Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GINS2P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:38614370-38615532  UCSC
Coordinates (T2T) chr20:40344025-40345187  UCSC
Coordinates (hg19) chr20:37243013-37244175  UCSC
Strand -
Parental Sequence NM_016095.3
Parental seq. overlap 1056 bp
Parental seq. overlap (%) 39.9%
Genomic Region Intragenic (ARHGAP40)
Retrocopy Summary GINS2P1, located on chr20:38614370-38615532, is a retrocopy of the parental gene GINS2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GINS2
Full Name GINS complex subunit 2
Also known as HSPC037|PSF2|Pfs2
Coordinate chr16:85676198-85688954
Strand -
Gene summary The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GINS2P1
Bonobo Pan paniscus GINS2P1
Gorilla Gorilla gorilla GINS2P1
Orangutan Pongo abelii GINS2P2
Gibbon Nomascus leucogenys GINS2P2
Green monkey Chlorocebus sabaeus GINS2P1
Crab-eating macaque Macaca fascicularis GINS2P1
Rhesus Macaca mulatta GINS2P1
Baboon Papio anubis GINS2P2
Golden snub-nosed monkey Rhinopithecus roxellana GINS2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GINS2P1
GGGACACTGAAGGGCCCAAGGAGACTGTGAGGCCCGAGCTGGCCACTCGCGCCGCCATGGACGTGGCCGAGGTCGAGTTCCTGGCTGAGAAGGAGCTGGTTACCATTATCCCCAACTTCAGTCTGGACAAGAGCTACCTCATTGGGGTGGGTACCTGGGGCCTTTTAACCCTGGTTTACCAGTGGAAGTACCCCCGTGGCTGGCAATTAACCTGAAACAAAAGCAGAAATGTCGACTGCTCCCTCCGGAGTGGATGAACATAGAAAAGTTGGAGAAGATGAGGGATCATGAATGAAAGGAAGAAACTTTTTTACCTCAATGCCCACCAGCCTTTACTACATGGAACTTACCAAGCTCCCATTAAATCATGCTTCAGACAACATCCCGAAGGCAGACGAAATCCGGACCCTGGTCAAGGATATATGGGACACTCGTATAGCCAAACTCCGAGTGTCTGCTGACAGCTTTGTGAGGCAACAGGAGGCACATGCCAAGCCGGATAACTTGACCTTGATGGAGATCAACCCCAGCGGGACTTTCCTCACACAAGCGCTCAACCACACGTACAAACTCGCACAAACCTCCAGCCTTCGGAGAGTACTCAGTCTCAGGACTTCTAGAGAAAGGCCTGGTGCAGGCAGCTTGCTGGGGGATGTGACGCTCAGGACGTGATGAGGTACTCATGGTTCTGGAGCTCTAGAGACACTTTTGAATGCATGAAAAACGTGCGATGGTGCAAGGAATGGATTCATGACATTGTTGGAGAAGCAACAAGTTTGTGGCTAGTCCTTAAAACTTAGCTCCCTGGGACATTCTTCAATTCCACATCTACTTCTAGAAATCAGCCTTCTCTGCCCCCTCTTTTGAGAAAGAAAAAAGCTTTAGGCAAATAAGTTATTGTCCCTAGCAGAGCCGCTTGGGTCTCCTGCATGGAAACCGTCACCTTGGGTAAGTGTTCAGTGACTGGTAGGTGTAGATATAGCAGGAGTGGCCATGTGGCCAATGGTTTTTTTTCCCCCTTCTTGATCCTGATTTCTTGGGCTAAATTTAGACGCTCCTATAGAGATGGGTCACAGAGAAGGATGGTAGATGGTGCAGCTAATGATGCTGACCAGTGCTTATGCTCTAAGCCCCGATCCACAATAAAAATGGACCCAACTCAA
>NM_016095.3
