Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDK8P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:112931297-112931461  UCSC
Coordinates (T2T) chr2:113357825-113357989  UCSC
Coordinates (hg19) chr2:113688874-113689038  UCSC
Strand -
Parental Sequence NM_001260.3
Parental seq. overlap 152 bp
Parental seq. overlap (%) 5%
Genomic Region Intergenic
Retrocopy Summary CDK8P1, located on chr2:112931297-112931461, is a retrocopy of the parental gene CDK8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDK8
Full Name cyclin dependent kinase 8
Also known as IDDHBA|K35
Coordinate chr13:26254125-26405238
Strand +
Gene summary This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Homology

Species Scientific Name Retrocopy
Orangutan Pongo abelii CDK8P1
Green monkey Chlorocebus sabaeus CDK8P1
Crab-eating macaque Macaca fascicularis CDK8P1
Rhesus Macaca mulatta CDK8P1
Baboon Papio anubis CDK8P1
Golden snub-nosed monkey Rhinopithecus roxellana CDK8P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDK8P1
AACCACACGAATGGAACTGGCCACCCAGGGAATCAAGACAGCAGTCACACACATTGAAGAAAGTGAGGCTTGTTCCTCCTACCACTACTGCAGGTGGACTTTTCATGGCCTCAGACTATCAGCATTCCAATACAAATGCTGCCTGTATCCCAACCCTGGACCAAA
>NM_001260.3
GAGGAGGTACCGGCTGTTGTGCGGCTCTGCCCTTCTGTTtgagtgtatgggagagtgagtgagtgagtgagtgtgagcgtgtgtgtgagagcgtgaggcgtgagtgcgcgtgtgagAGGACGAGAGCCCGCCTGGCCGCCCCGCCGCTCCCGCCGCAGCAGGAGCAGAACGCGCGGCCGGAGAGAGCGGCGGAGCCGGCGCCCAGGGAGCCCGCGGGGACAAGGGCAGAGACACCGCTCCCCACCCCCAGCCCTCGTCCCTCGGCTCTCCTTCGCCGGGGGATCCTCCCCGTTCCTCCACCCCCGGCCGGCCTCTGCCCCGCCGTCCCCCTGGATGTCCCTGGCGCTTTCGCGGGGCCTCCTCCTGCTCTTGCCGCATCAGTCGGGCTGGTGCTGCGGCCGGCGGGCGTAGAGCGGGCGGGTTCCCGGGGGCTGCGGCTGCCCGTGCTTccccggtccccacccctgccccccggccccccgacccagctctccggccTCAGAGGCTGTGACAATGGACTATGACTTTAAAGTGAAGCTGAGCAGCGAGCGGGAGCGGGTCGAGGACCTGTTTGAATACGAGGGCTGCAAAGTTGGCCGAGGCACTTATGGTCACGTCTACAAAGCCAAGAGGAAAGATGGGAAGGATGATAAAGACTATGCTTTAAAACAAATAGAAGGAACTGGGATCTCTATGTCGGCATGTAGAGAAATAGCATTACTTCGAGAGCTTAAGCATCCAAACGTCATTTCTCTTCAAAAGGTGTTTCTGTCTCATGCTGATAGGAAGGTGTGGCTTCTGTTTGACTATGCTGAACATGACCTCTGGCATATAATCAAGTTTCACAGAGCTTCTAAAGCAAACAAGAAGCCAGTTCAGTTACCTCGGGGAATGGTGAAGTCACTATTATATCAGATCCTAGATGGTATTCACTACCTGCATGCTAACTGGGTGTTGCACAGAGATTTGAAACCTGCTAATATTTTAGTTATGGGTGAAGGTCCTGAGCGAGGAAGAGTAAAAATTGCTGACATGGGCTTTGCCCGATTATTTAATTCACCTTTGAAGCCTTTAGCAGATTTGGATCCAGTGGTTGTTACATTCTGGTACCGAGCCCCTGAACTACTTCTTGGAGCAAGGCATTATACCAAAGCTATTGATATTTGGGCTATAGGGTGTATATTTGCAGAACTACTAACGTCAGAACCAATATTTCACTGTCGACAAGAGGACATCAAAACTAGTAATCCTTATCACCATGACCAGCTGGACAGAATATTCAATGTAATGGGATTTCCTGCAGATAAAGATTGGGAAGATATAAAAAAGATGCCTGAACATTCAACATTAATGAAAGATTTCAGAAGAAATACGTATACCAACTGCAGCCTTATCAAGTATATGGAAAAACATAAAGTTAAACCAGATAGTAAAGCATTCCACTTGCTTCAGAAGCTGCTTACCATGGACCCAATAAAGCGAATTACCTCAGAACAGGCTATGCAGGACCCCTATTTCTTAGAAGACCCACTTCCTACATCAGACGTTTTTGCCGGTTGTCAAATCCCTTACCCAAAACGAGAATTTTTAACGGAAGAAGAACCTGATGACAAAGGAGACAAAAAGAACCAGCAGCAGCAGCAGGGCAATAACCACACTAATGGAACTGGCCACCCAGGGAATCAAGACAGCAGTCACACACAGGGACCCCCGTTGAAGAAAGTGAGAGTTGTTCCTCCTACCACTACCTCAGGTGGACTTATCATGACCTCAGACTATCAGCGTTCCAATCCACATGCTGCCTATCCCAACCCTGGACCAAGCACATCACAGCCGCAGAGCAGCATGGGATACTCAGCTACCTCCCAGCAGCCTCCACAGTACTCACATCAGACACATCGGTACTGAGCTGCATCGGAATCTTGTCCATGCACTGTTGCGAATGCTGCAGGGCTGACTGTGCAGCTCTCTGCGGGAACCTGGTATGGGCCATGAGAATGTACTGTACAACCACATCTTCAAAATGTCCAGTAGCCAAGTTCCACCACTTTTCACAGATTGGGGTAGTGGCTTCCAAGTTGTACCTATTTTGGAGTTAGACTTGAAAAGAAAGTGCTAGCACAGTTTGTGTTGTGGATTTGCTACTTCCATAGTTTACTTGACATGGTTCAGACTGACCAATGCATTTTTTTCAGTGACAGTCTGTAGCAGTTGAAGCTGTGAATGTGCTAGGGGCAAGCATTTGTCTTTGTATGTGGTGAATTTTTTCAGTGTAACAACATTATCTGACCAATAGTACACACACAGACACAAAGTTTAACTGGTACTTGAAACATACAGTATATGTTAACGAAATAACCAAGACTCGAAATGAGATTATTTTGGTACACCTTTCTTTTTAGTGTCTTATCAGTGGGCTGATTCATTTTCTACATTAATCAGTGTTTTCTGACCAAGAATATTGCTTGGATTTTTTTGAAAGTACAAAAAGCCACATAGTTTTTCCAGAAAGGTTTCAAAACTCCCAAAGATTAACTTCCAACTTATAAGTTTGTTTTTATTTTCAATCTATGACTTGACTGGTATTAAAGCTGCTATTTGATAGTAATTAAATATGTTGTCATTGATATAAACCTGTTTGGTTCAGCAAACAAACTAAAATGATTGTCATAGACAGTGTTTTATTTTTCCTGTTGGTGTTGCTGATTTGTGAGCATGCTTTAAGATGAAAAAAGCATGAATGATAACTTCCTTAAAAAGGTGCGGCATCCAATTCAAATATTTTCGTCCTGATTTTAAAGCTGGTTGGTGTAGTGCTATTAAAATTTCGTTCAGTTAATTTTCCTTTTGAAAACTTGTTCGCACGTTGTTTAGGGTGCCCTTACTTCAGCAAAGGAGAAGGAGTAGGAGAGCCTTAGAATTTTTGAGGAAAAAAAAACCTATAACATACAATGTACTGTATCAAACTATTTTACATGAATGACACAAGTATTCTGAATAAAAAATAATTGAACATTGTTAAAAACAAGGTGTTATGTAATAAATTTATTTTTCATAAATCAAAA

Publications

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