Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACTR1AP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:110183999-110186837  UCSC
Coordinates (T2T) chr2:110606904-110609738  UCSC
Coordinates (hg19) chr2:110941576-110944414  UCSC
Strand +
Parental Sequence NM_005736.4
Parental seq. overlap 2552 bp
Parental seq. overlap (%) 88.7%
Genomic Region Intragenic (NPHP1)
Retrocopy Summary ACTR1AP1, located on chr2:110183999-110186837, is a retrocopy of the parental gene ACTR1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACTR1A
Full Name actin related protein 1A
Also known as ARP1|Arp1A|CTRN1
Coordinate chr10:102479229-102502712
Strand -
Gene summary This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACTR1AP1
Bonobo Pan paniscus ACTR1AP1
Gorilla Gorilla gorilla ACTR1AP1
Orangutan Pongo abelii ACTR1AP1
Gibbon Nomascus leucogenys ACTR1AP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACTR1AP1
ATGGCACTAGCGGCAGACCCAACTGGTAGTTCCTTCCCCAGGAGAGATTCCTCTGCCGTGGAGTCTTACGATACAATCACCAACCAGCCTGTCATGATCGACAATGAATCTGGTGTGATTAAAGCTGGTTTTGCTGGTGATCAGATCCACAAATACTGCTTTCCAAAGTATGTGGGCCTACCCATGCATATTCGTATCATGGCAGGAGCCCTTGAAGGTGACATCTTCATTGGCTTCAAAGCCAAGGAGCACCAAGGGCTGCTCTCAATCTGCTATCTCACGGAGCATGGCATTGTCAAGGACTGGAACGACATGGAACACATCTGGCAATATGTCTATTCTAAGGACCAGCTGCAGACTTTCTCAGAGGAGCATCTCGTGCTCCTCACTGAGGCACCTTTAAACCCACAAAGACACCAGGAATGAGCTGCCAACGTTTTCTTCAAGAGCTTCAATGTGCCTGCTATTTTCATCTCCATGTAAGCTGTGCTCAGCCTTTATGCCACAGGCAGGACCACGGGGGTGGTGCTGGATTCTGGGGATGGCATCACCCATGCTGTGCCCATCTATCAGGGCTTTGCCATGCCCCACTCCATCATGCGAATTGACATCGCAAGCTGGAACATCTCTCGCTTCCTGCACCTCTACCTGCATAAGGAGGGCTATGATTTCCACTCATCGTTTGAGATTTCCACTCATCCTTTGAGTTTGAGATTGTCAAGGCCATAAAAGAAAGACCCTCCTACCTATCCATAAACCCCCAGAAGGAAGAGACACTAGAGACAGAGAAGGCTCAGTACTACCTGCCTGATGGCAGCACCATTGAGATTGGTCCTTCCCAATTCCGGGCCCCTGAGCTGCTCTTCAGGCCAGACTTGATCAGGGAGGAGAGTGAAGGCATCCACAAGGTCCTGGTGTTCGCCATCCAGAAGTCAGACATGGACCTGCAGTTCACACTTTTCTCCAACATCGTCCTCTTGGGAGGCTCTACCTTGTTCAAAGGTTTTGGTGACAGGCTACTGAGTGAAGTGAAGATCAGGATATTTGCACCTCAGGAGAGACTGTATTCCACGTGGATTGAGGGCTCTATCCTTGCCTCCATGACACCTTTAAGAAGATGTGGGTCTCCAAGAAGGAATATGAGGAAGACGGTGCCTGATCTATCCACAGGAAAACCTTCTAATGTTGGGATATCATCTTCACCTCTCTCTGAAGTTAACTCCACTTTAAAACTCGCTTTGTTGAGTCAGAGTGTTTGTGAGGAATTGCCTGTGTGTGTGAGTGCATGTGTGTATACAAGTGTGTGAGCACATGCAAGTGCCATGTGGCCCAGGGACCCCAGGTCCAGAAAGGATGAGGAACTACCCACGATGGTGATGGCCTGAGGCCTGGGGGTGACCATTAACTGGCTCCTGACAGGGAAGAACACTGGCAGAGGCTGCACTCCCTCCTCAGGTGGGCCTCTGACTGGCTGCAGGGAACTCCGTTTACTACCACGGGGAGACAGAGGGAGATAAACCACCCCCTGGGAGACCTTGCTGCTGCCCATCCTAGGCTGGACTGGCCCCACCCTCACTCCCACCCACCAGGGTGCCCTGAGGACCCAGGCAGCTGCTGCCTCCCCTTGCTGGTCACTCCGCTATCAATGCCCCCTGACTGGGCACTGAGGACTGGGGCTGGGGTTGACCTCTGTCTGGTTTTGTTGCCATTTTGGTTTGGGAGGCTAGAAAAGCATCCCAAGAGCTAATACAGAGACTGGAAAGTCAGGAGGGAGCAGGAAGCCCTCATGTTCACCAGGGAACAGGACCACACCAGCCACTGGAGGAGGGCAGGAGTAGTACTCCCCCTGAATGGCTGCAGAGATAATGTTCCCAGCCCATTCCCCTTCCAGGGGCCTTGGGAGAGTTTAAGGTGCCTGCTGATTCCAGGTCCTTGCTTTCCATCCGTTCTTGTTGCAATGCCATCTTCAAACAGTTTTATTTATTGAAGTGTTTGTTCAGTAAGGGGATGGAGAGAGGGAGCTCACTGCCTCCTGCCCTGCCACACTAATGTTTATAGCACCTAAGCTTAGCCTAGCCTCCAGGGCCCCGCCTCTCCCTGCTGATGGTAAGCGGACAGTGTCCACAGGTTGCAGGACCATTTGAAATTGGTAGCTATACTCAAAGACACTCCCACCAGCCTCTTTCTCCCTCTTTCTCTTGCTCACTGCCATAGAATCAACAGGCTGGTTGCTGGTTAGATTTTCTGAAACAGGAGGTAGAATTTTTCTTTGGCAGAGGCCCCTAAACAAGGAAGGGGTGTTGGAGAGCCAGTGTCCTTAGGACTGGAGAAAGCTGCAATTAACCATGTTGCCTTTTGCCACTATAGCTGACCAGGCAACTAAGCTGTAGAGGTGGGATGGCCCCCTCTTGGCTGATCTTGGGCCACTCTTGACCTTGGACCTGCTTGGTTAAGGAGGGAGAGGGCCAGACCAGAGTGCCAGGAGCTAATGGAGCCAGGCCTGACTCCTAGGAGTAGTCCAAAGGCCTTTAGCCCAGGTGGTGCAAAGCTGGGGCCAGCCTGTCTTCACCGGCACCCTCACCTGTGACACCATGACCCACCCCAATCCCAGACTCCATGCAGTAGTCTCCCCCATGCTGTCCTATGACCAAAGGCCCCTGCCAGGTATGGGCCAAAGGAGCAGGTGTGTGTGAAAGCGATGTAGCACCCCACAGACTGCAGTGCACTTAACAACTCACCTCCCTTCTCTTAGCCCAAGCCTGTCCCTCGCACAGCCTTGCACAAACCACACTGCCTGATGGGGCTCAGTGTACTGAAATAAAGTCATTCTGATAGACAC
>NM_005736.4
GTCAGTGGCGCTAGCGGCGGACCCGGCTGGGCAGTTCCTTCCCCAGAAGGAGAGATTCCTCTGCCATGGAGTCCTACGATGTGATCGCCAACCAGCCTGTCGTGATCGACAACGGATCCGGTGTGATTAAAGCTGGTTTTGCTGGTGATCAGATCCCCAAATACTGCTTTCCAAACTATGTGGGCCGACCCAAGCACGTTCGTGTCATGGCAGGAGCCCTTGAAGGCGACATCTTCATTGGCCCCAAAGCTGAGGAGCACCGAGGGCTGCTTTCAATCCGCTATCCCATGGAGCATGGCATCGTCAAGGATTGGAACGACATGGAACGCATTTGGCAATATGTCTATTCTAAGGACCAGCTGCAGACTTTCTCAGAGGAGCATCCTGTGCTCCTGACTGAGGCGCCTTTAAACCCACGAAAAAACCGGGAACGAGCTGCCGAAGTTTTCTTCGAGACCTTCAATGTGCCCGCTCTTTTCATCTCCATGCAAGCTGTACTCAGCCTTTACGCTACAGGCAGGACCACAGGGGTGGTGCTGGATTCTGGGGATGGAGTCACCCATGCTGTGCCCATCTATGAGGGCTTTGCCATGCCCCACTCCATCATGCGCATCGACATCGCGGGCCGGGACGTCTCTCGCTTCCTGCGCCTCTACCTGCGTAAGGAGGGCTACGACTTCCACTCATCCTCTGAGTTTGAGATTGTCAAGGCCATAAAAGAAAGAGCCTGTTACCTATCCATAAACCCCCAAAAGGATGAGACGCTAGAGACAGAGAAAGCTCAGTACTACCTGCCTGATGGCAGCACCATTGAGATTGGTCCTTCCCGATTCCGGGCCCCTGAGTTGCTCTTCAGGCCAGATTTGATTGGAGAGGAGAGTGAAGGCATCCACGAGGTCCTGGTGTTCGCCATTCAGAAGTCAGACATGGACCTGCGGCGCACGCTTTTCTCTAACATTGTCCTCTCAGGAGGCTCTACCCTGTTCAAAGGTTTTGGTGACAGGCTCCTGAGTGAAGTGAAGAAACTAGCTCCAAAAGATGTGAAGATCAGGATATCTGCACCTCAGGAGAGACTGTATTCCACGTGGATTGGGGGCTCCATCCTTGCCTCCCTGGACACCTTTAAGAAGATGTGGGTCTCCAAAAAGGAATATGAGGAAGACGGTGCCCGATCCATCCACAGAAAAACCTTCTAATGTCGGGACATCATCTTCACCTCTCTCTGAAGTTAACTCCACTTTAAAACTCGCTTTCTTGAGTCGGAGTGTTTGCGAGGAACTGCCtgtgtgtgagtgcgtgtgtggatatgagtgtgtgtgCACATGCGAGTGCCGTGTGGCCCTGGGACCCTGGGCCCAGAAAGGACGATGAACTACCTGCAGTGGTGATGGCCTGAGGCCTGGGGTTGACCACTAACTGGCTCCTGACAGGGAAGAGCGCTGGCAGAGGCTGTGCTCCCTCCTCAGGTGGCCTCTGGCTGGCTGTGGGGGACTCCGTTTACTACCACAGGGAGACAGAGGGAGGTAAGCCATCCCCCGGGAGACCTTGCTGCTGACCATCCTAGGCTGGGCTGGCCCCACCCTCACCCCCACCCCCAGGGTGCCCTGAGGCCCCAGGCAGCTGCTGCCTCCACTATCGATGCCTCCTGACTGCACACTGAGGACTGGGACTGGGGTTGAGTTCTGTCTGGTTTTGTTGCCATTTTGGTTTGGGAGGCTGGAAAAGCACCCCAAGAGCTATTACAGAGACTGGAGTCAGGAGAGAGCAGGAGGCCCTCATGTTCACCAGGGAACAGGACCACACCGGCCACTGGAGGAGGGCAGGAGCAGTCCTCACTCTGAATGGCTGCAGAGTTAATGTTCCCAGCCCAGTCCCCTTTCGGGGGCCTTGGGAGAGTTTAAGGCACCTGCTGGTTCCAGGACCTCGCTTTCCATCTGTTCTTGTTGCAATGCCATCTTCAAACCGTTTTATTTATTGAAGTGTTTGTTCAGTTAGGGGCTGGAGAGAGGGAGCTTGCTGCCTCCTGCCTTGCTACACTAATGTTTACAGCACCTAAGCTTAGCCTCCAGGGCCCCACCTCTCCCAGCTGATGGTGAGCTGACAGTGTCCACAGGTTCCAGGACCATTTGAGATTGGAAGCTACACTCAAAGACACTCCCACCAGGCTCTTTCTCCCTTTTCCTCTTGCTCACTGCCCTGGAATCAACAGGCTGGTTGCTGGTTAGATTTTCTGAAACAGGAGGTAAAATTTTTCTTTGGCAGAGGCCCCTAAGCAAGGGAGGGGTGTTGGAGAGCCAGTGCCCTTAAGACTGGAGAAAGCTGCAATTTACCAAGTTGCCTTTTGCCACTGTAGCTGACCAGGGGACTAGGTTGTAGAGGTGGGAAGGCCCCCTCTGGGCTGATCTTGTGCCATTCTTGACCTTGGACCTGCTTGGTTAAGGAGGGAGTGGGCCAGACCAGAGTGCCAGGAGCTAATGGAGCCAGGCCTGACTCCTAGGAGTGGTCCAAAGGCCTTCAGCCTAGATGGTGCAAAGCTGGGGCCAGCCTGTCTTCACCGGCACCCTCACCTGTGACACCAAGACCCACCCCAATCCCAGACTTCACACAGTATTCTCCCCCACGCCGTCCTATGACCAAAGGCCCCTGCCAGGTGTGGGCCACAGCAGCAGGTATGTGTGAAAGCAACGTAGCGCCCCGCGGACTGCAGTGCGCTTAACCAACTCACCTCCCTTCTCTTAGCCCAAGCCTGTCCCTCGCACAGCCTCGCACAAACCACATTGCCTGGTGGGGCCCAGTGTACTGAAATAAAGTCGTTCCGATAGACACGTCA

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