GGGACGCTGAGGGGCCCGAGGAGACCGTGAGGCTCTGGCCTGCAGCTCGCGCCGCCATGGACGCTGCCGAGGTCGAATTCCTCGCCGAGAAGGAGCTGGTTACCATTATCCCCAACTTCAGTCTGGACAAGATCTACCTCATCGGGGGGGACCTGGGGCCTTTTAACCCTGGTTTACCCGTGGAAGTGCCCCTGTGGCTGGCGATTAACCTGAAACAAAGACAGAAATGTCGCCTGCTCCCTCCAGAGTGGATGGATGTAGAAAAGTTGGAGAAGATGAGGGATCATGAACGAAAGGAAGAAACTTTTACCCCAATGCCCAGCCCTTACTACATGGAACTTACGAAGCTCCTGTTAAATCATGCTTCAGACAACATCCCGAAGGCAGACGAAATCCGGACCCTGGTCAAGGATATGTGGGACACTCGTATAGCCAAACTCCGAGTGTCTGCTGACAGCTTTGTGAGACAGCAGGAGGCACATGCCAAGCTGGATAACTTGACCTTGATGGAGATCAACACCAGCGGGACTTTCCTCACACAAGCGCTCAACCACATGTACAAACTCCGCACGAACCTCCAGCCTCTGGAGAGTACTCAGTCTCAGGACTTCTAGAGAAAGGCCTGGTGCAGGCGGCTTGCTGGGGGATGTGAGCGCTCAGGACGTGATGAGGTACTCGTGGTTCTGGAGCTCTAGAAACACTTCTGATGCATGAAAAATGTGTGATGGTGCAAGGAATGGATTCAGGATGTTGTTGGAGAAACAAGTTTGTGATTAGTCCTTAAAACTTAGCTCCCTGGGACATTCTTCAATTCCACATCTGTTTCTAGAAACCAGCCCTTTTTCCCCCCACTTTTGAGAAATAAAAAAGCCTTAGGTAAATAAGTCATTCTCCCTAGCAGAGCCACTTGGGTCTCCTGCATGGAAGCCATCACACTTGGGCAGGTGTTCAGTGACTGGTAGGTGTAGATACAGCAGGAGTGGCCATGTGGTCCACGGCTTTTTACCCCTTCTTGATCCTGATTTCTTGGGCTGAATTTAGACTCTCTCACAGAGGTGGCTCACAGAGAAGGATGGCAGATGGTGCAGCCAACAATGCTGACCGGTGCTTATCCTCTAAGCCCTGATCCACAATAAAAATGGACCCAACTCAGCTCTGACTCTCTAGGTTTTTGTGCTGCGTAACTACCAAGTAAAAGGACTGAGCCTGTGGCTGAGATGACTCAGTCAACGAAACTGAGGCACACGGCAGTTAAGTGGAAACTGCAGACCAACACCTGGGGTGTCTCCTTCTCTTGGCTACTTCTAGCTCAGGTTTAATGGGTTGCTTATCAAGAGGAGAGTCAGGAAAAAAACGAATCCAATGTATTGAGCATGAGTGACAATGTATTGAGCATGAGTGACAATGCTAGAAGAAAAGTCACTTTCAGTGCTGCTCTTGATGGATTTGGGGAAGGATTCTTTGTTGTAGGTAACAGTGGGCTCAGGGGAAATTATTTTTTTCCTAAGAGAAAATTACTTTATTCGTAGCATTTTGGAAATGTTAGGACCTTTACAGAAATTACATTACCTTGAGAGGTGAAATGATCGTCCAGCATCATGCAATGGATAGAAGGTTCTGTAATCAGCTTTAAAAAAAACTTTAATTTTTggccgggcacattggcttggctcatgcatgtaatcccagcactttgggaggccaaggcaggtggatcacaaggccaggagattgagactatcctggctaacatggtgaaaccccgtctctattaaaaatacaaaaaaaaaaaaatttgccaggtgtggtggcacacgcctatagtcgcagctactcgggaggctgaggcaggagaatcgcttgaacccgagaggcggaggttgtagtgagccaagattgcaccactgtactcctgcctgggcaacgagagcaagactctgtctcaaacaaaaaaaattttaactttttttttagacagggtctcgttctgtcatccaggctgcagtagagtggcgtgattatagctcactgcagcctcgaactcctgggttcacacagttctcccaccacagcctcccaaagcactgggattgcaagcatgagccgccatgcctggcCAGCCTATTTTTGGCTGGACACCAGTGGGCCAAAAGCAGTGGGGTGCTGTCTGGGGAGCTCTGAGAATGCGCATGTGTGACAGGCTGAGCCTAAAGACTTATCACCCAGCATCTGCCCTCCAGTGTCTAGCATGCTGCACACTATCACTCCATGTTGCTGCCCACGTGTCCCCGCCAGGCAGGTTTTGGTGGTTATTTGGACACTGAAGGGTCAGACCTGGAAGACTGGGACCAAAAGATGAGGTCTCCATAATTTAAGGTGCTGTTCAGACTTGGTTCAGCTCATAGGACTTGTTCTTTCATCTCAGCCTTCCTTGGAATCCTCCTGCTTTCATCTGGGGATCTTTTAGAATGAAACCACTTGTTATTGTGGAGGGCAAGGGGTCCTAATGCCCTCCTCTTAGAGCCTGAGCCAGTGGAGGCAGCTCCGTCTGCGGAGATGTATAGTTATTGAGCTTTTCTTTGTTTGGCTTTGTTTTATATCATAAAAAAGATTTTCCTCTTAACATAA

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