Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NEFHP2
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:41996539-41999433  UCSC
Coordinates (T2T) chr20:43728410-43731304  UCSC
Coordinates (hg19) chr20:40625179-40628073  UCSC
Strand -
Parental Sequence XM_011530200.2
Parental seq. overlap 1516 bp
Parental seq. overlap (%) 33.5%
Genomic Region Intergenic
Retrocopy Summary NEFHP2, located on chr20:41996539-41999433, is a retrocopy of the parental gene NEFH. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NEFH
Full Name neurofilament heavy chain
Also known as CMT2CC|NFH
Coordinate chr22:29480218-29491390
Strand +
Gene summary Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NEFHP2
Bonobo Pan paniscus NEFHP2
Gorilla Gorilla gorilla NEFHP2
Orangutan Pongo abelii NEFHP2
Gibbon Nomascus leucogenys NEFHP2
Green monkey Chlorocebus sabaeus NEFHP1
Crab-eating macaque Macaca fascicularis NEFHP2
Rhesus Macaca mulatta NEFHP2
Baboon Papio anubis NEFHP2
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NEFHP2
AGAAAAAAGACACCAAGGAGGAGAAGGCCACCGAGGCCAAGAAGCCTGAGGAGAAACCCAAGACAGAGGCCAAAACCAAGGAGGATGACAAGACCCTCTCAAGGGACCCAAGCAAACATAAAGCAGAAAAGGCTGAAAAATCCTCCAGCACAGACCAAAAAGACAGCAGGCCTCCAGAGAAAGCCACAGAAGACAAGGCTGCCAAGGGGAAGTAAGGCACGGAGAAAGGAATGTCTGGAGCAGCCAAAGAAACTCAGAAGGGGCCCAGAGCTCAAGGATCGGAGTAATGCAATTTTCACTTTTTCTCTCTTAATGTAAGAAGAAACTGCTTAGATGATGGGGCCTTCTTCTTCAAACAGGAATTTCTGTTAGCAATATGTTAGCAAGAGAGGGCACTCCCAGCCCCCTGCCCCCACACCCTCCCCAAGCGATGGACAATTGTTATGAAAGCTTATGTAGCTGAATGTGGTACATGCTGAATGCCACACGTAAACTCTTGACTATAAAAAACTGCCTCCCTCCTTTCCAAATAAGTGCATTTATTTCCTCCATGTGCAACTGACAGATGACCACAATAATGAATGAGCAGTTACAAACACATTATGCTTGACATGTCTTAAACTATTTCTACATGCCTTCTGTTTTCCAAAGGAGTGGTCAAGCCCTTGCCCAGAGCTCTCTATTCTAGAAGAGCTGCCCAGGTGGGGCTGGGCACTGGCCACTGAATTATGCCAGTGCGCACTTTCCACTGGAGTCCACTTTCAACTTCTTCTGTGCAATAAAACCAAGTGTTTATAAAATGAGCCAAGTCCCCAGTGAAGGAAGAAGCAAAGTCTCCAGCTGAGGTCAAGTCCCCTGAAAAGGCCTGAAAAGGCCAAGTCCCCAACAAAGGAGGAAGCGAAGTCCTCTGAGAAGGAAGAGGCAAAATCTTCAGCTGAAGTCAAGTTTGGGCTCGAAAAGCCCAAAGAATCCAAAGTTGAAGCCAAGAAGGAAGAGACTAAAGATAAGAAAAAAGCAGCCACCCCAGAGAAGGAGGCTCCTGCCAATGTGGAGGTGAAGGAAGACGCTAAACCCAAAGAGATGACAGGTGGCCAAGAAGGAACCAGATGATGCCAAAGCCAAGGGACCTACCAAACGCACCTGCTCCAGCCATGATGAGCTTCCGAAGCGCGGACGCGTTGCTGGGCGCCCTGTTCCTGCCGTTGCACGGCGGTGGCAGCCTCCACTACGCTCTGGCCCCAAAGAGCGGCACAGGCGGGACGCGCTCGGCCGCTGGCTCCTCCAGCGGCTTCCACTCGTGGACGTGGACGTCCGTGAGCTCCGTGTCCGCCTCGCCCAGCCGCCGCCTCGAGCACCGACTCGCTGGACACGCTGAGCAACCAGCCAGAGGGATGCGTGGTGGCGGCTGCTACAACGAGCAGTGAGGAGGAGCAGCTGCAGGCGCCGACGGACCGCTTTGCGGGCTACATCGACAAGGAGCGGCAGCTGGAGGTGCACAACCGCAGCCTGGAGGGCGAGGCAGCGGCCCTGCAGCAGCAGCAGGCGGGCCGCGAGGTCCGTGAGACGCGCGGTGCGATGCTGCGCCTGGGCAGCTGCGCCTGGAACAGGAGCACCTGCTCGAGGACATCGCGCACGTGTGCCAGCGCCTCGACAACGAGCTCTGGCAGCGCGAGGAGGCCGAGGCGGCAGCCCGCGCACTCACGCGCTGCACGCAGGAGGCCGAGGCGGCGCGCGTGGAACTGCAGAAGCAGGTGCAAGCGCTGCAGGAGGAGTGCGGCTACCTGTCGCGCCACTACCAGGAGGAGCAGGTGGTCGAGCTGCTCGGCCAGACCCAGGGCTGCGGCGCCGCGCAGGTGCAGGCTGAGTTGCGCAACGCTCTCAAGGGCGAAGTGACATCGGCGCTGAGCGAGATCGGCGCGGCGTGCAGCTTGAAGGCCATGCGGTGCAGAGCACGCTGCAGTCCGAGGAGTGGTTCTGAGTAAGGCTGGACTGACGTTAGAGGCAGCGAAGGTGAACATAGATGCCATGTGCTCAGCGTAGGAGGAGATAACTGAGTACCGGCGTCAGCTGCAGGCCAGGACCACAGAGCTGGAGGCACTGAAAAGCACCAAGGGCTCACTGGAGAGGCAGCGCTCTGAGCTGGAGGACCGTCATCAGGCCAACATTGCCTCCTACGAGGAAGTCATTCAGCAACTGGATGCCGAGCTGAGGACCACCAAGTGGGAGATGATAGCCCAGCTGCGAGAATACTGGGACCTGCTTAATGTCGAGATGGCTTTGGATATAGAGATAGCCGCTTACAGAAAACTCCTGGAAGGCGAAGAGTGTCGGACTAGCTTCGGCCCAATTCCTTTCTCGCTTCCAGAAGGACTCCCCAAAATTCCCTCCGTGTCCACTCACATAAAGGTCAAAAGTGAAGAGAAGATCAAAGTGGTAGAGAAGTCAGAGAAACTGTGATTGTGGGGGAACAGATGGAGGAGACCCaagtgactgaagaagtgactgaagaagAGGAGAAAGAGGCCAGAGAGGAGGAGGGCAAGGAGGAAGAAGAGGGTGAAGAGGAGGGGGCAGAAGGGGGAGAAGAAGCAAAGTCTCCCCCAACAGAAGAGGCCACATCCCCAGAAAAGGAAGCCAAGTCCCCAGTGAATGAAGAGGCAAAGTCACCAGCTGAGGCCAAGTCCCCAGAGAAAGAGGAAGCAAAATCCCCAGCCGAGGTCAAGTTCCCCGAGAAGGCCAAGTCCCCAGCAAAGGAAAAGGCAAAATCACCAGCTGAGGCCAAGTCTCCAGAGAAGGCCAAG
