Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPP1R2P2
Plot displaying the genomic locations of a retrocopy (in chr21) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr21:35886891-35890230  UCSC
Coordinates (T2T) chr21:34269936-34273275  UCSC
Coordinates (hg19) chr21:37259189-37262528  UCSC
Strand +
Parental Sequence NM_001291504.2
Parental seq. overlap 2792 bp
Parental seq. overlap (%) 81.1%
Genomic Region Intergenic
Retrocopy Summary PPP1R2P2, located on chr21:35886891-35890230, is a retrocopy of the parental gene PPP1R2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPP1R2
Full Name protein phosphatase 1 regulatory inhibitor subunit 2
Also known as IPP-2|IPP2|PPP1R2A
Coordinate chr3:195514428-195543348
Strand -
Gene summary Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPP1R2P7
Bonobo Pan paniscus PPP1R2P7
Gorilla Gorilla gorilla PPP1R2P7
Orangutan Pongo abelii PPP1R2P7
Gibbon Nomascus leucogenys PPP1R2P6
Green monkey Chlorocebus sabaeus PPP1R2P1
Crab-eating macaque Macaca fascicularis PPP1R2P1
Rhesus Macaca mulatta PPP1R2P1
Baboon Papio anubis PPP1R2P1
Golden snub-nosed monkey Rhinopithecus roxellana PPP1R2P3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PPP1R2P2
GTTCGGCGTCGGCGTCGCTCCGCGCGGGGGCTCCAGGCCGAAGTCTCGCCGCGGGCTGCGAGTCAAATGCCGGTGGTTAAGGGCGCTCGAGAGGCCTCTACCCGTTTGGCGTTGGCTCTGGCGTCTGGGTCGTTGTGTCCTGACAACCGCTCAGGTAACCGTTTCCTAGACAGCGGGTGCGGCTACTTTAGCCCTGAGCGTGCTCTGCGGCTGCCTGCGGGTCTCAGCTAGTGTCCGACCCCTCTCTTCGCGGACTCCACGCCGAGCAGCCACCCTGAGCCAAGAGCCGGAAGTCCCGGCATTGGCGGCCTGGACAGCCTCGCACCGGCCAATCAAGGAGAACCTCAAGAACAACTTCCTCTATGACTTCCTCTACGGCGGTGTCGGCCTAACAGCTCCACGGGAGTGTGGACGAGGAGCTGAGCAAAAAAATTCCAGAAGTGAGATGAAATGAACATCCTGGCGACATATCATCCAGCAGACAAAGACTATGGTTTATGAAAATAGATGAACCAAGCACTTCTTCCCATCGTATTATAGGTGATGATGAAGATGTATGTAGTGATACAGAGACCACTGAAACCATGGAACGAGATATCTTAGCTAAGAAATTCGCTGCTGCTTGAAGGCTCGGAGCCAAAGTATAGGGTTCAGGAATAAGATAGCAGCAGAGAGGAGGATAGTGACCTCTCACCTGAAGAACAAGAAAAAAAGCGACAATTTGAAATGAAAAGGAAGTTTCACTACAATGAAGGACTCAATATCATCAAACTAGCTAGACAATTTCAAAAGACCTAAATGATGACGAAGATGAAGAAATGTTAGAGACTGTAGATGGAGAAAGCATGAATACGGAAAAATCAAATCAAGGATCTACTGCAAGTGACCAACAGCAAAAGAAATCACGAAGTTCATAGAAGAGATTTGTTCAACGCTGCAATTGTTAGATATAAACCCTGTTACTATAATGCATTGCTTCTTGTTCTCCACAATTCATGACTGAAGTACCAAAATGCATACCAGTTATTATATATTGCCAAGAATTAAATGATAACCTTATAGAGACTGATAATGCCTAAAATATATTCTTGTGCATAGTACTTTACCACAAATACAGTGTAATATCATCAGTCCAAAACTGCATTACTTTTGTAAAAAACACTGGTTAATTTGTATAAGATATCATATAACTTTTTATGCTTTAGAGGTTAAACAATGTCTTTGGGGGGGAACATTTATTGTCATCACTCTAAATGTGGTGGTAGCTCTTATAAAGTTTGTTGTTGTTTTAATCAAAAGCCAACTGAACAGCATATAAAGACTGATAAATATTCAGGCTGAGTAGTATTTTAACGCTTGTCTTCAACTTGATTTGTCTGTTTAATTGAAAAGGGTTGTAAGAGTTACCGTTGCATTTTCTGGCCTACTACCTTTAAAATTCCTGTTGTGTTTCTTTGTATTTACAAGGAAAGGTCTGAACTTTTTCTTGTCAAAACTAGCTTTTTTCCGACAAATAAATTATCAGGTTAAACTTGCACTAATGTCTCCTCACACTGGGCAGACTTCAGAGCAGCTTTTTTTCAATAAATATTCTAATGTAGCTATCTCAGCATTCCCTTTAAATACCTGTCTTAACCTCCTGCTTTTATTTCTTACCCCTTTCCTCACATAGGCACACAATCCTTTACCTTTTAAAGGATCATTAAGATTGTCACAACGTTAGGAACTCTTTCTCTCACTCTTCTGTCATTTGCTGCAATATTGAAATTCTTATTTTGACCATCAATGCCTATGAATTCTTCTAATACACGAAGCAAATAGATTAAGTAGCAGCAGTACTATAGGCAGGAAATACAGTTTAACTGCTGAATTTCTATACCTCTCTCATTTACAGCTTGCTAATTAAATTGTTATTATCAGTTTTTTTGGCTTAATTAGACTTAAGAAAACAATTAACTGAGGGGCATGAGGAGAGAATTGTGTGTAACCAGTGATATGATTATTACTGAAAGTACAGACAAAAGTAAGCCTGGACATTGTTTAATTTAAATACTTTAAATAGTCCCTGCTTTAAGGGAATACGATAATATATACTATGACAAATGTACTTTATTCTTCTAACACAGTAAGAATTACTTGGAATTTTTTCCTGAAATGAAGTGCAGGAAAGCCCTGTGCATCTTGGGTTAGTGATGGTTTCATTTCTAGCCAATTATTTGTATCTTAAGTTTTTGTTAGTACCAAAATAATCTGTTATATGAACAGACTTTTAAAATAATTTCTGTATATTATATATATAAGAAAGCTTTTATTGAACAGCTTATCTTCCACTTGCAAGTTTATGGAAATATCAGTATGTCAAAATAAATAAAAAGTGGGAGAATTATTTGGTATTAGAAGAATGTTTTAATTATTTTGATTTTTTTAATGGGATATAATCAAAGTACTGCTGAACTATAGGTGCAGTATTCTACTAAACATTTCAGCTAGTAATACCACTGATTTAGAAACAAAACTGCTTATCTCTGCCTTCTGAATTTAGAATGTTGAGATTACCTGTTTAAATCTGTTTTGGGGGATGTAGACATTAAGTCTGTACATACATGTGTACATATATTCATGCACCTTCTGATTTTGGTTTTCTTGTTTTTGAGTTCTTAGAAAGTATTCACATACTCTTTTTTTTGGTAGAAGTAGCTGTTGTACAATGAAGAAAAGGATAAGACTTTAAACAGTTGATTCTGTTTGTGTTTTCTCCAAATTATTTTTTGAAATTTACCTTACAAGCAAACTCATTTTCTGGTTTTCAGAAATAGATGATTATTTCAGAGCAGTAAGACATGACAAACAGCATGCCCAGGAGGATTTTAGGTAGTCAAATTCAGCTGAGAAAAAGGTGTTTTCAAGTCATAAGTTGCTCATTGATATGGTATGAACTAGTCAAAATATGAACCATTATAATTCAAGTTAGATTTTCTTCTGGAGAGACAGATTTGAATGTTCAGTTCGGGATGACTAAAATTTGACATAATGGTATAAATGGATTGTTAAGAATAACTTTAAGTTGAAGATTAAAGCAAGATGCCATTTTCCCCATGACTTCGATTTTGTTTACATTTTTTCCTTTAAGTTAGT
>NM_001291504.2
GCTTCGGCGTCGCGTCGCTCCTGCGCTGGAGCTCTAGGCCGGCGTCTCTCCGCGAGCCGCGGGTCAAGTGCCAGTGGCTAAGGGTGCGCGAGTAGCCGCCACCCGTTCGGCGTTGGCTCTGGCGTCGGGGTCGTTGTGTCGTGACAACCGCTGCGGTAGCCGTTTCCGAGGCAGCAGTTGCGGCCGCTTTAGCCCTGAGCGGGATCTGCGGCTGCCTGCGAGTCTCTGCTGTGCCGACCCTTCTCTTCGCGGACCCCACGCCAAGCAGCGACCCTGAGCCGACAGCCGGAGCGCCCGGCAATGGCGGCCTCGACGGCCTCGCACCGGCCCATCAAGGGGATCTTGAAGAACAAGACCTCTACGACTTCCTCTATGGTGGCGTCGGCCGAACAGCCCCGCGGGAATGTCGACGAGGAGCTGAGCAAAAAATCCCAGAAGTGGGATGAAATGAACATCTTGGCGACGTATCATCCAGCAGACAAAGACTATGGTTTAATGAAAATAGATGAACCAAGCACTCCTTACCATAGTATGATGGGGGATGATGAAGATGCCTGTAGTGACACCGAGGCCACTGAAGCCATGGCGCCAGACATCTTAGCCAGGAAATTAGCTGCAGCTGAAGGCTTGGAGCCAAAGTATCGGATTCAGGAACAAGAAAGCAGTGGAGAGGAGGATAGTGACCTCTCACCTGAAGAACGAGGTAAAAAAAAGCGACAATTTGAAATGAAAAGGAAGCTTCACTACAATGAAGGACTCAATATCAAACTAGCCAGACAATTAATTTCAAAAGACCTACatgatgatgatgaagatgaagaaatgttagagactgcagatggagaaagcatgaatacggaagaatcaaatcaagGATCTACTCCAAGTGACCAACAGCAAAACAAATTACGAAGTTCATAGACGAGATTTGTTCAACACTGCAATTGTTTGTTAGATGTAAACCCTGTGACTATAGTACGTTGCTTCTTGTTCTTCACAATTCATGACTTAAGTACCAAAATGCATACCAGTTATTATATATTGCCAAGAATTAAATGATAAACTTAGAGACTGATTAGACTGAAAATGCCTAATCGATATATATATTCTTGTGCCTAGTACTTTACCACAAATACAGTGTAATATCATCAGTCCAAAACTGCATTACTTTTGTAAAAACACTGGTTAATTTGTATAAGATATTATAGAGCTTTTTATGCTTTAGAAGTTAAACAATATCTTTGGGGGGGAACTAATTTATTTTCATCACTTGAAATGTGGTAGCTCTTACAAAGTTTATTGATTTGATTTTTTTAAAAATCAAAAGCCAATTGAACAACAGGATATATAGACTGATAAATATTTAGGCTGAATAGTATTTTAACACTTGTCTTCAACTTGATTTGTCTGTTTAATTGAAAAGAATTATAAGAGTTACTGTTGCATTTTCTGACCTACTATTTTTAAAATTCCTGTTGAGTTTCTTTGTGTTTACAAGGAAAGGACTGAACTTTTTCTCATCAAAACTAGCTTTTTTCCCCACAAATAAATTATCAGGTTAAACTTTCACCAATGTCTGCTCTGTTTTTTGTTTTTGGGGGGTTTTTGTTTGTTTTTGTTTTTTAATGTTTTTGGTACACTGGGCAGACTTCAGAGCAGTTTTTTAAAAAAATAAATATTCTAATGTAGCTATCTCGCCATTCCCTTTAAATACCTGTCTTAACCTCCTGCTTTTCTTTCCTACTCCTTTCCACACATACGCACACAATCTTCTACCTTTTAAAGGATCATTAAGACTGTCACCACATTAGGAGCTCTTTCTCTCACTCTTCTGTCATTTGCTGCTATGTTGAAATTCTTATTTTGACCATCAATGCCTATGAATTCTTCTAATACGTGAAGAAAATAGTTTGAGTAGCAGCAGTGCTATAGGTGGGAAATACAGTTTAGCTGCTGAATTTCTATACCTCTCTGATTTACAGATTGCTAATTAAATGGCTATTATTAGTTTGGATTAATTAGACTTAAGAAAACAACTAACTGAGGGTTTTTTTTGTTTGTTTTTTGAGGGTTTTCTTTGCATGAGAATTGTATGTAACCAGTGATATGATTATTCCTGAATGTACAGACAGAAGTAAGCCTGGACATTGTTAAATAGTCCCTGCTTTAAGGGACTACGATAATGTGTACTATGACAAACGTGCTTTATTCTTCTAACGCAGTAAGAATTAGGTGGAATTTTTTCCTTCAACCAAGTGCAGGAAAGCCCTGTGTGTCTTGGTTTAGTTATGGTTTCATTTCTAGCCATACAATTGATGAATTGTGTACAACTTTTGTTAGTACCAAAATAATCTGTTATATGAACAGACTTCTAAAATAACGTCTGTATATTTTATATATAGATACATATATGAAAGAAGGCTTTTATTGAACAGCTTATCTTCCACTTGCAGGTTTATGGAAACAGCAGTATTTGAAAATAAATAAAAAGTGGGAGAATTCCTTGCTGTTAGAAGAATGTGGCCATTATTTTGATTTTTTGAATGAGATATATAATCAAAGTACTGCTGAACTGTGAGTGCAGTATTCTAAACATTTCAGCTAGGAATACCACTGATTTAGAAACAAAACTGTTTGTCTCTGGTTTCTGAATTTAAAATGTTGGGATTACCTGTTTAAATCTGTCTTGGGGGATGTAGAGATTAAGTCTGTACATGTGCGTGCACATATATTCATGCACCCTCTGATTTTGGTTTTCTTGTTTCTGAGTTCTTAGAAAGTACCCACATACTCTTTTTTTTTTTTTGTAGAAGTAGCTGTCATAGAGTGAAGAAAAGGATAAGACTTTAAACAGTTGATTCTTTTTGTGTTTTCTACAAACTATTTTTTGAAATTTAAATCACAAACTCATTTTCTGGTTTTTAGAAAGTAGATGATGATTTCAGAGGAGTAAGGCATGCCAAGCAGCATGCTCAGTGGGGTTTTAGGCTGTCACATGCAGCTGAGAAAAGGTATGTTCAAGTCATAAGTAGGTAATTGATAGGGTATGAACTAGTCAAAATATGAACCATTATGATTCAAGTTAGATTTTCCTCTGGAGAGACAGATCTGAATGTTCAGTTCTAGCCAAGGTAGATTTTACTTTCAACTTTTTAATCAGTATCACTTTCTGTGCTTAACTATTTGGTGTTACCTTGTCTGTTTTCATTTGTCTAAAATTCTGCAGAGATGACTAAAATTTGACATAATGGTGTAAATGGATTGTTAAGGTAACTTTCAGTTGAAGATTAAAGCAAGATGCCATTTTCCCCATGACTTTGGTTTTGTTTACATTTTTCCCTTTCAGTTAGTATACACTACACGTACTGTAATAAAATACAATAATATGA

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