Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZFP91P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:127840605-127841650  UCSC
Coordinates (T2T) chr2:128275842-128276887  UCSC
Coordinates (hg19) chr2:128598179-128599224  UCSC
Strand -
Parental Sequence NM_001197051.2
Parental seq. overlap 941 bp
Parental seq. overlap (%) 16.3%
Genomic Region Intergenic
Retrocopy Summary ZFP91P1, located on chr2:127840605-127841650, is a retrocopy of the parental gene ZFP91. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZFP91
Full Name ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
Also known as DMS-8|DSM-8|DSM8|FKSG11|PZF|ZFP-91|ZNF757
Coordinate chr11:58579063-58621550
Strand +
Gene summary The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZFP91P1
Bonobo Pan paniscus ZFP91P1
Gorilla Gorilla gorilla ZFP91P1
Orangutan Pongo abelii ZFP91P1
Gibbon Nomascus leucogenys ZFP91P1
Green monkey Chlorocebus sabaeus ZFP91P1
Crab-eating macaque Macaca fascicularis ZFP91P1
Rhesus Macaca mulatta ZFP91P1
Baboon Papio anubis ZFP91P1
Golden snub-nosed monkey Rhinopithecus roxellana ZFP91P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZFP91P1
GCTGTATCCCACCAGAGGAAGGCCGAGTATCCCAGCGCGGGAGGAGCAGCCCCCCGTGCCAGGCCTCCCGATGTCCCCAGGCAGCAGCCCCAGGCTGCAAAATCCCTACCTCCAGTTCAGGGCAAGAAGAGTCCACGACTCCTATGCCAACAACTGATAAAGATTGCAAAGAAGAAAAAGAGGAAGATGATTCTGCCCTCCCTCGGGAAGTTTACATTGCTGCATCCAGACCTAGCTGGGGATGGTGCAGTAGGAGCAGGACATGTGTTTCTCCTCATGGTGATACAGAGAACACCTGAAGCTCTCGGTGCAAGACTGGTTCATTGCAGCTCATCTGCAAATCAGAACCAAGTACAGACCAACTCGATTATGATGTTGGAGAAGAGCATCAGTCTCCAGGTGGCATTAGCAAGGAGGAAGAAGAAGAGATTAATCAGTGAAGAGGAGATGCTATTCAAAGTTGACCCAAGAGATGAGACCTACAAACCCCTCTTAGAAAGGGAAACCCCAAAGCCACGCGAAAATCAGGGAAGGTGAAAGGAGAGAAGGAGAGGAGGGAAATTAAAGTGGAAGTAGAGGTAGAGGTGAAAGAAGAGGAGAATGAAATTAGGGAGGATAAGGAACCTCTGAGGAAGAGAGGAAGAAGATGGAAAGATGGCAGAAGTCCACATTTACCCAGAAGGAGAAAAAAGCCTGCAACCCAGTATGTCCGTTGTGAGATGGAAGGATGTGGAACTGTCCTTGCCCATCCTGGCTATTGACAGCACCACGTTAAATAGCATTTGTTGAAGAAAAAATACGTATGTCTGCATCCCTCCTGTGGACTACTCTGTAGGCTCCAGAAGCAACTTCTATGACATGCCAAACATCATACAGATCAAAGGGATTCTGTCTGTGAATACTGTGCTCAGGCCTTCAAGAGTTCCCACAATCTGGTAGTGCACCAGATTGTTCACATTGGCGAGAAGCCGTTATTACAATGTGAGATCTGTAAATTTACTTATCGGCAAAAGGCGTCTCTTAATTGGCACATAAAGAAGCATGAg
