Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name POLR2DP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:112995504-112996476  UCSC
Coordinates (T2T) chr2:113422034-113423006  UCSC
Coordinates (hg19) chr2:113753081-113754053  UCSC
Strand +
Parental Sequence NM_004805.4
Parental seq. overlap 788 bp
Parental seq. overlap (%) 15.6%
Genomic Region Intergenic
Retrocopy Summary POLR2DP1, located on chr2:112995504-112996476, is a retrocopy of the parental gene POLR2D. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POLR2D
Full Name RNA polymerase II subunit D
Also known as HSRBP4|HSRPB4|RBP4|RPB16|RPB4
Coordinate chr2:127843553-127858155
Strand -
Gene summary This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes POLR2DP1
Bonobo Pan paniscus POLR2DP1
Gorilla Gorilla gorilla POLR2DP1
Orangutan Pongo abelii POLR2DP1
Green monkey Chlorocebus sabaeus POLR2DP1
Crab-eating macaque Macaca fascicularis POLR2DP3
Rhesus Macaca mulatta POLR2DP3
Baboon Papio anubis POLR2DP3
Golden snub-nosed monkey Rhinopithecus roxellana POLR2DP3
Marmoset Callithrix jacchus POLR2DP4
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>POLR2DP1
ACGCGGCACGGCAATGGCAGCAGGCGGCAGCGATCCACGGGCTGACGATGTAGAGGAGGACACTTCACAGCTCCTTTTTCCTAAAGAGTTTGAAACAGCGGAGACCCTTCTAAATTCAGAAGTTCATATGCTTCTGGAACATCGAAAGCAATAGAACGAGAGTGCAGAGGATGAACAGGAACTCTCAGAAGTCTTCATGAAAACAATGAAACTACACAGGCCGTTTCAGTGGTTTCGAAAACAGAGAGACCATTGCCAGTGTTCGTAGCTCTAGAAAAACCTTCATAAATTTGAGTTGGTCTGTTTGGCCAACCTTTGCCCAGAGACTGCTGAGGAGTCCAAGGCTCTAATCCCAAACTTGGAGGGGTGGTTTGAAGATGAGGAGCTGCAGCAGGTTCTTGATGATATCCAGACAAAGCACAGCTTTCAGTATTAATCCCTAAACATCACTGCTGCTTGGAGAAACTATGGCCCCACAGGGTCTGGGGCTGATTTGCATAGACATTTCATTGTAGAAGACAGTTGGGAATTCCTTTGGAGAAAACAGCCCAACTTGCTGTTGGGTTAGGTTGCTGTTTCAAATAATTCGTAGGTCCAGGTGACATGTAATCTTGGAGCAGCCTTGTGCAGTGGCTGCCAGTGGCTTCCTGAGTGTGCCCTGGGAAGTGTGAGGTGGCTCGGGTGGGAGGGGGTGTCATATTAGCCACACTGTTGACTCCCTCATTCATGACTTTTGGCCCCCACGTTATCTTGTATTCTTAATACTTCATGTTTTAATTTCAGTGTGTTTATACGTTTTGAAACTAGACCAGAACATAGTAGACTTTATAGAGAAAGACCAGTTTTATCTAGATGCCAAAGGAAGAATTAAACCACTGTTATTGTTTGAGAC
>NM_004805.4
