Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KANK1P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:5927779-5929312  UCSC
Coordinates (T2T) chr20:5968115-5969648  UCSC
Coordinates (hg19) chr20:5908425-5909958  UCSC
Strand -
Parental Sequence NM_001354343.2
Parental seq. overlap 1128 bp
Parental seq. overlap (%) 22.1%
Genomic Region Intergenic
Retrocopy Summary KANK1P1, located on chr20:5927779-5929312, is a retrocopy of the parental gene KANK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KANK1
Full Name KN motif and ankyrin repeat domains 1
Also known as ANKRD15|CPSQ2|KANK
Coordinate chr9:470295-746104
Strand +
Gene summary The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KANK1P1
Bonobo Pan paniscus LOC117977259P1
Gorilla Gorilla gorilla KANK1P1
Orangutan Pongo abelii KANK1P1
Gibbon Nomascus leucogenys KANK1P1
Green monkey Chlorocebus sabaeus KANK1P1
Crab-eating macaque Macaca fascicularis KANK1P1
Rhesus Macaca mulatta KANK1P1
Baboon Papio anubis KANK1P1
Golden snub-nosed monkey Rhinopithecus roxellana KANK1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KANK1P1
GGGATCTCAGAAGGAAAGCTGGTCAGCAGCCAGGATGCCTTCCCCGCTCAGGAAAGGACATGGTCTCTAGTGAACCTGACAGACAACCAGATGGCCGCTGGCCTCCATATGCACAAACAATGAAAGTACACTGGAGCCCATTATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCATGAAAAAGAATCTTCAGTTTGTTGGCATTAATGGAGGTTATGCAACAACTTCAAGTGATGATTTTCACACAGATGAAAGCTCTTCTTCTGAGTCAGATGACGAGTGTGATGTCATTGAGTGTCATTGAGTAGTATCCTCTTGAAGAAGACGAGGATGAAGACACTTGGGGAATGGCCAAAGGGCACCATGCCATTAACATTGAAGGTTTCAAGTTGGCCAGGGTGGAAGATGAAATGCAGTTTCAAGAACGTGAACCTGAGAAGGTGAAAATCAGAGGGAGGTATAAATTAAGTGAAAAAATGTTGTCTGCTTGCAACTTACTGAAAAATAATATAAATGACCCCAAAGCTGTGACCAGCAAAGATATGAGGTTCTGTCTGAACACCCTCCAGCACAAGGGGTTCTGCGTGTCCAGTCAGAAGTTAGCCATTGCAGCCACCCTGGGAGACTACAGAGCTGCTTTTGAGGCTACCTCCCTGGATGCCCTCTACTAGGTCATCAACTTGGCAGATGGCAACAGCAACACAGCCCTCCATTACAGCATGTCCCACTCCAATTTTGAGATTGTGAAGCTGCTGTTGGACACCCACATGTGTAACGTGGATCACCAGAACAAGGGGCTATACCTTCATCATGCTGGCGGCCCTCGCAGCTGCGGAAGCAGAGGACATGCAGGTTGGGGAAGAACTCTGGCTGAAAGGTGAGCCTCAAAGCCAGTCAGCTGGGGCAGATGGCCCTCATGCTGCAGTCAGTTACTGTGCAGATCGGCATGGTGTATGGTCTGCCGGCCTGTGGGGCTCAGGTCAACCTCCAGGACGACAAGGGCTCCATGGTCCTCATTGTGCCAGCAAGCACGGGCACATGGAGATCATCAAGCTGCTGCTGGCCCAGCTGGGCTGCAACGTCCACCTGCAGGACAATGATGGCAGCACCATGCTCTCGATCGCCCTGGAAGTGGGGCACAAGGGCATCACTGTTCTTCTGTATGCCCACATCAGCTTTGCAAAAGCTCAGTCTCCGGGCACCCCTAGGCTTGGAATGAAGCCACAGAGTTTCATTTGATTGATTGTATGCAAATAGCCCTCCATTTTAATGCCACCATTAAGCTGCCAACTGTGCCTGTTGGAATGACAGACACTGAATGTATATGCATTGTGCCTGAGCTCACCAGCAAACAGAAGCATAAAGCCCAGGGCTAAAGACTGAAGCTTTCACAGTGCAGAGACTGCCAGCCTGGGCACACATGCCTCCTTTCTGGCCATCTTCTGTCTGCGTACGGTGCACTTTAACCTACTCTGTGTTGCTGTTGAGTCTCTGCTCTGTTATGTACAGCCATAGGGAATTGTGACCTGAC
