Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PABPC1P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:146587379-146589228  UCSC
Coordinates (T2T) chr2:147037547-147039396  UCSC
Coordinates (hg19) chr2:147344947-147346796  UCSC
Strand +
Parental Sequence NM_002568.4
Parental seq. overlap 1628 bp
Parental seq. overlap (%) 56.8%
Genomic Region Intergenic
Retrocopy Summary PABPC1P2, located on chr2:146587379-146589228, is a retrocopy of the parental gene PABPC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PABPC1
Full Name poly(A) binding protein cytoplasmic 1
Also known as PAB1|PABP|PABP1|PABPC2|PABPL1
Coordinate chr8:100702916-100722088
Strand -
Gene summary This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PABPC1P2
Bonobo Pan paniscus PABPC1P2
Gorilla Gorilla gorilla PABPC1P2
Orangutan Pongo abelii PABPC1P2
Gibbon Nomascus leucogenys PABPC1P9
Green monkey Chlorocebus sabaeus PABPC1P3
Crab-eating macaque Macaca fascicularis PABPC1P6
Rhesus Macaca mulatta PABPC1P6
Baboon Papio anubis PABPC1P5
Marmoset Callithrix jacchus PABPC1P5
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PABPC1P2
ATGATTTTTGTCCCTCGGCGCGTGCCCTTGCTCCCCGCCCCCGGCTGCGAGACCCCCGGCCCGGCACTCGCTCTCCTCCTGTCACGAAAGGGTCGCGGCCTGTAGCCCTGTGGGCAGCCGTGCCGCGATGAACCCCAGCGCCCCCAGCTACCACATGGCCTCGCTGTATGTGGGGGACCTGCACCCCGACGTGACTGAATTGATGTTCCAAGAGAAGTTTAGCTCGACAGGTCCACCCTCACCATCCGGGTCTTTAGGGACTGGCTCACCCACCTCTTCGTGGGCTACGTGTCCGTGAACTTCCTGCAGCCGGCAGACGCGGAGCGTGCTCTGGCCACCATGAACTTTGATGTTATAAAGGGCAAGCCAGTATAAGTCCTGTGGTCTCAGCGCGATCTATCGCTGCGCAAAAGTGGAGTGGGCAACGTATTCGTTAAAAACCAGGACAAATCCGTTGAGAAAGCACTGTGTGATGCATTTTCTGCTTTTGGTAACTTCCTTTCGTGTAAGGTAGTTTGTGATGAAAATGGTTCTAAGGGCTGTGGATCTGTACACTTTGAGACACAGGAAGCAGCTGAAGGAGCTATTGAAAAAATGGATGGGATGCTCCTGAATGGTCTCAATGTATTTGTTGGACGGTTTAGGTCTCCTAAAGAACAAGAAGCAGAACTTGGAGCTAGGGCAAAAGAGTCCAAAGTTGGACCTGCCTCAAGTGTAAAAGTAATAACTGATGAAGGTGGAAAATCCAAAGGATTTGGATTTGTAAGCTTTGAAAGGCATGAAGATCCACAGACAGCTATGGATGTGAATGGAAAGGAGTTCAGTGGAAATCAAACTTACATTTGTCTAGCTCCGAAAAAAGTGGAAGAGCAGACAGAACTTAAGTGCAAATTTGAACAGATGAAGCAAGATAGAATCACCAGATACCAGGGTGCTAACGTTTGTGTGAAAAATCTTGATGAGAGTATTGATGATGAACGTCTCCAGAAAGAATTTTCTCCATTTGGTATAATCAATAGTGCAAATGTTATGATGGAGGGTGGTTGCAGCAAAAGGTTTGGCTTTGTATGTTTCTCCTCCCCAGAAGAAGTAGCTAAAGCAGTTACAGCAATGAACGGTAAAATTGTGGCCAGCAAGCCATTGCATGTAGCTTTAGCTCAGTGCAAAGAACAGCGCCTGGCTCACTTCACTAACCAATACATGCAGAAGATGGCAAGTGTACGAGCTGTGCCCCACCCTGTAATCAACCCCTACCAGCCAGCACCTTCTACATGTTACTTCGTAGCAGCTATCCCACAGACCCAGAACCGTGCTGCATACTATCCTCCTGGCCAAATTGCTCAACTAAGACCAAGTCCTCCCTGGGCTGTTCAGAGTGTCAGACCTTATCCATTCCAAATATGACCTGTGCTATCCGCTCAGCTGCTCGTAACCACCACTCTGAGACCAGCTTCTTCACAGGTTCCACCAGTCATGTCCACACAGTATGTTGCTAACTCATCAATACAGACAATTAGTCCATGTCCTGTAGCTGCTGCTGCTGGCTCCACTCCTGCGGTCTACATCATTCCACAGTACAAATATGCTTCAGGAATTCTCATTCCTCAGCAGCATCTTAAAGCACATCCACAGGTTACCAGGAAGCAGCTTGCTGTTCATGTCCAAGGTCAAAAACTTTTGACTGCTTCCATGTTAGCATCTGCCCCTCTTCAGCAGCAGAAGCAGATATTGGGTGAAAGACTCTTTCCTCTTATTCAAGCCACGCACCCTACTCTTGCTGGTAAAATCACTGGCATGTTATTGGAGCTTGATAATTTAAAACTTCTTCATATGCTTGTGTCTCCGGAGTC
>NM_002568.4
CCCCTTCTCCCCGGCGGTTAGTGCTGAGAGTGCGGAGTGTGTGCTCCGGGCTCGGAACACACATTTATTATTAAAAAATCCAAAAAAAATCTAAAAAAATCTTTTAAAAAACCCCAAAAAAATTTACAAAAAATCCGCGTCTCCCCCGCCGGAGACTTTTATTTTTTTTCTTCCTCTTTTATAAAATAACCCGGTGAAGCAGCCGAGACCGACCCGCCCGCCCGCGGCCCCGCAGCAGCTCCAAGAAGGAACCAAGAGACCGAGGCCTTCCCGCTGCCCGGACCCGACACCGCCACCCTCGCTCCCCGCCGGCAGCCGGCAGCCAGCGGCAGTGGATCGACCCCGTTCTGCGGCCGTTGAGTAGTTTTCAATTCCGGTTGATTTTTGTCCCTCTGCGCTTgctccccgctcccctccccccggctccggcccccagccccGGCACTCGCTCTCCTCCTCTCACGGAAAGGTCGCGGCCTGTGGCCCTGCGGGCAGCCGTGCCGAGATGAACCCCAGTGCCCCCAGCTACCCCATGGCCTCGCTCTACGTGGGGGACCTCCACCCCGACGTGACCGAGGCGATGCTCTACGAGAAGTTCAGCCCGGCCGGGCCCATCCTCTCCATCCGGGTCTGCAGGGACATGATCACCCGCCGCTCCTTGGGCTACGCGTATGTGAACTTCCAGCAgccggcggacgCGGAGCGTGCTTTGGACACCATGAATTTTGATGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGTAGGCAACATATTCATTAAAAATCTGGACAAATCCATTGATAATAAAGCACTGTATGATACATTTTCTGCTTTTGGTAACATCCTTTCATGTAAGGTGGTTTGTGATGAAAATGGTTCCAAGGGCTATGGATTTGTACACTTTGAGACGCAGGAAGCAGCTGAAAGAGCTATTGAAAAAATGAATGGAATGCTCCTAAATGATCGCAAAGTATTTGTTGGACGATTTAAGTCTCGTAAAGAACGAGAAGCTGAACTTGGAGCTAGGGCAAAAGAATTCACCAATGTTTACATCAAGAATTTTGGAGAAGACATGGATGATGAGCGCCTTAAGGATCTCTTTGGCAAGTTTGGGCCTGCCTTAAGTGTGAAAGTAATGACTGATGAAAGTGGAAAATCCAAAGGATTTGGATTTGTAAGCTTTGAAAGGCATGAAGATGCACAGAAAGCTGTGGATGAGATGAACGGAAAGGAGCTCAATGGAAAACAAATTTATGTTGGTCGAGCTCAGAAAAAGGTGGAACGGCAGACGGAACTTAAGCGCAAATTTGAACAGATGAAACAAGATAGGATCACCAGATACCAGGGTGTTAATCTTTATGTGAAAAATCTTGATGATGGTATTGATGATGAACGTCTCCGGAAAGAGTTTTCTCCATTTGGTACAATCACTAGTGCAAAGGTTATGATGGAGGGTGGTCGCAGCAAAGGGTTTGGTTTTGTATGTTTCTCCTCCCCAGAAGAAGCCACTAAAGCAGTTACAGAAATGAACGGTAGAATTGTGGCCACAAAGCCATTGTATGTAGCTTTAGCTCAGCGCAAAGAAGAGCGCCAGGCTCACCTCACTAACCAGTATATGCAGAGAATGGCAAGTGTACGAGCTGTTCCCAACCCTGTAATCAACCCCTACCAGCCAGCACCTCCTTCAGGTTACTTCATGGCAGCTATCCCACAGACTCAGAACCGTGCTGCATACTATCCTCCTAGCCAAATTGCTCAACTAAGACCAAGTCCTCGCTGGACTGCTCAGGGTGCCAGACCTCATCCATTCCAAAATATGCCCGGTGCTATCCGCCCAGCTGCTCCTAGACCACCATTTAGTACTATGAGACCAGCTTCTTCACAGGTTCCACGAGTCATGTCAACACAGCGTGTTGCTAACACATCAACACAGACAATGGGTCCACGTCCTGCAGCTGCAGCCGCTGCAGCTACTCCTGCTGTCCGCACCGTTCCACAGTATAAATATGCTGCAGGAGTTCGCAATCCTCAGCAACATCTTAATGCACAGCCACAAGTTACAATGCAACAGCCTGCTGTTCATGTACAAGGTCAGGAACCTTTGACTGCTTCCATGTTGGCATCTGCCCCTCCTCAAGAGCAAAAGCAAATGTTGGGTGAACGGCTGTTTCCTCTTATTCAAGCCATGCACCCTACTCTTGCTGGTAAAATCACTGGCATGTTGTTGGAGATTGATAATTCAGAACTTCTTCATATGCTCGAGTCTCCAGAGTCACTCCGTTCTAAGGTTGATGAAGCTGTAGCTGTACTACAAGCCCACCAAGCTAAAGAGGCTGCCCAGAAAGCAGTTAACAGTGCCACCGGTGTTCCAACTGTTTAAAATTGATCAGGGACCATGAAAAGAAACTTGTGCTTCACCGAAGAAAAATATCTAAACATCGAAAAACTTAAATATTATGGAAAAAAAACATTGCAAAATATAAAATAAATAAAAAAAGGAAAGGAAACTTTGAACCTTATGTACCGAGCAAATGCCAGGTCTAGCAAACATAATGCTAGTCCTAGATTACTTATTGATTTAaaaacaaaaaaacacaaaaaaatagtaaaatataaaaacaaattaATGTTTTATAGACCCTGGGAAAAAGAATTTTCAGCAAAGTACAAAAATTTAAAGCATTCCTTTCTTTAATTTTGTAATTCTTTACTGTGGAATAGCTCAGAATGTCAGTTCTGTTTTAAGTAACAGAATTGATAACTGAGCAAGGAAACGTAATTTGGATTATAAAATTCTTGCTTTAATAAAAATTCCTTAAACAGTG

Publications

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