Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NCLP2
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:33357410-33357745  UCSC
Coordinates (T2T) chr20:35084615-35084950  UCSC
Coordinates (hg19) chr20:31945216-31945551  UCSC
Strand +
Parental Sequence NM_005381.3
Parental seq. overlap 296 bp
Parental seq. overlap (%) 7.5%
Genomic Region Intergenic
Retrocopy Summary NCLP2, located on chr20:33357410-33357745, is a retrocopy of the parental gene NCL. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NCL
Full Name nucleolin
Also known as C23|Nsr1
Coordinate chr2:231453531-231464484
Strand -
Gene summary Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NCLP2
Bonobo Pan paniscus NCLP2
Gorilla Gorilla gorilla NCLP2
Gibbon Nomascus leucogenys NCLP1
Crab-eating macaque Macaca fascicularis NCLP2
Rhesus Macaca mulatta NCLP2
Baboon Papio anubis NCLP3
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NCLP2
CTGGTGGCAAAGGCCAGGGAGGCTTTGGAGGGCAAGGAGGCTTCCAAGGAGGCAGAGGAGGAAGAAGAGACCACAGCTACAGGAAAGAAGATGAAGTTTGAAAAGCTTCTTCTATCCTTGTCTTTTCCTCTTCCATTTGAAAGGACTCGGGTTTTTACTCTGTGCCTGATCCATCACAGAGCCTTCTGAGGACATTCCAAGATTGTCTACAGTCCTGTGGTCCACTTGGAAATTCAGACAGATAATATTTCAAGGGGATAGTTGGTTTTGACTGAATACTCATGAAAACTTTTAAAGAAATGAGTGATAGAGCTAACCCATATCTGTAAGTTTTGA
>NM_005381.3
AGTCTCGAGCTCTCGCTGGCCTTCGGGTGTACGTGCTCCGGGATCTTCAGCACCCGCGGCCGCCATCGCCGTCGCTTGGCTTCTTCTGGACTCATCTGCGCCACTTGTCCGCTTCACACTCCGCCGCCATCATGGTGAAGCTCGCGAAGGCAGGTAAAAATCAAGGTGACCCCAAGAAAATGGCTCCTCCTCCAAAGGAGGTAGAAGAAGATAGTGAAGATGAGGAAATGTCAGAAGATGAAGAAGATGATAGCAGTGGAGAAGAGGTCGTCATACCTCAGAAGAAAGGCAAGAAGGCTGCTGCAACCTCAGCAAAGAAGGTGGTCGTTTCCCCAACAAAAAAGGTTGCAGTTGCCACACCAGCCAAGAAAGCAGCTGTCACTCCAGGCAAAAAGGCAGCAGCAACACCTGCCAAGAAGACAGTTACACCAGCCAAAGCAGTTACCACACCTGGCAAGAAGGGAGCCACACCAGGCAAAGCATTGGTAGCAACTCCTGGTAAGAAGGGTGCTGCCATCCCAGCCAAGGGGGCAAAGAATGGCAAGAATGCCAAGAAGGAAGACAGTgatgaagaggaggatgatgacagtgaggaggatgaggaggatgacgaggacgaggatgaggatgaagatgaAATTGAACCAGCAGCGATGAAAGCAGCAGCTGCTGCCCCTGCCTCAGAGgatgaggacgatgaggatgacgaagatgatgaggatgacgatgacgatgaggaagatgACTCTGAAGAAGAAGCTATGGAGACTACACCAGCCAAAGGAAAGAAAGCTGCAAAAGTTGTTCCTGTGAAAGCCAAGAACGTGGCtgaggatgaagatgaagaagaggatgatgaggacgaggatgacgacgacgacgaagatgatgaagatgatgatgatgaagatgatgaggaggaggaagaagaggaggaggaAGAGCCTGTCAAAGAAGCACCTGGAAAACGAAAGAAGGAAATGGCCAAACAGAAAGCAGCTCCTGAAGCCAAGAAACAGAAAGTGGAAGGCACAGAACCGACTACGGCTTTCAATCTCTTTGTTGGAAACCTAAACTTTAACAAATCTGCTCCTGAATTAAAAACTGGTATCAGCGATGTTTTTGCTAAAAATGATCTTGCTGTTGTGGATGTCAGAATTGGTATGACTAGGAAATTTGGTTATGTGGATTTTGAATCTGCTGAAGACCTGGAGAAAGCGTTGGAACTCACTGGTTTGAAAGTCTTTGGCAATGAAATTAAACTAGAGAAACCAAAAGGAAAAGACAGTAAGAAAGAGCGAGATGCGAGAACACTTTTGGCTAAAAATCTCCCTTACAAAGTCACTCAGGATGAATTGAAAGAAGTGTTTGAAGATGCTGCGGAGATCAGATTAGTCAGCAAGGATGGGAAAAGTAAAGGGATTGCTTATATTGAATTTAAGACAGAAGCTGATGCAGAGAAAACCTTTGAAGAAAAGCAGGGAACAGAGATCGATGGGCGATCTATTTCCCTGTACTATACTGGAGAGAAAGGTCAAAATCAAGACTATAGAGGTGGAAAGAATAGCACTTGGAGTGGTGAATCAAAAACTCTGGTTTTAAGCAACCTCTCCTACAGTGCAACAGAAGAAACTCTTCAGGAAGTATTTGAGAAAGCAACTTTTATCAAAGTACCCCAGAACCAAAATGGCAAATCTAAAGGGTATGCATTTATAGAGTTTGCTTCATTCGAAGACGCTAAAGAAGCTTTAAATTCCTGTAATAAAAGGGAAATTGAGGGCAGAGCAATCAGGCTGGAGTTGCAAGGACCCAGGGGATCACCTAATGCCAGAAGCCAGCCATCCAAAACTCTGTTTGTCAAAGGCCTGTCTGAGGATACCACTGAAGAGACATTAAAGGAGTCATTTGACGGCTCCGTTCGGGCAAGGATAGTTACTGACCGGGAAACTGGGTCCTCCAAAGGGTTTGGTTTTGTAGACTTCAACAGTGAGGAGGATGCCAAAGCTGCCAAGGAGGCCATGGAAGACGGTGAAATTGATGGAAATAAAGTTACCTTGGACTGGGCCAAACCTAAGGGTGAAGGTGGCTTCGGGGGTCGTGGTGGAGGCAGAGGCGGCTTTGGAGGACGAGGTGGTGGTAGAGGAGGCCGAGGAGGATTTGGTGGCAGAGGCCGGGGAGGCTTTGGAGGGCGAGGAGGCTTCCgaggaggcagaggaggaggaggTGACCACAAGCCACAAGGAAAGAAGACGAAGTTTGAATAGCTTCTGTCCCTCTGCTTTCCCTTTTCCATTTGAAAGAAAGGACTCTGGGGTTTTTACTGTTACCTGATCAATGACAGAGCCTTCTGAGGACATTCCAAGACAGTATACAGTCCTGTGGTCTCCTTGGAAATCCGTCTAGTTAACATTTCAAGGGCAATACCGTGTTGGTTTTGACTGGATATTCATATAAACTTTTTAAAGAGTTGAGTGATAGAGCTAACCCTTATCTGTAAGTTTTGAATTTATATTGTTTCATCCCATGTACAAAACCATTTTTTCCTACAAATAGTTTGGGttttgttgttgtttcttttttttgttttgtttttgttttttttttttttGCGTTCGTGGGGTTGTAAAAGAAAAGAAAGCAGAATGTTTTATCATGGTTTTTGCTTCAGCGGCTTTAGGACAAATTAAAAGTCAACTCTGGTGCCagacgtgttacttcctaaagagtgtttcccctggaatgtcactggagagcatggcaaagccagctctgccacttgcttcacccatcccAATGGAAATGGCTTAGTGCGTGTTTCCAGTATCCCAGCCCTAACTAACTTGGTTGAAATGCTGGTGAGGGGACCTGCTCCTGCAGCCCTGGTGCTGACTTGAAGGCTGCTGCAGCTTCTCCTACTTTTAGCAGGTCTGAGGATTATGTCCTGAAGACCACTCTGGAAAGAGGTGCAGGAACAGATTAGTCAGGTTTCCTAGGACAAGGAAGAGCTTCAGGGAAGAgcagtggctaactcctgtaatcccaacacttggggaggccgaggcaggcagatcaactgaggtcaggagttgaagaccagcctggccaacatggtgaaagcccatctctactaaaaatacaaaaattagctgggcatggtggtgtactcctgtagtcccagctactcaggaggctgaagcgggagagtcacgtgaacccgggaagcagagtgagctgagcacacactactatactccaggctgggtaacaaagcgagactcccatctcccaaaaaGCAGTTCTGGAATAGAACTCACGCTAGATGGATAGACCAGTGGACACTTTGGAACCTTGGGGCTGGGGAGGAAACTGCCCATCCAGTAAACCCCCAAAAAGCCATTTGTTCTGCACTACGTATATTGCTTATTCTTTCTGGTCTTAAGTACTTGCCTCTCAACCTCCCTTTTTAGTAAAAGACAAGGCCACGTGAGAGGCGGGACTATCAACATTGTGATGAATTTACTTGAAACCCAGTGCCCAAAATCAATGTAGGTAGCCAAGTCCAAAAACCTGTTCTAGTCCAACTAGTGAAATCAAACTGTGATACTTGGATAAGCTTAGAAGGAAACGTGAAGAATACGTAGCTGCTTTGGGTTTACTCTGGTTCAGTTGGGCTGTTGAAATCTTAACATCCTTGGGCTTATCACCTACTGCTTGTCAGCCCTGTTCCATGTCCAGGGGATGGGGGTGGTGACAATCCAGTTCCAAGACCCTCATGCTCTAGAGAGGAAGGTGGCCAGCCAGGGTTGTAACTACGATGAAAAAGCAGTGGGAGGGTCTCCTATGAGGCAAGCCTAAGGACAAAAAGGAAGGCCTTGCAGCCTGTATTCTGGATAAGGAATTAAAAGCTCAGTTAATTGAAGCCCA

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