Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DPH3P1
Plot displaying the genomic locations of a retrocopy (in chr20) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr20:62845596-62846175  UCSC
Coordinates (T2T) chr20:64645158-64645737  UCSC
Coordinates (hg19) chr20:61476948-61477527  UCSC
Strand +
Parental Sequence NM_206831.3
Parental seq. overlap 527 bp
Parental seq. overlap (%) 13.1%
Genomic Region Intergenic
Retrocopy Summary DPH3P1, located on chr20:62845596-62846175, is a retrocopy of the parental gene DPH3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DPH3
Full Name diphthamide biosynthesis 3
Also known as DELGIP|DELGIP1|DESR1|DPH3A|KTI11|ZCSL2
Coordinate chr3:16257061-16264943
Strand -
Gene summary This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DPH3P1
Bonobo Pan paniscus DPH3P1
Orangutan Pongo abelii DPH3P1
Gibbon Nomascus leucogenys DPH3P2
Crab-eating macaque Macaca fascicularis DPH3P2
Rhesus Macaca mulatta DPH3P2
Baboon Papio anubis DPH3P2
Golden snub-nosed monkey Rhinopithecus roxellana DPH3P3
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DPH3P1
AGAAGTTAGACCCTCGGAGCTGGTCTCGGACTGCTGGGGCGTCACCCCTTCAGCAACCCCCGCTGACCATGGCAGTATTTCATGACGAGGTGGAAATCGAGGACTTCCAATATGACGAGGACTCGGAGACATATTTCTGTCCCTGCCCATGCGGAGATAACTTCTCCATCACCAAGGAAGAGCTGGAGAATGGGGAAGGTGTGGCAATGTGTCCAGGCTGCTCTCTCATTATAAAAGTGATTTATGACAAAGATCAGTTTGCGTGTGGAGAAACAGTGCCAGTGCCTTCAGTCAACAAAGAATGAGTTAAATGCTAAGGAAGCCTTCAGGAATCCGAACCCTGAACAGCTGGAAATGAGCCCAGATAGAAACTTCAAATGCAAAGCTCCTGGCTTCGTGGAGACACAGCCATTTGTGATTTGCTGTTCTGTAGGCGTGTTGTGGATTCTTTCCATCAACTGCTGATTTCATCTTCAGGAAGCAAGTCCATAACATGACGTATCTGGAGTTTGTGCTTAGAACCTTAAATTGGAAGCATTCTTAATTATCCATCTAAATTTAAAAGACGATAATTTAAAAA
>NM_206831.3
GAAGTTAAACCCTCGGAGCTGGCCTCGGACTGCTGGGGCGTTACCCCTTCGGCCACCCCCGCTGACCATGGCAGTGTTTCATGACGAGGTGGAAATCGAGGACTTCCAATATGACGAGGACTCGGAGACGTATTTCTATCCCTGCCCATGTGGAGATAACTTCTCCATCACCAAGGAAGATTTGGAGAATGGGGAAGACGTGGCAACGTGTCCTAGCTGCTCTCTCATTATAAAAGTGATTTATGACAAAGATCAGTTTGTGTGTGGAGAAACAGTCCCAGCCCCTTCAGCCAACAAAGAATTAGTTAAATGCTGAAGAAGCCTTCAGGAATCCAAATCCTGAACATTTGGAATGAGCCCAGATAGAAATATCGAATGCAAAGCTACTGGCTTCACAGAGACAACCATTTATGATTTGCTGTTCTGTAAGAGTGTGGATTCTTTCTATCAACTGCTGATATCATCTTCAGGAAGCAAGTCCATAACATGACATATCTGGATTTTGTGCTTAGAACCTTAAATTGGAAGCATTCTTAATTATGCATCTAAATTTAAAAGAAGATAATTTCAAAACAGTGCTTTCTTTCCCTTGGTTTCATCATTTTCATATCTTAAACCAAATTACTTCGGTATCTGACAACAGCATCATCTACCTCAGTCATTAGGATTTCTTAATAAAAAAGAGATTGTATTTTTGACTTGGTTATTAAGATTATTAAAATTAGCCCTTCCTTTGAAATATGACATCAGCTTTGCTGTTCTAAATTTAAAATTAGTTGCTTCATCAGTACCACACTTCCAGTTTCTATACCAAGCCAGTCTCCTCAGTTTTCCCATTAGAATGGACATGTTCTGTTCAGCGTGTCATTTCTGTAATGCTTCATGCAGAGAGTTTGGTCATAGTATTAAAGAGAAAATACAGTGAGGTCACAATGTCTCCAGAGCTAAAAGTTAGTGAACAAGAAAGAAAGTCCAAAATGAAGTGATGAAAGAATGAGGACTTTTCTTATATTCTGCATATTCCTTGGAAGTCAGGACAAGATGAAAAGAAAAACATCCAAAAGAAGTGAAATTGGTGACAGAATGAGAGGAGCAAAGCATACCAGTGTAGTAAGTGGAATGTTTGAATGACTTTGCCAGGTCAGAGCAAGTAATATTTCTGTATCTGAGTTTTTGTTTGTGTTTTGATAAGGCTAATGAAATTGCATTCCAGGTAGGGGTTAACGTCAAATTTCCATGGCTGGTAGCTGTGCTTTTGGCATATCACAGTGTTGTGTCACTACTACAAGGTAAAGCATCTACAGCGGAGAATGAGCTTGAAAATGAGAGACCTATTGTGAATAAATATGCCCATGAGAGCATATTTAATAAGCCTCTATAACATGCAGCCAAACCAGACATTCACTCCTGCAGAGAAATGTTGCCCTGGAGAAAAAGAAATATATAAAGATAGGCTATCACCCTTCTTTTGCTGCAGTACTAAGCATAGCAAGAAATTAGAATCATTTACATTGGAAATTTGAAAATTCCCTTTATATACACAACTTTACTGTGTATAAATAAAAAATATTTATTAATGCAGTGATGTCCGTCAGGTTGTTTTAGGAATGGCTTCTGCAATTAGAAAAATAGCTTGCTAGAATGTAAATGTTCTGTTACTGGTAAATGTACTGCACACATTCATTGGACGTTAAAACAAGTGAGTAGCCTTTTTTACCTGCCAGCAGCATGGCTGTGTGCAGCCACTAGGCTGAGACAATAAATTACCAAAAATTATAATGTACCGAGCTGAAAATGCTCAGTACATTATGTGGCATATTCTGGATGTGATGAGAAATCTCATTGCCATTTGGGACACTGACATCCCAGAAGTAATCCACAACTGCTTTGCAAAAGCAAAGTGACTGCTCAGATGAACAGAGCAGAGTACTCACTCACTATGGTGGCATCAGCTGCAAAGCAAAATGAACTGTCCCATGATCATGTTGATGGTTTTCTAGATACTGCCAACATGTTAGCTCTTTCTGATGCTGATGAGTTTCAAACACGAACAGACACCCTTGATGTGGGTTTGCTAAGAACATAGAAGAACAGGAAGAAAAGTTGCCAGGTTCACACATCCCAGGAAAAAAGAAGCATAAAAAGCATTAGCAGTCAGTGACTGATGATAATGCTGCAATAATGGGAATGGTTTTGTTTCTAAACCAAATTATTTCTAAATCAAATCATTTATTGCTTTGTTTCTAAAGCAATTGAGTCACTAAGTTTGTGAACTGTAGGAGAACACATCAAGATTGAATCCTGTGTTAAGCAGAAGGTAAAACCAGAgccaggcgcagtggctcgtgcctgtaatcccagctactcaggaagctaaggcaggaggatcatgtgaggccaggagttcaagactagcctgggcaacatagaaagaccctgtctctaaaaaatcttcttttaattagcaaggtgtggggccttgagcaaattgcttgggcccaggagtttgaggctgtggtgagctgtgatcacaccactgcgttccagcctgtgtgacagggcaagacctcatgcctaaaaaataaagagaaaGCAGAGTAAAACTGGACTCTGAGATACGACTAAAGTTCTGTGTGATACGTGTGCCTTATTTAGCTCAAGACATTCCTGGAGCACCTATAAAAACTGACTTGTAATCCAGGCTATGTCTCTTTTTAGCTTCGTAATCTTTGGCAAGGCCATTGGATTCTTCAGCTGTACAATTAGGAGACTCGATCAGGTGATTGCCTTTCTCAGCTGTCAGTTCTCTAATTTCAGGCTTGGTAGCTTGTAGGAACTGAAATTGCAATTAAAACCTTTATAAACTCAAACTAAATCATGAATTACAGAAAAAGTCCATTCTTCCAAAACTTGATGTTACCACACTTACAAGTTTAAAATATGAAGTCGACTGTTTAAAGGATTCTGCATATATTCTAGTGTGCACATTCAGAAACATTTTTCTTGGAAAAAGTACCCAACATTTTTTATAACTGCACATATTAATTTATTGCCAGAATAAATTGCATTGCATGCTAAATAAAGTCAGATAATTCAAATCCATTTGCTTTTATGTAGTTTTTCTTCTAAATGTCAACATTTTGAATTAAAATGTTTATGATTTTATATGAGGTAGAAATCTTAACTGCTTTGGGGTATTGTTAATAGACTTTTTGTTATGGACAGTAGTTTTTAAATAAGGAAATTGCCAATTTCTACAGTTTGGGCTCTGGATTTCTATTGTTTGGGAAAAAAATAACTGAGTCAAGTGGTAGTAAGACAAAGTTGACATTCTTAGATGAGTAACTCAGTTTATTACAAGGAAAGAAAACTGATTGTTTAAGGCTGATGATCAATTCTTGGagtggtttcagagcccagctctggtcagaagacaatttgaatcttagttcctccactgtgatctccgagaagttacttaataattatattctggtttgtgaaatctggatcatagtacctctttgacagggttgctgtgTGAACCCATTCATTCTGCAATTAGAAAAATAGCTGTCATGTGCTATGCACTAGGCAAAGAAGTACCTGTCACATGCTAGGCACTAGGGGAAGAAGATTCGGTTTCTACATTTGGAAACTTAGTGGAACTAGAAGAGACAGAAGCAAGATTACAGATGAGTTAGAGCCCCCAAGGAAACAAACCAGGTGATGTGGGAGAGAGTAACTGGGTCAGGTGACTTTTTAAGGGAGTCTGAGCTCTGGCACTTTTTCTAAGACCTGAAGGATGAGAAGGAAACAGCCTTGTGAAAATGATTAAATGAGCTAGTATCTATAAAACATGACAGCTAATGCCTGTCATGTGCAAAAAATGGTTAACTATTCTAACTCCGAAAGGAATTAAACATTGTTTTGCGCTTTCtcctagtccatgttctgctgctgtaacaatacctgagactggataatttatcaagaataaaggttaatttggctcatga

Publications

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