Retrocopy Name | PRCPP1 |
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Species | Homo sapiens | |
Coordinates (hg38) | chr2:101520935-101521172 UCSC | |
Coordinates (T2T) | chr2:101979612-101979849 UCSC | |
Coordinates (hg19) | chr2:102137397-102137634 UCSC | |
Strand | - | |
Parental Sequence | NM_001319214.2 | |
Parental seq. overlap | 209 bp | |
Parental seq. overlap (%) | 6.5% | |
Genomic Region |
Intergenic |
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Retrocopy Summary | PRCPP1, located on chr2:101520935-101521172, is a retrocopy of the parental gene PRCP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes. |
Gene Name | PRCP |
Full Name | prolylcarboxypeptidase |
Also known as | HUMPCP|PCP |
Coordinate | chr11:82822936-82901691 |
Strand | - |
Gene summary | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
Species | Scientific Name | Retrocopy | |
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Chimpanzee | Pan troglodytes | PRCPP1 |
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Gorilla | Gorilla gorilla | PRCPP1 |
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Orangutan | Pongo abelii | PRCPP1 |
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Green monkey | Chlorocebus sabaeus | PRCPP1 |
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Crab-eating macaque | Macaca fascicularis | PRCPP1 |
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Rhesus | Macaca mulatta | PRCPP1 |
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Baboon | Papio anubis | PRCPP1 |
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Golden snub-nosed monkey | Rhinopithecus roxellana | PRCPP1 |
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Marmoset | Callithrix jacchus | PRCPP1 |
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Bonobo | Pan paniscus | Without Homology |
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Gibbon | Nomascus leucogenys | Without Homology |
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Mouse lemur | Microcebus murinus | Without Homology |
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Mouse | Mus musculus | Without Homology |
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Rat | Rattus norvegicus | Without Homology |
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Chinese hamster | Cricetulus griseus | Without Homology |
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Rabbit | Oryctolagus cuniculus | Without Homology |
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Pig | Sus scrofa | Without Homology |
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Cow | Bos taurus | Without Homology |
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Sheep | Ovis aries | Without Homology |
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Dolphin | Tursiops truncatus | Without Homology |
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Horse | Equus caballus | Without Homology |
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Dog | Canis familiaris | Without Homology |
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Panda | Ailuropoda melanoleuca | Without Homology |
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Cat | Felis catus | Without Homology |
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Pale spear-nosed bat | Phyllostomus discolor | Without Homology |
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Velvety free-tailed bat | Molossus molossus | Without Homology |
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Greater mouse-eared bat | Myotis myotis | Without Homology |
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Kuhl's pipistrelle | Pipistrellus kuhlii | Without Homology |
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Greater horseshoe bat | Rhinolophus ferrumequinum | Without Homology |
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Egyptian rousette | Rousettus aegyptiacus | Without Homology |
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Sloth | Choloepus didactylus | Without Homology |
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Tasmanian Devil | Sarcophilus harrisii | Without Homology |
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Opossum | Monodelphis domestica | Without Homology |
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Platypus | Ornithorhynchus anatinus | Without Homology |
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Chicken | Gallus gallus | Without Homology |
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Turkey | Meleagris gallopavo | Without Homology |
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Zebra Finch | Taeniopygia guttata | Without Homology |
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Budgerigar | Melopsittacus undulatus | Without Homology |
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Painted Turtle | Chrysemys picta | Without Homology |
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Lizard | Anolis Carolinensis | Without Homology |
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Frog | Xenopus tropicalis | Without Homology |
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Zebrafish | Danio rerio | Without Homology |
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Drosophila | Drosophila melanogaster | Without Homology |
>PRCPP1 |
TGAACTTCACTCGTGGAACTTGAAGGAGTTTTCTGATAACTGTTTTAAACAGTGGGGTGTGAGACAGAGGCCCTCCTGGATCACTACGGTGTGTGGAGGCAAAAACATGAGTTCGCACATGGACATCATTTTCAGCAATGGCAAACTAGACCCCTGGTCAGGAGGTGGAGTAACCAAGGACATCACAGACACCTTGGTTGCAGTTACCATCTCAGAGGGGCCCACCGTTTAGATCTCT |
>NM_001319214.2 |
AGCGAGGAAATCCTACAAGCATCTGGAAACGACCATTTTCGTCAAACTGCGGGGGTTCATGTGGGATGTGGCTGAGGAACTGAAAGCTATGTTGGTGTTTGCTGAACATCGATACTATGGAGAGTCTCTCCCCTTTGGTGACAACTCATTCAAGGATTCCAGACACTTGAATTTCCTGACATCAGAACAAGCTCTGGCTGATTTTGCAGAGTTAATCAAACACTTGAAAAGAACAATCCCAGGAGCTGAAAATCAACCTGTCATTGCCATAGGAGGCTCCTATGGTGGCATGCTTGCCGCCTGGTTTAGGATGAAATATCCTCATATGGTAGTTGGAGCTCTTGCAGCTTCTGCCCCTATCTGGCAGTTTGAGGATTTAGTACCTTGTGGTGTATTTATGAAGATCGTAACTACAGATTTTAGGAAAAGCGGTCCACATTGTTCAGAGAGCATCCACAGGTCCTGGGATGCCATTAATCGACTCTCAAATACTGGCAGTGGTTTGCAGTGGCTTACTGGAGCCCTTCACTTATGCAGCCCATTAACTTCTCAGGACATCCAACATTTGAAAGACTGGATCTCTGAAACCTGGGTGAATCTGGCAATGGTGGACTATCCTTATGCCTCTAACTTTTTACAGCCTTTGCCTGCTTGGCCTATCAAGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTATGACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCagggacacagagagacagagagagagagaCTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGGGCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAAATATTTCCTTTACTTTCCCTGGCATCTGGGAGATACAGGAAAATCTTTGTCTTATTTTGGGAGCCTTCAGTTCTCATTGTAATGAGTTGTCTATCAAAGCATTTGGTAACTATTTTGTTTCAGCATCACAGAACAATCGATTTGGGTGGGAATTTAAGGGCCAAAACAATACTAGTTTTTATTCTTTGTCAACTAAGAAATTAAATAATGCAGGGTTTATGGGCTCAATAGAGGATATTCTTACAATTTATTTTACGATTTTAGGGTTTTTCCCTTGTGTAGAATCTTTAAAATACTTTGCCATTTTATTTGATGTTGATTATTTGGATGAGTTACATTATTCTGAAGAAACAAACTGCAAAAAATAGAATTTTTTGGCAAGCATAATTGTATCCTATTACTGTATGCATTTTAGGAATATAGATAGCAGCCTTAATTGAAGTGAGTATAATTATAATATGCTAAGGTTTAATTTTAACATGAAAAAGAATTGGAGTGTCAGATAAGCCTTATTATTTAAAGCATCCCTCTAATAAAACTGCACTTTTTACTGACAGGGAAAGAGA |
PMID - Link | Title |
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No publications available for this retrocopy |