGTCGCCTTGATGTATCGCCTATACATGGCAGAGGACTGAACACCTCCTCAGAAGTCAGCGCAGGAAGAGCCTGCTTTGGACACGGGAGAAAAGAAGCCATTGCTAACTACTTCAACTGACAGAAACCTTCACTTGAAAACAATGATTTTAATATATCTCTTTCTTTTTCTTCCGACATTAGAAACAAAACAAAAAGAACTGTCCTTTCTGCGCTCAAATTTTTCGAGTGTGCCTTTTTATTCATCTACTTTATTTTGATGTTTCCTTAATGTGTAATTTACTTATTATAAGCATGATCTTTTAAAAATATATTTGGCTTTTAAAGTATGCACCGTGTTTGCCTGTTTGGTGTATAATTGTCTTTAATGTTTAGAATCTGGTTATTTAGAGGATTCCTTCAATGTGTTACTCATCCAGACCCACAGAGGCCATATGACTGGAGGTGCGGGAAATAGGTTTGAGTGTCTCCTTTCACATCGTCACATCTCATTGAGTAACCATGTATTGTATGCTTCCGATATAGTTTCTTTTTTTCAAGGAAATTAAGAAAGGCCAGAAATTATAGTTTAAGGATTTCTAATAATTGTCCTACTTGAAATAGATCTTAAAAAGAAAGTAGCggctgggcatcgtggctcacacctgtaagcccagcactttgggaggctgaggtgggtggatcacttgaggtcaggagttcaagaccagcctgaccaacatggtgaaaccctgtctctactaaaaatacaaaattagcagggcgtagtggcgcatgcctgtaatcccggctacttgggaggctgaggcaggagaattgcttgaacccaggaggcagaggttgtagtgagctgagatcgcgccgttgaactccagctgggcaacaagagtgaaactctgtctcaaaaaaaaaagaaaGTAGCCTACAGGGCCTATAAGAGAGACTTCTTATCTTCACTGATTGAAAAACATCAGCAACTTAAAAACACATGAACCATGAGAGGGCATCGCAACTGTCCATTCTCTCAGCTTACACGTATCATTGCAAAGGCACTCACAGCTTCATAGGTTCTAAAGTTTTAAGAATTCCTCATTCAGAGAGTAGAATTGTTTGTAAACTCTTCTAAGGAAAGGCTGGTTTTCTAATTTGTAAGGAGATTGTGGGACATTGGAATCTGATCTTTGAAGAAATTTAGCGGCTAGTGTCAAGCTCTGAAGAGTTCTGGTGTGGCTCTGTCTCCTCCTGGGGGCTCTAAGGGGCTGATTCAGTCATCTTACTTCCCATTTATTATTCTCTGCCTTATGTGTTATTCTTTTAAATGTGGAAACTTGAAAGCTGAATTTGTTAGAACCCAGTACATGTGTCATTGGCTGTGACTGCATTTGCACTGGCATGAGCTGACAAACCACGAGGTTCTTCAGAAGTGACCGCGTGCAGTGGAAAGGAATTGTGTTGTTCTTACAGAGTACAACCTTTATAATCAAATAGGATGCACCGCCTTTGCCTTCTTTAGTCACTGAAAGTTGACAAGTAGTTTCTATTTCAAAATAAATTACAACACTTGTTAAGGGACCTATGTAAATATTTCAATATTTTTGGTTGTGATTTTTAGCTATAAAGCTTCACATTTTAGTAGTTTTTAAAACATTGCTCCTAAATCAACTATGAAGTGAATCGAAGTGGGTCAGTCGTACCTTAGATGACATTAAAGGGTTAACTTGTAAATCATTTTTAAGATGTTGAGTAATAGCATCTGTATATCGTTAAGAAACATAACAGTTGAACTTTGACATTTTTATCAGTGACTCAGCAATTTGCTGCTGTGGCTGGCAATGTTTCTTCATGTGTTTTGGGAACAACATGTGGAGTAAAGGAGAGTTTACTTCCTAATTTTAACATTTACAGTTTGTGCAGCCAGACTCTCAAGGAAAGATATTTGACACTTTTTTCTCTATTGCTTTCCCTTCAGAGAGGTGAGAGACTTCAGAGGCTGCCCTTTCTTTTCATCTGCTGCTtgtgaaaggaaaacatcttgggcccccagaatcactaaggaaaactcaagctggaaactgcttagggccaacctgcctcccattctactcagtcaagcctctgctcactgagagagaggcatatctgattgcttcctttggaaaggctaatcagaaactcagaagaatgcaaccctttgtgtctcacctctctgtgacctggaagctccctcctgctttgagtcttcctgcctttgcttcaaggtgtcccgcctttccaaacagaaccaatgtacttcttacatatattgatcaatgtctcatgtctccctaaaatgcataaaaccaagctgtgccctgaccaccttgggtacatgtcattaggacctcctgatgctttgtcacgggcatgtcctcaaccttggcaaagtaaactttcttttttttttttttttgtttttgagacagagtctcactctgtcgcccaggctggagtgcagtggtatgatcttggctcactgcaacctccgactcccaggttcaagtgattctcctgccccagcctcctgagtagctgggactacaggcgtatgccaccatgcctagctaatttttttgtatttttagtagagacgggatttcaccatgttagccaggctggtcttgaactcctgacctcaggcaatccacccgcctcaggctcgcaaagtgctggaattacaggcatgagccactgtgccgggcctattccttgactttcttaataaagttgttttcactttgca

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