Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBXW11P1
Plot displaying the genomic locations of a retrocopy (in chr21) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr21:31623951-31628661  UCSC
Coordinates (T2T) chr21:29991925-29996636  UCSC
Coordinates (hg19) chr21:32996264-33000974  UCSC
Strand -
Parental Sequence NM_001378978.1
Parental seq. overlap 2262 bp
Parental seq. overlap (%) 37.8%
Genomic Region Intergenic
Retrocopy Summary FBXW11P1, located on chr21:31623951-31628661, is a retrocopy of the parental gene FBXW11. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBXW11
Full Name F-box and WD repeat domain containing 11
Also known as BTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|Hos|NEDJED
Coordinate chr5:171861549-172006638
Strand -
Gene summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus FBXW11P1
Gorilla Gorilla gorilla FBXW11P1
Orangutan Pongo abelii FBXW11P1
Green monkey Chlorocebus sabaeus FBXW11P1
Rhesus Macaca mulatta FBXW11P1
Baboon Papio anubis FBXW11P1
Golden snub-nosed monkey Rhinopithecus roxellana FBXW11P1
Chimpanzee Pan troglodytes Without Homology
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FBXW11P1
ATCAATAGCATTTTAAAGGACCAATAAACAGCCTCCTATAAATTAAACCTCTTCCTGTGGAAGCATGCTCTACTACTAAAGGGAAGGTCCTTGGGCTCCGATTTGTCCTTTGCATTGAGAACGGTGTGGGGATCAATGTGTGTGTATGTGATTTATCGAGTTGGCTTTGCTTTTTTAGTTTTTCTTAAAAAAAATCCTTCCTTCCCATGTTACTAATTTATGTTTTTGAGAAGTTGAGTCTCAAAGCGTAAACAATAAACCTCCATTCATAAGGCAGATGTTGTAAGCTTGATGGTGGTTGTGAAAGTGATTTAGTTTTGACCTCTTTTCGTCCTACAACTTCAATATCAAACTGCTCAGGAAAGCCCAGGGGGAAGGTAGGGGCAGAGGAGGAGACAATTCGGAATGAATGAATAGATTTTTTGTTGTTTTTGCTTGTTTAATATAGAAGTCCCCCTTGTTCCTTGGGAGATCATGGCCTTTGAATATGTACACAACCTTTGAATTGTTCCTACTAAATTATAGCAAGGGACTTTGGCACCCAAGGAATTCTGACTTTCTGGGATTATAATAGTAAATTCCCAGCCATACTCTGGACTTTATTTTGCTAACCATAATTGAGCAAATGTAAATTACTGCTATATTAATGTTTTAAAGCACTGGGATAGTCTAATTCTAACTTGTAGTTAATTATGTTTGCCAATTATTTGTTTGAAATAAATTTGTGTCTGAACAGCTATTGAAACTGTTCAATTGTACAGATATTATTCATGACAGCTTTGTACTGTGGAATGTGCTTAATCAAAAACAAAAAAGTTTGAATTTTAAGGAGAATCTTGTTTTAAAATGTAATTTCTAAAGTTGAACATGAATGTTTTATTTGTTGTACAGTATATATTATACAATAGAGAGGTAACTTAAACATTTTTGTTCTTATTCTTTTTCTCATAAGTACTCCTGAGTACTAGTGGTCACTTCCCGTAGTATTCATTTGGCTTCACTGTCAAAAATCATTATTCTGTGCAGTTGTGGCCCTGGGAAGGGGAAATAATAAGGCCCTATTGACGGGCTGTCCTGGCTCTGGAATTCATGCATCCTGTCCTTGCCAAGGTTCTGGCAGGGCCCGCTGGTGTGTTGGAGCCTGCAGGTCAGGTCAGGCTGGTTCAGAGGTCCATGCTGAGGGGAGGGCACTCCTAAGTGGTGTAAAGCCTCAAGTCCATGAATCCCACCCCAGTCATCTCTGGTGTCACGTGCTGCTGCGGCCTCAGCAGGTTCTCAAAGCTCCCGAGTACTCCCGAGTACACAGCCCAAATGTGTAAATGGCACTGTCTCCCTGATGGTGCATGGAAAGGACGTTGGCATCTGGCACTATCACCCTGACAGTGCATGGAAAGGACATTGGCATCCAGTTGGCACTCCTTCTCCCTTATTCAATATTAGGTTTGATTTGCCCTTTGCCGTTGTTTCCAAAGATCAAGGAATGTCAATAACCCTTTTATTAACTGTTCTCTGAACCGCAACCATCTCCTGATATTTGGTAGAGTAACACCTTTATATGTGTGCTTGCCTCCTAATTTAAAATACTGTATTCACATGTAGATATAATGTACATAACAGTTTAACTTCAAAGTTGCTGGGGTCAGGGCCCCCTGCACTTGAGACACTAATACAGAGTGTGTTCGCGCTTAGCCATGGACTGGACTCAAGAACCTGATACCAGGGTTGATGTGGATTACCTGGAACCCTTCCTGCAGTATTCCTACAGTGTTTTTATTTTGTTGTCATCTATAAGTCAGTTATTATCTCCCAACATAGCTCTTTTATTTTATTTTTAAAACACTTCAGTTCTGGAAGATCAAGATGAAGATAAGTCCCCAAAGAAAAATACTCCTTGGCAGATAAGTAATGGAACATCATTTGTGATCATCTCCAGAAAGAGGCCATCAGAAGGAAACTACCAAAAAGAAAAAGACTTGTATATTCAATATTTTAACCAGGGGTCTGAATCAGATCAGTTGGAATTTGTGGAACATCTTATTTCACGAATGTGTCATTATCACCATGGACGTATCAACTCTTACCTGAAGCCCATGTTGCAGCAGGACTTTATTACTGCTTTACCCGAGCAAGGCTTAGATCACATAGCAGAAAACATTCTTTTGTACCTGGTTACCAGGTCTCTGTGTGCAGCAGAGCTGGTATGTAAAGGATGGCAGGGATTGATCTCAGAATGAATGCTTTGGAAGAAGCTGATTGAACGAATGGTACACACTGATCCCCTATGGAAAGGACTTTCAGAAAGAAGAGGGTGGGATCAGTACCTGTTTCAAAACAGACCCATATCTAGCCCTCCAAATTCATTTTATAGGTCATTATACCCAAACATTATCCAGGATATAGAGACTATAGAATCCACCTAGCGGTGTGGCCGACACAGCTTGCAGAGGATTCAGTACCACTCTGAAAATAGTAAAGGTGTCTATGGTTTACAGTACGATGATGAAAAAATTATCAGTGGCCTACAAGATAATTAAGATTTGGGATAAAACCAGCCTGGAATGTTTGAAAGTGTTAATGGCCACACAGGTTCTGTCCTCTATCTGCAGTAGGATGAGCGTGTCATTGTAACTGGCTCTTCGGATTCTACGGTGAGAGTGTGGGAAGTGAACACGGGTGAAGTTCTTAACACATTAATCCACCACAATGAGGATGTACTGCACTTACGCTTCAGCAGTGGACTGATGGTGACCTGTTCCAAGGACCGCTCCATTGCTGTGTGGGACATGGCTTCTGCGACCGATATCACTTTACGTGGTGTCCTGGTTGTCCACTGAGCTGCTGTCAACGTAGTAGACTTTGACGAGAAATACATCGTGTCTGCCTCTGGTGACAGGACCATCAAAGTCTGGAGCATGAGCACCTGTGAATTTGCTCGTACTCTCAATGGGCACAAGCGAGTCTTGTCTCCAGTACAGGGATGGGCTGGTTGTTAGTGGATCATCAGATCATACCATTAGGCTCTTGGATATTGAATGTGGCTCCTGTTTAAGAGTCCTAGAGGGACATGAAGAATTGGTCCGATGCATCCAGTTTGATAACAAGAGGATGGTCAGCCGGGCCTATGATGGGAAAATTAAAGTTTAGGACTTGCAAGCCGCTCTTGACCCTCGAGCCCCAGCAAGCACATTGTGTTTGCGCACATTGGTGGAACATTCTGGACATGTGTTTTGCCTACAGTTTGATGAGTTTCAAATCGTCAGCAGCTCCCATGATGACACTATTTTGATTTGTGGTTTCTTAAATGTGCCTCCCAGTGCCCAGAATGAGACCCATTCCCCCTCCAGAACATACACTTACATCTCTAGATAACAGTCTGCACTTTCACCCGTTTCCGGGTTTTCTAGTCTTGAACTACTGGCTACGTGGCTACCAATGCCTAAGGGAGTTCGTTCACAGCTGAGTTATGAAGCTGGAATTGGTTCTAGACGCTGGGTAGATGCAAAGCAGCCTAACTCTTCAAGTCCCGACATTTCTCACCTCTGATTCCAGCTCTACTTTGAGAAGGAGACCTTAGCTTCACTGACTTGAAAGTAGCACAGAAGCCCATTTCCTTCCCTCATTAGTGAAAAAATCTAATGTTTCAAATGTAAACTGATCATAGAAAAGGAACATAGAATCTGTTTTACAGAAGTAAATTGACGCCAAGAGAAGTCTTGGCCTCTAATTTATATTGCTTTGCACTTTGGTTTGATACTAAGAAACAGCATTCTTCTTCAGTGAAATTTTGGGTGCCAAACACCTACTCAGAATGTCCACGGCTTTCATTTTCAAAAGTTAACATTCTCCTTTTGACCGTCCAAGTCATTATGAATTTTGACTTGCTGTATTAGGAACATGTTGGACAATGGAAAAATCTCTCTGGGTCGTTTTAGTAATATGTTTTGGATTATACTTCCTTTCTATACCAATTTCTTTTAATTTAAAGAACTGTAAGTCAGTT
>NM_001378978.1
GCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAgccgcctccgcctctgccgcctccgccgtcgcctcctccgccCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGCACTCATCACTAGAAAGCACTCACAAGAGCTTCTGATTGGAAGAGAAAGATGATTAGATTACCCTGTAAGAAGCCAGCAGAAATTGATGCTATCACTTTAGGAAAGGCGATCCTGCCTCCTCCACGGGTAACACTTCAGTTATGGAAGATCAAAATGAAGATGAGTCCCCAAAGAAAAATACTCTTTGGCAGATAAGTAATGGAACATCATCTGTGATCGTCTCCAGAAAGAGGCCATCAGAAGGAAACTATCAAAAAGAAAAAGACTTGTGTATTAAATATTTTGACCAGTGGTCTGAATCAGATCAAGTGGAATTTGTGGAACATCTTATTTCACGAATGTGTCATTATCAGCATGGACATATTAACTCTTACCTGAAGCCCATGTTGCAGCGGGACTTTATTACCGCTTTACCAGAGCAAGGCTTAGATCACATAGCAGAAAACATTCTTTCGTACCTGGATGCCAGGTCTCTGTGTGCAGCAGAGCTGGTATGTAAAGAATGGCAGCGAGTGATCTCAGAAGGAATGCTTTGGAAGAAGCTGATTGAACGAATGGTACGCACTGATCCCCTATGGAAAGGACTTTCAGAAAGAAGAGGGTGGGATCAGTACCTGTTTAAAAACAGACCCACAGATGGCCCTCCAAATTCATTTTATAGGTCATTATACCCAAAGATTATCCAGGATATAGAGACTATAGAATCTAACTGGCGGTGTGGACGACACAACTTGCAGAGGATTCAGTGCCGCTCTGAAAATAGTAAAGGTGTCTACTGTTTACAGTACGATGATGAAAAAATTATCAGTGGCCTACGAGATAATTCTATTAAGATATGGGATAAAACCAGCCTGGAATGTTTGAAAGTGTTAACAGGACACACAGGCTCTGTCCTCTGTCTGCAGTATGATGAGCGTGTCATTGTAACTGGCTCTTCAGATTCTACGGTGAGAGTGTGGGATGTGAACACGGGTGAAGTTCTTAACACATTGATCCACCACAATGAGGCTGTATTGCACTTACGCTTCAGCAATGGACTGATGGTGACCTGTTCCAAGGACCGCTCCATTGCTGTGTGGGACATGGCTTCTGCGACCGACATCACTTTACGCCGTGTCCTGGTTGGCCACCGGGCTGCCGTCAATGTAGTAGACTTTGACGACAAGTACATCGTGTCTGCCTCTGGTGACAGGACCATCAAAGTCTGGAGCACGAGCACCTGTGAATTTGTTCGTACTCTCAATGGGCACAAGCGGGGCATTGCCTGTCTCCAGTACAGGGATCGCCTGGTTGTTAGTGGATCATCAGATAATACCATTAGGCTCTGGGATATTGAATGTGGTGCCTGTTTAAGAGTCCTAGAGGGACATGAAGAATTGGTCCGATGCATCCGGTTTGATAACAAGAGGATTGTCAGTGGGGCCTATGATGGGAAAATTAAAGTTTGGGACTTGCAAGCTGCTCTTGACCCTCGAGCCCCAGCAAGCACATTGTGTTTGCGCACATTGGTGGAACATTCTGGACGTGTGTTTCGGCTCCAGTTTGATGAGTTTCAGATCATCAGCAGCTCCCATGATGACACTATTTTGATTTGGGATTTCTTAAATGTGCCTCCCAGTGCCCAGAATGAGACCCGTTCTCCCTCCAGAACATACACTTACATCTCTAGATAACAGTCTGCACTTTCACCCGTTTCAGGGTTTTCTAGTCTTGAACTACTGGCTACGTGGCTACCAAATGCCTAAGGGAGTTCGTTCACAGCTGAGTTATGAAGCTGGAATTGGTTCTAGACGCTGGGTAGATGCAAAGCAGCCTAACTCTTCAAGTACCGACATTTCTCACCTCTGATTCCGGCTCTCCTTTGAGAAGGAGACCTTAGCTTCCCCGGCTTCAAGTAGAACAGAAGCCCGTTTCCTTCCCTCATCAGTGAAAAAATCTAATGTTTCAAATGTAAATTGTTCATAGAAAAGGAACATAGAATCTGTTTTACAGAAGTAAATCGACCGTCAAGAGAAGACTTGGCCTCTAATTTATATTGCTTTGCACTTTGGTTTGATATTAAGAAACAGCATTCTTCTTCAGTGAAATTTTGGGTGCCAAACACCTACCCAGAATGTCCAGGGCTTTCATTTTCAAAAGTTAGCATTCTCCTTTTGACCGTCCAAGTCATTATGAATTCTGACTTGTTGTATTAGGAACATGTTGGACAGTGGAAAATTTTCTCTGGATTGTTTTAGTAATATTTTTGGGATTATACTTCCTTTCTGTACCAATTTCTTTTAATTTAAAGAACTATAAGTCAGTTATATTATCTACCAACAGGTAATATAGCTCTTTCTTTTATTAACTGTTCTCTGTCCCCCAACCATCTCCTGATATTTGGTAGAGTAACACCTTTATACGTGTGCTTGCCTCCTAATTTAAAATACTGTATTCGCATGTAGATATAATGTACATAACAGTTTAACCTCAAAGTTGCTGGAGTCAGGGCCCCCTGTGCTTGAGACACTAATACAGAGTGTGTTCGCACTTAGCCATGGGCTGGGCTCAAGAACCTGATACCTGGGTTGATGTGGATTACCTAGAACCCTTCCTGCAGTATTCATACAGTGTTTTTATTTTGTTGTTGTCATtgcgtgtgtgtggtttgtgtgtgtTTTTAATGAGAATCTTGTTTTAAAATGTAATTTCTAAGGTTTAACACCAAAATGTTTTATTTGTTGTGGAGTATATATTATACAATAGAGAGGTACCTTAAACATTTTTTGTTCTTATTCTTTTTCTCATAAGTACTCCTGAGTACAAGTGGTCACCTCCCATAGTATTCATTTGGCTTCGCTGTCAAAAATCATTATTCTGTGCAGTCGTGGCCCTGGGAAGGGGAAATAAGAAGGCCCTGTTGACGGGCTGTCTTGGCTCTGGAATTCATGCATCCTGGCCTTGCCAAGGTTCTGGCAGGGCCTGCTGGTGTGTTGGAGCCTGCAGGGCAGGTCAGGCTGGTTCAGAGGCCCATGCTGAGGGGTGGGTGCTCTGAAGTGGAGTGAAGCCTCAAGCCCATGAATGCCACCCCAGTCATCTCTGGTGTCAGCTGCTGCTGTGGCCCCAGCAGGTTCTCAAAGCTCCCAAGTCCTCCCTACGACACAGCCCAAATGTGTAAATGGCACTGTTGCCCTGACAGTGCATGGAAAGGACGTTGGCATCCAATTGGCACTCCTTCTCCCTTATTCAATATTAGGTTTGATTTGCCCTTCGCCATTGTTTCCAAAGATCAAGGAATGTCAATAACATTTTAAAGGACCAATAAACAGCCTCCTATAAAGTAAACCTCTTCCCGTGGAAGCACACTCTACTACTAAAGGGAAGGCCCTGGGCTCTGATTTGTCCTTTGCATTGAGAACGGTGTGGGGATCAGTGTGTGTGTATGTGATTTGTTTATTGAGTTGGCTTTGCTTTTTTAGTTTTTCTTTTAAAAATAAAATCCTTCCTTCCCATGTTACTAAATTAATTTATGTTTTTGAGAGGTTGAGTCTCAAAGTGTAAACAATAAACCTCCATTCATAAGGTGGATGTTGTAAGCTTGATGGTGGTTGTGAAAGTGATTTAGCTTTGACCACTTTTCATCCTACAGCTTCAATATCAAACTGGTTAGGAAAGCCCAGGGGGAAGGGAGGGGGCAGGGGAGGAGGCAATTCTGAATGAATGAATGGATTTTTTGTTGTTTTTGCATGTTTAATATAGAAGTTCCCCTCGTTCCTTGGGAGATGATGGCCTTTGAATATGCAGACAACCTTTGAATTGTGCCTACTAAATTATAGCAGGGGACTTTGGCACCCAAGGAGTTCTGACTTTCTGGGATTATAATAGTAATTCCCAGCCATACTCTGGACTTTATTTTGCTAACCATAACTGAGCAAATGTAAATTACTGCTATATTAATGTTTTAAAGCACTGGGATAGTCTAATTCTAACTTGTAATTAATTATGTTTGCCAATTATCTGTTTGAAATAAATTTGTGTCTGAACAGCTATTGAAACTGTTAAATTGTACAGATATTATTCATGACAGCTTTGTACTGTGGAATGTGCTTAATAAAAAACAAAAAAGTTTGACTTTTGTCCAGTAAATTGCTAAGTAATGTCAATAAATCGAGTATGGGTATTATGCAGTGCACCTAATCTGGCTTCATGCAATTGTTACTTCAGCTACTGATTCAAAGCCAATACTCTTAATAAAGTGTTGCAATACTCTGA

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