Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDK7P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:157210335-157211525  UCSC
Coordinates (T2T) chr2:157663496-157664686  UCSC
Coordinates (hg19) chr2:158066847-158068037  UCSC
Strand -
Parental Sequence NM_001324077.1_2
Parental seq. overlap 1140 bp
Parental seq. overlap (%) 82.4%
Genomic Region Intergenic
Retrocopy Summary CDK7P1, located on chr2:157210335-157211525, is a retrocopy of the parental gene CDK7. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDK7
Full Name cyclin dependent kinase 7
Also known as CAK|CAK1|CDKN7|HCAK|MO15|STK1|p39MO15
Coordinate chr5:69234795-69277430
Strand +
Gene summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CDK7P1
Bonobo Pan paniscus CDK7P1
Gorilla Gorilla gorilla CDK7P1
Orangutan Pongo abelii CDK7P1
Gibbon Nomascus leucogenys CDK7P1
Green monkey Chlorocebus sabaeus CDK7P1
Crab-eating macaque Macaca fascicularis CDK7P1
Rhesus Macaca mulatta CDK7P1
Baboon Papio anubis CDK7P1
Golden snub-nosed monkey Rhinopithecus roxellana CDK7P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDK7P1
GATACTAATGCAATGGAGCCTGGTGGACAGAAGCGGCTGTTGGAGGCTTTAAGTTTGCCACGGTTTACAAGGCCAGAGATAAGAATACCAACCAAATTGTCACCATTAAGAAAATCAAACTTGGACATAGATCAGAAGCTAAAAATGGTATAAACAGAACAGCCTTAAGAGAGATACAATTATTACAAGAGCTAAGTCATCCAAATATAATTGGTCTCCTTGATGCTTTTGGATGTAAGTCTAATATTAGCCTTGTCTTTGGTTTTATGGAAACTGATCTAGAGGTTATAATAAAGGATAATAGTCTTGTGCTGACACCGTCACACATCAAAGCCTGCATGTTGATGACTCTTCAAGGATTAGAATATTTACATCAACATTGGATCCTACATAGGGATCTGAAACCAAGCAACTTGTTGCTAGATGAAAATGGAGTTCTAAAACTGGCAGATTTTGGCCTGGCCAAATCATTTGGGAGCCCCAGTAGAGCTTATACATATCAGGTTGCAACCAGGTGGTATCAGGCCCCTGAGTTACTATTTGGAGCTAGGATGTATGGTGTAGGTGTGGACATGTGGGCTGTTGGCTGTATATTAGCAGAGTTACTTCTAAGGGTTCCTTTTTTGTCAGGAGATTCAGAGCTTGATCAGCTAACAAGAATATTTGGGCACACCAACTGAGGAACAGTGGCCGGACATGTGTAGTCTTCCAGATTATGTGACATTTAAGAGTTTCCCTGGAATCCCATGGCATCACATCTTCAGTGCAGCAGGAGACGACTTACTAGATCTCATACAAGGCTTATTCTTATTTAATCCATGTGTTCGAATTACGGCCACACAGGCACTGAAAATGAAGTATTTCAGTAATCGGCCAGGGCCAACACCTGGATGTCAGCTGCCAAGACCCAACTGTCCAGTGGAAACCTTAAAGGAGCAATCAAATCCTGCTTTGGCGACAAAAAGGAAAAGAACACAGGCCTTGGAACAAGGAGGATTGCCCAAGAAACTAATTTTTTAAAGAGAACACTGGACAACATTTTACTACTGAAGGAAATAGTCAAAAAGGCAAATAATGAAAAAATAGTAAACATTAAGTAAATGCTGTGGAAGTGAATTTGTAAATATTCTACACATGTAAAATATATAAAACTATGGGTTATTTTTATTAAATGTATTTTAAAATa
>NM_001324077.1_2
GGAACGCCAACCGCCTGGGCCTAGCGCAGCTTCCTCCGCCCACCACGGAAGTGAGGCGGGGATACTAAAGCGACGGAGCCCGGTGGACGGAAGTGGGTGTTGGAGGCTTTAAGTTTGCCACCGTTTACAAGGCCAGAGATAAGAACACCAACCAAATTGTCGCCATTAAGAAAATCAAACTTGGACATAGATCAGAAGCTAAAGATGGTATAAATAGAACCGCCTTAAGAGAGATAAAATTATTACAGGAGCTAAGTCATCCAAATATAATTGGTCTCCTTGATGCTTTTGGACATAAATCTAATATTAGCCTTGTCTTTGATTTTATGGAAACTGATCTAGAGGTTATAATAAAGGATAATAGTCTTGTGCTGACACCATCACACATCAAAGCCTACATGTTGATGACTCTTCAAGGATTAGAATATTTACATCAACATTGGATCCTACATAGGGATCTGAAACCAAACAACTTGTTGCTAGATGAAAATGGAGTTCTAAAACTGGCAGATTTTGGCCTGGCCAAATCTTTTGGGAGCCCCAATAGAGCTTATACACATCAGGTTGTAACCAGGTGGTATCGGGCCCCCGAGTTACTATTTGGAGCTAggatgtatggtgtaggtgtggacatgtgggctgttggctgtATATTAGCAGAGTTACTTCTAAGGGTTCCTTTTTTGCCAGGAGATTCAGACCTTGATCAGCTAACAAGAATATTTGAAACTTTGGGCACACCAACTGAGGAACAGTGGCCGGACATGTGTAGTCTTCCAGATTATGTGACATTTAAGAGTTTCCCTGGAATACCTTTGCATCACATCTTCAGTGCAGCAGGAGACGACTTACTAGATCTCATACAAGGCTTATTCTTATTTAATCCATGTGCTCGAATTACGGCCACACAGGCACTGAAAATGAAGTATTTCAGTAATCGGCCAGGGCCAACACCTGGATGTCAGCTGCCAAGACCAAACTGTCCAGTGGAAACCTTAAAGGAGCAATCAAATCCAGCTTTGGCAATAAAAAGGAAAAGAACAGAGGCCTTAGAACAAGGAGGATTGCCCAAGAAACTAATTTTTTAAAGAGAACACTGGACAACATTTTACTACTGAGGGAAATAGCCAAAAAGGCAAATAATGGAAAAATAGTAAACATTAAGTAAATGCTGTAGAAGTGAGTTTGTAAATATTCTACACATGTAAAATATGTAAAACTATGGGTTATTTTTATTAAATGTATTTTAAAATAAAAATTTAATTCTGGTTTTTCTGATTAGAGTGCAAAAGTGAGAAAAGTTCAATACTCTTGAAATGTAGAATTGAAAATGCATTAGGGAAAACTTAATAAAAATTATTACCAGTTATTTGGAAGATCTGA

Publications

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