GCTCCGCGCTTCTGCTTCcggcggcgctggtggtggcgcgcggcgcggcgcggcgatggcggcgggtggcagcgATCCGCGGGCTGGCGACGTAGAGGAGGACGCCTCACAGCTCATCTTTCCTAAAGAGTTTGAAACAGCTGAGACACTTCTAAATTCAGAAGTTCATATGCTTCTGGAACATCGAAAGCAGCAGAATGAGAGTGCAGAGGACGAACAGGAGCTCTCAGAAGTCTTCATGAAAACATTAAACTACACAGCCCGTTTCAGTcgtttcaaaaacagagagaccattgccagtgttcgtagcttgctaCTCCAGAAAAAGCTTCATAAGTTTGAGTTGGCCTGTTTGGCCAACCTTTGCCCAGAGACTGCTGAGGAGTCCAAGGCTCTAATCCCAAGCTTGGAGGGACGGTTTGAAGATGAGGAGCTGCAGCAGATTCTTGATGATATCCAGACAAAGCGCAGCTTTCAGTATTAATCTCCAAACATCACTGCTGCTCGGAGAAACCACATCCCCAGGCATAACACCACCTTCCCACTGTCTGGGGCTGACTTGCACAGAAATTCTGTTGAAGACAGTTGAGAATTCCTTTGGAGAAAACAGCCCAGCTTGGCGTGGGGTTAGGTTGCTGTTTCAAATAACTCACAGGCCCAGGTGACATGGAATCTTGGAGCAGCCTTGTGCAGTGGCAGCCAGTGGCTTCCTGAACGTGCCTCTGCGAAGTGTGAGATGAGGGGTCACATAACCACACTGTTGACTACCTCATTCCTGGTTTTTGGCCTCCACATCATCTTTTTTCTTAATATTTCATGTTTTAATTTCAGGGTGTTTATACTTTTTGAAACTAGACCAGAAGATAGTAGACTTTATAGAGAAAGACCAGTTTTACCTAGATACTAAAGGAAGAATTAAACCGCTGTTAGTTTGAAATGCtttttttttttttttttaaatggagatagggtcttaactcttgtccaggctggaggagtgcagtcgtacagtcatggctcactgaagtcttgaccccgctgcctcagcctcccaaataactggggccacaggtgtgcaccacaactctcagctaatttttaaaattttttatagaggtggggttttactatgctgtccagactggtcttaaactcctgggctcaagtgatccccctgccttggcctcccaaactggtgagattacaggcatgagccaccacaactggccTGAAATTCTTAAAGGATGGGAGTGTCGATGACAGCACCTTGGCATCGTTGTGCCTAACCTGGGAGACGGAAGAAGCACGCCATGGGAAGTGTTTACACTTGGGGACAAGTGCTAAGTATTGTGGAGCCCATAGCCCCTTGAGATAGATGGCTACTTTGCCTTTCTTCTTGAACTGTCTTGCAGAATGTGGATTTGGGGTAAGTGGTCTTGAAGGATTCATTTAGTCACCCTCAAATTAAGATTTTTACTTCATCTTTCTTGGGCCTGCACCTCCAAGATAACAAAGAAGAAGCAATGGTCGTGCCAAAGAGGTCCACAACCAGGTGTGCACTGTTCACTGCAGCCCATTTGCTGTATGAACTGTGGTTGTTGTGTGCCCAATGACAAGGCTACTAAGAAATTCATCATTTGAAACGTAGAGGCCGCAGCAGTCAGCGATGTTTCTGAAATGAGCATCCTTGACGCCTGTGTACTTCCCAGGCTGGATGTGAAGCTACATTACCATGTGAGTTGTGCCATTCACAGCACAGTGGTGAGGAATTGAGCTCATGAAGCAGGCAAGGACCGAACACCTCCACCCCAACGTAGACCTGCAGGTGCTGCCCCATGACCTCCACCAAAGCCCATATAAGGAGCGGAGTTGTTAAGGACTGAAGAAAAACTTCTCTGGAGAAAAATAAAATTGCAATTCTACTTAAAAAAATTTTTTTTTTTTTTTACTTCATAGGCCAGGCTTGAAGTTCTGAACACTTTGAAGTCTCCAATTATGAGAGATCCAGTCTAAGCCTCTGGCCTGCTAATTAGCAATAAGTGCTTTATTTGGAAGGAGGGAGTCATCCACTCTTGAGCCACTGCAGTGAAGTCACTTGATCTCAGTCTGGGGGAAAACACTTCAATAGCTAAACATTCTAGCTTTGATTTTTCTGAAGGGAATACACTTGTTTTCAATTTTGGGGTTTTTCTTTGGGGCACTTGCTTGACTCTGTATGAACTTGTGATCCAAGGAAAAAGGAGAAAGAACAGTGTTGGCTTTTAAAATCAGGATGGTTTTATGTTTGCTACGAAATAAGGCAAGAATAAAAAAttcttatttttatttatttatttattttttgagatagagtctggctgtgttgcccaggatgcaatggcgcaatcttggctcactgcaacctctgccttctgggttcaagtgattctcctgcctcagcctcccaagtagctgggattacaggtacctgccaccacgcctggctaattttttgtgtttttagtagagacagggtttcaccacgttcgccaggctagtcttgaactgacctcaagtgatcctcccacctcggcttcccaaagtgctgggattacaggcgtgagccaccgGCCAATCTTTTTATccttgagcaacttcgcttctttgagcctcattggtgttctcaattgtgaaatatggataatagtatctgccccatgggtattttgagaaggttgaatgaacaggaaattattacaaagagcctagaggtgtctgatatatagtatgttccagtaaatgttcactattcttAGCATCTCAGGCAGATGAGCTAGTATAGATAGATGATTAAGTCAGCTTGCTTCATAGAAATTAGTGCAAGAATTTGTTAGCCTACCAACTGATAGTATCAGACTTGGAAAATAAATGAAATTGggccaggcgtggtggctcacccttgtaatcccagcgctttcagaggccgaggcaggcggatcacctgaggttgggagtttgagaccatcctgaccaacatggagaaaccccgtctctacttaaaatacaaaattagcggggcgtggtggcgcatgcctgtaatctcagctactctggaggctgaggcaggagaattgcttgaacctgggaggcagagggggtggcgagccaagattgcaccattgtactccagcctaggcaacaagagcgaaactgtctcaaaaaaaaaaaaaaaaaaaaaGTGAAATTGCTTACCCAAATCTACAGTTAACTTTCGTTTTTTaatgcttgatgaatttgcatgtcattcttgggcagtggccatgctgtcttctctgtattgttccaatttgggtatatgtgctgccaaagtgagtacTGCAGAATTATTTCTTGAGAGAGGCACTTACATGTGCTGATTGGCACTAAAGCAGTGGAATGGGAAGAAGAGACTTGGAAGGCAGCCCAGACGATCCAGGCGTGTGCTAGATGGCAACTGAGGAGCACGGTGCTACCATCTTTACTGGTGTTTCCacctatgtgccaggggttctgtgagctacctgagaatactgaagtatataatgctctggcacatagttaggcactaatcagtggtatttatcaAGGTGATTAAAAGCAGATTTAAAAAGCAGCTCACAGTTgggcgcggtggctcacacctgtaatcccagcactttgggaggccgaggcgggtggatcaccagaggtcagaagttcgagaccagcctggccaacgttgtgaaaccctgtctctactaaaaatacaaaaattggccacgtgtggtggcgggcacctgtaatcctagctacttgggaagctgagacaggagaattgcttgaacccgggaggtggaggttgcagtgagccaagatcatgccattgcactccagcctgggcaacaagagcgagactccatcttgaaaaaaaataaaataataaaaaGCAGCTCATACTAGGGAACTTGGTAAAGCAACCTCATGCTGTTGTAGGTTGAAAGCCTGGTCAGCTATTCTGCAAGACAGTCAAAAATTGTTTACAGGGCTGGACAGCATATTGCTATTGAAAAATAGCTATTAGGAGACCTTGCACAATTTGTGAAACATTGTTAGGCTCATTGTACTGTGTAAAATCAGGAAAGAATTTGGGAACATACTGATACAACAAAAAGATAGGTTGTCAAACCCTCACTTCACCAGAAAGCTAAATTAACCAGATAAGTCTTTCTGAAAGTTTTAGtgtcttagtttgttcctgcgctgtaacagaataccttagactgggtaacctataaataataggaatttatttctcacagttttggaggctggcaaatgcaagatccaggtgctggtacgttcagtgtctggcaagggcggctttctggtccaagatggtgcctttttttctgcatcttccatagggaatgaacactccttatggtagaagggatggaaggaccaggctttttttttttttttttttggatacagcaggatcttgctctgtcgcccaggctggagtgcagtggcatgattaaggttcactgcagcctcaatctcccactctccagcgatcatcccacctcagcctcttggatagctgggaccacaggcacgagctaccatgcctggctaatttattttttgtagagacggggtttcgccatgttgcccaggctggtctggaatttctgacctctagcagtccacctgtttccgcctcccaaatgctgagattagaggcatgagtcactgcacccagcccgcagcctcttttataagggcattaatccccttcatgagggatattctctcatgacttaatcacctgccaaagaccccacctcttaatactacatcagtgatgggttcaatgtatcaattgggtgggagggggcacattcagaccatagcaTCTAGTCATTCTGGTTTTATTAAGATTTATTAGACCTGAGGCATGAAAAATAGCATACTGGATGGGACTTCAGCATCGATGAGTTGCCTTAGTAATACTGTTAATAAAAAGCACTAAATATGC

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