Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DSTNP1
Plot displaying the genomic locations of a retrocopy (in chr21) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr21:46653595-46654024  UCSC
Coordinates (T2T) chr21:45039945-45040374  UCSC
Coordinates (hg19) chr21:48073507-48073936  UCSC
Strand -
Parental Sequence NM_006870.4
Parental seq. overlap 325 bp
Parental seq. overlap (%) 9.5%
Genomic Region Intergenic
Retrocopy Summary DSTNP1, located on chr21:46653595-46654024, is a retrocopy of the parental gene DSTN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DSTN
Full Name destrin, actin depolymerizing factor
Also known as ACTDP|ADF|HEL32|bA462D18.2
Coordinate chr20:17569173-17609919
Strand +
Gene summary The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DSTNP4
Bonobo Pan paniscus DSTNP4
Gorilla Gorilla gorilla DSTNP3
Orangutan Pongo abelii DSTNP4
Gibbon Nomascus leucogenys DSTNP3
Green monkey Chlorocebus sabaeus DSTNP1
Crab-eating macaque Macaca fascicularis DSTNP2
Rhesus Macaca mulatta DSTNP2
Baboon Papio anubis DSTNP1
Golden snub-nosed monkey Rhinopithecus roxellana DSTNP5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DSTNP1
GGCTGTCATTTTTTGTCCCAGTGCAGACAAAGTGCATTGTTGTAGAAGGAGGTGAAGAGACCTTGGTTGGAGATGTCTAAGTGTAGCCATAAGCGGTCCTTCAAGCATGTGGTGGCAATGTTTCCTGAAAAAGATGTCTCTGTACTTTGTATGAGGCAAGCTTTAAAACCAAGGAATCCAGAAGAGTTGATGGTTTTGTGTGTGTGCGTGTGGGCACCAGAACTAGCACCTCTGAAAAGTAAAATGATCTACATGAGCTCCAGGGAATGCAACCAAAAAGAAATATCAAGGCATAAAACATGAACATCAAGCAAAGGGGCCAGAAGTCCTCAGAAGTGCAAGCTGCTGATTAACTATGCTGCATTTTTTATGACGTGAAAGTTCGGAAATGCTCCACGCCa
>NM_006870.4
GCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCAGCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGCCTCAGGAGTGCAAGTAGCTGATGAAGTATGTCGCATTTTTTATGACATGAAAGTTCGTAAATGCTCCACACCAGAAGAAATCAAGAAAAGAAAGAAGGCTGTCATTTTTTGTCTCAGTGCAGACAAAAAGTGCATCATTGTAGAAGAAGGCAAAGAGATCTTGGTTGGAGATGTTGGTGTAACCATAACTGATCCTTTCAAGCATTTTGTGGGAATGCTTCCTGAAAAAGATTGTCGCTATGCTTTGTATGATGCAAGCTTTGAAACAAAAGAATCCAGAAAAGAAGAGTTGATGTTTTTTTTGTGGGCACCAGAACTAGCACCTCTGAAAAGTAAAATGATCTATGCAAGCTCCAAGGATGCAATTAAAAAGAAATTTCAAGGCATAAAACATGAATGTCAAGCAAATGGACCAGAAGATCTCAATCGGGCTTGTATTGCTGAAAAGTTAGGTGGATCCTTAATTGTAGCCTTTGAAGGATGCCCTGTGTAGATTATTCAGTGCCACAAATTGAAAGCTTCCATGTTTAATGTTATCCTCTTGCTATATAAATAAAGCAAATATATTTAGGCCAGGGTCTCACTGAGGGGGAGCTGTCTTGTCATCTTTTAGAGTAAACTATTCTATAAACATATGCAAACAGCCCTAAATAAATCTAAAGTCTAAAGTTTTATTGATGTGAAATTAAATTCTTATTGGCCAAATGCCTGTTTTGATGAGTTGATTTATAAAGATTTTTGTTAAGCTCAGGATTTTAAATTACACAGTTCACAAACAGTAAAGGCCATGTGAAGAGAATTATTACATCTTTATTAACCTCAGCATTTACTTTGTTTCTTTTGCTTAGGAAATTGCTCATAATCTGGTTATAATTTTGGTCCAAATTCTTTATTCTTCCTTGAGCTAAGCAGAATAATGGAATATAATATGTCTTCATAATATAACAACACTAATACACTAATAGTAAGATTAAGTTAGGCAGTCTTCTACCAAATGTGTAATGGAGATTGCCTCAAAATTGTGTCCACATAATCCACGCTCATCTTGCAAAGCGCTATTTCAGGCACATCATTGGAATACAGGAAGTAGCCCTGCACCTGCCAGTGAGCTCGCCATTCACTGATTGGAAGAGTGACCTGGCATCTTGGAAATCATTGTGTGTCTTCAGGAGAATGTGCAGTGTCTTGTAACAACTAATTATAATGCAAATTAGGGCTACATTGTAATCTGCTTTGTTAATGAAAATGATAAAACAGAATATTGACAAGCTAGGACACCTGTGGTATCTTTAATTGTATCTCCTTCAGAAGTTTGCTTCTTATGGTATAATAAAGTATGGAAGAATATTGAGTATATGTTTACTCTGGGCCTGGGAGAACTTAACTTTCTAGAGCAGTTTGTTGACTTGTGTGCAATGGGGAGAGGTACCATGATGACACTCACAGGGAGCCACTGTTCACTGACACTTGGAAGCGGTCATTGTTAATATCACGGGCGTAACACTTTGAACGATATAGAGATGCACAAACAGTTGAACTTAGAAGTAGCAGTATTGGCTTTATGTAATAAAGGAAGCATTTTTGACTTACCTCTCGTGTAATTTTCATGTGTGAATTGGGAATACAGGATTTTGCCTTCCATATGGGGTAAGGCATTGAGGTTTGGGTATTTCCAATAATTAAGAGTTAAGGTTggctgagtgtggtggctcactcctgtaatcccagcattttgggaggccgaggcaagaggatagtttgaggccaggagtttgacaatcagcgtgggcaacatagtgggatctcatctactaaaaataaacaaaattagccgggtgtggtggtgcacgtcagtagtcccagctactttggatgctgaggtgggaggatcacttgagcccaggaggtgagctgagatcgtgccactgtactccagcctggatgacagagcaagaccttgtctcaaaaaaaaaaaaaaaaGTCACAACTCCCTCTGGTGAATAAGAAAGTTGGTGTAAAAGTTGGGAACGTTTTCAATGTTTATTACACTATAAGTGTAAtaaatattatacaaaattataaattcacatttaaaatttagaaAATAGAGAAAAGGGAAATTATACATTGTCCTACCACATGCCATCACATGGTTAGCATTTTGATACACAGCTGTGCATTATTACATGTCAAAgactgcatatactatggtggtcccatacaattataatgtattttctactgtaattagatacacaaataccattgtgttacagttgccgacagtattcagtatagtaacgtgctgtccaggtttgtggtctaggagtaataggctctaccatacagcctaggtgtgtagtaggctatgccactaggtttaagtgcagtctagggtgGGGAACATTTTAATGTTGATCCACATGCCAGGTGTTTGTGAGACAAGATTATGCTTTAATCAAAATATTTTGGAATTGTCTAGAAAATAGTGCTGGCTGCTTGTCATTCATCCTGAATTGCTTGTTTCTTTACTTTGTAGCAATGCTTTTAGTGTGGGttttgttttttgagacagggtctcactctttcccccaggctagagtgcagtggtgcaatcataactcactgcatccttgaactcttgggctccagcaagcctcctgccttggcctcctaaagtgctgtgattacaggtgtgagccactgtgtcctgcTAGTGATTGTGATTAACAGGCCTCCAGGGAAGTGCCATAAGCCCAAGACTGCCGTACTCAAAAGTCAGCCATGTAGGTAAAGCAAGATATTTGGTCAAGGAGTTTTAGAAGGAGATTTTTCCTGTGGTGTTGGCTTAAGTGTGGCACTGTTGTGCGTGTGTGAGGTGTCTTCTGTGGGAAGGATTTCAAACAGTACAAAGGGATGTGATGTAAGCATCCAGAACTCACTCCAGAAATTGAATAAAATGCTAGTAGTTAGTCTCTAGGGGAACTTTTGAGAAAGTCTCAGTGGATTCCtgaggcccaagaattgtgctaacaagcactcaaggcgattctggtacataattagggttcagaCCTCAGCTGATTGGTCTACTGTTGGTCAGGAACAAAACTGCAAGTATACTCTGTTTCCAGAAAATACGTTTACCTCTTCACAAATGCTAACACACTGCAAAAATATGTTTGTGGAAAGCTGACTTAGTCTCATCTAGCGGTTACTCTCTTGCCCTGACAAAGCAGCAAATAAAGCCATTGCTAACAATTCAA

Publications

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