Summary

Retrocopy Name	HDAC1P3
Species	Homo sapiens
Coordinates (hg38)	chr2:164391636-164392362  UCSC
Coordinates (T2T)	chr2:164848967-164849693  UCSC
Coordinates (hg19)	chr2:165248146-165248872  UCSC
Strand	+
Parental Sequence	NM_004964.3
Parental seq. overlap	586 bp
Parental seq. overlap (%)	27.4%
Genomic Region	Intergenic
Retrocopy Summary	HDAC1P3, located on chr2:164391636-164392362, is a retrocopy of the parental gene HDAC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	HDAC1
Full Name	histone deacetylase 1
Also known as	GON-10|HD1|KDAC1|RPD3|RPD3L1
Coordinate	chr1:32292083-32333628
Strand	+
Gene summary	Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Homology

	Species	Scientific Name	Retrocopy
	Chimpanzee	Pan troglodytes	HDAC1P2
	Bonobo	Pan paniscus	HDAC1P2
	Gorilla	Gorilla gorilla	HDAC1P2
	Orangutan	Pongo abelii	HDAC1P2
	Gibbon	Nomascus leucogenys	HDAC1P4
	Green monkey	Chlorocebus sabaeus	HDAC1P2
	Crab-eating macaque	Macaca fascicularis	HDAC1P4
	Rhesus	Macaca mulatta	HDAC1P4
	Baboon	Papio anubis	HDAC1P3
	Golden snub-nosed monkey	Rhinopithecus roxellana	HDAC1P6
	Marmoset	Callithrix jacchus	Without Homology
	Mouse lemur	Microcebus murinus	Without Homology
	Mouse	Mus musculus	Without Homology
	Rat	Rattus norvegicus	Without Homology
	Chinese hamster	Cricetulus griseus	Without Homology
	Rabbit	Oryctolagus cuniculus	Without Homology
	Pig	Sus scrofa	Without Homology
	Cow	Bos taurus	Without Homology
	Sheep	Ovis aries	Without Homology
	Dolphin	Tursiops truncatus	Without Homology
	Horse	Equus caballus	Without Homology
	Dog	Canis familiaris	Without Homology
	Panda	Ailuropoda melanoleuca	Without Homology
	Cat	Felis catus	Without Homology
	Pale spear-nosed bat	Phyllostomus discolor	Without Homology
	Velvety free-tailed bat	Molossus molossus	Without Homology
	Greater mouse-eared bat	Myotis myotis	Without Homology
	Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
	Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
	Egyptian rousette	Rousettus aegyptiacus	Without Homology
	Sloth	Choloepus didactylus	Without Homology
	Tasmanian Devil	Sarcophilus harrisii	Without Homology
	Opossum	Monodelphis domestica	Without Homology
	Platypus	Ornithorhynchus anatinus	Without Homology
	Chicken	Gallus gallus	Without Homology
	Turkey	Meleagris gallopavo	Without Homology
	Zebra Finch	Taeniopygia guttata	Without Homology
	Budgerigar	Melopsittacus undulatus	Without Homology
	Painted Turtle	Chrysemys picta	Without Homology
	Lizard	Anolis Carolinensis	Without Homology
	Frog	Xenopus tropicalis	Without Homology
	Zebrafish	Danio rerio	Without Homology
	Drosophila	Drosophila melanogaster	Without Homology

Expression

This retrocopy transcript is not present in the ARCHS4 database for expression quantificationThis retrocopy transcript is not present in the GTEx database for expression quantification.

Related Sequence

>HDAC1P3

GAAGAGGGTCAAAACAGAGGATGAAAAAGAGAAAGTCTCAAAGGAGAAGAAAGTCTCAAAGCCACAGAAGAGGAGAAAAGGAAAGAGGAGAAGCAAGAAGCCAAAGGGATCAAGGAGAAGATCAAGTTGGCCTGAGCAGACCTCTCCTGATTCATGGCTTCTTGCCAAGTCTCCCACCTTTTTCCCCTAACCCTTCAGtAAAAATTTATCAAATATAAGTATTCCCAGGGACTAAACAGAAACCAAGGCCCTGAGCCCATGGCAGCTATGCTGGGTGAGCTCTTCTAGGAGCTGCATTGCCACCCATCCCTCCCCAGTTTTTAACTTTGAACCATAAAAGGTGCCAAGTCTGGGTGGAAGTAATACTTTTATGCAACCATAAGACAAAATCCTGAAATGCCATGGGCCGCTTAGTAGCTTTGGAAAGGTGCCCTTATTGAGCATTCTAAAAGGGTTGGCTGGGTCTTTAAGGACCCACTGTTCTTCTCAGTCTCCTAAGGTTAACATCGCCCATTTTTAGGTTGGTTCTGTTTTCATAGCTCCCACTGGTCTCAAGTGAGCTAGGGAATTCACTCTGCCTGCCCTCTCTCTGTCTTGCCCCAGTTCTGAAGGGGTAGGGTGGTAGTCTAGTTTCCTTTTGAGATATTATTTTCATTTTTGTTTGACTCTTTGTGATAAAATGGTACATTTC

>NM_004964.3

CCCCTCCCCCCTGGGTCGGACGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGTGCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCACCATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATCCTGGAACTGCTAAAGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGTGACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATTTTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAGTGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGACACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGCGGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTGGATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGATTTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAGAAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAAATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGACCCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTCTCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCCAAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACCGAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAGTTGGCCTGAATGGACCTCTCCAGCTCTGGCTTCCTGCTGAGTCCCTCACGTTTCTTCCCCAACCCCTCAGATtttatattttctatttctctgtgtatttatataaaaatttattaaatataaatatCCCCAGGGACAGAAACCAAGGCCCCGAGCTCAGGGCAGCTGTGCTGGGTGAGCTCTTCCAGGAGCCACCTTGCCACCCATTCTTCCCGTTCTTAACTTTGAACCATAAAGGGTGCCAGGTCTGGGTGAAAGGGATACTTTTATGCAACCATAAGACAAACTCCTGAAATGCCAAGTGCCTGCTTAGTAGCTTTGGAAAGGTGCCCTTATTGAACATTCTAGAAGGGGTGGCTGGGTCTTCAAGGATCTCCTGTTTTTTTCAGGCTCCTAAAGTAACATCAGCCATTTTTAGATTGGTTCTGTTTTCGTACCTTCCCACTGGCCTCAAGTGAGCCAAGAAACACTGCCTGCCCTCTGTCTGTCTTCTCCTAATTCTGCAGGTGGAGGTTGCTAGTCTAGTTTCCTTTTTGAGATACTATTTTCATTTTTGTGAGCCTCTTTGTAATAAAATGGTACATTTCTATA

Publications

PMID - Link	Title
No publications available for this retrocopy