>XM_011530200.2
TCCCGCCCCGTCCCGGCCTCGCGCACCTGCTCAGGCCATGATGAGCTTCGGCGGCGCGGACGCGCTGCTGGGCGCCCCGTTCGCGCCGCTGCATGGCGGCGGCAGCCTCCACTACGCGCTAGCCCGAAAGGGTGGCGCAGGCGGGACGCGCTCCGCCGCTGGCTCCTCCAGCGGCTTCCACTCGTGGACACGGACGTCCGTGAGCTCCGTGTCCGCCTCGCCCAGCCGCTTCCGTGGCGCAGGCGCCGCCTCAAGCACCGACTCGCTGGACACGCTGAGCAACGGGCCGGAGGGCTGCATGGTGGCGGTGGCCACCTCACGCAGTGAGAAGGAGCAGCTGCAGGCGCTGAACGACCGCTTCGCCGGGTACATCGACAAGGTGCGGCAGCTGGAGGCGCACAACCGCAGCCTGGAGGGCGAGGCTGCGGCGCTGCGGCAGCAGCAGGCGGGCCGCTCCGCTATGGGCGAGCTGTACGAGCGCGAGGTCCGCGAGATGCGCGGCGCGGTGCTGCGCCTGGGCGCGGCGCGCGGTCAGCTACGCCTGGAGCAGGAGCACCTGCTCGAGGACATCGCGCACGTGCGCCAGCGCCTAGACGACGAGGCCCGGCAGCGAGAGGAGGCCGAGGCGGCGGCCCGCGCGCTGGCGCGCTTCGCGCAGGAGGCCGAGGCGGCGCGCGTGGACCTGCAGAAGAAGGCGCAGGCGCTGCAGGAGGAGTGCGGCTACCTGCGGCGCCACCACCAGGAAGAGGTGGGCGAGCTGCTCGGCCAGATCCAGggctccggcgccgcgcaggcgcagatgcaggccgagacgcgcgacgccctgaagtgcgacgtgacgtcggcgctgcgcgaGATTCGCGCGCAGCTTGAAGGCCACGCGGTGCAGAGCACGCTGCAGTCCGAGGAGTGGTTCCGAGTGAGGCTGGACCGACTGTCGGAGGCAGCCAAGGTGAACACAGACGCTATGCGCTCAGCGCAGGAGGAGATAACTGAGTACCGGCGTCAGCTGCAGGCCAGGACCACAGAGCTGGAGGCACTGAAAAGCACCAAGGACTCACTGGAGAGGCAGCGCTCTGAGCTGGAGGACCGTCATCAGGCCGACATTGCCTCCTACCAGGAAGCCATTCAGCAGCTGGACGCTGAGCTGAGGAACACCAAGTGGGAGATGGCCGCCCAGCTGCGAGAATACCAGGACCTGCTCAATGTCAAGATGGCTCTGGATATAGAGATAGCCGCTTACAGAAAACTCCTGGAAGGTGAAGAGTGTCGGATTGGCTTTGGCCCAATTCCTTTCTCGCTTCCAGAAGGACTCCCCAAAATTCCCTCTGTGTCCACTCACATAAAGGTGAAAAGCGAAGAGAAGATCAAAGTGGTGGAGAAGTCTGAGAAAGAAACTGTGATTGTGGAGGAACAGACAGAGGAGACCCaagtgactgaagaagtgactgaagaagaggagaaagaggccaaagaggaggagggcaaggaggaagaagggggtgaagaagaggaggcagaagggggagaagaagaaACAAAGTCTCCCCCAGCAGAAGAGGCTGCATCCCCAGAGAAGGAAGCCAAGTCACCAGTAAAGGAAGAGGCAAAGTCACCGGCTGAGGCCAAGTCCCCAGAGAAGGAGGAAGCAAAATCCCCAGCCGAAGTCAAGTCCCCTGAGAAGGCCAAGTCCCCTGAGAAGGCCAAGTCCCCAGAGAAGGAAGAGGCCAAGTCCCCTGAGAAGGCCAAGTCCCCAGTGAAGGCAGAAGCAAAGTCCCCTGAGAAGGCCAAGTCCCCAGTGAAGGCAGAAGCAAAGTCCCCTGAGAAGGCCAAGTCCCCAGTGAAGGAAGAAGCAAAGTCCCCTGAGAAGGCCAAGTCCCCAGTGAAGGAAGAAGCAAAGTCCCCTGAGAAGGCCAAGTCCCCAGTGAAGGAAGAAGCAAAGACCCCCGAGAAGGCCAAGTCCCCAGTGAAGGAAGAAGCTAAGTCCCCAGAGAAGGCCAAGTCCCCAGAGAAGGCCAAGACTCTTGATGTGAAGTCTCCAGAAGCCAAGACTCCAGCGAAGGAGGAAGCAAGGTCCCCTGCAGACAAATTCCCTGAAAAGGCCAAAAGCCCTGTCAAGGAGGAGGTCAAGTCCCCAGAGAAGGCGAAATCTCCCCTGAAGGAGGATGCCAAGGCCCCTGAGAAGGAGATCCCAAAAAAGGAAGAGGTGAAGTCCCCAGTGAAGGAGGAGGAGAAGCCCCAGGAGGTGAAAGTCAAAGAGCCCCCAAAGAAGGCAGAGGAAGAGAAAGCCCCTGCCACACCAAAAACAGAGGAGAAGAAGGACAGCAAGAAAGAGGAGGCACCCAAGAAGGAGGCTCCAAAGCCCAAGGTGGAGGAGAAGAAGGAACCTGCTGTCGAAAAGCCCAAAGAATCCAAAGTTGAAGCCAAGAAGGAAGAGGCTGAAGATAAGAAAAAAGTCCCCACCCCAGAGAAGGAGGCTCCTGCCAAGGTGGAGGTGAAGGAAGACGCTAAACCCAAAGAAAAGACAGAGGTAGCCAAGAAGGAACCAGATGATGCCAAGGCCAAGGAACCCAGCAAACCAGCAGAGAAGAAGGAGGCAGCACCGGAGAAAAAAGACACCAAGGAGGAGAAGGCCAAGAAGCCTGAGGAGAAACCCAAGACAGAGGCCAAAGCCAAGGAAGATGACAAGACCCTCTCAAAAGAGCCTAGCAAGCCTAAGGCAGAAAAGGCTGAAAAATCCTCCAGCACAGACCAAAAAGACAGCAAGCCTCCAGAGAAGGCCACAGAAGACAAGGCCGCCAAGGGGAAGTAAGGCAGGGAGAAAGGAACATCCGGAACAGCCAAAGAAACTCAGAAGAGTCCCGGAGCTCAAGGATCAGAGTAACACAATTTTCACTTTTTCTGTCTTTATGTAAGAAGAAACTGCTTAGATGACGGGGCCTCCTTCTTCAAACAGGAATTTCTGTTAGCAATATGTTAGCAAGAGAGGGCACTCCCAGGCCCCTGCCCCCAGGCCCTCCCCAGGCGATGGACAATTATGATAGCTTATGTAGCTGAATGTGATACATGCCGAATGCCACACGTAAACACTTGACTATAAAAACTGCCCCCCTCCTTTCCAAATAAGTGCATTTATTGCCTCTATGTGCAACTGACAGATGACCGCAATAATGAATGAGCAGTTAGAAATACATTATGCTTGAGATGTCTTAACCTATTCCCAAATGCCTTCTGTTTTCCAAAGGAGTGGTCAAGCCCTTGCCCAGAGCTCTCTATTCTGGAAGAGCGGTCCAGGTGGGGCCGGGGACTGGCCACTGAATTATGCCAGGGCGCACTTTCCACTGGAGTTCACTTTCAATTGCTTCTGTGCAATAAAACCAAGTGCTTATAAAATGAAAA

Publications

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