>NM_001354343.2
ACTGCAGCCGGAGGGAGACCTCGCCGGTGAAAGCTCAGCCTATGGCATCCGAGCGTGGCCGGCCAAGTTTACACGAATGTTGAAACTTCTCCTCACGGGGTGAGGATCGAGGGCGCCCGAGGCCGGGTCCGGCTGAGCTGGAGCGAGCTGTGCGGGGCAGCgcgggctggcggggagcgcggcgggcgccacgtggtagGAAAAGCAGGTGATATTCTCAGTGGAGACCAGGACAAGGAACAGAAAGACCCTTACTTTGTGGAGACCCCCTATGGTTATCAACTAGACTTAGATTTCCTCAAATATGTGGATGACATACAGAAGGGAAATACCATCAAAAGACTGAACATCCAGAAGAGGCGGAAGCCGTCCGTGCCATGCCCAGAACCCAGGACCACATCTGGTCAGCAAGGTATATGGACTTCCACTGAATCCCTCTCATCCTCCAACAGTGATGACAACAAGCAGTGCCCCAACTTCCTCATAGCCAGAAGTCAAGTTACATCAACTCCAATCTCAAAGCCACCTCCCCCTCTGGAGACCTCACTCCCTTTTCTTACCATCCCAGAAAATCGACAGCTGCCACCTCCCTCACCACAACTCCCAAAGCATAACCTTCATGTCACCAAGACACTGATGGAGACCCGGAGAAGACTGGAACAGGAGAGAGCCACCATGCAGATGACACCGGGTGAGTTCAGAAGGCCCAGGCTGGCCAGTTTTGGAGGCATGGGCACCACAAGCTCCCTCCCTTCTTTTGTGGGTTCTGGAAACCACAATCCTGCCAAGCACCAGCTTCAGAATGGATACCAAGGTAATGGGGATTATGGTAGCTATGCCCCAGCTGCTCCCACCACTTCCTCCATGGGGAGCTCCATCCGCCACAGCCCCCTGAGCTCAGGGATCTCCACCCCAGTGACCAACGTGAGCCCCATGCACCTGCAGCACATCCGCGAGCAGATGGCCATTGCTCTGAAACGCCTGAAGGAGCTGGAGGAGCAGGTGCGAACCATCCCTGTGCTCCAGGTAAAGATCTCTGTCTTGCAAGAAGAGAAAAGGCAGTTGGTCTCACAGCTGAAAAACCAAAGGGCTGCATCCCAGATCAATGTCTGTGGTGTGAGGAAGCGGTCCTATAGTGCGGGGAACGCCTCCCAGCTGGAACAGCTCTCCCGGGCCCGAAGAAGTGGCGGGGAATTATACATTGACTATGAGGAGGAAGAAATGGAGACCGTAGAACAGAGCACGCAGAGGATAAAGGAGTTCCGGCAACTTACAGCAGACATGCAAGCCCTGGAGCAGAAGATCCAGGACAGCAGCTGTGAGGCCTCCTCAGAGCTCAGGGAGAATGGAGAGTGCCGGTCTGTGGCTGTGGGTGCCGAGGAGAACATGAACGACATCGTCGTGTACCACAGAGGCTCCAGGTCCTGTAAGGATGCAGCTGTAGGGACACTTGTTGAGATGAGAAATTGTGGGGTCAGCGTGACAGAGGCCATGCTTGGAGTGATGACTGAAGCTGACAAAGAAATTGAGCTGCAACAGCAGACCATAGAATCCTTGAAGGAAAAGATCTATCGCCTAGAAGTACAGCTTAGAGAAACCACCCATGACCGGGAGATGACTAAACTGAAACAAGAGCTGCAGGCTGCTGGATCGAGGAAAAAGGTTGACAAAGCCACGATGGCCCAGCCGCTTGTTTTCAGTAAGGTGGTGGAGGCAGTGGTGCAGACCAGAGACCAAATGGTCGGCAGTCACATGGACCTGGTGGACACGTGTGTTGGGACCTCCGTGGAAACAAACAGTGTAGGCATCTCCTGCCAGCCTGAATGTAAGAATAAAGTCGTAGGGCCTGAGCTGCCTATGAATTGGTGGATTGTTAAGGAGAGGGTGGAAATGCATGACCGATGTGCTGGGAGGTCTGTGGAAATGTGTGACAAGAGTGTGAGTGTGGAAGTCAGCGTCTGCGAAACAGGCAGCAACACAGAGGAGTCTGTGAACGACCTCACACTCCTCAAGACAAACTTGAATCTCAAAGAAGTGCGGTCTATCGGTTGTGGAGATTGTTCTGTTGACGTGACCGTCTGCTCTCCAAAGGAGTGCGCCTCCCGGGGCGTGAACACTGAGGCTGTTAGCCAGGTGGAAGCTGCCGTCATGGCAGTGCCTCGTACTGCAGACCAGGACACTAGCACAGATTTGGAACAGGTGCACCAGTTCACCAACACCGAGACGGCCACCCTCATAGAGTCCTGCACCAACACTTGTCTAAGCACTTTGGACAAGCAGACCAGCACCCAGACTGTGGAGACGCGGACAGTAGCTGTAGGAGAAGGCCGTGTCAAGGACATCAACTCCTCCACCAAGACGCGGTCCATTGGTGTTGGAACGTTGCTTTCTGGCCATTCTGGGTTTGACAGGCCATCAGCTGTGAAGACCAAAGAGTCAGGTGTGGGGCAGATAAATATTAACGACAACTATCTGGTTGGTCTCAAAATGAGGACTATAGCTTGTGGGCCACCACAGTTGACTGTGGGGCTGACAGCCAGCAGAAGGAGCGTGGGGGTTGGGGATGACCCTGTAGGGGAATCTCTGGAGAACCCCCAGCCTCAAGCTCCACTTGGAATGATGACTGGCCTGGATCACTACATTGAGCGTATCCAGAAGCTGCTGGCAGAACAGCAGACACTGCTGGCTGAGAACTACAGTGAACTGGCAGAAGCTTTCGGGGAACCTCACTCACAGATGGGCTCCCTCAACTCTCAGCTCATCAGCACCCTGTCGTCTATCAACTCTGTCATGAAATCTGCAAGCACTGAAGAGCTGAGGAACCCTGACTTCCAGAAAACCAGTCTGGGTAAAATCACAGGCAATTATTTGGGATATACCTGTAAGTGTGGGGGCCTTCAGTCAGGAAGTCCCTTAAGCTCCCAGACATCCCAGCCTGAGCAAGAAGTGGGGACCTCAGAAGGAAAGCCAATCAGCAGCCTGGATGCCTTCCCCACTCAGGAAGGTACGCTGTCTCCAGTGAACCTGACAGACGACCAGATCGCCGCTGGCCTCTATGCATGTACAAACAATGAAAGTACACTGAAGTCCATCATGAAGAAGAAAGATGGTAACAAAGATTCAAATGGCGCAAAAAAGAATCTTCAGTTTGTTGGCATTAATGGAGGGTATGAATTAAGTGAAAAGATGTTGTCTGCATGCAACTTACTGAAAAATACTATAAATGACCCCAAAGCTTTGACCAGCAAAGATATGAGGTTCTGTCTGAACACCCTCCAGCACGAGTGGTTCCGCGTGTCCAGTCAGAAGTCAGCCATTCCAGCCATGGTGGGGGACTACATAGCTGCTTTTGAGGCCATTTCCCCAGATGTCCTCCGCTATGTCATCAACTTGGCAGACGGCAACGGCAACACAGCCCTCCATTACAGCGTGTCCCACTCCAACTTCGAGATTGTGAAGCTGCTGTTAGATGCCGATGTGTGTAATGTGGATCACCAGAACAAGGCAGGCTACACCCCCATCATGTTGGCGGCCCTCGCCGCTGTGGAAGCAGAGAAGGACATGCGGATTGTGGAAGAACTCTTCGGCTGTGGGGATGTGAATGCCAAAGCTAGTCAGGCGGGACAGACGGCCCTCATGCTGGCGGTCAGTCACGGACGGATAGACATGGTGAAGGGCCTTCTGGCCTGTGGGGCTGATGTCAACATCCAGGATGACGAGGGCTCCACGGCCCTCATGTGTGCCAGCGAGCACGGACACGTGGAGATTGTCAAGCTGCTGCTGGCCCAGCCCGGCTGCAACGGTCACCTAGAGGACAACGATGGCAGCACTGCGCTCTCAATCGCCCTGGAAGCAGGACACAAGGACATCGCTGTTCTTCTGTATGCCCATGTCAACTTTGCAAAAGCCCAGTCTCCGGGCACCCCTAGGCTTGGAAGGAAGACGTCTCCTGGCCCCACCCACCGAGGTTCATTTGATTGATTGTATGCAAATAGCCCTTTATTTACATGCCACTATTAAGCTGCTAATTGTTCCTGTTGGGGTGACAGATACTGAATGTATACGTATTGTGCCTGAGCTCACCAGCAAACAGAAGCATCAAGCCCAGGGGTAAAGGCTGAAGCTTTCACAGTGCAGAGACTGCTAGCCTGGGCACACACACCTCCTTTCTGGCCGTCTTCTGTGTAGGGCACACTTTAACCCAGTCTCTGTTGCTGTTGAGTCTCTGCTCCGTTTTGTACAGTCACAGGGAATTCTGATCTGAAGGGGCACCTTCTGTTCACTCCCACAAAGTGGTGTCTGGTTCTCACTGAGACGTTTTAAGATTTTTCCACAAATATTTATATGTACTAAATGTGGAACCATTAGAAAGTTCTTCCAAAATCTCATTCCAGCATAGTTTTGGATTTTTCTTTTGTCTTATTTTAAAATAAGGAAGTCGAGATGACTTTGATCATTGGTAACTTGGGCCTGGGCCAGACAAAGTATAAAACTTACAAAAGAATATTCTCATTTGGTCTTAACTAGGTAGATGTAATATATGACTTTTTATAAAAAGGGTATCTATATGAACTTGACACAGTATTTTCAGCTTTTGTATTCCATACTAAAGCCATGAAGAACTACACGTAACATCATCATTTGTATTAATTGCACAACTCCAATGCTAAAGGTTGGATTGTGTTAGAGGAATCGGCTCTGTATTTGCCTCTAGAGAAACACAGTGTTCTCTTTGTATTTATGGATTCCTTTTTACCGTGTCACATTTACTTTGGTCCTCTATGTATTTAAATGTTTGAAGTGCCTTAGACTCTTGCCATATTTTCAAAATAAAATTCCATTAAGCTCT

Publications

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