Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name PRCPP1
Wait
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:101520935-101521172  UCSC
Coordinates (T2T) chr2:101979612-101979849  UCSC
Coordinates (hg19) chr2:102137397-102137634  UCSC
Strand -
Parental Sequence NM_001319214.2
Parental seq. overlap 209 bp
Parental seq. overlap (%) 6.5%
Genomic Region Intergenic
Retrocopy Summary PRCPP1, located on chr2:101520935-101521172, is a retrocopy of the parental gene PRCP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PRCP
Full Name prolylcarboxypeptidase
Also known as HUMPCP|PCP
Coordinate chr11:82822936-82901691
Strand -
Gene summary This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PRCPP1
Gorilla Gorilla gorilla PRCPP1
Orangutan Pongo abelii PRCPP1
Green monkey Chlorocebus sabaeus PRCPP1
Crab-eating macaque Macaca fascicularis PRCPP1
Rhesus Macaca mulatta PRCPP1
Baboon Papio anubis PRCPP1
Golden snub-nosed monkey Rhinopithecus roxellana PRCPP1
Marmoset Callithrix jacchus PRCPP1
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.050.1
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth0123
log10(TPM+1)

Related Sequence

>PRCPP1
TGAACTTCACTCGTGGAACTTGAAGGAGTTTTCTGATAACTGTTTTAAACAGTGGGGTGTGAGACAGAGGCCCTCCTGGATCACTACGGTGTGTGGAGGCAAAAACATGAGTTCGCACATGGACATCATTTTCAGCAATGGCAAACTAGACCCCTGGTCAGGAGGTGGAGTAACCAAGGACATCACAGACACCTTGGTTGCAGTTACCATCTCAGAGGGGCCCACCGTTTAGATCTCT
>NM_001319214.2
AGCGAGGAAATCCTACAAGCATCTGGAAACGACCATTTTCGTCAAACTGCGGGGGTTCATGTGGGATGTGGCTGAGGAACTGAAAGCTATGTTGGTGTTTGCTGAACATCGATACTATGGAGAGTCTCTCCCCTTTGGTGACAACTCATTCAAGGATTCCAGACACTTGAATTTCCTGACATCAGAACAAGCTCTGGCTGATTTTGCAGAGTTAATCAAACACTTGAAAAGAACAATCCCAGGAGCTGAAAATCAACCTGTCATTGCCATAGGAGGCTCCTATGGTGGCATGCTTGCCGCCTGGTTTAGGATGAAATATCCTCATATGGTAGTTGGAGCTCTTGCAGCTTCTGCCCCTATCTGGCAGTTTGAGGATTTAGTACCTTGTGGTGTATTTATGAAGATCGTAACTACAGATTTTAGGAAAAGCGGTCCACATTGTTCAGAGAGCATCCACAGGTCCTGGGATGCCATTAATCGACTCTCAAATACTGGCAGTGGTTTGCAGTGGCTTACTGGAGCCCTTCACTTATGCAGCCCATTAACTTCTCAGGACATCCAACATTTGAAAGACTGGATCTCTGAAACCTGGGTGAATCTGGCAATGGTGGACTATCCTTATGCCTCTAACTTTTTACAGCCTTTGCCTGCTTGGCCTATCAAGGTAGTGTGCCAGTATTTGAAAAATCCCAATGTATCTGATTCACTGCTGCTGCAGAATATTTTCCAAGCTCTGAATGTATATTACAATTATTCGGGCCAGGTGAAATGCCTGAATATTTCAGAGACAGCAACTAGCAGTCTGGGAACACTGGGTTGGAGCTATCAGGCCTGCACAGAAGTAGTCATGCCCTTTTGTACTAATGGTGTCGATGACATGTTTGAACCTCACTCATGGAACTTAAAGGAACTTTCTGATGACTGTTTTCAACAGTGGGGTGTGAGACCAAGGCCCTCCTGGATCACTACTATGTATGGAGGCAAAAACATTAGTTCACACACAAACATTGTTTTCAGCAATGGTGAACTAGACCCCTGGTCAGGAGGTGGAGTAACTAAGGATATCACAGACACTCTGGTTGCAGTCACCATCTCAGAGGGGGCCCACCACTTAGATCTCCGCACCAAGAATGCCTTGGATCCTATGTCTGTGCTGTTAGCCCGCTCCTTGGAAGTTAGACATATGAAGAATTGGATCAGAGATTTCTATGACAGTGCGGGAAAGCAGCACTGAGAAACTTTTGATTGTTTTCAATTTCTTCTTTTATGTTCACACCACCACATTCCCATTCACTTTGATTTTCTACATGTAATTACCTTCTTTTGTTTATCATTAGATTTGATGGGGCCAAAGTTGAGATAGAATAGAGGGTGATGACGGTAAGAGCAAGTGTCCCATGAATGTGATTTCCTGGGTTCTCACTGTCTTTGCACCACGTCTAGGAAGAATCTTCTTGATAGCTCTCCCACACCATCAGTGGCCCTCATAACTGGAGTAGAGTTCCTGGTTGCTTTTCATAAGAGGGAGAGTTACTTTCTTTGTATCTCTGCAAGCAGAGATTTCTCTTTGGTTTTGAGGTTGAAGTGTCTTTGGCCCATTTGTAAGTCCCCATCCCTACCCTACACAAAGTAAAAGCAGAAGATAGATAAAAAATGATGTAATTGCAGCTGGTAGGATGTCTGGTGCCAATCCAGGAAGTGAGAGCCATTTCTTTTGTACCGGATTTAATGACTTTGAACTGTGCTGTAAATAAATAATACAGCTGGACCTTATACCTGTGTGTTGCTTCTGAAGCTCACTTCAACTCCGGCTGATGGAAATGCTGTGTGCACTGGGCTTAGCTGTTTTTGGAAAGTCCTTTAATTTTTTCTCTTCCACTTGGCAGCTTTTCTTAGTTCTGGGATGTTGGCCACTGTGGTACTGCCAGTAAGAAATCTGGCCTTTTTCTGCTCCATTTCTCTTTGTTTCTAAGGTCAGTTTTAATTTGTTTGAATTCTGCCAGTTTAGGAAAATGACTCTGTTTTGTCTTTTTAAATCTGAGCAAGCTTTATGCTGTAGTCACTAATTATATTTCAGTAAGAAGCCTTTAAAAATTGATGAATCAGCTATTCCAAAAGTAGAATATAGTAATATTCAGCTTTTAAATTTTTAAAATTTTATTTTCTGATAGTTGTTACTGCTGTCATTAAAACCAGAAGTGTTAGACACTAACAGGCAGGTGCACAAGAACTTTTCTGTATGACTTCCAAAAGACAAGCTGACTAATTCATGCAGGCAGCATATTTGACATTAATAAATGGCCAAGCCATTCCTATTTCCAAGGGGTTGGCTTCTTTCAAGCAGTTCTTACACTGAGACCTTTCTTCAGAGAGCTTTTCTAGGATAACAAATAGGGTTGGATCAAAACCTTTCagggacacagagagacagagagagagagaCTAACAGTTTCTACTCTGTTGAAAGATTTCTTCCTCCTTGTTTCTTTTCATTTTCTCTCAATAATTTTTTTTTCTTCACCCTGCCTTGGGAACATTTTCTGCTTTTAAAAAACTGTACCTTGAGCTTGATCATTTTTATGGCATTTTTTTTTTTTAAGGGCATATATAGAGTTCATTCTTGGGATGGAAAGCTGAAATATTTCCTTTACTTTCCCTGGCATCTGGGAGATACAGGAAAATCTTTGTCTTATTTTGGGAGCCTTCAGTTCTCATTGTAATGAGTTGTCTATCAAAGCATTTGGTAACTATTTTGTTTCAGCATCACAGAACAATCGATTTGGGTGGGAATTTAAGGGCCAAAACAATACTAGTTTTTATTCTTTGTCAACTAAGAAATTAAATAATGCAGGGTTTATGGGCTCAATAGAGGATATTCTTACAATTTATTTTACGATTTTAGGGTTTTTCCCTTGTGTAGAATCTTTAAAATACTTTGCCATTTTATTTGATGTTGATTATTTGGATGAGTTACATTATTCTGAAGAAACAAACTGCAAAAAATAGAATTTTTTGGCAAGCATAATTGTATCCTATTACTGTATGCATTTTAGGAATATAGATAGCAGCCTTAATTGAAGTGAGTATAATTATAATATGCTAAGGTTTAATTTTAACATGAAAAAGAATTGGAGTGTCAGATAAGCCTTATTATTTAAAGCATCCCTCTAATAAAACTGCACTTTTTACTGACAGGGAAAGAGA

Publications

PMID - Link Title
No publications available for this retrocopy