Summary

Retrocopy Name	TXNP8
Species	Homo sapiens
Coordinates (hg38)	chr2:169766000-169766159  UCSC
Coordinates (T2T)	chr2:170246000-170246159  UCSC
Coordinates (hg19)	chr2:170622510-170622669  UCSC
Strand	-
Parental Sequence	NM_001244938.2
Parental seq. overlap	140 bp
Parental seq. overlap (%)	20.7%
Genomic Region	Intergenic
Retrocopy Summary	TXNP8, located on chr2:169766000-169766159, is a retrocopy of the parental gene TXN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	TXN
Full Name	thioredoxin
Also known as	TRDX|TRX|TRX1|Trx80
Coordinate	chr9:110243810-110256507
Strand	-
Gene summary	The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Homology

	Species	Scientific Name	Retrocopy
	Chimpanzee	Pan troglodytes	TXNP4
	Bonobo	Pan paniscus	TXNP4
	Gorilla	Gorilla gorilla	TXNP4
	Gibbon	Nomascus leucogenys	TXNP9
	Green monkey	Chlorocebus sabaeus	TXNP5
	Crab-eating macaque	Macaca fascicularis	TXNP8
	Rhesus	Macaca mulatta	TXNP10
	Baboon	Papio anubis	TXNP8
	Golden snub-nosed monkey	Rhinopithecus roxellana	TXNP9
	Orangutan	Pongo abelii	Without Homology
	Marmoset	Callithrix jacchus	Without Homology
	Mouse lemur	Microcebus murinus	Without Homology
	Mouse	Mus musculus	Without Homology
	Rat	Rattus norvegicus	Without Homology
	Chinese hamster	Cricetulus griseus	Without Homology
	Rabbit	Oryctolagus cuniculus	Without Homology
	Pig	Sus scrofa	Without Homology
	Cow	Bos taurus	Without Homology
	Sheep	Ovis aries	Without Homology
	Dolphin	Tursiops truncatus	Without Homology
	Horse	Equus caballus	Without Homology
	Dog	Canis familiaris	Without Homology
	Panda	Ailuropoda melanoleuca	Without Homology
	Cat	Felis catus	Without Homology
	Pale spear-nosed bat	Phyllostomus discolor	Without Homology
	Velvety free-tailed bat	Molossus molossus	Without Homology
	Greater mouse-eared bat	Myotis myotis	Without Homology
	Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
	Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
	Egyptian rousette	Rousettus aegyptiacus	Without Homology
	Sloth	Choloepus didactylus	Without Homology
	Tasmanian Devil	Sarcophilus harrisii	Without Homology
	Opossum	Monodelphis domestica	Without Homology
	Platypus	Ornithorhynchus anatinus	Without Homology
	Chicken	Gallus gallus	Without Homology
	Turkey	Meleagris gallopavo	Without Homology
	Zebra Finch	Taeniopygia guttata	Without Homology
	Budgerigar	Melopsittacus undulatus	Without Homology
	Painted Turtle	Chrysemys picta	Without Homology
	Lizard	Anolis Carolinensis	Without Homology
	Frog	Xenopus tropicalis	Without Homology
	Zebrafish	Danio rerio	Without Homology
	Drosophila	Drosophila melanogaster	Without Homology

Expression

This retrocopy transcript is not present in the GTEx database for expression quantification.

This retrocopy transcript is not present in the ARCHS4 database for expression quantification

Related Sequence

>TXNP8

AACCTTACAATTTTTTAAAAAGAGACAAAATGTGGTTGAATTATCTGGAGCTAATAAGAAAAAACTTGAAGCAACCATTAATCAATCTAATCATGTTCTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTTATTTACAAT

>NM_001244938.2

GAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGCCGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACCATTAATGAATTAGTCTAATCATGTTTTCTGAAAATATAACCAGCCATTGGCTATTTAAAACTTGTAATTTTTTTAATTTACAAAAATATAAAATATGAAGACATAAACCCAGTTGCCATCTGCGTGACAATAAAACATTAATGCTAACACTTTTTAAAACCGTCTCATGTCTGAATAGCTTTCAAAATAAATGTGAAATGGTCATTTAATGTATTTTCCTATATTCTCAATCACTTTTTAGTAACCTTGTAGGCCACTGATTATTTTAAGATTTTAAAAATTATTATTGCTACCTTAATGTATTGCTACAAAAATCTCTTGTTGGGGGCAATGCAGGTAATAAAGTAGTATGTTGTTATTTGTTA

Publications

PMID - Link	Title
No publications available for this retrocopy