Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name PIGPP3
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Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:33965131-33966147  UCSC
Coordinates (T2T) chr20:35691473-35692489  UCSC
Coordinates (hg19) chr20:32552937-32553953  UCSC
Strand +
Parental Sequence NM_153682.3
Parental seq. overlap 578 bp
Parental seq. overlap (%) 81%
Genomic Region Intergenic
Retrocopy Summary PIGPP3, located on chr20:33965131-33966147, is a retrocopy of the parental gene PIGP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PIGP
Full Name phosphatidylinositol glycan anchor biosynthesis class P
Also known as DCRC|DCRC-S|DEE55|DSCR5|DSRC|EIEE55|PIG-P
Coordinate chr21:37065364-37073071
Strand -
Gene summary This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PIGPP4
Bonobo Pan paniscus PIGPP3
Gorilla Gorilla gorilla PIGPP5
Orangutan Pongo abelii PIGPP4
Gibbon Nomascus leucogenys PIGPP4
Green monkey Chlorocebus sabaeus PIGPP1
Crab-eating macaque Macaca fascicularis PIGPP3
Rhesus Macaca mulatta PIGPP3
Baboon Papio anubis PIGPP4
Golden snub-nosed monkey Rhinopithecus roxellana PIGPP3
Marmoset Callithrix jacchus PIGPP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.2
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth012
log10(TPM+1)

Related Sequence

>PIGPP3
GGTCGGCGCTTGCACAGGGAACTCAGTGCTGAGATTGTCTCAAGCCCCAGGAAAAATGGTGGAAAATTCACTGTCACCATTGCCAGAAAGACCGATTTATGGCCTTCTGCTTCTCTTAAGCTCCCAATTTGGCTTCATACTTTACCTCGTGTAGGCTTCTATTCCTGAATCTTGGCTAAACTCCTTAGGTTTAACCTATTGGCCTCAAAAATATTGGACAGTTGCATTACCTCTCTACTTCCTTATTACTATAGTAATTGGCTATGTGCTCTTGTTTGTACCCCATTCACTCGACTCCATTCGTACAATCACAGATAACTATGCTAAAAATCAACAGCAGAAGAAATACTAAGAGGAGGCCATTCCAGCATTAAGAGCTATTTCTATTTAGTGAAGTAAACCAAATTTTCTTTCTTGTAGCCAAAGACCTTTACACCAAAAACTGAAATGTACCTGGCCAaCTAACACCAAGCATTTATTTATTTATAAGTTTTTGCCATCGTAATTTTGACCATAAATTAATTCAACCATCTCTCTTATTAATAGAGGAGATGTAAAAATTGTAAATTGATCTTCTCTTAGATTATGTTCAATGAATATTGTAAGTGTTCTCATGTATTGTTAATGAACAGAATAAA
>NM_153682.3
CTTTCCCTCAGGTTTTCCTCTTCCCCACTGCGGCTCCCCAGTCGGCGCTTGCGCGGAGAACTCAGCGCTGAGATTGTCTAAAGCCCCAGGAAAAATGGTGGAAAATTCACCGTCGCCATTGCCAGAAAGAGCGATTTATGGCTTTGTTCTTTTCTTAAGCTCCCAATTTGGCTTCATACTTTACCTCGTGTGGGCCTTTATTCCTGAATCTTGGCTAAACTCTTTAGGTTTAACCTATTGGCCTCAAAAATATTGGGCAGTTGCATTACCTGTCTACCTCCTTATTGCTATAGTAATTGGCTACGTGCTCTTGTTTGGGATTAACATGATGAGTACCTCTCCACTCGACTCCATCCATACAATCACAGATAACTATGCAAAAAATCAACAGCAGAAGAAATACCAAGAGGAGGCCATTCCAGCCTTAAGAGATATTTCTATTAGTGAAGTAAACCAAATGTTCTTTCTTGCAGCCAAAGAACTTTACACCAAAAACTGAACTGTGTGTAACCATAGTAACACCAAGCACGTATTTATTTATAAGTTTTTGCCATTATAATTTTGACCATAAATTAATTTGACCATCTCTCTTATTAATAGAGAAGTAAAAAATGTAAGTTGACCTTCTCTTAGATTATGTTCAATGAATATTGTAAATGTTCAAGTATTGTTAATGAATAGAATAAATACAATATTGCATTCCCATA

Publications

PMID - Link Title
No publications available for this retrocopy