RCPedia: Rtcs

Summary

Retrocopy Name	RPL8P2	Plot displaying the genomic locations of a retrocopy (in chr21) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr21:30263347-30263881 UCSC
Coordinates (T2T)	chr21:28629218-28629752 UCSC
Coordinates (hg19)	chr21:31635665-31636199 UCSC
Strand	-
Parental Sequence	NM_033301.3
Parental seq. overlap	482 bp
Parental seq. overlap (%)	49.3%
Genomic Region	Intergenic
Retrocopy Summary	RPL8P2, located on chr21:30263347-30263881, is a retrocopy of the parental gene RPL8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	RPL8
Full Name	ribosomal protein L8
Also known as	L8
Coordinate	chr8:144789769-144792390
Strand	-
Gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	RPL8P4
Bonobo	Pan paniscus	RPL8P4
Gorilla	Gorilla gorilla	RPL8P5
Orangutan	Pongo abelii	RPL8P3
Green monkey	Chlorocebus sabaeus	RPL8P1
Crab-eating macaque	Macaca fascicularis	RPL8P3
Rhesus	Macaca mulatta	RPL8P3
Baboon	Papio anubis	RPL8P3
Golden snub-nosed monkey	Rhinopithecus roxellana	RPL8P8
Marmoset	Callithrix jacchus	RPL8P8
Gibbon	Nomascus leucogenys	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>RPL8P2
GCCCAGCTCAACATTGGCAATGTTCTCTCTGTGGATACCATGCCTGAGAGGTACAATCATGTGCTGCTTGGAGGAGAAGCCTAGAGACCATGGCAAGCTGACCCAGGCATCAGGGAACTATGCCACAGTTATCTCCCACAATCCTGAGACCAAGAAGAGCCGTGTAAAGCTACCCTCTGGCTCCAAGAAGGTTACCTCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCAAATTGACAAACCCATCCTGAAGGCTGGCTGGGCATACCACAGATATAAGGCAAAGAGGAACTGCTGGCCACAAGTACGGGGTGGGGTGTGAACATGAACCCTGTGGAGCATCATTTCGGAGGGAGGTGGCAGCCACCAGCACATCGGCAAGCCCTCCACCATCTGCAGAGATGCCTCTGCTGGCCAAAGTGGGTCTCATTGCTGCCCGCCAGACGGGATAGTCTAGGGAACCAAGACCGGGCAGGAGAAAGAGAACTAGTGCTGTTCTCAATAAAGTTTGTCCTTATGCCAC

>NM_033301.3
CTCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGCTGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGGTTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATTGGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGGGCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATCTCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAATATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCACATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGAACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCA

>NM_033301.3 

CTCTTTCGGCCGCGCTGGTGAACAGGTAGGTCATCCTTGCGGCCTTGCGGCATGGGCAGTATCCGCCGCCATCCTCTTCCGTGAGGCGCGCTGAGACCCGGACCGGCCCTCCTGAGAGGATGCCGGTGCGGGCGCCCGCGGAGAGGGACCCGTCGCCATGGGCCGTGTGATCCGTGGACAGAGGAAGGGCGCCGGGTCTGTGTTCCGCGCGCACGTGAAGCACCGTAAAGGCGCTGCGCGCCTGCGCGCCGTGGATTTCGCTGAGCGGCACGGCTACATCAAGGGCATCGTCAAGGACATCATCCACGACCCGGGCCGCGGCGCGCCCCTCGCCAAGGTGGTCTTCCGGGATCCGTATCGGTTTAAGAAGCGGACGGAGCTGTTCATTGCCGCCGAGGGCATTCACACGGGCCAGTTTGTGTATTGCGGCAAGAAGGCCCAGCTCAACATTGGCAATGTGCTCCCTGTGGGCACCATGCCTGAGGGTACAATCGTGTGCTGCCTGGAGGAGAAGCCTGGAGACCGTGGCAAGCTGGCCCGGGCATCAGGGAACTATGCCACCGTTATCTCCCACAACCCTGAGACCAAGAAGACCCGTGTGAAGCTGCCCTCCGGCTCCAAGAAGGTTATCTCCTCAGCCAACAGAGCTGTGGTTGGTGTGGTGGCTGGAGGTGGCCGAATTGACAAACCCATCTTGAAGGCTGGCCGGGCGTACCACAAATATAAGGCAAAGAGGAACTGCTGGCCACGAGTACGGGGTGTGGCCATGAATCCTGTGGAGCATCCTTTTGGAGGTGGCAACCACCAGCACATCGGCAAGCCCTCCACCATCCGCAGAGATGCCCCTGCTGGCCGCAAAGTGGGTCTCATTGCTGCCCGCCGGACTGGACGTCTCCGGGGAACCAAGACTGTGCAGGAGAAAGAGAACTAGTGCTGAGGGCCTCAATAAAGTTTGTGTTTATGCCA

Publications

PMID - Link	Title
No publications available for this retrocopy