>NM_001197051.2
GTGgcgcgcgcgcgcgcgccgcCAGCGGTAGCGGACCTTGAGTGGCAGGGGGTGGGGGGGGCGCCCTCGGAGCCGGGCGGAGGGGAGGGGGGAAAGAGGAGCGCAGGGTGAGAGTGAGCCGCAGGCTTCGGGAGGCGAGGGGGCGGGGGGAGCAGcgccgaggccgccgcctccgcctccgccgccTAGGACTAGGGGGTGGGGGACGGACAAGCCCCGATGCCGGGGGAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAACAACGGCCCCCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGgccgctgcggccgccgccgccgcagcTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGACGTCCCCGGGCAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACAACTGATAAAGATCCCAAGGAAGAAAAAGAGGAAGAAGACGATTCTGCCCTCCCTCAGGAAGTTTCCATTGCTGCATCTAGACCTAGCCGGGGCTGGCGTAGTAGTAGGACATCTGTTTCTCGCCATCGTGATACAGAGAACACCCGAAGCTCTCGGTCCAAGACCGGTTCATTGCAGCTCATTTGCAAGTCAGAACCAAATACAGACCAACTTGATTATGATGTTGGAGAAGAGCATCAGTCTCCAGGTGGCATTAGTgaagaggaagaggaggaggaagaagagATGTTAATCAGTGAAGAGGAGATACCATTCAAAGATGATCCAAGAGATGAGACCTACAAACCCCACTTAGAAAGGGAAACCCCAAAGCCACGGAGAAAATCAGGGAAGGTAAAAGAAGAgaaggagaagaaggaaattaaagtggaagtagaggtggaggtgaaagAAGAGGAGAATGAAATTAGAGAGGATGAGGAACCTCCAAGGAAGAGAGGAAGAAGACGAAAAGATGACAAAAGTCCACGTTTACCCAAAAGGAGAAAAAAGCCTCCAATCCAGTATGTCCGTTGTGAGATGGAAGGATGTGGAACTGTCCTTGCCCATCCTCGCTATTTGCAGCACCACATTAAATACCAGCATTTGCTGAAGAAGAAATATGTATGTCCCCATCCCTCCTGTGGACGACTCTTCAGGCTTCAGAAGCAACTTCTGCGACATGCCAAACATCATACAGATCAAAGGGATTATATCTGTGAATATTGTGCTCGGGCCTTCAAGAGTTCCCACAATCTGGCAGTGCACCGGATGATTCACACTGGCGAGAAGCCATTACAATGTGAGATCTGTGGATTTACTTGTCGACAAAAGGCATCTCTTAATTGGCACATGAAGAAACATGATGCAGACTCCTTCTACCAGTTTTCTTGCAATATCTGTGGCAAAAAATTTGAGAAGAAGGACAGCGTAGTGGCACACAAGGCAAAAAGCCACCCTGAGGTGCTGATTGCAGAAGCTCTGGCTGCCAATGCAGGCGCCCTCATCACCAGCACAGATATCTTGGGCACTAACCCAGAGTCCCTGACGCAGCCTTCAGATGGTCAGGGTCTTCCTCTTCTTCCTGAGCCCTTGGGAAACTCAACCTCTGGAGAGTGCCTACTGTTAGAAGCTGAAGGGATGTCAAAGTCATACTGCAGTGGGACGGAACGGGTGAGCCTGATGGCTGATGGGAAGATCTTTGTGGGAAGCGGCAGCAGTGGAGGCActgaagggctggttatgaactcagatatactcggtgctaccacagaggttctgattGAAGATTCAGACTCTGCCGGACCTTAGTGGACAGGAAGACTTGGGGCATGGGACAGCTCAGACTTTGTATTTAAAAGTTAAAAAGGACAAAAAAAAAATCTAAAGCATTTAAAATCTAGTGAAATAACTGAAGGGCCTGCTCTTTCCATTGTGGATCACAGCACACACATACATACACCCTCCACCTCCCCATCCCCTGTTCTCCCTCTGTTGCTCCCCTTATAAAATTGATGTTGTCTTTACCAGAAAGGTAGACAAAAAAGAAGCAGCAGCAGCTCTTAAAGTGAGGGTTATTCTCATACTCGGTTCCAGCCATCAGCAGACTTCCTGCTCATCGGCAGATCCCCCTTTCCAACCTGTAACTCTGATGTGCTCTGGATCAGCTTTTAACTTTTAATCATATATTACTGTCTTCTAAATCCCTTCTCCTCCTCTACTGCTGCCCTATGGTTCTGGCTCCTACCCCCTGCGGCACACTTATCTTCAAATACCATAGAATTCTAATCTCTGGAGGCTGGCAGCTTGACTTGGCACTTTAGGGCCCCTTAGCAGGGTGAGCTGTTAAAACAGCACACATCTCTCATCCCCTCTTCCTTTATTCCCCCCTGGGTTTCAGAAAGGAAGGATATATGGGGACCACCTCCCCCTTCTTTGATCCCAGCATCTCAGTCCCCCTCCCAACCCTCCATATGGCTCTCAATGGTGCTCACTTGCTTGGAAGCAGGCTCCCAATAGGGAGGGGGCTGCCCTCTACAGTCTCTTTGACTGTAAGACAGGGCTCTGTATCAGTGAGACGATGAGAAAAGTCCCAGGCTAATGGCAGAAATTTGCACTTTGAACATGTGTGTTTTTGTGTTGTGGAACCTGAGATTCCTTATTTATTAACAGGAAGTCTGATTTTTTTTTTTTGGAGTCTTTGTTGCTATATTTTGTGGGGCTGGGAGAGAGAGATTAGATTATTTTGACATGGGATCCCTTCCATAACAGGTACTTTGAAGGCAAGACATAGGGTTGAAGAAGCACAGCCAGCCTCTGAAATCATAGCTCTCCAGTGGCTTTTAAAGAAAGCTGGTCCTCAGCACTAACAAAATCACTACAATAGCCTAGTGCTTTTTTGGAAGCCTTTTTAGGGAAGAATGTTAGGTTCATGGTAACTAGTATGCTCTTTGAGATTTTTACAGTGTTGAAACTTAAGAATTTTGAGAGGGTGAGGAGGGTTGTTCAGAATCTAAATTACAGATAGATGATTGTTTCTTGTGAATTTGTTTCTTTTCCTTTTTTTTTGTCCCTACCATTTCCTTACATTTCCCTTGGGGCCCATCTCTGGCTCCTTGCTTTTTGTTTCTTGCTTTGCTTTATCAGTTCATTCCAGCTCCCTGTTAGTGAAGGACACTGCTGTTAGTGAAGGAACAAAGTCTATGAGTCCTAAAATTTTAAGTCAAAGAAAACTGCTCTGTTTCCCCTTTAGTAACACTTCTGAAGAGGAAAAACTTCAATAGCCAAAGTTAATAATCCTATATAATAATTGCTTTGGCTTTCACCTAAAATTCTGGGCATCACAATTTCCTTGGGATAGAGGTTGTGTTGGGGAATAGATTGCTTATTGCTGTTCACTGGAGAGAAAAGGTAGTGTTTTTGTACAAGGTCATACCGCCAGAAGCCCCAAATCCTATTTTGGCTCATCTTCAGGTAAAGAGTAATTCCTATCCTGTGTGCCTCAGAAGCTAGAATCGAAGGCTTACCCTATTCATTGTTTATTGTCAGAAATGCATGATGGCTCTTGGAAAGAATGACGTTTTGCTGGAAAAAAAAAAAAGAACAGTTTGTGTTTCACAAACATGGCTTATCAATTTTTTCAAAGAATTCTTTTTTCCCAAAAAGAGGAGTAACAAAATGTCATTTCTGAAAGAGGCTTACTTTATACCAACTAGTGTCAGCATTTGGGATGCCAGGGAACAGAGAGTGAGACACCTACAATCACCAGTCTCAAATGCGCTATTGTTTCTTTTCAGAGTGTTGCAGATTTGCCATTTCTCCATAATATGGGGATAGAAAATGGAATAAAGATAGAAGGGATGTAGAATATGCTTTCCTGCCAACATGGTTTGGAGTCGACTTTGGTATATTGACTAGATTTGAAAATACAAGATTGATTAGATGAATCTACAAAAAAGTTGTCCTCCTCTCAGGTCCCTTTTACACTTTTTGACTAACTAGCATCTATATTCCACACTTAGCTTTTTTGTCACACTTATCCTTTGTCTCCGTAAATTTCATTTGCAGTGGTTAGTCATCAGATATTTTAGCCACCTACACAAAAGCAAACTGCATTTTTAAAAATCTTTCTGAGATGGGAGAAAATGTATTCTCCTTTCCTATACCGCTCTCCCAACAAAAAAACAACTAGTTAGTTCTACTAATTAGAAACTTGCTGTACTTTTTCTTTTCTTTTAGGGGTCAAGGACCCTCTTTATAGCTACCATTTGCCTACAATAAATTATTGCAGCAGTTTGCAATACTAAAATATTTTTTATAGACTTTATATTTTTCCTTTTGATAAAGGGATGCTGCATAGTAGAGTTGGTGTAATTAAACTATCTCAGCCGTTTCCCTGCTTTCCCTTCTGCTCCATATGCCTCATTGTCCTTCCAGGGAGCTCTTTTAATCTTAAAGTTCTACATTTCATGCTCTTAGTCAAATTCTGTTACCTTTTTAATAACTCTTCCCACTGCATATTTCCATCTTGAATTGGTGGTTCTAAATTCTGAAACTGTAGTTGAGATACAGCTATTTAATATTTCTGGGAGATGTGCATCCCTCTTCTTTGTGGTTGCCCAAGGTTGTTTTGCGTAACTGAGACTCCTTGATATGCTTCAGAGAATTTAGGCAAACACTGGCCATGGCCGTGGGAGTACTGGGAGTAAAATAAAAATATCGAGGTATAGACTAGCATCCACATAGAGCACTTGAACCTCCTTTGTACCTGTTTGGGGAAAAAGTATAATGAGTGTACTACCAATCTAACTAAGATTATTATAGTCTGGTTGTTTGAAATACCATTTTTTTCTCCTTTTGTGTTTTTCCCACTTTCCAATGTACTCAAGAAAATTGAACAAATGTAATGGATCAATTTAAAATATTTTATTTCTTAAAAGCCTTTTTTGCCTGTTGTAATGTGCAGGACCCTTCTCCTTTCATGGGAGAGACAGGTAGTTACCTGAATATAGGTTGAAAAGGTTATGTAAAAAGAAATTATAATAAAAGGGATACTTTGCTTTTCAAATCTTTGTTTTCTCTTATTCTAGGTAAGGCATATTAAAAATAAATATGTAAAGAAGAAAAATAAAAGTTGTCTTCATGGAAGCAACTTGTCTTCCTTGGTTGTACTGAGTTACAGTTATCCTAGGGGTGAAACATGTGATGCTGCTAAGCAAACCAAATGCCCTCAGAACAGGTGTTATGTGGGGCATACTATTGTTTGCTTTTGTTGAGAATCAGGTGGTTAATTTTTGACTGTTCTTGATTTCTAATGCTGAAATGACATGATTCTGTTATTCAGCAAACTTGGAAATCTTGATGTTTTGACAACTGCCTCCTAGGAAAACTGGCCATATGTTAATTAACCTAGTAGATGGAAAATTAAGGATTATGTGAGGTTAATTTTACCCTGATAATGACAAAACCTTGATAGCATTTAATATTAATACTTCTTCTCAAAATTGAATGTTTATATCAAGTACTGATTTTTATTTTAAAAAAGAAAAAACTATAATCCTTCTGCCTTCCAAAAGCCATGCTGTGATAGCTGCCCAGGCTGCTCTGTTACATCTCCCATTTATTGTTTACTTTTATAAATTTGCTTCTAAGATGG

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